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Modern Rheumatology Volume 21, 2011 - Issue 2
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Case Report

Successful tocilizumab treatment in a patient with adult-onset Still’s disease complicated by chronic active hepatitis B and amyloid A amyloidosis

Dai KishidaDepartment of Internal Medicine, Center for Rheumatic Diseases, Dohgo Spa Hospital, 21-21 Otsu Dohgo-Himezuka, Matsuyama, Ehime 790-0858, Japan
,
Yasuaki OkudaDepartment of Internal Medicine, Center for Rheumatic Diseases, Dohgo Spa Hospital, 21-21 Otsu Dohgo-Himezuka, Matsuyama, Ehime 790-0858, JapanCorrespondence[email protected]
,
Makoto OnishiDepartment of Internal Medicine, Center for Rheumatic Diseases, Dohgo Spa Hospital, 21-21 Otsu Dohgo-Himezuka, Matsuyama, Ehime 790-0858, Japan
,
Masashi TakebayashiDepartment of Internal Medicine, Center for Rheumatic Diseases, Dohgo Spa Hospital, 21-21 Otsu Dohgo-Himezuka, Matsuyama, Ehime 790-0858, Japan
,
Kenichiro MatobaDepartment of Internal Medicine, Center for Rheumatic Diseases, Dohgo Spa Hospital, 21-21 Otsu Dohgo-Himezuka, Matsuyama, Ehime 790-0858, Japan
,
Kazuo JouyamaDepartment of Internal Medicine, Center for Rheumatic Diseases, Dohgo Spa Hospital, 21-21 Otsu Dohgo-Himezuka, Matsuyama, Ehime 790-0858, Japan
,
Akihiro YamadaDepartment of Internal Medicine, Center for Rheumatic Diseases, Dohgo Spa Hospital, 21-21 Otsu Dohgo-Himezuka, Matsuyama, Ehime 790-0858, Japan
,
Naoya SawadaDepartment of Internal Medicine, Center for Rheumatic Diseases, Dohgo Spa Hospital, 21-21 Otsu Dohgo-Himezuka, Matsuyama, Ehime 790-0858, Japan
,
Sho MokudaDepartment of Internal Medicine, Center for Rheumatic Diseases, Dohgo Spa Hospital, 21-21 Otsu Dohgo-Himezuka, Matsuyama, Ehime 790-0858, Japan
&
Kiyoshi TakasugiDepartment of Internal Medicine, Center for Rheumatic Diseases, Dohgo Spa Hospital, 21-21 Otsu Dohgo-Himezuka, Matsuyama, Ehime 790-0858, Japan
 show all
Pages 215-218 | Received 14 Jul 2010, Accepted 15 Sep 2010, Published online: 02 Jan 2014

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Yasuaki Okuda. (2019) AA amyloidosis – Benefits and prospects of IL-6 inhibitors. Modern Rheumatology 29:2, pages 268-274.
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Stéphane Mitrovic & Bruno Fautrel. (2018) Complications of adult-onset Still’s disease and their management. Expert Review of Clinical Immunology 14:5, pages 351-365.
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Yumi Tsuchida, Shuji Sumitomo, Hirofumi Shoda, Kanae Kubo, Keishi Fujio & Kazuhiko Yamamoto. (2017) Macrophage activation syndrome associated with tocilizumab treatment in adult-onset Still’s disease. Modern Rheumatology 27:3, pages 556-557.
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Mauro Viganò, Giuseppe Serra, Giovanni Casella, Glenda Grossi & Pietro Lampertico. (2016) Reactivation of hepatitis B virus during targeted therapies for cancer and immune-mediated disorders. Expert Opinion on Biological Therapy 16:7, pages 917-926.
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Christos Koutsianas, Konstantinos Thomas & Dimitrios Vassilopoulos. (2016) Prevention of HBV reactivation in patients treated with biologic agents. Expert Review of Clinical Pharmacology 9:4, pages 579-589.
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Andreas Woerner, Annette von Scheven-Gête, Rolando Cimaz & Michaël Hofer. (2015) Complications of systemic juvenile idiopathic arthritis: risk factors and management recommendations. Expert Review of Clinical Immunology 11:5, pages 575-588.
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Alice Courties, Gilles Grateau, Peggy Philippe, René-Marc Flipo, Leonardo Astudillo, Bérengère Aubry-Rozier, Isabelle Fabreguet, Wafki Fahd, Olivier Fain, Pascal Guggenbuhl, Eric Hachulla, Thomas Papo, Christophe Richez, Jean Sibilia, Jacques Morel, Francis Berenbaum & Jérémie Sellam. (2015) AA amyloidosis treated with tocilizumab: case series and updated literature review. Amyloid 22:2, pages 84-92.
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Sabeeda Kadavath & Petros Efthimiou. (2015) Adult-onset Still's disease—pathogenesis, clinical manifestations, and new treatment options. Annals of Medicine 47:1, pages 6-14.
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Yasuaki Okuda, Makoto Ohnishi, Kenichiro Matoba, Kazuo Jouyama, Akihiro Yamada, Naoya Sawada, Sho Mokuda, Yousuke Murata & Kiyoshi Takasugi. (2014) Comparison of the clinical utility of tocilizumab and anti-TNF therapy in AA amyloidosis complicating rheumatic diseases. Modern Rheumatology 24:1, pages 137-143.
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Rie Suematsu, Akihide Ohta, Emi Matsuura, Hiroki Takahashi, Takao Fujii, Takahiko Horiuchi, Seiji Minota, Yoshiaki Ishigatsubo, Toshiyuki Ota, Shuji Takei, Sachiko Soejima, Hisako Inoue, Syuichi Koarada, Yoshifumi Tada & Kohei Nagasawa. (2012) Therapeutic response of patients with adult Still’s disease to biologic agents: multicenter results in Japan. Modern Rheumatology 22:5, pages 712-719.
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Articles from other publishers (21)

Shruti Bajad, Shounak Ghosh, Dhaval Tanna & Rajiva Gupta. (2023) Adult-onset Still's disease - Taming the beast: The path less taken. Medical Journal Armed Forces India 79:2, pages 247-248.
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Jae Ho Han, Mi-Hyun Ahn, Ju-Yang Jung, Ji-Won Kim, Chang-Hee Suh, Ji Eun Kwon, Hyunee Yim & Hyoun-Ah Kim. (2022) Elevated expression of TLR2 and its correlation with disease activity and clinical manifestations in adult-onset Still’s disease. Scientific Reports 12:1.
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M. Fauter, M. Gerfaud-Valentin, M. Delplanque, S. Georgin-Lavialle, P. Sève & Y. Jamilloux. (2020) Complications de la maladie de Still de l’adulte. La Revue de Médecine Interne 41:3, pages 168-179.
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M. Delplanque, J. Pouchot, S. Ducharme-Bénard, B.J Fautrel, A. Benyamine, L. Daniel, T. Gendre, G. Grateau & S. Georgin-Lavialle. (2020) AA amyloidosis secondary to adult onset Still's disease: About 19 cases. Seminars in Arthritis and Rheumatism 50:1, pages 156-165.
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Christos Koutsianas, Konstantinos Thomas & Dimitrios Vassilopoulos. (2020) Reactivation of hepatitis B virus infection in rheumatic diseases: risk and management considerations. Therapeutic Advances in Musculoskeletal Disease 12, pages 1759720X2091264.
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Le-Feng Chen, Ying-Qian Mo, Jun Jing, Jian-Da Ma, Dong-Hui Zheng & Lie Dai. (2017) Short-course tocilizumab increases risk of hepatitis B virus reactivation in patients with rheumatoid arthritis: a prospective clinical observation. International Journal of Rheumatic Diseases 20:7, pages 859-869.
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Christos Koutsianas, Konstantinos Thomas & Dimitrios Vassilopoulos. (2017) Hepatitis B Reactivation in Rheumatic Diseases. Rheumatic Disease Clinics of North America 43:1, pages 133-149.
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J. Steuart Richards, Sharon Dowell & Mercedes Quinones. 2017. Comorbidity in Rheumatic Diseases. Comorbidity in Rheumatic Diseases 345 380 .
Carolina Diez Morrondo, Lucia Pantoja Zarza, Jenaro Graña Gil, Jose Antonio Pinto Tasende, Paula Dios Diez & Juan Manuel Barja López. (2016) Benefit of Tocilizumab Therapy for Adult-Onset Still Disease Complicated With Acute Respiratory Distress Syndrome. JCR: Journal of Clinical Rheumatology 22:5, pages 291-293.
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Fidaa Bouezzedine, Olivier Fardel & Philippe Gripon. (2015) Interleukin 6 inhibits HBV entry through NTCP down regulation. Virology 481, pages 34-42.
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Worawit Louthrenoo. (2015) Treatment considerations in patients with concomitant viral infection and autoimmune rheumatic diseases. Best Practice & Research Clinical Rheumatology 29:2, pages 319-342.
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Jung Il Lee. (2015) Reactivation of Hepatitis B Virus in Patients with Rheumatologic Disease Treated with Biologic Disease Modifying Anti-rheumatic Drugs: Screening and Treatment. Journal of Rheumatic Diseases 22:5, pages 282.
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Elena Riera Alonso & Alejandro Olivé. 2015. Rheumatology. Rheumatology 720 726 .
Edward Keystone & Mohammed A. Omair. 2015. Rheumatology. Rheumatology 485 491 .
Alexandre Thibault Jacques Maria, Alain Le Quellec, Christian Jorgensen, Isabelle Touitou, Sophie Rivière & Philippe Guilpain. (2014) Adult onset Still's disease (AOSD) in the era of biologic therapies: Dichotomous view for cytokine and clinical expressions. Autoimmunity Reviews 13:11, pages 1149-1159.
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Beatriz Tejera, Melania Mart?nez-Morillo, Susana Holgado & Alejandro Oliv?. (2014) Amiloidosis secundaria en la enfermedad de Still del adulto. Medicina Cl?nica 143:2, pages 92-93.
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Dandan Xuan, Yiqi Yu, Linyun Shao, Jiali Wang, Wenhong Zhang & Hejian Zou. (2013) Hepatitis reactivation in patients with rheumatic diseases after immunosuppressive therapy—a report of long-term follow-up of serial cases and literature review. Clinical Rheumatology 33:4, pages 577-586.
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Toshio Tanaka, Atsushi OgataMasashi Narazaki. (2013) Tocilizumab: An Updated Review of Its Use in the Treatment of Rheumatoid Arthritis and Its Application for Other Immune-Mediated Diseases. Clinical Medicine Insights: Therapeutics 5, pages CMT.S9282.
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Hubert de Boysson, J?rome F?vrier, Am?lie Nicolle, Christophe Auzary & Lo?k Geffray. (2012) Tocilizumab in the treatment of the adult-onset Still's disease: current clinical evidence. Clinical Rheumatology 32:1, pages 141-147.
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Dimitrios Vassilopoulos & Leonard H. Calabrese. (2012) Management of rheumatic disease with comorbid HBV or HCV infection. Nature Reviews Rheumatology 8:6, pages 348-357.
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Toshio Tanaka & Tadamitsu Kishimoto. (2012) Immunotherapeutic implication of IL-6 blockade. Immunotherapy 4:1, pages 87-105.
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