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Modern Rheumatology Volume 23, 2013 - Issue 2
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Original Article

Elevation of KL-6 serum levels in clinical trials of tumor necrosis factor inhibitors in patients with rheumatoid arthritis: a report from the Japan College of Rheumatology Ad Hoc Committee for Safety of Biological DMARDs

Masayoshi HarigaiThe Ad Hoc Committee for the Safety of Biological DMARDs, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0001, Japan;Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan;Department of Medicine and Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku,Tokyo, JapanCorrespondence[email protected]
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Akito TakamuraThe Ad Hoc Committee for the Safety of Biological DMARDs, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0001, Japan;Department of Medicine and Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku,Tokyo, Japan
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Tatsuya AtsumiThe Ad Hoc Committee for the Safety of Biological DMARDs, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0001, Japan;Department of Internal Medicine II, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
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Makoto DohiThe Ad Hoc Committee for the Safety of Biological DMARDs, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0001, Japan;Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
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Shintaro HirataThe Ad Hoc Committee for the Safety of Biological DMARDs, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0001, Japan;The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Japan, Kitakyushu, Fukuoka, Japan
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Hideto KamedaThe Ad Hoc Committee for the Safety of Biological DMARDs, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0001, Japan;Division of Rheumatology and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine, Keio University, Tokyo, Japan
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Hayato NagasawaThe Ad Hoc Committee for the Safety of Biological DMARDs, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0001, Japan;Department of Rheumatology/Clinical Immunology, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan
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Yohei SetoThe Ad Hoc Committee for the Safety of Biological DMARDs, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0001, Japan;Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
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Takao KoikeSapporo Medical Center NTT EC, Chuo-ku, Sapporo, Hokkaido, Japan;Global Center of Excellence Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University, Tokyo, Japan
&
Nobuyuki MiyasakaThe Ad Hoc Committee for the Safety of Biological DMARDs, Japan College of Rheumatology, 1-1-24 Toranomon, Minato-ku, Tokyo 105-0001, Japan;Department of Medicine and Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku,Tokyo, Japan
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Pages 284-296 | Received 16 Jan 2012, Accepted 19 Apr 2012, Published online: 02 Jan 2014

Citations (14)

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T Matsuo, M Hashimoto, I Ito, T Kubo, R Uozumi, M Furu, H Ito, T Fujii, M Tanaka, C Terao, H Kono, M Mori, M Hamaguchi, W Yamamoto, K Ohmura, S Morita & T Mimori. (2019) Interleukin-18 is associated with the presence of interstitial lung disease in rheumatoid arthritis: a cross-sectional study. Scandinavian Journal of Rheumatology 48:2, pages 87-94.
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Articles from other publishers (13)

Toshihiko Hoashi, Shun Miyazaki, Saeko Ozaki, Susumu Ichiyama, Michiko Ito, Naoko Kanda & Hidehisa Saeki. (2023) Change in Serum KL-6 Level during Biologic Treatment for Psoriasis. Journal of Nippon Medical School 90:2, pages 194-201.
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Hiroaki Iwata, Naoya Haga, Tatsuro Sugai & Yasuyuki Fujita. (2020) Serum Krebs von den Lungen‐6 levels in psoriatic patients under treatment with biologics. The Journal of Dermatology 48:3, pages 376-379.
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Hiroshi Furukawa, Shomi Oka, Takashi Higuchi, Kota Shimada, Atsushi Hashimoto, Toshihiro Matsui & Shigeto Tohma. (2021) Biomarkers for interstitial lung disease and acute-onset diffuse interstitial lung disease in rheumatoid arthritis. Therapeutic Advances in Musculoskeletal Disease 13, pages 1759720X2110225.
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Takashi Ono, Takuya Iwasaki, Yukiko Terada, Kentaro Abe, Jinhee Lee, Manabu Mochizuki & Kazunori Miyata. (2020) Serum KL-6 elevation in a uveitis patient with Behçet's disease treated with adalimumab. American Journal of Ophthalmology Case Reports 18, pages 100660.
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Takuya Masuda, Atsushi Yoshida, Fumiaki Ueno, Shintaro Hara, Haruaki Nabeta, Shotaro Umezawa, Mayuki Shirai, Yoshihide Morikawa, Toshio Morizane, Yutaka Endo & Toshifumi Hibi. (2019) A Patient with KL-6 Elevation with Anti-TNFα Who Could Receive Long-Term Use without Interstitial Pneumonia after Class Switch of Anti-TNFα. Inflammatory Intestinal Diseases 4:1, pages 35-40.
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Masahiro Kamata & Yayoi Tada. (2018) Safety of biologics in psoriasis. The Journal of Dermatology 45:3, pages 279-286.
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Sadatomo Tasaka. 2018. Lung Disease Associated with Rheumatoid Arthritis. Lung Disease Associated with Rheumatoid Arthritis 187 199 .
Hideto Kameda. 2018. Drug-Induced Lung Injury. Drug-Induced Lung Injury 165 176 .
Hitoshi Tokuda, Masayoshi Harigai, Hideto Kameda, Kazunori Tomono, Noboru Takayanagi, Akira Watanabe, Sadatomo Tasaka, Takafumi Suda, Kazuhiro Tateda & Junichi Kadota. (2017) Consensus statements for medical practice: Biological agents and lung disease [Abridged English translation by the Japanese Respiratory Society]. Respiratory Investigation 55:3, pages 229-251.
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Y. Higashi, K. Tada, M. Shimokawa, K. Kawai & T. Kanekura. (2016) Elevation of serum KL-6 in patients with psoriasis treated with anti-tumour necrosis factor-α therapy. Clinical and Experimental Dermatology 41:1, pages 88-90.
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Koichi Yanaba, Yoshinori Umezawa, Reiko Sakakihara, Miki Chiba, Toshihiro Ito, Sota Kikuchi, Osamu Fukuchi, Akihiko Asahina, Hidehisa Saeki & Hidemi Nakagawa. (2015) Infliximab and adalimumab, unlike ustekinumab, increase serum KL ‐6 levels in Japanese patients with psoriasis . The Journal of Dermatology 42:8, pages 828-829.
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Atsushi Ogata, Kazuhide Tanimura, Toyohiko Sugimoto, Hiroshi Inoue, Yukitomo Urata, Tsukasa Matsubara, Masakazu Kondo, Yukitaka Ueki, Mitsuhiro Iwahashi, Shigeto Tohma, Shuji Ohta, Yukihiko Saeki & Toshio Tanaka. (2014) Phase III Study of the Efficacy and Safety of Subcutaneous Versus Intravenous Tocilizumab Monotherapy in Patients With Rheumatoid Arthritis. Arthritis Care & Research 66:3, pages 344-354.
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Kenji Takahashi, Hiroshi Nakamura, Kenji Takenouchi, Norishige Iizawa, Masahito Koiwa, Akiko Sato, Yusuke Mochizuki, Hiroshi Watanabe & Shinro Takai. (2014) Serum KL-6 Elevation and Possible Pulmonary Involvement in Patients with Rheumatoid Arthritis Treated with Biological Agents. Journal of Nippon Medical School 81:6, pages 364-371.
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