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Modern Rheumatology Volume 12, 2002 - Issue 2
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ORIGINAL ARTICLE

T-cell receptor ζ mRNA with an alternatively spliced 3′ untranslated region is generated predominantly in the peripheral blood T cells of systemic lupus erythematosus patients

K. TsuzakaSecond Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe 350-8550, JapanCorrespondence[email protected]
,
N. OnodaSecond Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe 350-8550, Japan
,
K. YoshimotoSecond Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe 350-8550, Japan
,
Y. SetoyamaSecond Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe 350-8550, Japan
,
K. SuzukiSecond Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe 350-8550, Japan
,
M. PangSecond Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe 350-8550, Japan
,
T. AbeSecond Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe 350-8550, Japan
&
T. TakeuchiSecond Department of Internal Medicine, Saitama Medical Center, Saitama Medical School, 1981 Kamoda, Kawagoe 350-8550, Japan
 show all
Pages 167-173 | Received 17 Sep 2001, Accepted 17 Dec 2001, Published online: 02 Jan 2014

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Read on this site (2)

TSUTOMU TAKEUCHI, KENSEI TSUZAKA & TOHRU ABE. (2004) ALTERED EXPRESSION OF THE T CELL RECEPTOR-CD3 COMPLEX IN SYSTEMIC LUPUS ERYTHEMATOSUS. International Reviews of Immunology 23:3-4, pages 273-291.
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Makiyo Takaya, Naoto Tamura, Kazunori Kato, Shigeto Kobayashi, Kazuhiko Haruta, Michiko Tajima, Mutsuko Hara, Kwang-Seok Yang, Hiroshi Tsuda & Hiroshi Hashimoto. (2003) CD154 expression and mRNA stability of activated CD4-positive T cells in patients with systemic lupus erythematosus. Modern Rheumatology 13:3, pages 220-226.
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Articles from other publishers (9)

Pingping Ren, Luying Lu, Shasha Cai, Jianghua Chen, Weiqiang Lin & Fei Han. (2021) Alternative Splicing: A New Cause and Potential Therapeutic Target in Autoimmune Disease. Frontiers in Immunology 12.
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Ziwei LiaoLingling ZhouChunyan WangZhifeng HeXu WangXiaodan LuoShaohua ChenLijian YangHuo TanYangqiu Li. (2015) Characteristics of TCRζ , ZAP-70 , and FcɛRIγ Gene Expression in Patients with T- and NK/T-Cell Lymphoma . DNA and Cell Biology 34:3, pages 201-207.
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T. Warchoł, P. Piotrowski, M. Lianeri, D. Cieślak, M. Wudarski, P. Hrycaj, J. K Łącki & P. P. Jagodziński. (2009) The CD3Z 844 T>A polymorphism within the 3′-UTR of CD3Z confers increased risk of incidence of systemic lupus erythematosus . Tissue Antigens 74:1, pages 68-72.
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Kensei Tsuzaka, Yuka Itami, Chika Kumazawa, Miyuki Suzuki, Yumiko Setoyama, Keiko Yoshimoto, Katsuya Suzuki, Tohru Abe & Tsutomu Takeuchi. (2008) Conservative sequences in 3′UTR of TCRζ mRNA regulate TCRζ in SLE T cells. Biochemical and Biophysical Research Communications 367:2, pages 311-317.
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Claire L. Gorman, Andrew I. Russell, Zhuoli Zhang, Deborah Cunninghame Graham, Andrew P. Cope & Timothy J. Vyse. (2008) Polymorphisms in the CD3Z Gene Influence TCRζ Expression in Systemic Lupus Erythematosus Patients and Healthy Controls . The Journal of Immunology 180:2, pages 1060-1070.
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Kensei Tsuzaka, Kyoko Nozaki, Chika Kumazawa, Kiyono Shiraishi, Yumiko Setoyama, Keiko Yoshimoto, Tohru Abe & Tsutomus Takeuchi. (2006) TCRζ mRNA splice variant forms observed in the peripheral blood T cells from systemic lupus erythematosus patients. Springer Seminars in Immunopathology 28:2, pages 185-193.
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Kensei Tsuzaka, Kyoko Nozaki, Chika Kumazawa, Kiyono Shiraishi, Yumiko Setoyama, Keiko Yoshimoto, Katsuya Suzuki, Tohru Abe & Tsutomu Takeuchi. (2006) DNA Microarray Gene Expression Profile of T Cells with the Splice Variants of TCRζ mRNA Observed in Systemic Lupus Erythematosus. The Journal of Immunology 176:2, pages 949-956.
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Kensei Tsuzaka, Yumiko Setoyama, Keiko Yoshimoto, Kiyono Shiraishi, Katsuya Suzuki, Tohru Abe & Tsutomu Takeuchi. (2005) A Splice Variant of the TCR ζ mRNA Lacking Exon 7 Leads to the Down-Regulation of TCR ζ, the TCR/CD3 Complex, and IL-2 Production in Systemic Lupus Erythematosus T Cells. The Journal of Immunology 174:6, pages 3518-3525.
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Kensei Tsuzaka, Izumi Fukuhara, Yumiko Setoyama, Keiko Yoshimoto, Katsuya Suzuki, Tohru Abe & Tsutomu Takeuchi. (2003) TCRζ mRNA with an Alternatively Spliced 3′-Untranslated Region Detected in Systemic Lupus Erythematosus Patients Leads to the Down-Regulation of TCRζ and TCR/CD3 Complex. The Journal of Immunology 171:5, pages 2496-2503.
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