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Postgraduate Medicine Volume 107, 2000 - Issue 1

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Original Articles

Alcohol-acetaminophen syndrome

Even moderate social drinkers are at risk

Peter Draganov Dr Draganov is assistant professor of medicine, division of gastroenterology, hepatology, and nutrition, University of Florida College of Medicine, Gainesville. Me was formerly a fellow in gastroenterology and hepatology, department of medicine, Medical University of South Carolina College of Medicine, Charleston.Correspondence[email protected]

, MD,

Hugh Durrence Dr Durrence is in community family medicine practice in Charleston.

, MD, RPh,

Christopher Cox Dr Cox is a resident in internal medicine, New York University Medical Center, New York City.

, MD &

Adrian Reuben Dr Reuben is professor of medicine, director of liver studies, and medical director of liver transplantation, division of gastroenterology/hepatology, Medical University of South Carolina College of Medicine.

, MBBS, FRCP

Pages 189-195 | Published online: 30 Jun 2015

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https://doi.org/10.3810/pgm.2000.01.831

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Arinze Linus Ezugwu, Emeka Godwin Anaduaka, Christian Chiazor Chibuogwu & Timothy Prince Chidike Ezeorba. (2023) Meat tenderization using acetaminophen (paracetamol/APAP): A review on deductive biochemical mechanisms, toxicological implications and strategies for mitigation. Heliyon 9:5, pages e15628.
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Benny Antony, Merina Benny, Binu T. Kuruvilla, Nishant Kumar Gupta & Sherina Jacob. (2022) Acute and sub chronic toxicity studies with herbal pain relieving formula (Rhuleave-K™) in rats. Regulatory Toxicology and Pharmacology 133, pages 105214.
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Sulochana Singh, Malabika Talukdar & Upendranath Dash. (2022) Study of Interactions of Acetaminophen in Water and Water–Methanol Mixture at T = 298.15–313.15 K: A Conductivity Approach with Solution Thermodynamics. Russian Journal of Physical Chemistry A 96:S1, pages S8-S15.
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Samuel James Offor, Cecilia Nwadiuto Amadi, Ifeyinwa Chijioke-Nwauche, Jose E. Manautou & Orish E. Orisakwe. (2022) Potential deleterious effects of paracetamol dose regime used in Nigeria versus that of the United States of America. Toxicology Reports 9, pages 1035-1044.
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Sou Hyun Kim, Hun Ji Choi, Hyeji Seo, Doyoung Kwon, Jaesuk Yun & Young-Suk Jung. (2021) Downregulation of Glutathione-Mediated Detoxification Capacity by Binge Drinking Aggravates Acetaminophen-Induced Liver Injury through IRE1α ER Stress Signaling. Antioxidants 10:12, pages 1949.
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Aditi Ghosh, Isaac Berger, Christopher H. Remien & Anuj Mubayi. (2021) The role of alcohol consumption on acetaminophen induced liver injury: Implications from a mathematical model. Journal of Theoretical Biology 519, pages 110559.
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Bryan Hedgpeth, Roy Missall, Anna Bambaci, Matthew Smolen, Sevgi Yavuz, Jessica Cottrell, Tinchun Chu & Sulie L. Chang. (2019) A Review of Bioinformatics Tools to Understand Acetaminophen-Alcohol Interaction. Medicines 6:3, pages 79.
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Min You & Gavin E. Arteel. (2019) Effect of ethanol on lipid metabolism. Journal of Hepatology 70:2, pages 237-248.
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Thomas M. Caparrotta, Daniel J. Antoine & James W. Dear. (2017) Are some people at increased risk of paracetamol-induced liver injury? A critical review of the literature. European Journal of Clinical Pharmacology 74:2, pages 147-160.
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Jonathan G. Stine & Naga P. Chalasani. (2017) Drug Hepatotoxicity. Clinics in Liver Disease 21:1, pages 103-113.
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. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 474 493 .

Kalipatnapu Rao. 2012. Forensic Toxicology. Forensic Toxicology 27 32 .

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C. D. Oscier & Q. J. W. Milner. (2009) Peri-operative use of paracetamol. Anaesthesia 64:1, pages 65-72.
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Scott A. Strassels, Ewan McNicol & Rosy Suleman. (2008) Pharmacotherapy of Pain in Older Adults. Clinics in Geriatric Medicine 24:2, pages 275-298.
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Richard C. Dart & Elise Bailey. (2012) Does Therapeutic Use of Acetaminophen Cause Acute Liver Failure?. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 27:9, pages 1219-1230.
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Konstantinos G. MoulakakisGiorgos Sfyroeras, Polivios Pavlidis, Nikolaos Besias, Dimitrios Maras & Vassilios Andrikopoulos. (2016) Hypercoagulable State Due to Alcohol-Paracetamol Syndrome Producing Acute Limb Ischemia. Vascular and Endovascular Surgery 41:4, pages 362-365.
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Rebecca Prevost. (2016) Pharmacy Review: Osteoarthritis: The Pharmacist's Perspective. American Journal of Lifestyle Medicine 1:4, pages 271-273.
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Deborah Dillon McDonald, Mary Grace Amendola, Elsa Interlandi, Karen Wall, Brent Lewchik, Lissy Polouse, Noreen Pace, Susada Inthavong & Ling Li. (2007) Effect of Reading Additional Safety Information on Planned Use of Over-the-Counter Analgesics. Public Health Nursing 24:3, pages 230-238.
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Alfio Bertolini, Anna Ferrari, Alessandra Ottani, Simona Guerzoni, Raffaella Tacchi & Sheila Leone. (2006) Paracetamol: New Vistas of an Old Drug. CNS Drug Reviews 12:3-4, pages 250-275.
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Parivash Nourjah, Syed Rizwanuddin Ahmad, Claudia Karwoski & Mary Willy. (2006) Estimates of acetaminophen (paracetomal)-associated overdoses in the United States. Pharmacoepidemiology and Drug Safety 15:6, pages 398-405.
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Alexandre Louvet, Jeanne Boitard, S?bastien Dharancy, Arnaud Duriez, Pierre Deltenre, Jean-Claude Paris & Philippe Mathurin. (2006) La m?saventure th?rapeutique du parac?tamol chez le buveur excessif. Gastroent?rologie Clinique et Biologique 30:5, pages 769-774.
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Katrina A. Bramstedt, Judy Stowe & Brent Lemberg. (2016) The Dilemma of Alcohol Use by Potential Living Liver Donors. Progress in Transplantation 16:1, pages 24-27.
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Feng Yang & Daniel A. Beard. (2006) Thermodynamically based profiling of drug metabolism and drug–drug metabolic interactions: A case study of acetaminophen and ethanol toxic interaction. Biophysical Chemistry 120:2, pages 121-134.
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. 2006. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions. Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions 2679 2693 .

Robert S. McCuskey, Nancy W. Bethea, Jennifer Wong, Margaret K. McCuskey, Edward R. Abril, Xiangdong Wang, Yoshiya Ito & Laurie D. DeLeve. (2005) Ethanol binging exacerbates sinusoidal endothelial and parenchymal injury elicited by acetaminophen. Journal of Hepatology 42:3, pages 371-377.
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Garry G Graham, Kieran F Scott & Richard O Day. (2005) Tolerability of Paracetamol. Drug Safety 28:3, pages 227-240.
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Gary H. Wynn, Kelly L. Cozza, Michael J. Zapor, Glenn W. Wortmann & Scott C. Armstrong. (2005) Antiretrovirals, Part III: Antiretrovirals and Drugs of Abuse. Psychosomatics 46:1, pages 79-87.
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Gregory M. Peterson. (2005) Selecting Nonprescription Analgesics. American Journal of Therapeutics 12:1, pages 67-79.
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M Lahouel, S Boulkour, N Segueni & J.P Fillastre. (2004) Effet protecteur des flavonoïdes contre la toxicité de la vinblastine, du cyclophosphamide et du paracétamol par inhibition de la peroxydation lipidique et augmentation du glutathion hépatique. Pathologie Biologie 52:6, pages 314-322.
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Duncan Reid & Wayne Hazell. (2003) Paracetamol poisoning: Which nomogram should we use?. Emergency Medicine Australasia 15:5-6, pages 486-496.
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Frank Vinholt Schiødt & William M Lee. (2003) Fulminant liver disease. Clinics in Liver Disease 7:2, pages 331-349.
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Matthew Q Bromer & Martin Black. (2003) Acetaminophen hepatotoxicity. Clinics in Liver Disease 7:2, pages 351-367.
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Sharon A. Center, Karen L. Warner & Hollis N. Erb. (2002) Liver glutathione concentrations in dogs and cats with naturally occurring liver disease. American Journal of Veterinary Research 63:8, pages 1187-1197.
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Adrian Reuben. (2002) Wine hath drowned more men than the sea. Hepatology 36:2, pages 516-518.
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Kevin P. Wallace, Sharon A. Center, Fiona H. Hickford, Karen L. Warner & Scott Smith. (2002) S-Adenosyl-L-Methionine (SAMe) for the Treatment of Acetaminophen Toxicity in a Dog. Journal of the American Animal Hospital Association 38:3, pages 246-254.
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Lars E. Schmidt, Kim Dalhoff & Henrik Enghusen Poulsen. (2002) Acute versus chronic alcohol consumption in acetaminophen-induced hepatotoxicity. Hepatology 35:4, pages 876-882.
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A. Del Favero. 2001. 115 126 .

E. Tanaka, K. Yamazaki & S. Misawa. (2008) Update: the clinical importance of acetaminophen hepatotoxicity in non-alcoholic and alcoholic subjects. Journal of Clinical Pharmacy and Therapeutics 25:5, pages 325-332.
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E. Tanaka, K. Yamazaki & S. Misawa. (2000) Update: the clinical importance of acetaminophen hepatotoxicity in non-alcoholic and alcoholic subjects. Journal of Clinical Pharmacy and Therapeutics 25:5, pages 325-332.
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Alcohol-acetaminophen syndrome

Even moderate social drinkers are at risk

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Alcohol-acetaminophen syndrome

Even moderate social drinkers are at risk

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