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Modern Rheumatology Volume 21, 2011 - Issue 4
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Original Article

In rheumatoid arthritis patients treated with tocilizumab, the rate of clinical disease activity index (CDAI) remission at 24 weeks is superior in those with higher titers of IgM-rheumatoid factor at baseline

Shin-ya KawashiriUnit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, JapanCorrespondence[email protected]
,
Atsushi KawakamiUnit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
,
Naoki IwamotoUnit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
,
Keita FujikawaUnit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
,
Toshiyuki AramakiUnit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
,
Mami TamaiUnit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
,
Satoshi YamasakiUnit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
,
Hideki NakamuraUnit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
,
Tomoki OriguchiNagasaki University School of Health Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8520, Japan
,
Yukitaka UekiCenter for Rheumatic Disease, Sasebo Chuo Hospital, Sasebo, Japan
,
Kiyoshi MigitaDepartment of General Internal Medicine, NHO National Nagasaki Medical Center, Nagasaki, Japan
,
Akinari MizokamiDepartment of Internal Medicine, Nagasaki Municipal Hospital, Nagasaki, Japan
,
Kiyoshi AoyagiDepartment of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
&
Katsumi EguchiUnit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
 show all
Pages 370-374 | Received 30 Jul 2010, Accepted 14 Dec 2010, Published online: 02 Jan 2014

Citations (13)

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Anne C. Bay-Jensen$suffix/text()$suffix/text(), Anne Sofie Siebuhr$suffix/text()$suffix/text(), Dres Damgaard$suffix/text()$suffix/text(), Patryk Drobinski$suffix/text()$suffix/text(), Christian Thudium$suffix/text()$suffix/text(), Joachim Mortensen$suffix/text()$suffix/text() & Claus H Nielsen$suffix/text()$suffix/text(). (2021) Objective and noninvasive biochemical markers in rheumatoid arthritis: where are we and where are we going?. Expert Review of Proteomics 18:3, pages 159-175.
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Maurizio Benucci, Maria Infantino & Mariangela Manfredi. (2020) Biomarkers and pharmacoeconomics in rheumatoid arthritis: a good marriage. Journal of Medical Economics 23:9, pages 923-925.
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Articles from other publishers (11)

György Nagy, Pál Géher, László Tamási, Edit Drescher, Péter Keszthelyi, Judit Pulai, László Czirják, Zoltán Szekanecz, Gergely Kiss & László Kovács. (2022) Real-world evidence on methotrexate-free subcutaneous tocilizumab therapy in patients with rheumatoid arthritis: 24-week data from the SIMPACT study. Rheumatology Advances in Practice 6:2.
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Takahiro Okada, Noriko Kohyama, Miki Takenaka, Takashi Yamaguchi, Tatsuya Kurihara, Kosuke Sakurai, Yusuke Miwa & Mari Kogo. (2021) Scoring Model to Predict a Low Disease Activity in Elderly Rheumatoid Arthritis Patients Initially Treated with Biological Disease-modifying Antirheumatic Drugs. Internal Medicine 60:12, pages 1827-1834.
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Kim Lauper, Denis Mongin, Florenzo Iannone, Eirik Klami Kristianslund, Tore K Kvien, Dan Nordström, Karel Pavelka, Manuel Pombo-Suarez, Ziga Rotar, Maria Jose Santos, Catalin Codreanu, Galina Lukina, Delphine S Courvoisier & Cem Gabay. (2018) Comparative effectiveness of subcutaneous tocilizumab versus intravenous tocilizumab in a pan-European collaboration of registries. RMD Open 4:2, pages e000809.
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Sarah Brown, Colin C Everett, Kamran Naraghi, Claire Davies, Bryony Dawkins, Claire Hulme, Christopher McCabe, Sue Pavitt, Paul Emery, Linda Sharples & Maya H Buch. (2018) Alternative tumour necrosis factor inhibitors (TNFi) or abatacept or rituximab following failure of initial TNFi in rheumatoid arthritis: the SWITCH RCT. Health Technology Assessment 22:34, pages 1-280.
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Vasco C. Romão, Edward M. Vital, João Eurico Fonseca & Maya H. Buch. (2017) Right drug, right patient, right time: aspiration or future promise for biologics in rheumatoid arthritis?. Arthritis Research & Therapy 19:1.
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Tsutomu Takeuchi, Nobuyuki Miyasaka, Takashi Inui, Toshiro Yano, Toru Yoshinari, Tohru Abe & Takao Koike. (2017) High titers of both rheumatoid factor and anti-CCP antibodies at baseline in patients with rheumatoid arthritis are associated with increased circulating baseline TNF level, low drug levels, and reduced clinical responses: a post hoc analysis of the RISING study. Arthritis Research & Therapy 19:1.
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C.A. Wijbrandts & P.P. Tak. (2017) Prediction of Response to Targeted Treatment in Rheumatoid Arthritis. Mayo Clinic Proceedings 92:7, pages 1129-1143.
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Fabrizio Cantini, Laura Niccoli, Carlotta Nannini, Emanuele Cassarà, Olga Kaloudi, Ennio Giulio Favalli, Andrea Becciolini, Martina Biggioggero, Maurizio Benucci, Francesca Li Gobbi, Valentina Grossi, Maria Infantino, Francesca Meacci, Mariangela Manfredi, Serena Guiducci, Silvia Bellando-Randone, Marco Matucci-Cerinic, Rosario Foti, Marcella Di Gangi, Marta Mosca, Chiara Tani, Fabrizio Palmieri & Delia Goletti. (2016) Tailored first-line biologic therapy in patients with rheumatoid arthritis, spondyloarthritis, and psoriatic arthritis. Seminars in Arthritis and Rheumatism 45:5, pages 519-532.
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Keisuke Izumi, Yuko Kaneko, Misato Hashizume, Keiko Yoshimoto & Tsutomu Takeuchi. (2015) Baseline Serum Osteopontin Levels Predict the Clinical Effectiveness of Tocilizumab but Not Infliximab in Biologic-Naïve Patients with Rheumatoid Arthritis: A Single-Center Prospective Study at 1 Year (the Keio First-Bio Cohort Study). PLOS ONE 10:12, pages e0145468.
Crossref
Dušanka Martinović Kaliterna, Jure Aljinović, Dijana Perković, Daniela Marasović Krstulović, Ivanka Marinović & Tonko Vlak. (2013) Does tocilizumab contribute to elevation of rheumatoid factor and induction of paradoxical syaloadenitis in rheumatoid arthritis patients?Trägt eine Therapie mit Tocilizumab zur Erhöhung des Rheumafaktors und zur Induktion einer paradoxen Sialadenitis bei einer Patientin mit rheumatoider Arthritis bei?. Wiener klinische Wochenschrift 126:3-4, pages 126-129.
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R.J. Maneiro, Eva Salgado, Loreto Carmona & Juan J. Gomez-Reino. (2013) Rheumatoid factor as predictor of response to abatacept, rituximab and tocilizumab in rheumatoid arthritis: Systematic review and meta-analysis. Seminars in Arthritis and Rheumatism 43:1, pages 9-17.
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