Advanced search
Publication Cover
Dialogues in Clinical Neuroscience Volume 16, 2014 - Issue 1
Submit an article Journal homepage
1,223
Views
54
CrossRef citations to date
0
Altmetric
Clinical Research

Endogenous and exogenous electric fields as modifiers of brain activity: rational design of noninvasive brain stimulation with transcranial alternating current stimulation

Los campos eléctricos endógenos y exógenos como modificadores de la actividad cerebral: un diseño racional de estimulación cerebral no invasora mediante estimulación transcraneal con corriente alterna

Champs électriques endogènes et exogènes pour modifier l'activité cérébrale: procédure rationnelle de stimulation cérébrale non invasive avec stimulation transcrânienne par courant alternatif

Flavio FröhlichDepartment of Psychiatry, Department of Cell Biology and Physiology, Department of Biomedical Engineering, Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USACorrespondence[email protected]
Pages 93-102 | Published online: 01 Apr 2022

Citations (54)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Julianna H Prim, Sangtae Ahn, Maria I Davila, Morgan L Alexander, Karen L McCulloch & Flavio Fröhlich. (2019) Targeting the Autonomic Nervous System Balance in Patients with Chronic Low Back Pain Using Transcranial Alternating Current Stimulation: A Randomized, Crossover, Double-Blind, Placebo-Controlled Pilot Study. Journal of Pain Research 12, pages 3265-3277.
Read now
Joseph B. Hopfinger, Jonathan Parsons & Flavio Fröhlich. (2017) Differential effects of 10-Hz and 40-Hz transcranial alternating current stimulation (tACS) on endogenous versus exogenous attention. Cognitive Neuroscience 8:2, pages 102-111.
Read now

Articles from other publishers (52)

Aaron P. Jones, Natalie B. Bryant, Bradley M. Robert, Teagan S. Mullins, Michael C. S. Trumbo, Nicholas A. Ketz, Michael D. Howard, Praveen K. Pilly & Vincent P. Clark. (2023) Closed-Loop tACS Delivered during Slow-Wave Sleep Reduces Retroactive Interference on a Paired-Associates Learning Task. Brain Sciences 13:3, pages 468.
Crossref
Vinícius Gomes Machado, Ana Beatriz Sorgenfrei Brun & Elisangela Ferretti Manffra. (2023) Effects of the radio electric asymmetric conveyer (REAC) on motor disorders: An integrative review. Frontiers in Medical Technology 5.
Crossref
Richard Ambron. (2023) Toward the unknown: consciousness and pain. Neuroscience of Consciousness 2023:1.
Crossref
Edoardo Pinzuti, Patricia Wollstadt, Oliver Tüscher & Michael Wibral. (2023) Information theoretic evidence for layer- and frequency-specific changes in cortical information processing under anesthesia. PLOS Computational Biology 19:1, pages e1010380.
Crossref
Eric Bond. (2023) The contribution of coherence field theory to a model of consciousness: electric currents, EM fields, and EM radiation in the brain. Frontiers in Human Neuroscience 16.
Crossref
Toshikazu Shinba, Takaki Nedachi & Shinji Harakawa. (2022) Alterations in Heart Rate Variability and Electroencephalogram during 20‐Minute Extremely Low Frequency Electric Field Treatment in Healthy Men during the Eyes‐Open Condition . IEEJ Transactions on Electrical and Electronic Engineering 18:1, pages 38-44.
Crossref
Mengsen Zhang, Rachel B. Force, Christopher Walker, Sangtae Ahn, L. Fredrik Jarskog & Flavio Frohlich. (2022) Alpha transcranial alternating current stimulation reduces depressive symptoms in people with schizophrenia and auditory hallucinations: a double-blind, randomized pilot clinical trial. Schizophrenia 8:1.
Crossref
Adriana Farcas & Felicia Iftene. (2022) Findings, limitations and new directions in tACS studies in schizophrenia research: A scoping review. Journal of Psychiatric Research 151, pages 291-298.
Crossref
Kaspar A. Schindler, Tobias Nef, Maxime O. Baud, Athina Tzovara, Gürkan Yilmaz, Gerd Tinkhauser, Stephan M. Gerber, Oriella Gnarra, Jan D. Warncke, Narayan Schütz, Samuel E. J. Knobel, Markus H. Schmidt, Paul Krack, Flavio Fröhlich, Raphael Sznitman, Simon Rothen & Claudio L. A. Bassetti. (2021) NeuroTec Sitem-Insel Bern: Closing the Last Mile in Neurology. Clinical and Translational Neuroscience 5:2, pages 13.
Crossref
Justin Riddle, Amber McFerren & Flavio Frohlich. (2021) Causal role of cross-frequency coupling in distinct components of cognitive control. Progress in Neurobiology 202, pages 102033.
Crossref
Wei A. Huang, Iain M. Stitt, Ehsan Negahbani, D. J. Passey, Sangtae Ahn, Marshall Davey, Moritz Dannhauer, Thien T. Doan, Anna C. Hoover, Angel V. Peterchev, Susanne Radtke-Schuller & Flavio Fröhlich. (2021) Transcranial alternating current stimulation entrains alpha oscillations by preferential phase synchronization of fast-spiking cortical neurons to stimulation waveform. Nature Communications 12:1.
Crossref
Flavio Frohlich & Justin Riddle. (2021) Conducting double-blind placebo-controlled clinical trials of transcranial alternating current stimulation (tACS). Translational Psychiatry 11:1.
Crossref
Flavio Frohlich & Leah Townsend. (2021) Closed-Loop Transcranial Alternating Current Stimulation: Towards Personalized Non-invasive Brain Stimulation for the Treatment of Psychiatric Illnesses. Current Behavioral Neuroscience Reports 8:2, pages 51-57.
Crossref
Osama Elyamany, Gregor Leicht, Christoph S. Herrmann & Christoph Mulert. (2020) Transcranial alternating current stimulation (tACS): from basic mechanisms towards first applications in psychiatry. European Archives of Psychiatry and Clinical Neuroscience 271:1, pages 135-156.
Crossref
Conor F. Underwood & Louise C. Parr-Brownlie. (2021) Primary motor cortex in Parkinson’s disease: Functional changes and opportunities for neurostimulation. Neurobiology of Disease 147, pages 105159.
Crossref
Zeinab Esmaeilpour, Greg Kronberg, Davide Reato, Lucas C. Parra & Marom Bikson. (2021) Temporal interference stimulation targets deep brain regions by modulating neural oscillations. Brain Stimulation 14:1, pages 55-65.
Crossref
Chih-Ming Cheng, Cheng-Ta Li & Shih-Jen Tsai. 2021. Major Depressive Disorder. Major Depressive Disorder 333 349 .
Dirk K. F. Meijer, Igor Jerman, Alexey V. Melkikh & Valeriy I. Sbitnev. 2021. Rhythmic Oscillations in Proteins to Human Cognition. Rhythmic Oscillations in Proteins to Human Cognition 213 361 .
Flavio Fröhlich, Rachel Force, Wei Angel Huang, Caroline Lustenberger, Trevor McPherson, Justin Riddle & Christopher Walker. 2021. Transcranial Direct Current Stimulation in Neuropsychiatric Disorders. Transcranial Direct Current Stimulation in Neuropsychiatric Disorders 211 242 .
Flavio Fröhlich & Caroline Lustenberger. (2020) Neuromodulation of sleep rhythms in schizophrenia: Towards the rational design of non-invasive brain stimulation. Schizophrenia Research 221, pages 71-80.
Crossref
James Dowsett, Christoph S. Herrmann, Marianne Dieterich & Paul C.J. Taylor. (2019) Shift in lateralization during illusory self‐motion: EEG responses to visual flicker at 10 Hz and frequency‐specific modulation by tACS . European Journal of Neuroscience 51:7, pages 1657-1675.
Crossref
Ibtisam A. Abbas Al-Darkazly & S. M. Rezaul Hasan. (2020) Extra-Low-Frequency Pulse Stimulated Conformational Change in Blood-Cell Proteins and Consequent Immune Activity Transformation. IEEE Journal of Translational Engineering in Health and Medicine 8, pages 1-13.
Crossref
Sankaraleengam Alagapan, Hae Won Shin, Flavio Fröhlich & Hau-tieng Wu. (2019) Diffusion geometry approach to efficiently remove electrical stimulation artifacts in intracranial electroencephalography. Journal of Neural Engineering 16:3, pages 036010.
Crossref
Guoshi Li, Craig S Henriquez & Flavio Fröhlich. (2019) Rhythmic modulation of thalamic oscillations depends on intrinsic cellular dynamics. Journal of Neural Engineering 16:1, pages 016013.
Crossref
Daniel L. Kenney-Jung, Caren J. Blacker, Deniz Doruk Camsari, Jonathan C. Lee & Charles P. Lewis. (2019) Transcranial Direct Current Stimulation. Child and Adolescent Psychiatric Clinics of North America 28:1, pages 53-60.
Crossref
Farrokh Mansouri, Peter Fettes, Laura Schulze, Peter Giacobbe, Jose Zariffa & Jonathan Downar. (2018) A Real-Time Phase-Locking System for Non-invasive Brain Stimulation. Frontiers in Neuroscience 12.
Crossref
Qing‐Mei Kong, Hong Qiao, Chao‐Zhong Liu, Ping Zhang, Ke Li, Li Wang, Ji‐Tao Li, Yun'Ai Su, Ke‐Qing Li, Chao‐Gan Yan, Philip B. Mitchell & Tian‐Mei Si. (2018) Aberrant intrinsic functional connectivity in thalamo‐cortical networks in major depressive disorder. CNS Neuroscience & Therapeutics 24:11, pages 1063-1072.
Crossref
Min D. Tang-Schomer, Taylor Jackvony & Sabato Santaniello. (2018) Cortical Network Synchrony Under Applied Electrical Field in vitro. Frontiers in Neuroscience 12.
Crossref
Randolph F. Helfrich, Ian C. Fiebelkorn, Sara M. Szczepanski, Jack J. Lin, Josef Parvizi, Robert T. Knight & Sabine Kastner. (2018) Neural Mechanisms of Sustained Attention Are Rhythmic. Neuron 99:4, pages 854-865.e5.
Crossref
Ehsan Negahbani, Florian H. Kasten, Christoph S. Herrmann & Flavio Fröhlich. (2018) Targeting alpha-band oscillations in a cortical model with amplitude-modulated high-frequency transcranial electric stimulation. NeuroImage 173, pages 3-12.
Crossref
Salvatore Domenic Morgera. 2018. Electric Field. Electric Field.
Christoph S. Herrmann & Daniel Strüber. (2017) What Can Transcranial Alternating Current Stimulation Tell Us About Brain Oscillations?. Current Behavioral Neuroscience Reports 4:2, pages 128-137.
Crossref
Yogi A. Patel, Ansel George, Alan D. Dorval, John A. White, David J. Christini & Robert J. Butera. (2017) Hard real-time closed-loop electrophysiology with the Real-Time eXperiment Interface (RTXI). PLOS Computational Biology 13:5, pages e1005430.
Crossref
Preeya Khanna & Jose M Carmena. (2017) Beta band oscillations in motor cortex reflect neural population signals that delay movement onset. eLife 6.
Crossref
Manuel Varlet, Alanna Wade, Giacomo Novembre & Peter E. Keller. (2017) Investigation of the effects of transcranial alternating current stimulation (tACS) on self-paced rhythmic movements. Neuroscience 350, pages 75-84.
Crossref
Didier Pinault. (2017) A Neurophysiological Perspective on a Preventive Treatment against Schizophrenia Using Transcranial Electric Stimulation of the Corticothalamic Pathway. Brain Sciences 7:12, pages 34.
Crossref
Marta Parazzini, Serena Fiocchi, Andrea Cancelli, Carlo Cottone, Ilaria Liorni, Paolo Ravazzani & Franca Tecchio. (2017) A Computational Model of the Electric Field Distribution due to Regional Personalized or Nonpersonalized Electrodes to Select Transcranial Electric Stimulation Target. IEEE Transactions on Biomedical Engineering 64:1, pages 184-195.
Crossref
Lorenza S. ColzatoLorenza S. Colzato, Vera Mekern, Michael A. Nitsche & Roberta Sellaro. 2017. Theory-Driven Approaches to Cognitive Enhancement. Theory-Driven Approaches to Cognitive Enhancement 133 145 .
Philip M. Lewis, Richard H. Thomson, Jeffrey V. Rosenfeld & Paul B. Fitzgerald. (2016) Brain Neuromodulation Techniques. The Neuroscientist 22:4, pages 406-421.
Crossref
Caroline Lustenberger, Michael R. Boyle, Sankaraleengam Alagapan, Juliann M. Mellin, Bradley V. Vaughn & Flavio Fröhlich. (2016) Feedback-Controlled Transcranial Alternating Current Stimulation Reveals a Functional Role of Sleep Spindles in Motor Memory Consolidation. Current Biology 26:16, pages 2127-2136.
Crossref
Crystal Edler Schiller, Sarah L. Johnson, Anna C. Abate, Peter J. Schmidt & David R. Rubinow. 2011. Comprehensive Physiology. Comprehensive Physiology 1135 1160 .
Flavio Fröhlich. (2015) Tuning out the Blues – Thalamo-Cortical Rhythms as a Successful Target for Treating Depression. Brain Stimulation 8:6, pages 1007-1009.
Crossref
Bettina Pollok, Ann-Christin Boysen & Vanessa Krause. (2015) The effect of transcranial alternating current stimulation (tACS) at alpha and beta frequency on motor learning. Behavioural Brain Research 293, pages 234-240.
Crossref
Toralf Neuling, Philipp Ruhnau, Marco Fuscà, Gianpaolo Demarchi, Christoph S. Herrmann & Nathan Weisz. (2015) Friends, not foes: Magnetoencephalography as a tool to uncover brain dynamics during transcranial alternating current stimulation. NeuroImage 118, pages 406-413.
Crossref
Xile Wei, Bingjie Li, Meili Lu, Guosheng Yi & Jiang Wang. (2015) Modulation of spike coding by subthreshold extracellular electric fields and neuronal morphology. International Journal of Modern Physics B 29:21, pages 1550148.
Crossref
Andrew F. Leuchter, Ian A. Cook, David Feifel, John W. Goethe, Mustafa Husain, Linda L. Carpenter, Michael E. Thase, Andrew D. Krystal, Noah S. Philip, Mahendra T. Bhati, William J. Burke, Robert H. Howland, Yvette I. Sheline, Scott T. Aaronson, Dan V. Iosifescu, John P. O'Reardon, William S. Gilmer, Rakesh Jain, Karl S. Burgoyne, Bill Phillips, Paul J. Manberg, Joseph Massaro, Aimee M. Hunter, Sarah H. Lisanby & Mark S. George. (2015) Efficacy and Safety of Low-field Synchronized Transcranial Magnetic Stimulation (sTMS) for Treatment of Major Depression. Brain Stimulation 8:4, pages 787-794.
Crossref
Caroline Lustenberger, Michael R. Boyle, A. Alban Foulser, Juliann M. Mellin & Flavio Fröhlich. (2015) Functional role of frontal alpha oscillations in creativity. Cortex 67, pages 74-82.
Crossref
Andrew F. Leuchter, Aimee M. Hunter, David E. Krantz & Ian A. Cook. (2015) Rhythms and blues: modulation of oscillatory synchrony and the mechanism of action of antidepressant treatments. Annals of the New York Academy of Sciences 1344:1, pages 78-91.
Crossref
Xile Wei, Danhong Zhang, Meili Lu, Jiang Wang, Haitao Yu & Yanqiu Che. (2015) Endogenous field feedback promotes the detectability for exogenous electric signal in the hybrid coupled population. Chaos: An Interdisciplinary Journal of Nonlinear Science 25:1, pages 013113.
Crossref
Flavio Fröhlich. 2015. Computational Neurostimulation. Computational Neurostimulation 41 73 .
Ruairidh M. Battleday, Timothy Muller, Michael S. Clayton & Roi Cohen Kadosh. (2014) Mapping the Mechanisms of Transcranial Alternating Current Stimulation: A Pathway from Network Effects to Cognition. Frontiers in Psychiatry 5.
Crossref
Weifeng Xu, Brian S. Wolff & Jian-young Wu. (2014) Low-intensity electric fields induce two distinct response components in neocortical neuronal populations. Journal of Neurophysiology 112:10, pages 2446-2456.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.