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Postgraduate Medicine Volume 105, 1999 - Issue 2
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Original Articles

Clinically significant drug interactions

What you need to know before writing prescriptions

Michael D. Johnson Dr Johnson was clinical instructor and Dr White is associate professor and director, Sacred Heart Medical Center drug studies unit, department of pharmacy practice, College of Pharmacy, Washington State University, Spokane. Dr Johnson has just matriculated into medical school at Kirksville College of Osteopathic Medicine, Kirksville, Missouri.Correspondence[email protected]
, PharmD,
Gary Newkirk Dr Newkirk is director, family medicine residency program, and clinical professor, department of family medicine, University of Washington School of Medicine, Seattle.
, MD &
John R. White Jr Dr Johnson was clinical instructor and Dr White is associate professor and director, Sacred Heart Medical Center drug studies unit, department of pharmacy practice, College of Pharmacy, Washington State University, Spokane. Dr Johnson has just matriculated into medical school at Kirksville College of Osteopathic Medicine, Kirksville, Missouri.
, PharmD
Pages 193-222 | Published online: 30 Jun 2015

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R. J. Weaver. (2001) Assessment of drug-drug interactions: concepts and approaches. Xenobiotica 31:8-9, pages 499-538.
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Articles from other publishers (25)

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Susan K. Paulson, Rebecca N. Wood-Horrall, Randall Hoover, Megan Quintas, Laura E. Lawrence & Sue K. Cammarata. (2017) The Pharmacokinetics of the CYP3A Substrate Midazolam After Steady-state Dosing of Delafloxacin. Clinical Therapeutics 39:6, pages 1182-1190.
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Sanmoy Karmakar, Sreerupa Biswas, Rammohan Bera, Samiran Mondal, Amit Kundu, Md Asif Ali & Tuhinadri Sen. (2015) Beverage-induced enhanced bioavailability of carbamazepine and its consequent effect on antiepileptic activity and toxicity. Journal of Food and Drug Analysis 23:2, pages 327-334.
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Robert Twycross, Joy Ross, Aleksandra Kotlinska-Lemieszek, Sarah Charlesworth, Mary Mihalyo & Andrew Wilcock. (2015) Variability in Response to Drugs. Journal of Pain and Symptom Management 49:2, pages 293-306.
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. 2015. Arzneimitteltherapie in der Palliativmedizin. Arzneimitteltherapie in der Palliativmedizin 863 966 .
Domenic A. Ciraulo, Richard I. Shader & David J. Greenblatt. 2011. Pharmacotherapy of Depression. Pharmacotherapy of Depression 33 124 .
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Ramon Fit?-Mora. (2009) Torsade de pointes relacionadas con el uso de rupatadina. Revista Espa?ola de Cardiolog?a 62:3, pages 330-331.
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Henry J. Mann. (2006) Drug-Associated Disease: Cytochrome P450 Interactions. Critical Care Clinics 22:2, pages 329-345.
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Clive P Page, Michael J Curtis, Michael J A Walker & Brian B Hoffman. 2006. Integrated Pharmacology. Integrated Pharmacology 65 82 .
Ben Chadwick, Derek G. Waller & J. Guy Edwards. (2018) Potentially hazardous drug interactions with psychotropics. Advances in Psychiatric Treatment 11:6, pages 440-449.
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Diane L Nykamp, Casey L Blackmon, Paul E Schmidt & Andrea G Roberson. (2005) QTc Prolongation Associated with Combination Therapy of Levofloxacin, Imipramine, and Fluoxetine. Annals of Pharmacotherapy 39:3, pages 543-546.
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Domenic A. Ciraulo, Lucy Tsirulnik-Barts, Richard I. Shader & David J. Greenblatt. 2004. Pharmacotherapy of Depression. Pharmacotherapy of Depression 33 117 .
Jeffrey C. Delafuente. (2003) Understanding and preventing drug interactions in elderly patients. Critical Reviews in Oncology/Hematology 48:2, pages 133-143.
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Michael A. Crouch, Lynn Limon & Angela T. Cassano. (2012) Clinical Relevance and Management of Drug‐Related QT Interval Prolongation. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 23:7, pages 881-908.
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C Kragelund, CE Thomsen, A Bardow, AM Pedersen, B Nauntofte, J Reibel & LA Torpet. (2003) Oral lichen planus and intake of drugs metabolized by polymorphic cytochrome P450 enzymes. Oral Diseases 9:4, pages 177-187.
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Pedro A. Munera, James M. Perel & Miya Asato. (2002) Medication Interaction Causing Seizures in a Patient with Bipolar Disorder and Cystic Fibrosis. Journal of Child and Adolescent Psychopharmacology 12:3, pages 275-276.
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Iwonna Rahden-Staron, Hanna Czeczot & Maria Szumilo. (2001) Induction of rat liver cytochrome P450 isoenzymes CYP 1A and CYP 2B by different fungicides, nitrofurans, and quercetin. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 498:1-2, pages 57-66.
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Pascal Bonnabry, Johann Sievering, Thierry Leemann & Pierre Dayer. (2001) Quantitative Drug Interactions Prediction System (Q-DIPS). Clinical Pharmacokinetics 40:9, pages 631-640.
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Kristin Wiisanen Weitzel, Julie M. Wickman, Sara Grimsley Augustin & J.Grady Strom. (2000) Zaleplon: a pyrazolopyrimidine sedative-hypnotic agent for the treatment of insomnia. Clinical Therapeutics 22:11, pages 1254-1267.
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Nick P. Beckey, David Parra & Amy Colon. (2000) Retrospective Evaluation of a Potential Interaction Between Azithromycin and Warfarin in Patients Stabilized on Warfarin. Pharmacotherapy 20:9, pages 1055-1059.
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Dennis M. Grasela, Frank P. LaCreta, Georgia D. Kollia, Diane M. Randall & Howard D. Uderman. (2012) Open‐Label, Nonrandomized Study of the Effects of Gatifloxacin on the Pharmacokinetics of Midazolam in Healthy Male Volunteers. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 20:3, pages 330-335.
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Jay S. Cohen. (2000) Should Patients be Given an Initial Low Test Dose of Sildenafil?. Drug Safety 23:1, pages 1-9.
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