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Dialogues in Clinical Neuroscience Volume 19, 2017 - Issue 2
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Translational Research

Affective neuroimaging in generalized anxiety disorder: an integrated review

Neuroimágenes de las emociones en el trastorno de ansiedad generalizada: una revisión integradora

Neuro-imagerie des émotions et anxiété généralisée : une analyse globale

Gregory A. FonzoDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA; Stanford Neurosciences Institute, Stanford University, Stanford, California, USA; Veterans Affairs Palo Alto Healthcare System and the Sierra-Pacific Mental Illness Research, Education, and Clinical Center (MIRECC), Palo Alto, California, USACorrespondence[email protected]
&
Amit EtkinDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA; Stanford Neurosciences Institute, Stanford University, Stanford, California, USA; Veterans Affairs Palo Alto Healthcare System and the Sierra-Pacific Mental Illness Research, Education, and Clinical Center (MIRECC), Palo Alto, California, USA
Pages 169-179 | Published online: 01 Apr 2022

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Bella Schanzer, Ana Maria Rivas-Grajales, Aamir Khan & Sanjay J Mathew. (2019) Novel investigational therapeutics for generalized anxiety disorder (GAD). Expert Opinion on Investigational Drugs 28:11, pages 1003-1012.
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Mbemba Jabbi & Charles B. Nemeroff. (2019) Convergent neurobiological predictors of mood and anxiety symptoms and treatment response. Expert Review of Neurotherapeutics 19:6, pages 587-597.
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Articles from other publishers (47)

Xiaoyan Zhai, Ronghong Jiao, Aihua Ni & Xueyi Wang. (2023) Case report: Anxiety and depression as initial symptoms in a patient with acute hypoxia and patent foramen ovale. Frontiers in Psychiatry 14.
Crossref
Jonas L. Steinhäuser, Adam R. Teed, Obada Al-Zoubi, René Hurlemann, Gang Chen & Sahib S. Khalsa. (2023) Reduced vmPFC-insula functional connectivity in generalized anxiety disorder: a Bayesian confirmation study. Scientific Reports 13:1.
Crossref
Fanny Weber-Goericke & Markus Muehlhan. (2023) High and low worriers do not differ in unstimulated resting-state brain connectivity. Scientific Reports 13:1.
Crossref
Nicole J. LeBlanc, Anna Bartuska, Lillian Blanchard & Luana Marques. 2023. The Massachusetts General Hospital Handbook of Cognitive Behavioral Therapy. The Massachusetts General Hospital Handbook of Cognitive Behavioral Therapy 65 80 .
Saren H. Seeley, Jessica R. Andrews‐Hanna, John J. B. Allen & Mary‐Frances O'Connor. (2022) Dwelling in prolonged grief: Resting state functional connectivity during oxytocin and placebo administration. Human Brain Mapping 44:1, pages 245-257.
Crossref
Yuanyuan Cheng, Yue Wang, Wen Zhang, Junbo Yin, Jicheng Dong & Jintong Liu. (2022) Relationship between intestinal flora, inflammation, BDNF gene polymorphism and generalized anxiety disorder: A clinical investigation. Medicine 101:29, pages e28910.
Crossref
Andrea L. Nelson, Leanne Quigley, Jonathan Carriere, Elizabeth Kalles, Daniel Smilek & Christine Purdon. (2022) Avoidance of mild threat observed in generalized anxiety disorder (GAD) using eye tracking. Journal of Anxiety Disorders 88, pages 102577.
Crossref
Parnian Shobeiri, Amirali Kalantari, Antônio L. Teixeira & Nima Rezaei. (2022) Shedding light on biological sex differences and microbiota–gut–brain axis: a comprehensive review of its roles in neuropsychiatric disorders. Biology of Sex Differences 13:1.
Crossref
Sahar Jahed, Nicholas O. Daneshvari, Angela L. Liang, Lisa N. Richey, Barry R. Bryant, Akshay Krieg, Michael J.C. Bray, Tejus Pradeep, Licia P. Luna, Nicholas T. Trapp, Melissa B. Jones, Daniel A. Stevens, Carrie Roper, Eric L. Goldwaser, Emily Berich-Anastasio, Alexandra Pletnikova, Katie Lobner, Daniel J. Lee, Margo Lauterbach, Haris I. Sair & Matthew E. Peters. (2022) Neuroimaging Correlates of Syndromal Anxiety Following Traumatic Brain Injury: A Systematic Review of the Literature. Journal of the Academy of Consultation-Liaison Psychiatry 63:2, pages 119-132.
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Sandra J. Llera, Ki Eun Shin, Thane M. Erickson, Amy Przeworski & Michelle G. Newman. 2022. Comprehensive Clinical Psychology. Comprehensive Clinical Psychology 336 355 .
Shuang Hu, Xiao-jun Li, Samuel Law, Chen-yu Shen, Guan-qun Yao, Xiao-qian Zhang, Juan Li, Gui-fang Chen, Bo Xu, Xiao-min Liu, Xiang-yun Ma, Kun Feng & Po-zi Liu. (2021) Prefrontal cortex alterations in major depressive disorder, generalized anxiety disorder and their comorbidity during a verbal fluency task assessed by multi-channel near-infrared spectroscopy. Psychiatry Research 306, pages 114229.
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Andrew R. Gerlach, Helmet T. Karim, Joseph Kazan, Howard J. Aizenstein, Robert T. Krafty & Carmen Andreescu. (2021) Networks of worry—towards a connectivity-based signature of late-life worry using higher criticism. Translational Psychiatry 11:1.
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Chris Baeken, Yanfeng Xu, Guo-Rong Wu, Robrecht Dockx, Kathelijne Peremans & Rudi De Raedt. (2021) Hostility in medication-resistant major depression and comorbid generalized anxiety disorder is related to increased hippocampal–amygdala 5-HT2A receptor density. European Archives of Psychiatry and Clinical Neuroscience 271:7, pages 1369-1378.
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Julie Petersen, Clarissa W. Ong, Allison S. Hancock, Ronald B. Gillam, Michael E. Levin & Michael P. Twohig. (2021) An Examination of the Relationship Between Perfectionism and Neurological Functioning. Journal of Cognitive Psychotherapy 35:3, pages 195-211.
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Jaryd Hiser, Brett Schneider & Michael Koenigs. (2021) Uncertainty Potentiates Neural and Cardiac Responses to Visual Stimuli in Anxiety Disorders. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 6:7, pages 725-734.
Crossref
Shankar Tumati, Martin P. Paulus & Georg Northoff. (2021) Out-of-step: brain-heart desynchronization in anxiety disorders. Molecular Psychiatry 26:6, pages 1726-1737.
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Goran Šimić, Mladenka Tkalčić, Vana Vukić, Damir Mulc, Ena Španić, Marina Šagud, Francisco E. Olucha-Bordonau, Mario Vukšić & Patrick R. Hof. (2021) Understanding Emotions: Origins and Roles of the Amygdala. Biomolecules 11:6, pages 823.
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Megan Kate Finnegan, Stephanie Kane, Wendy Heller & Heidemarie Laurent. (2021) Mothers’ neural response to valenced infant interactions predicts postpartum depression and anxiety. PLOS ONE 16:4, pages e0250487.
Crossref
Brenda WJH Penninx, Daniel S Pine, Emily A Holmes & Andreas Reif. (2021) Anxiety disorders. The Lancet 397:10277, pages 914-927.
Crossref
Johannah Bashford‐Largo, Joseph Aloi, Jennie Lukoff, Kimberly Johnson, Stuart F. White, Matthew Dobbertin, Robert James Blair & Karina S. Blair. (2020) Reduced top‐down attentional control in adolescents with generalized anxiety disorder. Brain and Behavior 11:2.
Crossref
Kamini Ho Pian & Monique Nederstigt. 2021. Slaapstoornissen in de psychiatrie. Slaapstoornissen in de psychiatrie 229 253 .
Catherine Elorette, Brittany L. Aguilar, Vera Novak, Patrick A. Forcelli & Ludise Malkova. (2020) Dysregulation of behavioral and autonomic responses to emotional and social stimuli following bidirectional pharmacological manipulation of the basolateral amygdala in macaques. Neuropharmacology 179, pages 108275.
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Frauke Nees, Michaela Ruttorf, Xaver Fuchs, Mariela Rance & Nicole Beyer. (2019) Volumetric brain correlates of approach-avoidance behavior and their relation to chronic back pain. Brain Imaging and Behavior 14:5, pages 1758-1768.
Crossref
Mia A. McLean, Gabrielle Simcock, Guillaume Elgbeili, David P. Laplante, Sue Kildea, Elizabeth Hurrion, Belinda Lequertier, Vanessa E. Cobham & Suzanne King. (2020) Disaster-related prenatal maternal stress, and childhood HPA-axis regulation and anxiety: The QF2011 Queensland Flood Study. Psychoneuroendocrinology 118, pages 104716.
Crossref
Karina S. Blair, Johannah Bashford-Largo, Niraj Shah, Jennie Lukoff, Jaimie Elowsky, Steven Vogel, Amanda Emmert, Ru Zhang, Matthew Dobbertin, Seth Pollak & James R. Blair. (2020) Sexual Abuse in Adolescents Is Associated With Atypically Increased Responsiveness Within Regions Implicated in Self-Referential and Emotional Processing to Approaching Animate Threats. Frontiers in Psychiatry 11.
Crossref
D Porta-Casteràs, MA Fullana, D Tinoco, I Martínez-Zalacaín, J Pujol, DJ Palao, C Soriano-Mas, BJ Harrison, E Via & N Cardoner. (2020) Prefrontal-amygdala connectivity in trait anxiety and generalized anxiety disorder: Testing the boundaries between healthy and pathological worries. Journal of Affective Disorders 267, pages 211-219.
Crossref
Angelika Schmitt, Neeraj Upadhyay, Jason Anthony Martin, Sandra Rojas Vega, Heiko Klaus Strüder & Henning Boecker. (2020) Affective Modulation after High-Intensity Exercise Is Associated with Prolonged Amygdalar-Insular Functional Connectivity Increase. Neural Plasticity 2020, pages 1-10.
Crossref
Peng Zhao, Rui Yan, Xinyi Wang, Jiting Geng, Mohammad Ridwan Chattun, Qiang Wang, Zhijian Yao & Qing Lu. (2020) Reduced Resting State Neural Activity in the Right Orbital Part of Middle Frontal Gyrus in Anxious Depression. Frontiers in Psychiatry 10.
Crossref
Georg Northoff. 2020. Anxiety Disorders. Anxiety Disorders 71 90 .
Giampaolo Perna, Alessandra Alciati, Erika Sangiorgio, Daniela Caldirola & Charles B. Nemeroff. 2020. Anxiety Disorders. Anxiety Disorders 489 521 .
Jürgen Hoyer & Katja Beesdo-Baum. 2020. Klinische Psychologie & Psychotherapie. Klinische Psychologie & Psychotherapie 1099 1119 .
Yi-huan Chen, Jie Bai, Di Wu, Shou-fen Yu, Xiao-ling Qiang, Hua Bai, Hua-ning Wang & Zheng-wu Peng. (2019) Association between fecal microbiota and generalized anxiety disorder: Severity and early treatment response. Journal of Affective Disorders 259, pages 56-66.
Crossref
M Wu, DS Mennin, M Ly, HT Karim, L Banihashemi, DL Tudorascu, HJ Aizenstein & C Andreescu. (2019) When worry may be good for you: Worry severity and limbic-prefrontal functional connectivity in late-life generalized anxiety disorder. Journal of Affective Disorders 257, pages 650-657.
Crossref
Chunliang Feng, Zaixu Cui, Dazhi Cheng, Rui Xu & Ruolei Gu. (2018) Individualized prediction of dispositional worry using white matter connectivity. Psychological Medicine 49:12, pages 1999-2008.
Crossref
Bastiaan Goossen, Jeffrey van der Starre & Colin van der Heiden. (2019) A review of neuroimaging studies in generalized anxiety disorder: “So where do we stand?”. Journal of Neural Transmission 126:9, pages 1203-1216.
Crossref
Haijun Duan, Xuewei Wang, Zijuan Wang, Wenlong Xue, Yuecui Kan, Weiping Hu & Fengqing Zhang. (2019) Acute Stress Shapes Creative Cognition in Trait Anxiety. Frontiers in Psychology 10.
Crossref
Mengshi Dong, Likun Xia, Min Lu, Chao Li, Ke Xu & Lina Zhang. (2019) A failed top-down control from the prefrontal cortex to the amygdala in generalized anxiety disorder: Evidence from resting-state fMRI with Granger causality analysis. Neuroscience Letters 707, pages 134314.
Crossref
Mia A. McLean, Vanessa E. Cobham, Gabrielle Simcock, Sue Kildea & Suzanne King. (2019) Toddler Temperament Mediates the Effect of Prenatal Maternal Stress on Childhood Anxiety Symptomatology: The QF2011 Queensland Flood Study. International Journal of Environmental Research and Public Health 16:11, pages 1998.
Crossref
Jens Plag & Jürgen Hoyer. (2019) Die generalisierte Angststörung – ein Update. PSYCH up2date 13:03, pages 243-260.
Crossref
Lisa-Maria Schönfeld & Lars Wojtecki. (2019) Beyond Emotions: Oscillations of the Amygdala and Their Implications for Electrical Neuromodulation. Frontiers in Neuroscience 13.
Crossref
Anne S. Berry, Robert L. WhiteIIIIII, Daniella J. Furman, Jenna R. Naskolnakorn, Vyoma D. Shah, Mark D'Esposito & William J. Jagust. (2019) Dopaminergic Mechanisms Underlying Normal Variation in Trait Anxiety. The Journal of Neuroscience 39:14, pages 2735-2744.
Crossref
Liyuan Li, YiFeng Wang, Liangkai Ye, Wang Chen, Xinju Huang, Qian Cui, Zongling He, Dongfeng Liu & Huafu Chen. (2019) Altered Brain Signal Variability in Patients With Generalized Anxiety Disorder. Frontiers in Psychiatry 10.
Crossref
Tiffany A. Kolesar, Elena Bilevicius, Alyssia D. Wilson & Jennifer Kornelsen. (2019) Systematic review and meta-analyses of neural structural and functional differences in generalized anxiety disorder and healthy controls using magnetic resonance imaging. NeuroImage: Clinical 24, pages 102016.
Crossref
Brianna Adamson, Nicole Letourneau & Catherine Lebel. (2018) Prenatal maternal anxiety and children's brain structure and function: A systematic review of neuroimaging studies. Journal of Affective Disorders 241, pages 117-126.
Crossref
Cristina Ottaviani. (2018) Brain‐heart interaction in perseverative cognition. Psychophysiology 55:7.
Crossref
Erin S. Kenzie, Elle L. Parks, Erin D. Bigler, David W. Wright, Miranda M. Lim, James C. Chesnutt, Gregory W. J. Hawryluk, Wayne Gordon & Wayne Wakeland. (2018) The Dynamics of Concussion: Mapping Pathophysiology, Persistence, and Recovery With Causal-Loop Diagramming. Frontiers in Neurology 9.
Crossref
Meltem Weger & Carmen Sandi. (2018) High anxiety trait: A vulnerable phenotype for stress-induced depression. Neuroscience & Biobehavioral Reviews 87, pages 27-37.
Crossref

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