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Dialogues in Clinical Neuroscience Volume 8, 2006 - Issue 3
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Pharmacological Aspects

Contributions of molecular biology to antipsychotic drug discovery: promises fulfilled or unfulfilled?

Contribuciones de la biología molecular al descubrimiento de fármacos antipsicóticos: ¿promesas cumplidas o incumpiidas?

Apports de la biologie moléculaire à la dêcouwetle des médicaments antipsychotiques: promesses tenues ou non?

Bryan L. RothDepartments of Biochemistry, Psychiatry, Neurosciences, and Oncology, National Institute of Mental Health Psychoactive Drug Screening Program, Case Western Reserve University Medical School, Cleveland, Ohio, USA (Current affiliation: Departments of Pharmacology, Medicinal Chemistry and Natural Products, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA)Correspondence[email protected]
Pages 303-309 | Published online: 01 Apr 2022

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Kathinka Evers. (2009) Personalized medicine in psychiatry: ethical challenges and opportunities. Dialogues in Clinical Neuroscience 11:4, pages 427-434.
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V.T. Ramaekers, J.M. Sequeira & E.V. Quadros. (2016) The basis for folinic acid treatment in neuro-psychiatric disorders. Biochimie 126, pages 79-90.
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Elizabeth E Steinberg, Daniel J Christoffel, Karl Deisseroth & Robert C Malenka. (2015) Illuminating circuitry relevant to psychiatric disorders with optogenetics. Current Opinion in Neurobiology 30, pages 9-16.
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V.T. Ramaekers, B. Thöny, J.M. Sequeira, M. Ansseau, P. Philippe, F. Boemer, V. Bours & E.V. Quadros. (2014) Folinic acid treatment for schizophrenia associated with folate receptor autoantibodies. Molecular Genetics and Metabolism 113:4, pages 307-314.
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Panos Bitsios & Panos Roussos. (2011) Tolcapone, COMT polymorphisms and pharmacogenomic treatment of schizophrenia . Pharmacogenomics 12:4, pages 559-566.
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Ann M. Mortimer. 2011. Handbook of Schizophrenia Spectrum Disorders, Volume III. Handbook of Schizophrenia Spectrum Disorders, Volume III 23 49 .
Erik H. F. Wong, Frank Yocca, Mark A. Smith & Chi-Ming Lee. (2010) Challenges and opportunities for drug discovery in psychiatric disorders: the drug hunters' perspective. The International Journal of Neuropsychopharmacology 13:09, pages 1269-1284.
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Niels H Jensen, Ramona M Rodriguiz, Marc G Caron, William C Wetsel, Richard B Rothman & Bryan L Roth. (2007) N-Desalkylquetiapine, a Potent Norepinephrine Reuptake Inhibitor and Partial 5-HT1A Agonist, as a Putative Mediator of Quetiapine's Antidepressant Activity. Neuropsychopharmacology 33:10, pages 2303-2312.
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F. Iris, M. Gea, P. -H. Lampe, G. Dine & P. Santamaria. (2008) Integrative biology in the discovery of relevant biomarkers monitoring cognitive disorders pathogenesis and progressionLa biologie intégrative dans la découverte de biomarqueurs spécifiques au suivi de la pathogénèse de désordres cognitifs et leur évolution. Bio Tribune Magazine 28:1, pages 8-23.
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Lois Winsky, Jamie Driscoll & Linda Brady. 2008. Animal and Translational Models for CNS Drug Discovery. Animal and Translational Models for CNS Drug Discovery 59 74 .
François Iris. 2009. Biomarkers for Psychiatric Disorders. Biomarkers for Psychiatric Disorders 473 522 .
J A Gray & B L Roth. (2007) The pipeline and future of drug development in schizophrenia. Molecular Psychiatry 12:10, pages 904-922.
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