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Original Article

Efficacy and safety of additional use of tacrolimus in patients with early rheumatoid arthritis with inadequate response to DMARDs—a multicenter, double-blind, parallel-group trial

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Pages 458-468 | Received 17 Nov 2010, Accepted 28 Jan 2011, Published online: 02 Jan 2014

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Yuko Kaneko, Yutaka Kawahito, Masayo Kojima, Takeo Nakayama, Shintaro Hirata, Mitsumasa Kishimoto, Hirahito Endo, Yohei Seto, Hiromu Ito, Keiichiro Nishida, Isao Matsushita, Toshihisa Kojima, Naoyuki Kamatani, Kiichiro Tsutani, Ataru Igarashi, Mieko Hasegawa, Nobuyuki Miyasaka & Hisashi Yamanaka. (2021) Efficacy and safety of tacrolimus in patients with rheumatoid arthritis – A systematic review and meta-analysis. Modern Rheumatology 31:1, pages 61-69.
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Ayako Nakajima, Eisuke Inoue, Atsuo Taniguchi, Shigeki Momohara & Hisashi Yamanaka. (2016) Effectiveness of tacrolimus in comparison with methotrexate or biologics in propensity score-matched patients with rheumatoid arthritis. Modern Rheumatology 26:6, pages 836-843.
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Masako Hara, Naoki Ishiguro, Kou Katayama, Masakazu Kondo, Takayuki Sumida, Tsuneyo Mimori, Satoshi Soen, Kota Nagai, Tomonobu Yamaguchi & Kazuhiko Yamamoto. (2014) Safety and efficacy of combination therapy of iguratimod with methotrexate for patients with active rheumatoid arthritis with an inadequate response to methotrexate: An open-label extension of a randomized, double-blind, placebo-controlled trial. Modern Rheumatology 24:3, pages 410-418.
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Yoshiya Tanaka, Shinichi Kawai, Tsutomu Takeuchi, Kazuhiko Yamamoto & Nobuyuki Miyasaka. (2013) Prevention of joint destruction by tacrolimus in patients with early rheumatoid arthritis: a post hoc analysis of a double-blind, randomized, placebo-controlled study. Modern Rheumatology 23:6, pages 1045-1052.
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Articles from other publishers (9)

Ren‐Xiao Wang, Mi Zhou, Hui‐Lai Ma, Yuan‐Biao Qiao & Qing‐Shan Li. (2021) The Role of Chronic Inflammation in Various Diseases and Anti‐inflammatory Therapies Containing Natural Products. ChemMedChem 16:10, pages 1576-1592.
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Kichul Shin, Han Joo Baek, Young Mo Kang, Hoon-Suk Cha, Seong Wook Kang, Sung-Hwan Park, Jae-Bum Jun, Yun Jong Lee, In Ah Choi & Yeong Wook Song. (2019) Efficacy and safety of add-on tacrolimus versus leflunomide in rheumatoid arthritis patients with inadequate response to methotrexate. International Journal of Rheumatic Diseases 22:6, pages 1115-1122.
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Dong Hyuk SheenSeung Jae HongSang Heon LeeHye Soon LeeWon Tae ChungHongsi JiangSungmin LeeDae Hyun Yoo. (2019) Effectiveness and Safety of Tacrolimus in Patients with Active Rheumatoid Arthritis with Inadequate Response to Disease-modifying Anti-rheumatic Drugs: The TREASURE Study. Journal of Rheumatic Diseases 26:1, pages 20.
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Taio Naniwa, Shiho Iwagaitsu & Mikiko Kajiura. (2018) Long-term efficacy and safety of add-on tacrolimus for persistent, active rheumatoid arthritis despite treatment with methotrexate and tumor necrosis factor inhibitors. International Journal of Rheumatic Diseases 21:3, pages 673-687.
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Eun-Young Park, Seung-Geun Lee, Eun-Kyoung Park, Dong-Wan Koo, Ji-Heh Park, Geun-Tae Kim, Hee-Sang Tag, Hyun-Ok Kim & Young-Sun Suh. (2018) Drug survival and the associated predictors in South Korean patients with rheumatoid arthritis receiving tacrolimus. The Korean Journal of Internal Medicine 33:1, pages 193-202.
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Kota Ishida, Katsuhisa Shiraki & Takashi Yoshiyasu. (2015) Evaluation of the Safety and Effectiveness of Add-On Tacrolimus in Patients with Rheumatoid Arthritis Who Failed to Show an Adequate Response to Biological DMARDs: The Interim Results of a Specific Drug Use-Results Survey of Tacrolimus. Drugs in R&D 15:4, pages 307-317.
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Chak Sing Lau, Faith Chia, Andrew Harrison, Tsu‐Yi Hsieh, Rahul Jain, Seung Min Jung, Mitsumasa Kishimoto, Ashok Kumar, Khai Pang Leong, Zhanguo Li, Juan Javier Lichauco, Worawit Louthrenoo, Shue‐Fen Luo, Peter Nash, Chin Teck Ng, Sung‐Hwan Park, Bagus Putu Putra Suryana, Parawee Suwannalai, Linda Kurniaty Wijaya, Kazuhiko Yamamoto, Yue Yang & Swan Sim Yeap. (2015) APLAR rheumatoid arthritis treatment recommendations . International Journal of Rheumatic Diseases 18:7, pages 685-713.
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Hiraku Motomura, Isao Matsushita, Eiko Seki, Hayato Mine & Tomoatsu Kimura. (2013) Inhibitory effect of tacrolimus on progression of joint damage in patients with rheumatoid arthritis. International Journal of Rheumatic Diseases 17:7, pages 749-754.
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Ala Qabaja, Tamer Jarada, Abdallah Elsheikh & Reda Alhajj. (2014) Prediction of gene-based drug indications using compendia of public gene expression data and PubMed abstracts. Journal of Bioinformatics and Computational Biology 12:03, pages 1450007.
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