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Original Article

Genetic Influences on the Retention of Inorganic Mercury

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Pages 17-23 | Published online: 07 Aug 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Cheryl A. Fields, Jonathan Borak & Elan D. Louis. (2017) Mercury-induced motor and sensory neurotoxicity: systematic review of workers currently exposed to mercury vapor. Critical Reviews in Toxicology 47:10, pages 815-848.
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Vasco Branco, Sam Caito, Marcelo Farina, João Teixeira da Rocha, Michael Aschner & Cristina Carvalho. (2017) Biomarkers of mercury toxicity: Past, present, and future trends. Journal of Toxicology and Environmental Health, Part B 20:3, pages 119-154.
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Gustavo Rafael Mazzaron Barcelos, Kátia Cristina de Marco, Denise Grotto, Juliana Valentini, Solange Cristina Garcia, Gilberto Úbila Leite Braga & Fernando Barbosa$suffix/text()$suffix/text(). (2012) Evaluation of Glutathione S-transferase GSTM1 and GSTT1 Polymorphisms and Methylmercury Metabolism in an Exposed Amazon Population. Journal of Toxicology and Environmental Health, Part A 75:16-17, pages 960-970.
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Julia J. Wirth & Renée S. Mijal. (2010) Adverse Effects of Low Level Heavy Metal Exposure on Male Reproductive Function. Systems Biology in Reproductive Medicine 56:2, pages 147-167.
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Michael D Martin & James S Woods. (2006) The safety of dental amalgam in children. Expert Opinion on Drug Safety 5:6, pages 773-781.
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Mohammad H. Rahbar, Maureen Samms-Vaughan, Yuansong Zhao, Sepideh Saroukhani, Jan Bressler, Manouchehr Hessabi, Megan L. Grove, Sydonnie Shakespeare-Pellington & Katherine A. Loveland. (2022) Interactions between Environmental Factors and Glutathione S-Transferase (GST) Genes with Respect to Detectable Blood Aluminum Concentrations in Jamaican Children. Genes 13:10, pages 1907.
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Karin Broberg & Natalia Pawlas. 2022. Handbook on the Toxicology of Metals. Handbook on the Toxicology of Metals 349 368 .
Claudia Gundacker, Klaudia Graf-Rohrmeister, Martin Gencik, Markus Hengstschläger, Karol Holoman, Petra Rosa, Renate Kroismayr, Ivo Offenthaler, Veronika Plichta, Theresa Reischer, Isabella Teufl, Wolfgang Raffesberg, Sigrid Scharf, Birgit Köhler-Vallant, Zoja Delissen, Stefan Weiß & Maria Uhl. (2021) Gene Variants Determine Placental Transfer of Perfluoroalkyl Substances (PFAS), Mercury (Hg) and Lead (Pb), and Birth Outcome: Findings From the UmMuKi Bratislava-Vienna Study. Frontiers in Genetics 12.
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Olga Marcela Medina Pérez, Oscar Flórez-Vargas, Giovanna Rincón Cruz, Fernando Rondón González, Linda Rocha Muñoz & Luz Helena Sánchez Rodríguez. (2021) Glutathione-related genetic polymorphisms are associated with mercury retention and nephrotoxicity in gold-mining settings of a Colombian population. Scientific Reports 11:1.
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Francesco Chirico, Egeria Scoditti, Carlo Viora & Nicola Magnavita. (2020) How Occupational Mercury Neurotoxicity Is Affected by Genetic Factors. A Systematic Review. Applied Sciences 10:21, pages 7706.
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Peggy Hiu Ying Chan, Kathy Yuen Yee Chan, Catherine Mary Schooling, Lai Ling Hui, Michael Ho Ming Chan, Albert Martin Li, Robert Chi Keung Cheung & Hugh Simon Lam. (2020) Association between genetic variations in GSH-related and MT genes and low-dose methylmercury exposure in children and women of childbearing age: a pilot study. Environmental Research 187, pages 109703.
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Homero C. Harari, Raul E. Harari & Ramiro I. Lopez. 2020. Information Resources in Toxicology. Information Resources in Toxicology 155 161 .
Geir Bjørklund, Bjørn Hilt, Maryam Dadar, Ulf Lindh & Jan Aaseth. (2019) Neurotoxic effects of mercury exposure in dental personnel. Basic & Clinical Pharmacology & Toxicology 124:5, pages 568-574.
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Zeinab Joneidi, Yousef Mortazavi, Fatemeh Memari, Amir Roointan, Bahram Chahardouli & Shahrbano Rostami. (2019) The impact of genetic variation on metabolism of heavy metals: Genetic predisposition?. Biomedicine & Pharmacotherapy 113, pages 108642.
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Yury I. Chernyak. (2018) POLYMORPHIC CYPS AND GSTS GENES’ LOCI IN WORKERS EXPOSED TO CHRONIC MERCURY VAPOR EXPOSURE. Hygiene and sanitation 97:10, pages 921-924.
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Geir Bjørklund, Anatoly V. Skalny, Md. Mostafizur Rahman, Maryam Dadar, Heba A. Yassa, Jan Aaseth, Salvatore Chirumbolo, Margarita G. Skalnaya & Alexey A. Tinkov. (2018) Toxic metal(loid)-based pollutants and their possible role in autism spectrum disorder. Environmental Research 166, pages 234-250.
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Jan Aaseth, Bjørn Hilt & Geir Bjørklund. (2018) Mercury exposure and health impacts in dental personnel. Environmental Research 164, pages 65-69.
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Karin Wahlberg, Tanzy M. Love, Daniela Pineda, Karin Engström, Gene E. Watson, Sally W. Thurston, Alison J. Yeates, Maria S. Mulhern, Emeir M. McSorley, J.J. Strain, Tristram H. Smith, Philip W. Davidson, Conrad F. Shamlaye, G.J. Myers, Matthew D. Rand, Edwin van Wijngaarden & Karin Broberg. (2018) Maternal polymorphisms in glutathione-related genes are associated with maternal mercury concentrations and early child neurodevelopment in a population with a fish-rich diet. Environment International 115, pages 142-149.
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Collin A. Eagles-Smith, Ellen K. Silbergeld, Niladri Basu, Paco Bustamante, Fernando Diaz-Barriga, William A. Hopkins, Karen A. Kidd & Jennifer F. Nyland. (2018) Modulators of mercury risk to wildlife and humans in the context of rapid global change. Ambio 47:2, pages 170-197.
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Bruce G. Marshall, Marcello M. Veiga, Robert J. Kaplan, Rebecca Adler Miserendino, Gary Schudel, Bridget A. Bergquist, Jean R. D. Guimarães, Luis G. S. Sobral & Carolina Gonzalez-Mueller. (2018) Evidence of transboundary mercury and other pollutants in the Puyango-Tumbes River basin, Ecuador–Peru. Environmental Science: Processes & Impacts 20:4, pages 632-641.
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Virginia Andreoli & Francesca Sprovieri. (2017) Genetic Aspects of Susceptibility to Mercury Toxicity: An Overview. International Journal of Environmental Research and Public Health 14:1, pages 93.
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Luz Helena Sánchez Rodríguez, Laura Andrea Rodríguez-Villamizar, Oscar Flórez-Vargas, Yolanda Vargas Fiallo, Álvaro Ordoñez & Myriam del Carmen Gutiérrez. (2016) No effect of mercury exposure on kidney function during ongoing artisanal gold mining activities in Colombia. Toxicology and Industrial Health 33:1, pages 67-78.
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Eunhee Ha, Niladri Basu, Stephan Bose-O’Reilly, José G. Dórea, Emeir McSorley, Mineshi Sakamoto & Hing Man Chan. (2017) Current progress on understanding the impact of mercury on human health. Environmental Research 152, pages 419-433.
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Rajendra Prasad Parajuli, Jaclyn M. Goodrich, Hwai-Nan Chou, Stephen E. Gruninger, Dana C. Dolinoy, Alfred Franzblau & Niladri Basu. (2016) Genetic polymorphisms are associated with hair, blood, and urine mercury levels in the American Dental Association (ADA) study participants. Environmental Research 149, pages 247-258.
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Renee M. Gardner & Jennifer F. Nyland. 2016. Environmental Influences on the Immune System. Environmental Influences on the Immune System 273 302 .
Esther Ng, P. Monica Lind, Cecilia Lindgren, Erik Ingelsson, Anubha Mahajan, Andrew Morris & Lars Lind. (2015) Genome-wide association study of toxic metals and trace elements reveals novel associations. Human Molecular Genetics 24:16, pages 4739-4745.
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Sabrina Llop, Ferran Ballester & Karin Broberg. (2015) Effect of Gene-Mercury Interactions on Mercury Toxicokinetics and Neurotoxicity. Current Environmental Health Reports 2:2, pages 179-194.
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Karin Broberg, Karin Engström & Shegufta Ameer. 2015. Handbook on the Toxicology of Metals. Handbook on the Toxicology of Metals 239 264 .
Anders Kasper Bruun Kristensen, Jane Frølund Thomsen & Sigurd Mikkelsen. (2013) A review of mercury exposure among artisanal small-scale gold miners in developing countries. International Archives of Occupational and Environmental Health 87:6, pages 579-590.
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Niladri Basu, Jaclyn M. Goodrich & Jessica Head. (2014) Ecogenetics of mercury: From genetic polymorphisms and epigenetics to risk assessment and decision-making. Environmental Toxicology and Chemistry 33:6, pages 1248-1258.
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Sabrina Llop, Karin Engström, Ferran Ballester, Elisa Franforte, Ayman Alhamdow, Federica Pisa, Janja Snoj Tratnik, Datja Mazej, Mario Murcia, Marisa Rebagliato, Mariona Bustamante, Jordi Sunyer, Αikaterini Sofianou-Katsoulis, Alexia Prasouli, Eleni Antonopoulou, Ioanna Antoniadou, Sheena Nakou, Fabio Barbone, Milena Horvat & Karin Broberg. (2014) Polymorphisms in ABC Transporter Genes and Concentrations of Mercury in Newborns – Evidence from Two Mediterranean Birth Cohorts. PLoS ONE 9:5, pages e97172.
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James P.K. Rooney. (2014) The retention time of inorganic mercury in the brain — A systematic review of the evidence. Toxicology and Applied Pharmacology 274:3, pages 425-435.
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Kristin G. Homme, Janet K. Kern, Boyd E. Haley, David A. Geier, Paul G. King, Lisa K. Sykes & Mark R. Geier. (2014) New science challenges old notion that mercury dental amalgam is safe. BioMetals 27:1, pages 19-24.
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Andréia Ávila Soares de Oliveira, Marilesia Ferreira de Souza, André van Helvoort Lengert, Marcelo Tempesta de Oliveira, Rossana Batista de Oliveira Godoy Camargo, Gilberto Úbida Leite Braga, Ilce Mara de Syllos Cólus, Fernando Barbosa & Gustavo Rafael Mazzaron Barcelos. (2014) Genetic Polymorphisms in Glutathione (GSH-) Related Genes Affect the Plasmatic Hg/Whole Blood Hg Partitioning and the Distribution between Inorganic and Methylmercury Levels in Plasma Collected from a Fish-Eating Population. BioMed Research International 2014, pages 1-8.
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Yuanyuan Zhang, Junhong Liu, Yuanming Zhou, Tingyun Gong, Jing Wang & Yinlin Ge. (2013) Enhanced phytoremediation of mixed heavy metal (mercury)–organic pollutants (trichloroethylene) with transgenic alfalfa co-expressing glutathione S-transferase and human P450 2E1. Journal of Hazardous Materials 260, pages 1100-1107.
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Issa E.A. Amara, Anwar Anwar-Mohamed, Ghada Abdelhamid & Ayman O.S. El-Kadi. (2013) Mercury modulates the cytochrome P450 1a1, 1a2 and 1b1 in C57BL/6J mice: in vivo and in vitro studies. Toxicology and Applied Pharmacology 266:3, pages 419-429.
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Karin Engström, Shegufta Ameer, Ludovic Bernaudat, Gustav Drasch, Jennifer Baeuml, Staffan Skerfving, Stephan Bose-O’Reilly & Karin Broberg. (2013) Polymorphisms in Genes Encoding Potential Mercury Transporters and Urine Mercury Concentrations in Populations Exposed to Mercury Vapor from Gold Mining. Environmental Health Perspectives 121:1, pages 85-91.
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Dorota Mrozek-Budzyn, Renata Majewska, Agnieszka Kieltyka & Malgorzata Augustyniak. (2012) Neonatal exposure to Thimerosal from vaccines and child development in the first 3years of life. Neurotoxicology and Teratology 34:6, pages 592-597.
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Raúl Harari, Florencia Harari, Lars Gerhardsson, Thomas Lundh, Staffan Skerfving, Ulf Strömberg & Karin Broberg. (2012) Exposure and toxic effects of elemental mercury in gold-mining activities in Ecuador. Toxicology Letters 213:1, pages 75-82.
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Jaclyn M. Goodrich & Niladri Basu. (2012) Variants of glutathione s-transferase pi 1 exhibit differential enzymatic activity and inhibition by heavy metals. Toxicology in Vitro 26:4, pages 630-635.
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Yi WangJaclyn M. GoodrichBrenda Gillespie, Robert Werner, Niladri BasuAlfred Franzblau. (2012) An Investigation of Modifying Effects of Metallothionein Single-Nucleotide Polymorphisms on the Association between Mercury Exposure and Biomarker Levels. Environmental Health Perspectives 120:4, pages 530-534.
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Barry Wright, Helen Pearce, Victoria Allgar, Jeremy Miles, Clare Whitton, Irene Leon, Jenny Jardine, Nicola McCaffrey, Rob Smith, Ian Holbrook, John Lewis, David Goodall & Ben Alderson-Day. (2012) A Comparison of Urinary Mercury between Children with Autism Spectrum Disorders and Control Children. PLoS ONE 7:2, pages e29547.
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Yi Wang, Jaclyn M. Goodrich, Robert Werner, Brenda Gillespie, Niladri Basu & Alfred Franzblau. (2012) An investigation of modifying effects of single nucleotide polymorphisms in metabolism-related genes on the relationship between peripheral nerve function and mercury levels in urine and hair. Science of The Total Environment 417-418, pages 32-38.
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Karin S Engström, Maria Wennberg, Ulf Strömberg, Ingvar A Bergdahl, Göran Hallmans, Jan-Håkan Jansson, Thomas Lundh, Margareta Norberg, Gerda Rentschler, Bengt Vessby, Staffan Skerfving & Karin Broberg. (2011) Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study. Environmental Health 10:1.
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Oscar N Ruiz, Derry Alvarez, Gloriene Gonzalez-Ruiz & Cesar Torres. (2011) Characterization of mercury bioremediation by transgenic bacteria expressing metallothionein and polyphosphate kinase. BMC Biotechnology 11:1.
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Jaclyn M. Goodrich, Yi Wang, Brenda Gillespie, Robert Werner, Alfred Franzblau & Niladri Basu. (2011) Glutathione enzyme and selenoprotein polymorphisms associate with mercury biomarker levels in Michigan dental professionals. Toxicology and Applied Pharmacology 257:2, pages 301-308.
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José G. Dórea. (2010) Making sense of epidemiological studies of young children exposed to thimerosal in vaccines. Clinica Chimica Acta 411:21-22, pages 1580-1586.
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Claudia Gundacker, Martin Gencik & Markus Hengstschläger. (2010) The relevance of the individual genetic background for the toxicokinetics of two significant neurodevelopmental toxicants: Mercury and lead. Mutation Research/Reviews in Mutation Research 705:2, pages 130-140.
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Bo-Eun Lee, Yun-Chul Hong, Hyesook Park, Mina Ha, Bon Sang Koo, Namsoo Chang, Young-Man Roh, Boong-Nyun Kim, Young-Ju Kim, Byung-Mi Kim, Seong-Joon Jo & Eun-Hee Ha. (2010) Interaction between GSTM1 / GSTT1 Polymorphism and Blood Mercury on Birth Weight . Environmental Health Perspectives 118:3, pages 437-443.
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Bo-Eun Lee, Yun-Chul Hong, Hyesook Park, Mina Ha, Bon Sang Koo, Namsoo Chang, Young-Man Roh, Boong-Nyun Kim, Young-Ju Kim, Byung-Mi Kim, Seong-Joon Jo & Eun-Hee Ha. (2009) Interaction between GSTM1/GSTT1 Polymorphism and Blood Mercury on Birth Weight. Environmental Health Perspectives 118:3, pages 437-443.
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Michael Schiraldi & Marc Monestier. (2009) How can a chemical element elicit complex immunopathology? Lessons from mercury-induced autoimmunity. Trends in Immunology 30:10, pages 502-509.
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Claudia Gundacker, Karl J. Wittmann, Martina Kukuckova, Günter Komarnicki, Imrich Hikkel & Martin Gencik. (2009) Genetic background of lead and mercury metabolism in a group of medical students in Austria. Environmental Research 109:6, pages 786-796.
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Bernard Testa & Stefanie D. Krämer. (2009) The Biochemistry of Drug Metabolism – An Introduction. Chemistry & Biodiversity 6:5, pages 591-684.
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Karin Schläwicke Engström, Ulf Strömberg, Thomas Lundh, Ingegerd Johansson, Bengt Vessby, Göran Hallmans, Staffan Skerfving & Karin Broberg. (2008) Genetic Variation in Glutathione-Related Genes and Body Burden of Methylmercury. Environmental Health Perspectives 116:6, pages 734-739.
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