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Modern Rheumatology Volume 21, 2011 - Issue 3
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Original Article

Comparative suppressive effects of tyrosine kinase inhibitors imatinib and nilotinib in models of autoimmune arthritis

Naotsugu AkashiClinical Immunology, Advanced Biochemical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8575, Japan;Translational Sciences Department, Development Division, Novartis Pharma K.K., 17-30 Nishi-Azabu 4-Chome Minato-ku, Tokyo 106-8618, Japan
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Isao MatsumotoClinical Immunology, Advanced Biochemical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8575, JapanCorrespondence[email protected]
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Yoko TanakaClinical Immunology, Advanced Biochemical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8575, Japan
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Asuka InoueClinical Immunology, Advanced Biochemical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8575, Japan
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Kayo YamamotoClinical Immunology, Advanced Biochemical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8575, Japan
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Naoto UmedaClinical Immunology, Advanced Biochemical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8575, Japan
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Yuki TanakaClinical Immunology, Advanced Biochemical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8575, Japan
,
Taichi HayashiClinical Immunology, Advanced Biochemical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8575, Japan
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Daisuke GotoClinical Immunology, Advanced Biochemical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8575, Japan
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Satoshi ItoClinical Immunology, Advanced Biochemical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8575, Japan
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Kaneo SekiguchiTranslational Sciences Department, Development Division, Novartis Pharma K.K., 17-30 Nishi-Azabu 4-Chome Minato-ku, Tokyo 106-8618, Japan
&
Takayuki SumidaClinical Immunology, Advanced Biochemical Applications, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 305-8575, Japan
 show all
Pages 267-275 | Received 04 Aug 2010, Accepted 16 Nov 2010, Published online: 02 Jan 2014

Citations (29)

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Isao Matsumoto, Izumi Kurata, Ayako Ohyama, Hoshimi Kawaguchi, Hiroshi Ebe, Atsumu Osada, Yuya Kondo, Hiroto Tsuboi & Takayuki Sumida. (2020) Revisit of autoimmunity to glucose-6-phosphate isomerase in experimental and rheumatoid arthritis. Modern Rheumatology 30:2, pages 232-238.
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Jun-Wei Yan, Yu-Jie Wang, Wen-Jia Peng, Jin-Hui Tao, Ya-Nan Wan, Bao-Zhu Li, Bin Mei, Bing Chen, Hua Yao, Guo-Jun Yang, Xiang-Pei Li, Dong-Qing Ye & Jing Wang. (2014) Therapeutic potential of interleukin-17 in inflammation and autoimmune diseases. Expert Opinion on Therapeutic Targets 18:1, pages 29-41.
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Articles from other publishers (27)

Mohamed Shalaby, Rania R. Abdelaziz, Hamdy A. Ghoneim & Ghada M. Suddek. (2023) Imatinib mitigates experimentally-induced ulcerative colitis: Possible contribution of NF-kB/JAK2/STAT3/COX2 signaling pathway. Life Sciences 321, pages 121596.
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Mahipal Reddy Donthi, Ranendra Narayan Saha, Gautam Singhvi & Sunil Kumar Dubey. (2023) Dasatinib-Loaded Topical Nano-Emulgel for Rheumatoid Arthritis: Formulation Design and Optimization by QbD, In Vitro, Ex Vivo, and In Vivo Evaluation. Pharmaceutics 15:3, pages 736.
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José Luis Marín-Rubio, Rachel E. Peltier-Heap, Maria Emilia Dueñas, Tiaan Heunis, Abeer Dannoura, Joseph Inns, Jonathan Scott, A. John Simpson, Helen J. Blair, Olaf Heidenreich, James M. Allan, Jessica E. Watt, Mathew P. Martin, Barbara Saxty & Matthias Trost. (2022) A Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Assay Identifies Nilotinib as an Inhibitor of Inflammation in Acute Myeloid Leukemia. Journal of Medicinal Chemistry 65:18, pages 12014-12030.
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Lydia Ntari, Christoforos Nikolaou, Ksanthi Kranidioti, Dimitra Papadopoulou, Eleni Christodoulou-Vafeiadou, Panagiotis Chouvardas, Florian Meier, Christina Geka, Maria C. Denis, Niki Karagianni & George Kollias. (2021) Combination of subtherapeutic anti-TNF dose with dasatinib restores clinical and molecular arthritogenic profiles better than standard anti-TNF treatment. Journal of Translational Medicine 19:1.
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Yi-Yong Baek, Bokyung Sung, Jun-Sub Choi, Hyeon-Kyu Go, Do-Hyung Kim, Joon Young Hyon & Ji Chang You. (2021) In Vivo Efficacy of Imatinib Mesylate, a Tyrosine Kinase Inhibitor, in the Treatment of Chemically Induced Dry Eye in Animal Models. Translational Vision Science & Technology 10:11, pages 14.
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Tomoko Sugiura, Hiroki Kamino, Yuko Nariai, Yohko Murakawa, Masahiro Kondo, Makoto Kawakami, Noboru Ikeda, Yuji Uchio & Takeshi Urano. (2020) Screening of a Panel of Low Molecular Weight Compounds That Inhibit Synovial Fibroblast Invasion in Rheumatoid Arthritis. The Journal of Immunology 205:12, pages 3277-3290.
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Reza Nejat & Ahmad Shahir Sadr. (2020) Are losartan and imatinib effective against SARS-CoV2 pathogenesis? A pathophysiologic-based in silico study. In Silico Pharmacology 9:1.
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Joong‐Hyun Song, Do‐Hyeon Yu, Tae‐Sung Hwang, Byung‐Joon Seung, Jung‐Hyang Sur, Young Joo Kim & Dong‐In Jung. (2020) Expression of platelet‐derived growth factor receptor‐α/ß, vascular endothelial growth factor receptor‐2, c‐Abl, and c‐Kit in canine granulomatous meningoencephalitis and necrotizing encephalitis. Veterinary Medicine and Science 6:4, pages 965-974.
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Semih Başcı, Naim Ata, Fevzi Altuntaş, Tuğçe Nur Yiğenoğlu, Mehmet Sinan Dal, Serdal Korkmaz, Sinem Namdaroğlu, Abdülkadir Baştürk, Tuba Hacıbekiroğlu, Mehmet Hilmi Doğu, İlhami Berber, Kürşat Dal, Mehmet Ali Erkurt, Burhan Turgut, Murat Çağlayan, Mustafa Okan Ayvalı, Osman Çelik, Mustafa Mahir Ülgü & Şuayip Birinci. (2020) Outcome of COVID-19 in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitors. Journal of Oncology Pharmacy Practice 26:7, pages 1676-1682.
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David Bernal-Bello, Beatriz Jaenes-Barrios, Alejandro Morales-Ortega, José Manuel Ruiz-Giardin, Virginia García-Bermúdez, Begoña Frutos-Pérez, Ana Isabel Farfán-Sedano, Cristina de Ancos-Aracil, Fernando Bermejo, Mario García-Gil, Antonio Zapatero-Gaviria & Juan Víctor San Martín-López. (2020) Imatinib might constitute a treatment option for lung involvement in COVID-19. Autoimmunity Reviews 19:7, pages 102565.
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Masoumeh Pirdadeh-Beiranvand, Abbas Afkhami & Tayyebeh Madrakian. (2020) Magnetic molecularly imprinted electrospun nanofibers for selective extraction of nilotinib from human serum. Analytical and Bioanalytical Chemistry 412:7, pages 1629-1637.
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Naofumi UesatoNaoki MiyagawaKoji InagakiReina KakefudaYoshihiro KitagawaYushi MatsuoTakayuki YamaguchiTakahiro HataKazutaka IkegashiraMutsuyoshi Matsushita. (2020) Pharmacological Properties of JTE-952, an Orally Available and Selective Colony Stimulating Factor 1 Receptor Kinase Inhibitor. Biological and Pharmaceutical Bulletin 43:2, pages 325-333.
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Joong Hyun Song, Tae Sung Hwang, Hee Chun Lee, Do Hyeon Yu, Byung Joon Seung, Jung Hyang Sur & Dong In Jung. (2019) Long-term management of canine disseminated granulomatous meningoencephalitis with imatinib mesylate: a case report. Veterinární medicína 64:2, pages 92-99.
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Kai Guo, Xin Bu, Chongfei Yang, Xiaorui Cao, Huan Bian, Qingsheng Zhu, Jinyu Zhu & Dawei Zhang. (2019) Treatment Effects of the Second-Generation Tyrosine Kinase Inhibitor Dasatinib on Autoimmune Arthritis. Frontiers in Immunology 9.
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Ann Christin Reiersølmoen, Jin Han, Eirik Sundby & Bård Helge Hoff. (2018) Identification of fused pyrimidines as interleukin 17 secretion inhibitors. European Journal of Medicinal Chemistry 155, pages 562-578.
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Iwona Majkowska, Yasuyuki Shitomi, Noriko Ito, Nathanael S. Gray & Yoshifumi Itoh. (2017) Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts. Journal of Biological Chemistry 292:16, pages 6633-6643.
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Alicia N. RizzoSaad SammaniAdilene E. EsquincaJeffrey R. JacobsonJoe G. N. Garcia, Eleftheria LetsiouSteven M. Dudek. (2015) Imatinib attenuates inflammation and vascular leak in a clinically relevant two-hit model of acute lung injury. American Journal of Physiology-Lung Cellular and Molecular Physiology 309:11, pages L1294-L1304.
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R. Scott Stephens, Laura Johnston, Laura Servinsky, Bo S. Kim & Mahendra Damarla. (2015) The tyrosine kinase inhibitor imatinib prevents lung injury and death after intravenous LPS in mice. Physiological Reports 3:11, pages e12589.
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Violeta Chitu, Cristina I. Caescu, E. Richard Stanley, Johan Lennartsson, Lars Rönnstrand & Carl-Henrik Heldin. 2015. Receptor Tyrosine Kinases: Family and Subfamilies. Receptor Tyrosine Kinases: Family and Subfamilies 373 538 .
R. Scott Stephens, Laura E. Servinsky, Otgonchimeg Rentsendorj, Todd M. Kolb, Alexander Pfeifer & David B. Pearse. (2014) Protein kinase G increases antioxidant function in lung microvascular endothelial cells by inhibiting the c-Abl tyrosine kinase. American Journal of Physiology-Cell Physiology 306:6, pages C559-C569.
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Manuela Pogliaghi, Laura Papagno, Sidonie Lambert, Ruxandra Calin, Vincent Calvez, Christine Katlama & Brigitte Autran. (2014) The tyrosine kinase inhibitor Dasatinib blocks in-vitro HIV-1 production by primary CD4+ T cells from HIV-1 infected patients. AIDS 28:2, pages 278-281.
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Laura Geraldino-Pardilla & Jon T. Giles. 2014. Encyclopedia of Medical Immunology. Encyclopedia of Medical Immunology 1088 1092 .
Christian Schmidt-Lauber, Saliha Harrach, Thomas Pap, Meike Fischer, Marion Victor, Marianne Heitzmann, Uwe Hansen, Manfred Fobker, Stefan-Martin Brand, Aleksandra Sindic, Hermann Pavenstädt, Bayram Edemir, Eberhard Schlatter, Jessica Bertrand & Giuliano Ciarimboli. (2012) Transport Mechanisms and Their Pathology-Induced Regulation Govern Tyrosine Kinase Inhibitor Delivery in Rheumatoid Arthritis. PLoS ONE 7:12, pages e52247.
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Jennifer L. Rogers, Donald S. Serafin, Roman G. Timoshchenko & Teresa K. Tarrant. (2012) Cellular Targeting in Autoimmunity. Current Allergy and Asthma Reports 12:6, pages 495-510.
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Adela Nacer, Alexandru Movila, Kerstin Baer, Sebastian A. Mikolajczak, Stefan H. I. Kappe & Ute Frevert. (2012) Neuroimmunological Blood Brain Barrier Opening in Experimental Cerebral Malaria. PLoS Pathogens 8:10, pages e1002982.
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Jing Jin GuCatherine P. LavauElena PugachevaErik J. SoderblomM. Arthur MoseleyAnn Marie Pendergast. (2012) Abl Family Kinases Modulate T Cell–Mediated Inflammation and Chemokine-Induced Migration Through the Adaptor HEF1 and the GTPase Rap1. Science Signaling 5:233.
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Dina S. El-Agamy. (2012) Anti-allergic effects of nilotinib on mast cell-mediated anaphylaxis like reactions. European Journal of Pharmacology 680:1-3, pages 115-121.
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