2,436
Views
75
CrossRef citations to date
0
Altmetric
Short Communications

Tumour exosomes display differential mechanical and complement activation properties dependent on malignant state: implications in endothelial leakiness

, , , , , , , & show all
Article: 29685 | Received 09 Sep 2015, Accepted 11 Nov 2015, Published online: 28 Dec 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Camila Leiva-Sabadini, Simon Alvarez, Nelson P Barrera, Christina M A P Schuh & Sebastian Aguayo. (2021) Antibacterial Effect of Honey-Derived Exosomes Containing Antimicrobial Peptides Against Oral Streptococci. International Journal of Nanomedicine 16, pages 4891-4900.
Read now
Elisa Lázaro-Ibáñez, Maarit Neuvonen, Maarit Takatalo, Uma Thanigai Arasu, Cristian Capasso, Vincenzo Cerullo, Johng S. Rhim, Kirsi Rilla, Marjo Yliperttula & Pia R.-M. Siljander. (2017) Metastatic state of parent cells influences the uptake and functionality of prostate cancer cell-derived extracellular vesicles. Journal of Extracellular Vesicles 6:1.
Read now

Articles from other publishers (73)

Sharat Chandra Barman, Dana Al Sulaiman, Xingchao Wang, Zhenglong Sun, Husam N. Alshareef & Chen-zhong Li. (2023) Bioelectrical and biomechanical properties of Extracellular Vesicles - Outlook and Electrochemical Biosensing. Current Opinion in Electrochemistry, pages 101311.
Crossref
Mi Ho Jeong, Hyungsoon Im & Joanna B. Dahl. (2023) Non‐Contact Microfluidic Analysis of the Stiffness of Single Large Extracellular Vesicles from IDH1‐Mutated Glioblastoma Cells. Advanced Materials Technologies 8:7.
Crossref
Koushik Debnath, Kevin Las Heras, Ambar Rivera, Stephen Lenzini & Jae-Won Shin. (2023) Extracellular vesicle–matrix interactions. Nature Reviews Materials 8:6, pages 390-402.
Crossref
Linyun Tan, Yitian Wang, Xin Hu & Li Min. (2023) The Roles of Exosomes in Metastasis of Sarcoma: From Biomarkers to Therapeutic Targets. Biomolecules 13:3, pages 456.
Crossref
Seokbeom Roh, Taeha Lee, Da Yeon Cheong, Yeonjin Kim, Soohwan Oh & Gyudo Lee. (2023) Direct observation of surface charge and stiffness of human metaphase chromosomes. Nanoscale Advances 5:2, pages 368-377.
Crossref
Elisabetta Vergani, Elena Daveri, Viviana Vallacchi, Laura Bergamaschi, Luca Lalli, Chiara Castelli, Monica Rodolfo, Licia Rivoltini & Veronica Huber. (2022) Extracellular vesicles in anti-tumor immunity. Seminars in Cancer Biology 86, pages 64-79.
Crossref
Elma Sakinatus Sajidah, Keesiang Lim, Tomoyoshi Yamano, Goro Nishide, Yujia Qiu, Takeshi Yoshida, Hanbo Wang, Akiko Kobayashi, Masaharu Hazawa, Firli R. P. Dewi, Rikinari Hanayama, Toshio Ando & Richard W. Wong. (2022) Spatiotemporal tracking of small extracellular vesicle nanotopology in response to physicochemical stresses revealed by HS‐AFM. Journal of Extracellular Vesicles 11:11.
Crossref
Debashish Paul, Anirban Paul, Dipanjan Mukherjee, Saroj Saroj, Manorama Ghosal, Suchetan Pal, Dulal Senapati, Jaydeb Chakrabarti, Samir Kumar Pal & Tatini Rakshit. (2022) A Mechanoelastic Glimpse on Hyaluronan-Coated Extracellular Vesicles. The Journal of Physical Chemistry Letters 13:36, pages 8564-8572.
Crossref
Yanling Cai & Di Wu. 2022. Extracellular Vesicles - Role in Diseases, Pathogenesis and Therapy. Extracellular Vesicles - Role in Diseases, Pathogenesis and Therapy.
Yu Zhang, Tuoyu Ju, Mingyan Gao, Zhengxun Song, Hongmei Xu, Zuobin Wang & Ying Wang. (2022) Electrical characterization of tumor-derived exosomes by conductive atomic force microscopy. Nanotechnology 33:29, pages 295103.
Crossref
Viktor Yu. Bairamukov, Anton S. Bukatin, Roman A. Kamyshinsky, Vladimir S. Burdakov, Evgeny B. Pichkur, Tatiana A. Shtam & Maria N. Starodubtseva. (2022) Nanomechanical characterization of exosomes and concomitant nanoparticles from blood plasma by PeakForce AFM in liquid. Biochimica et Biophysica Acta (BBA) - General Subjects 1866:7, pages 130139.
Crossref
Brateen Datta, Debashish Paul, Tina Dey, Suchetan Pal & Tatini Rakshit. (2022) Importance of Extracellular Vesicle Derived RNAs as Critical Colorectal Cancer Biomarkers. ACS Bio & Med Chem Au 2:3, pages 222-235.
Crossref
Meruyert Imanbekova, Sorina Suarasan, Yao Lu, Sarah Jurchuk & Sebastian Wachsmann-Hogiu. (2022) Recent advances in optical label-free characterization of extracellular vesicles. Nanophotonics 11:12, pages 2827-2863.
Crossref
Changjin Huang, Hui Li, Juliana S. Powell, Yingshi Ouyang, Stacy G. Wendell, Subra Suresh, K. Jimmy Hsia, Yoel Sadovsky & David Quinn. (2022) Assessing hypoxic damage to placental trophoblasts by measuring membrane viscosity of extracellular vesicles. Placenta 121, pages 14-22.
Crossref
Luke van der Koog, Timea B. Gandek & Anika Nagelkerke. (2021) Liposomes and Extracellular Vesicles as Drug Delivery Systems: A Comparison of Composition, Pharmacokinetics, and Functionalization. Advanced Healthcare Materials 11:5.
Crossref
Weinan Guo, Huina Wang & Chunying Li. (2021) Signal pathways of melanoma and targeted therapy. Signal Transduction and Targeted Therapy 6:1.
Crossref
Peiwen Fu, Jianguo Zhang, Haitao Li, Michael Mak, Wenrong Xu & Zhimin Tao. (2021) Extracellular vesicles as delivery systems at nano-/micro-scale. Advanced Drug Delivery Reviews 179, pages 113910.
Crossref
Barbara Bortot, Maura Apollonio, Enrico Rampazzo, Francesco Valle, Marco Brucale, Andrea Ridolfi, Blendi Ura, Riccardo Addobbati, Giovanni Di Lorenzo, Federico Romano, Francesca Buonomo, Chiara Ripepi, Giuseppe Ricci & Stefania Biffi. (2021) Small extracellular vesicles from malignant ascites of patients with advanced ovarian cancer provide insights into the dynamics of the extracellular matrix. Molecular Oncology 15:12, pages 3596-3614.
Crossref
Andrea Ridolfi, Lucrezia Caselli, Matteo Baldoni, Costanza Montis, Francesco Mercuri, Debora Berti, Francesco Valle & Marco Brucale. (2021) Stiffness of Fluid and Gel Phase Lipid Nanovesicles: Weighting the Contributions of Membrane Bending Modulus and Luminal Pressurization. Langmuir 37:41, pages 12027-12037.
Crossref
Ying-Chen Cheng, Yu-An Chang, Yi-Jen Chen, Hsu-Min Sung, Ivan Bogeski, Hong-Lin Su, Ya-Ling Hsu & Hui-Min David Wang. (2021) The Roles of Extracellular Vesicles in Malignant Melanoma. Cells 10:10, pages 2740.
Crossref
Michael LeClaire, James A. Wohlschlegel, Helena Chang, Madhuri Wadehra, Weibo Yu, JianYu Rao, David Elashoff, James K. Gimzewski & Shivani Sharma. (2021) Nanoscale Extracellular Vesicles Carry the Mechanobiology Signatures of Breast Cancer Cells. ACS Applied Nano Materials 4:9, pages 9876-9885.
Crossref
Bridgette Mkhobongo, Rahul Chandran & Heidi Abrahamse. (2021) The Role of Melanoma Cell-Derived Exosomes (MTEX) and Photodynamic Therapy (PDT) within a Tumor Microenvironment. International Journal of Molecular Sciences 22:18, pages 9726.
Crossref
Siyuan Ye, Wenzhe Li, Huayi Wang, Ling Zhu, Chen Wang & Yanlian Yang. (2021) Quantitative Nanomechanical Analysis of Small Extracellular Vesicles for Tumor Malignancy Indication. Advanced Science 8:18, pages 2100825.
Crossref
Laura Martinez-Vidal, Valentina Murdica, Chiara Venegoni, Filippo Pederzoli, Marco Bandini, Andrea Necchi, Andrea Salonia & Massimo Alfano. (2021) Causal contributors to tissue stiffness and clinical relevance in urology. Communications Biology 4:1.
Crossref
Csilla Fazakas, Mihály Kozma, Kinga Molnár, András Kincses, András Dér, Adrienn Fejér, Barnabás Horváth, Imola Wilhelm, István A. Krizbai & Attila G. Végh. (2021) Breast adenocarcinoma-derived exosomes lower first-contact de-adhesion strength of adenocarcinoma cells to brain endothelial layer. Colloids and Surfaces B: Biointerfaces 204, pages 111810.
Crossref
Mehdi Mohammadi, Hossein Zargartalebi, Razieh Salahandish, Raied Aburashed, Kar Wey Yong & Amir Sanati-Nezhad. (2021) Emerging technologies and commercial products in exosome-based cancer diagnosis and prognosis. Biosensors and Bioelectronics 183, pages 113176.
Crossref
Xin Shi, Nan Jiang, Jing Mao, Dan Luo & Yan Liu. (2021) Mesenchymal stem cell‐derived exosomes for organ development and cell‐free therapy. Nano Select 2:7, pages 1291-1325.
Crossref
Lucrezia Caselli, Andrea Ridolfi, Jacopo Cardellini, Lewis Sharpnack, Lucia Paolini, Marco Brucale, Francesco Valle, Costanza Montis, Paolo Bergese & Debora Berti. (2021) A plasmon-based nanoruler to probe the mechanical properties of synthetic and biogenic nanosized lipid vesicles. Nanoscale Horizons 6:7, pages 543-550.
Crossref
Lissette Retana Moreira, Alexa Prescilla-Ledezma, Alberto Cornet-Gomez, Fátima Linares, Ana Belén Jódar-Reyes, Jorge Fernandez, Ana Karina Ibarrola Vannucci, Luis Miguel De Pablos & Antonio Osuna. (2021) Biophysical and Biochemical Comparison of Extracellular Vesicles Produced by Infective and Non-Infective Stages of Trypanosoma cruzi. International Journal of Molecular Sciences 22:10, pages 5183.
Crossref
Sou Ryuzaki, Takao Yasui, Makusu Tsutsui, Kazumichi Yokota, Yuki Komoto, Piyawan Paisrisarn, Noritada Kaji, Daisuke Ito, Kaoru Tamada, Takahiro Ochiya, Masateru Taniguchi, Yoshinobu Baba & Tomoji Kawai. (2021) Rapid Discrimination of Extracellular Vesicles by Shape Distribution Analysis. Analytical Chemistry 93:18, pages 7037-7044.
Crossref
Dali Sun, Zhen Zhao, Sarah Spiegel, Yang Liu, Jia Fan, Pouya Amrollahi, Jing Hu, Christopher J. Lyon, Meihua Wan & Tony Y. Hu. (2021) Dye-free spectrophotometric measurement of nucleic acid-to-protein ratio for cell-selective extracellular vesicle discrimination. Biosensors and Bioelectronics 179, pages 113058.
Crossref
Brateen Datta, Debashish Paul, Uttam Pal & Tatini Rakshit. (2021) Intriguing Biomedical Applications of Synthetic and Natural Cell-Derived Vesicles: A Comparative Overview. ACS Applied Bio Materials 4:4, pages 2863-2885.
Crossref
Ayhan Yurtsever, Takeshi Yoshida, Arash Badami Behjat, Yoshihiro Araki, Rikinari Hanayama & Takeshi Fukuma. (2021) Structural and mechanical characteristics of exosomes from osteosarcoma cells explored by 3D-atomic force microscopy. Nanoscale 13:13, pages 6661-6677.
Crossref
Salvatore Andrea Gazze, Samantha J. Thomas, Jetzabel Garcia-Parra, David W. James, Paul Rees, Victoria Marsh-Durban, Randolph Corteling, Deyarina Gonzalez, R. Steven Conlan & Lewis W. Francis. (2021) High content, quantitative AFM analysis of the scalable biomechanical properties of extracellular vesicles. Nanoscale 13:12, pages 6129-6141.
Crossref
Cristina Rodriguez-Quijada & Joanna B. Dahl. (2021) Non-contact microfluidic mechanical property measurements of single apoptotic bodies. Biochimica et Biophysica Acta (BBA) - General Subjects 1865:4, pages 129657.
Crossref
Lefki‐Pavlina N. Giassafaki, Scheyla Siqueira, Emmanuel Panteris, Konstantina Psatha, Fani Chatzopoulou, Michalis Aivaliotis, Georgios Tzimagiorgis, Anette Müllertz, Dimitrios G. Fatouros & Ioannis S. Vizirianakis. (2020) Towards analyzing the potential of exosomes to deliver microRNA therapeutics. Journal of Cellular Physiology 236:2, pages 1529-1544.
Crossref
Jin Wang, Derek Chen & Emmanuel A. Ho. (2021) Challenges in the development and establishment of exosome-based drug delivery systems. Journal of Controlled Release 329, pages 894-906.
Crossref
Michael LeClaire, James Gimzewski & Shivani Sharma. (2020) A review of the biomechanical properties of single extracellular vesicles. Nano Select 2:1, pages 1-15.
Crossref
Viktor Bairamukov, Anton Bukatin, Sergey Landa, Vladimir Burdakov, Tatiana Shtam, Irina Chelnokova, Natalia Fedorova, Michael Filatov & Maria Starodubtseva. (2020) Biomechanical Properties of Blood Plasma Extracellular Vesicles Revealed by Atomic Force Microscopy. Biology 10:1, pages 4.
Crossref
Simone Pisano, Irene Pierini, Jianhua Gu, Andrea Gazze, Lewis Webb Francis, Deyarina Gonzalez, Robert Steven Conlan & Bruna Corradetti. (2020) Immune (Cell) Derived Exosome Mimetics (IDEM) as a Treatment for Ovarian Cancer. Frontiers in Cell and Developmental Biology 8.
Crossref
Andrea Ridolfi, Marco Brucale, Costanza Montis, Lucrezia Caselli, Lucia Paolini, Anne Borup, Anders T. Boysen, Francesca Loria, Martijn J. C. van Herwijnen, Marije Kleinjan, Peter Nejsum, Natasa Zarovni, Marca H. M. Wauben, Debora Berti, Paolo Bergese & Francesco Valle. (2020) AFM-Based High-Throughput Nanomechanical Screening of Single Extracellular Vesicles. Analytical Chemistry 92:15, pages 10274-10282.
Crossref
Bradley Whitehead, Anders T. Boysen, Maibritt Mardahl & Peter Nejsum. (2020) Unique glycan and lipid composition of helminth-derived extracellular vesicles may reveal novel roles in host-parasite interactions. International Journal for Parasitology 50:9, pages 647-654.
Crossref
Anders T. Boysen, Bradley Whitehead, Allan Stensballe, Anna Carnerup, Tommy Nylander & Peter Nejsum. (2020) Fluorescent Labeling of Helminth Extracellular Vesicles Using an In Vivo Whole Organism Approach. Biomedicines 8:7, pages 213.
Crossref
Xiao-Qing Ding, Zhe-Ying Wang, Di Xia, Rui-Xian Wang, Xiao-Rong Pan & Jian-Hua Tong. (2020) Proteomic Profiling of Serum Exosomes From Patients With Metastatic Gastric Cancer. Frontiers in Oncology 10.
Crossref
Yousuke Kikuchi, Nozomu Obana, Masanori Toyofuku, Noriyuki Kodera, Takamitsu Soma, Toshio Ando, Yoshihiro Fukumori, Nobuhiko Nomura & Azuma Taoka. (2020) Diversity of physical properties of bacterial extracellular membrane vesicles revealed through atomic force microscopy phase imaging. Nanoscale 12:14, pages 7950-7959.
Crossref
Raghavendra Gowda, Bailey M. Robertson, Soumya Iyer, John Barry, Saketh S. Dinavahi & Gavin P. Robertson. (2020) The role of exosomes in metastasis and progression of melanoma. Cancer Treatment Reviews 85, pages 101975.
Crossref
Soheila Mohammadi, Fatemeh Yousefi, Zahra Shabaninejad, Ahmad Movahedpour, Maryam Mahjoubin Tehran, Alimohammad Shafiee, Sanaz Moradizarmehri, Sarah Hajighadimi, Amir Savardashtaki & Hamed Mirzaei. (2019) Exosomes and cancer: From oncogenic roles to therapeutic applications. IUBMB Life 72:4, pages 724-748.
Crossref
Shujing Lin, Zixian Yu, Di Chen, Zhigang Wang, Jianmin Miao, Qichao Li, Daoyuan Zhang, Jie Song & Daxiang Cui. (2019) Progress in Microfluidics‐Based Exosome Separation and Detection Technologies for Diagnostic Applications. Small 16:9, pages 1903916.
Crossref
Lissette Retana Moreira, Daniel Vargas Ramírez, Fátima Linares, Alexa Prescilla Ledezma, Annette Vaglio Garro, Antonio Osuna, Jacob Lorenzo Morales & Elizabeth Abrahams Sandí. (2020) Isolation of Acanthamoeba T5 from Water: Characterization of Its Pathogenic Potential, Including the Production of Extracellular Vesicles. Pathogens 9:2, pages 144.
Crossref
S. Busatto, A. Zendrini, A. Radeghieri, L. Paolini, M. Romano, M. Presta & P. Bergese. (2020) The nanostructured secretome. Biomaterials Science 8:1, pages 39-63.
Crossref
S. Moein Moghimi, Dmitri Simberg, Emanuele Papini & Z. Shadi Farhangrazi. (2020) Complement activation by drug carriers and particulate pharmaceuticals: Principles, challenges and opportunities. Advanced Drug Delivery Reviews 157, pages 83-95.
Crossref
Fabio Perissinotto, Beatrice Senigagliesi, Lisa Vaccari, Maria Pachetti, Francesco D’Amico, Heinz Amenitsch, Barbara Sartori, Karin Pachler, Magdalena Mayr, Mario Gimona, Eva Rohde, Federica Caponnetto, Daniela Cesselli, Loredana Casalis & Pietro Parisse. 2020. 157 177 .
Miriam Romano, Andrea Zendrini, Lucia Paolini, Sara Busatto, Anna C. Berardi, Paolo Bergese & Annalisa Radeghieri. 2020. Nanomaterials for Theranostics and Tissue Engineering. Nanomaterials for Theranostics and Tissue Engineering 29 58 .
Wei Zhang, Peng Peng, Xiaoxuan Ou, Keng Shen & Xiaohua Wu. (2019) Ovarian cancer circulating extracelluar vesicles promote coagulation and have a potential in diagnosis: an iTRAQ based proteomic analysis. BMC Cancer 19:1.
Crossref
S. Moein Moghimi, Dmitri Simberg, Tore Skotland, Anan Yaghmur & A. Christy Hunter. (2019) The Interplay Between Blood Proteins, Complement, and Macrophages on Nanomedicine Performance and Responses. Journal of Pharmacology and Experimental Therapeutics 370:3, pages 581-592.
Crossref
Magdalena Surman, Anna Drożdż, Ewa Stępień & Małgorzata Przybyło. (2019) Extracellular Vesicles as Drug Delivery Systems - Methods of Production and Potential Therapeutic Applications. Current Pharmaceutical Design 25:2, pages 132-154.
Crossref
Ankita Gangotra & Geoff R. Willmott. 2019. Comprehensive Nanoscience and Nanotechnology. Comprehensive Nanoscience and Nanotechnology 227 244 .
Renee V. Goreham, Zeineb Ayed, Deanna Ayupova & Garima Dobhal. 2019. Comprehensive Nanoscience and Nanotechnology. Comprehensive Nanoscience and Nanotechnology 27 48 .
Mei Wang, Rong Qiu, Shaorong Yu, Xiaoyue Xu, Gang� Li, Rongmin Gu, Caihong Tan, Wei Zhu & Bo Shen. (2018) Paclitaxel‑resistant gastric cancer MGC‑803 cells promote epithelial‑to‑mesenchymal transition and chemoresistance in paclitaxel‑sensitive cells via exosomal delivery of miR‑155‑5p. International Journal of Oncology.
Crossref
Wenshuo Wang, Jing Luo & Shutao Wang. (2018) Recent Progress in Isolation and Detection of Extracellular Vesicles for Cancer Diagnostics. Advanced Healthcare Materials 7:20, pages 1800484.
Crossref
Raya Sorkin, Rick Huisjes, Filip Bošković, Daan Vorselen, Silvia Pignatelli, Yifat Ofir-Birin, Joames K. Freitas Leal, Jürgen Schiller, Debakshi Mullick, Wouter H. Roos, Giel Bosman, Neta Regev-Rudzki, Raymond M. Schiffelers & Gijs J. L. Wuite. (2018) Nanomechanics of Extracellular Vesicles Reveals Vesiculation Pathways. Small 14:39, pages 1801650.
Crossref
Lucia Paolini, Andrea Zendrini & Annalisa Radeghieri. (2018) Biophysical properties of extracellular vesicles in diagnostics. Biomarkers in Medicine 12:4, pages 383-391.
Crossref
Mahmoud Al Ahmad. (2018) Electrical Detection, Identification, and Quantification of Exosomes. IEEE Access 6, pages 22817-22826.
Crossref
Filomena A. Carvalho & Nuno C. Santos. 2018. Atomic Force Microscopy in Molecular and Cell Biology. Atomic Force Microscopy in Molecular and Cell Biology 55 76 .
Diana Boraschi, Paola Italiani, Roberto Palomba, Paolo Decuzzi, Albert Duschl, Bengt Fadeel & S. Moein Moghimi. (2017) Nanoparticles and innate immunity: new perspectives on host defence. Seminars in Immunology 34, pages 33-51.
Crossref
P. Parisse, I. Rago, L. Ulloa Severino, F. Perissinotto, E. Ambrosetti, P. Paoletti, M. Ricci, A. P. Beltrami, D. Cesselli & L. Casalis. (2017) Atomic force microscopy analysis of extracellular vesicles. European Biophysics Journal 46:8, pages 813-820.
Crossref
Paula Carpintero-Fernández, Juan Fafián-Labora & Ana O'Loghlen. (2017) Technical Advances to Study Extracellular Vesicles. Frontiers in Molecular Biosciences 4.
Crossref
Bo You, Ying Shan, Lili Bao, Jing Chen, Liu Yang, Qicheng Zhang, Wei Zhang, Zhenxin Zhang, Jie Zhang, Si Shi & Yiwen You. (2017) The biology and function of extracellular vesicles in nasopharyngeal carcinoma (Review). International Journal of Oncology.
Crossref
Stephan Stremersch, Stefaan C. De Smedt & Koen Raemdonck. (2016) Therapeutic and diagnostic applications of extracellular vesicles. Journal of Controlled Release 244, pages 167-183.
Crossref
Pieter Vader, Emma A. Mol, Gerard Pasterkamp & Raymond M. Schiffelers. (2016) Extracellular vesicles for drug delivery. Advanced Drug Delivery Reviews 106, pages 148-156.
Crossref
Aaron D. Flynn & Hang Yin. (2016) Lipid-Targeting Peptide Probes for Extracellular Vesicles. Journal of Cellular Physiology 231:11, pages 2327-2332.
Crossref
Iris Bischoff, Michael C. Hornburger, Bettina A. Mayer, Andrea Beyerle, Joachim Wegener & Robert Fürst. (2016) Pitfalls in assessing microvascular endothelial barrier function: impedance-based devices versus the classic macromolecular tracer assay. Scientific Reports 6:1.
Crossref
Sarah Heiler, Zhe Wang & Margot Zöller. (2016) Pancreatic cancer stem cell markers and exosomes - the incentive push. World Journal of Gastroenterology 22:26, pages 5971.
Crossref