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Clinical Focus: Anticoagulants and Hospital Protocols

Inhibitory Effect of Apixaban Compared With Rivaroxaban and Dabigatran on Thrombin Generation Assay

, PhD, , BS & , BS
Pages 19-25 | Published online: 13 Mar 2015

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Estella M. Davis, Erin M. Uhlmeyer, David P. Schmidt & Greg L. Schardt. (2014) Strategies for Urgent Reversal of Target-Specific Oral Anticoagulants. Hospital Practice 42:5, pages 108-125.
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Articles from other publishers (19)

Joseph R. Shaw, Lana A. Castellucci, Deborah Siegal & Marc Carrier. (2023) DOAC–associated bleeding, hemostatic strategies, and thrombin generation assays - a review of the literature. Journal of Thrombosis and Haemostasis 21:3, pages 433-452.
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Zeyu Guan, Roxanna Wang, Rawaa H. Hussain, James C. Fredenburgh, Iqbal H. Jaffer & Jeffrey I. Weitz. (2023) Rivaroxaban and apixaban are less effective than enoxaparin for the prevention of catheter-induced clotting in vitro. Journal of Thrombosis and Haemostasis 21:1, pages 76-82.
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Lars L. F. G. Valke, Sanna Rijpma, Danielle Meijer, Saskia E. M. Schols & Waander L. van Heerde. (2022) Thrombin generation assays to personalize treatment in bleeding and thrombotic diseases. Frontiers in Cardiovascular Medicine 9.
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Tamana Meihandoest, Jan-Dirk Studt, Adriana Mendez, Lorenzo Alberio, Pierre Fontana, Walter A. Wuillemin, Adrian Schmidt, Lukas Graf, Bernhard Gerber, Gabriela Monika Maeder, Cédric Bovet, Thomas C. Sauter & Michael Nagler. (2021) Automated Thrombin Generation Assay for Rivaroxaban, Apixaban, and Edoxaban Measurements. Frontiers in Cardiovascular Medicine 8.
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Bérénice Conversy, Marie-Claude Blais, Marilyn Dunn, Carolyn Gara-Boivin & Jérôme R.E. del Castillo. (2020) Corrigendum to “Anticoagulant activity of oral rivaroxaban in healthy dogs” [Vet. J. 223 (2017) 5–11]. The Veterinary Journal 263, pages 105522.
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Anica Petkovic, Faris Al-Khalili, Aleksandra Antovic, Majeed Ammar, Iva Pruner, Aleksandra Vranic, Nida Soutari, Nebojsa Zdravkovic, Rickard E. Malmström, Vladimir Jakovljevic & Jovan P. Antovic. (2020) Effects of rivaroxaban and dabigatran on global hemostasis in patients with atrial fibrillation. Blood Coagulation & Fibrinolysis 31:4, pages 243-252.
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Reinhard Mischke, Maike Teuber & Andreas Tiede. (2019) Measurements of endogenous thrombin potential using the CAT method in cats: Reference values and influence of the direct factor Xa inhibitor apixaban. Research in Veterinary Science 127, pages 113-121.
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Stephanie Makhoul, Marina Panova-Noeva, Véronique Regnault, Wolfram Ruf, Philip Wenzel & Jeremy Lagrange. (2019) Rivaroxaban Effects Illustrate the Underestimated Importance of Activated Platelets in Thrombin Generation Assessed by Calibrated Automated Thrombography. Journal of Clinical Medicine 8:11, pages 1990.
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Fakiha Siddiqui, Debra Hoppensteadt, Walter Jeske, Omer Iqbal, Alfonso Tafur & Jawed Fareed. (2019) Factor Xa Inhibitory Profile of Apixaban, Betrixaban, Edoxaban, and Rivaroxaban Does Not Fully Reflect Their Biologic Spectrum. Clinical and Applied Thrombosis/Hemostasis 25, pages 107602961984752.
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Joseph Rigano, Cheryl Ng, Harshal Nandurkar & Prahlad Ho. (2018) Thrombin generation estimates the anticoagulation effect of direct oral anticoagulants with significant interindividual variability observed. Blood Coagulation & Fibrinolysis 29:2, pages 148-154.
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Irina V. Gribkova, Elena N. Lipets, Irina G. Rekhtina, Alex I. Bernakevich, Dorzho B. Ayusheev, Ruzanna A. Ovsepyan, Fazoil I. Ataullakhanov & Elena I. Sinauridze. (2016) The modification of the thrombin generation test for the clinical assessment of dabigatran etexilate efficiency. Scientific Reports 6:1.
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S Nagalla, L Thomson, Y Oppong, B Bachman, I Chervoneva & WK Kraft. (2016) Reversibility of Apixaban Anticoagulation with a Four‐Factor Prothrombin Complex Concentrate in Healthy Volunteers. Clinical and Translational Science 9:3, pages 176-180.
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Brian J. Dale, Noel C. Chan & John W. Eikelboom. (2016) Laboratory measurement of the direct oral anticoagulants. British Journal of Haematology 172:3, pages 315-336.
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Armando Tripodi, Lidia Padovan, Chantarangkul Veena, Erica Scalambrino, Sophie Testa & Flora Peyvandi. (2015) How the Direct Oral Anticoagulant Apixaban Affects Thrombin Generation Parameters. Thrombosis Research 135:6, pages 1186-1190.
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Georges Jourdi, Virginie Siguret, Anne Céline Martin, Jean-Louis Golmard, Anne Godier, Charles-Marc Samama, Pascale Gaussem, Isabelle Gouin-Thibault & Bernard Le Bonniec. (2017) Association rate constants rationalise the pharmacodynamics of apixaban and rivaroxaban. Thrombosis and Haemostasis 114:07, pages 78-86.
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Joanne van Ryn, Oliver Grottke & Henri Spronk. (2014) Measurement of Dabigatran in Standardly Used Clinical Assays, Whole Blood Viscoelastic Coagulation, and Thrombin Generation Assays. Clinics in Laboratory Medicine 34:3, pages 479-501.
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Anita Kern, Katalin Várnai & Barna Vásárhelyi. (2014) Thrombin generation assays and their clinical application. Orvosi Hetilap 155:22, pages 851-857.
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Gines Escolar, Victor Fernandez-Gallego, Eduardo Arellano-Rodrigo, Jaume Roquer, Joan Carles Reverter, Victoria Veronica Sanz, Patricia Molina, Irene Lopez-Vilchez, Maribel Diaz-Ricart & Ana Maria Galan. (2013) Reversal of Apixaban Induced Alterations in Hemostasis by Different Coagulation Factor Concentrates: Significance of Studies In Vitro with Circulating Human Blood. PLoS ONE 8:11, pages e78696.
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Bérénice Conversy, Marie-Claude Blais, Marilyn Dunn, Carolyn Gara-Boivin, Lisa Carioto & Jérôme R.E. del Castillo. (2013) Rivaroxaban demonstrates in vitro anticoagulant effects in canine plasma. The Veterinary Journal 198:2, pages 437-443.
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