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Original Article

A phase 3 randomized, double-blind, multicenter comparative study evaluating the effect of etanercept versus methotrexate on radiographic outcomes, disease activity, and safety in Japanese subjects with active rheumatoid arthritis

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Pages 623-633 | Received 04 Jul 2012, Accepted 06 Aug 2012, Published online: 02 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Tsutomu Takeuchi, Nobuyuki Miyasaka, Ron D. Pedersen, Noriko Sugiyama & Tomohiro Hirose. (2021) Radiographic and clinical effects of 10 mg and 25 mg twice-weekly etanercept over 52 weeks in Japanese patients with active rheumatoid arthritis. Modern Rheumatology 31:2, pages 319-325.
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Tsutomu Takeuchi, Nobuyuki Miyasaka, Ron Pedersen, Noriko Sugiyama & Tomohiro Hirose. (2020) Radiographic and clinical outcomes following etanercept monotherapy in Japanese methotrexate-naïve patients with active rheumatoid arthritis. Modern Rheumatology 30:2, pages 259-268.
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Tsutomu Takeuchi, Nobuyuki Miyasaka, Shinichi Kawai, Naonobu Sugiyama, Hirotoshi Yuasa, Noriaki Yamashita, Noriko Sugiyama, Lorin Craig Wagerle, Bonnie Vlahos & Joseph Wajdula. (2015) Pharmacokinetics, efficacy and safety profiles of etanercept monotherapy in Japanese patients with rheumatoid arthritis: review of seven clinical trials. Modern Rheumatology 25:2, pages 173-186.
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Articles from other publishers (27)

Yoshiya Tanaka, Tsutomu Takeuchi, Daisuke Kato, Yuichiro Kaneko, Musashi Fukuda, Hiroyuki Izutsu, Mitsuhiro Rokuda & Désirée van der Heijde. (2023) Post hoc analysis of clinical characteristics of patients with radiographic progression in a Japanese phase 3 trial of peficitinib and methotrexate treatment (RAJ4) . Modern Rheumatology 33:1, pages 73-80.
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Ryutaro Takeda, Takumi Matsumoto, Yuji Maenohara, Yasunori Omata, Hiroshi Inui, Yuichi Nagase, Takuji Nishikawa & Sakae Tanaka. (2022) Increasing trend of radiographic features of knee osteoarthritis in rheumatoid arthritis patients before total knee arthroplasty. Scientific Reports 12:1.
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Eri Sugano, Eiichi Tanaka, Eisuke Inoue, Ryoko Sakai, Mai Abe, Kumiko Saka, Naohiro Sugitani, Moeko Ochiai, Rei Yamaguchi, Yoko Higuchi, Naoki Sugimoto, Katsunori Ikari, Ayako Nakajima, Hisashi Yamanaka & Masayoshi Harigai. (2022) Differences in patients’ population and efficacy/effectiveness of biologic disease–modifying antirheumatic drugs between randomized controlled trials and real-world settings in patients with rheumatoid arthritis – using the IORRA cohort. Modern Rheumatology 32:4, pages 675-685.
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Yoshiya Tanaka, Hiroyuki Okumura, Soyoung Kim, Julie Dorey, Piotr Wojciechowski, Justyna Chorąży, Daisuke Kato & Neil M. Schultz. (2021) Comparative Efficacy and Safety of Peficitinib Versus Tofacitinib and Baricitinib for Treatment of Rheumatoid Arthritis: A Systematic Review and Network Meta-Analysis. Rheumatology and Therapy 8:2, pages 729-750.
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Mingcai Wu, Mengjun Tao, Quanhai Wang, Xiaohua Lu & Hui Yuan. (2021) Fusion proteins of biologic agents in the treatment of rheumatoid arthritis (RA). Medicine 100:24, pages e26350.
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Yune-Jung Park, Ana Maria Gherghe & Desirée van der Heijde. (2020) Radiographic progression in clinical trials in rheumatoid arthritis: a systemic literature review of trials performed by industry. RMD Open 6:2, pages e001277.
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Tsutomu Takeuchi, Yoshiya Tanaka, Sakae Tanaka, Atsushi Kawakami, Manabu Iwasaki, Kou Katayama, Mitsuhiro Rokuda, Hiroyuki Izutsu, Satoshi Ushijima, Yuichiro Kaneko, Teruaki Shiomi, Emi Yamada & Désirée van der Heijde. (2019) Efficacy and safety of peficitinib (ASP015K) in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase III randomised, double-blind, placebo-controlled trial (RAJ4) in Japan. Annals of the Rheumatic Diseases 78:10, pages 1305-1319.
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Niels Graudal, Benjamin Skov Kaas-Hansen, Louise Guski, Thorbjørn Hubeck-Graudal, Nicky J. Welton & Gesche Jürgens. (2019) Different Original and Biosimilar TNF Inhibitors Similarly Reduce Joint Destruction in Rheumatoid Arthritis—A Network Meta-Analysis of 36 Randomized Controlled Trials. International Journal of Molecular Sciences 20:18, pages 4350.
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Paul Emery, Janet E. Pope, Klaus Kruger, Ralph Lippe, Ryan DeMasi, Sadiq Lula & Blerina Kola. (2018) Efficacy of Monotherapy with Biologics and JAK Inhibitors for the Treatment of Rheumatoid Arthritis: A Systematic Review. Advances in Therapy 35:10, pages 1535-1563.
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Gablu Kilcher, Noemi Hummel, Eva M Didden, Matthias Egger & Stephan Reichenbach. (2018) Rheumatoid arthritis patients treated in trial and real world settings: comparison of randomized trials with registries. Rheumatology 57:2, pages 354-369.
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Markus Gaubitz, Karl-Heinz Göttl, Olaf Behmer, Ralph Lippe, Thomas Meng & Peter-Andreas Löschmann. (2017) Etanercept is effective as monotherapy or in combination with methotrexate in rheumatoid arthritis: subanalysis of an observational study. Clinical Rheumatology 36:9, pages 1989-1996.
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Matt D. Stevenson, Allan J. Wailoo, Jonathan C. Tosh, Monica Hernandez-Alava, Laura A. Gibson, John W. Stevens, Rachel J. Archer, Emma L. Simpson, Emma S. Hock, Adam Young & David L. Scott. (2017) The Cost-effectiveness of Sequences of Biological Disease-modifying Antirheumatic Drug Treatment in England for Patients with Rheumatoid Arthritis Who Can Tolerate Methotrexate. The Journal of Rheumatology 44:7, pages 973-980.
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Jackie L Nam, Kaoru Takase-Minegishi, Sofia Ramiro, Katerina Chatzidionysiou, Josef S Smolen, Désirée van der Heijde, Johannes W Bijlsma, Gerd R Burmester, Maxime Dougados, Marieke Scholte-Voshaar, Ronald van Vollenhoven & Robert Landewé. (2017) Efficacy of biological disease-modifying antirheumatic drugs: a systematic literature review informing the 2016 update of the EULAR recommendations for the management of rheumatoid arthritis. Annals of the Rheumatic Diseases 76:6, pages 1113-1136.
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Simon Tarp, Daniel E. Furst, Anna Dossing, Mikkel ?stergaard, Tove Lorenzen, Michael S. Hansen, Jasvinder A. Singh, Ernest H. Choy, Maarten Boers, Maria E. Suarez-Almazor, Lars E. Kristensen, Henning Bliddal & Robin Christensen. (2017) Defining the optimal biological monotherapy in rheumatoid arthritis: A systematic review and meta-analysis of randomised trials. Seminars in Arthritis and Rheumatism 46:6, pages 699-708.
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Jasvinder A Singh, Alomgir Hossain, Amy S Mudano, Elizabeth Tanjong Ghogomu, Maria E Suarez-Almazor, Rachelle Buchbinder, Lara J Maxwell, Peter Tugwell & George A Wells. (2017) Biologics or tofacitinib for people with rheumatoid arthritis naive to methotrexate: a systematic review and network meta-analysis. Cochrane Database of Systematic Reviews.
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Hiroki Wakabayashi, Hitoshi Inada, Yosuke Nishioka, Masahiro Hasegawa, Akihiro Sudo & Kusuki Nishioka. (2016) Maintenance of efficacy and safety with subcutaneous golimumab in rheumatoid arthritis patients with low disease activity who previously received TNF inhibitors. Clinical Rheumatology 36:4, pages 941-946.
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Jasvinder A Singh, Alomgir Hossain, Elizabeth Tanjong Ghogomu, Amy S Mudano, Lara J Maxwell, Rachelle Buchbinder, Maria Angeles Lopez-Olivo, Maria E Suarez-Almazor, Peter Tugwell & George A Wells. (2017) Biologics or tofacitinib for people with rheumatoid arthritis unsuccessfully treated with biologics: a systematic review and network meta-analysis. Cochrane Database of Systematic Reviews 2017:3.
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Yan Cao, Wensong Zhang, Jie Wu, Hong Zhang & Hongyan Zhou. (2017) Peripheral Ulcerative Keratitis Associated with Autoimmune Disease: Pathogenesis and Treatment. Journal of Ophthalmology 2017, pages 1-12.
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Jasvinder A Singh, Alomgir Hossain, Elizabeth Tanjong Ghogomu, Amy S Mudano, Peter Tugwell & George A Wells. (2016) Biologic or tofacitinib monotherapy for rheumatoid arthritis in people with traditional disease-modifying anti-rheumatic drug (DMARD) failure: a Cochrane Systematic Review and network meta-analysis (NMA). Cochrane Database of Systematic Reviews 2016:11.
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Meng Chen, Dayong Peng, Zongzheng Zhang, Guilai Zuo & Gang Zhao. (2016) Efficacy of etanercept for treating the active rheumatoid arthritis: an updated meta-analysis. International Journal of Rheumatic Diseases 19:11, pages 1132-1142.
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Glen S Hazlewood, Cheryl Barnabe, George Tomlinson, Deborah Marshall, Daniel JA Devoe & Claire Bombardier. (2016) Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis: A network meta-analysis. Cochrane Database of Systematic Reviews 2016:8.
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Jasvinder A Singh, Alomgir Hossain, Elizabeth Tanjong Ghogomu, Ahmed Kotb, Robin Christensen, Amy S Mudano, Lara J Maxwell, Nipam P Shah, Peter Tugwell & George A Wells. (2016) Biologics or tofacitinib for rheumatoid arthritis in incomplete responders to methotrexate or other traditional disease-modifying anti-rheumatic drugs: a systematic review and network meta-analysis. Cochrane Database of Systematic Reviews 2016:5.
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Jonathan West, Simon Ogston & John Foerster. (2016) Safety and Efficacy of Methotrexate in Psoriasis: A Meta-Analysis of Published Trials. PLOS ONE 11:5, pages e0153740.
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Richard Conway, Candice Low, Robert J. Coughlan, Martin J. O?Donnell & John J. Carey. (2015) Risk of liver injury among methotrexate users: A meta-analysis of randomised controlled trials. Seminars in Arthritis and Rheumatism 45:2, pages 156-162.
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Lesley J. Scott. (2014) Etanercept: A Review of Its Use in Autoimmune Inflammatory Diseases. Drugs 74:12, pages 1379-1410.
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Yang Liu, Wei Fan, Hao Chen & Ming-Xia Yu. (2014) Risk of Breast Cancer and Total Malignancies in Rheumatoid Arthritis Patients Undergoing TNF-α Antagonist Therapy: a Meta-analysis of Randomized Control Trials. Asian Pacific Journal of Cancer Prevention 15:8, pages 3403-3410.
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Yuko Kaneko & Tsutomu Takeuchi. (2014) A Paradigm Shift in Rheumatoid Arthritis over the Past Decade. Internal Medicine 53:17, pages 1895-1903.
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