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Original Articles

Schizophrenia, Obesity, and Antipsychotic Medications: What Can We Do?

, MD, MPH & , MSN, APRN, NP-C, BC
Pages 18-33 | Published online: 30 Jun 2015

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Angela M. Cocoman & Darren Gallagher. (2019) A Retrospective Chart Review of Screening on the Prevalence of Metabolic Syndrome (MetS) in an Irish Community Mental Health Service. Issues in Mental Health Nursing 40:10, pages 895-901.
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Y Asahi, Y Kawai, M Sugimoto, T Suzuki, S Omichi & J Kotani. (2009) Anaesthesia for a morbidly obese patient with schizophrenia and intellectual disability. Southern African Journal of Anaesthesia and Analgesia 15:5, pages 32-33.
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Joshua T Kantrowitz & Leslie Citrome. (2008) Olanzapine: review of safety 2008. Expert Opinion on Drug Safety 7:6, pages 761-769.
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. (2008) Supplement Issue. Annals of Clinical Psychiatry 20:sup1, pages 1-32.
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Houda El Kirat, Asmaa Khattabi, Mohamed Khalis & Zakaria Belrhiti. (2023) Effects of physical activity and nutrient supplementation on symptoms and well-being of schizophrenia patients: An umbrella review. Schizophrenia Research 262, pages 112-120.
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Marco Carli, Shivakumar Kolachalam, Biancamaria Longoni, Anna Pintaudi, Marco Baldini, Stefano Aringhieri, Irene Fasciani, Paolo Annibale, Roberto Maggio & Marco Scarselli. (2021) Atypical Antipsychotics and Metabolic Syndrome: From Molecular Mechanisms to Clinical Differences. Pharmaceuticals 14:3, pages 238.
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Shohinee Sarma, Sanjeev Sockalingam & Satya Dash. (2021) Obesity as a multisystem disease: Trends in obesity rates and obesity‐related complications . Diabetes, Obesity and Metabolism 23:S1, pages 3-16.
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Mohammad Marie, Zareefa Shaabna & Manahel Saleh. (2020) Schizophrenia in the context of mental health services in Palestine: a literature review. International Journal of Mental Health Systems 14:1.
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Laís Bhering Martins, Silvia Fernandes Mauricio, Adaliene Versiani Matos Ferreira & Antônio Lúcio Teixeira. 2020. Obesity and Diabetes. Obesity and Diabetes 415 426 .
Halise Devrimci-Ozguven, Murad Atmaca, Zeynep Baran, Cengiz Cengisiz, Cem Çinar, Atila Erol, Yasin Genç, Hasan Karadağ, Kamuran Karakülah, Umut Karasu, Mehmet Cemal Kaya, Emre Kizil, Halil Özcan, Ahmet Tiryaki, Alp Üçok, Cenk Varlik, Sila Menekşe Yazar & Mesut Yildiz. (2019) Efficacy and Safety of Paliperidone Palmitate Treatment in Patients With Schizophrenia. Journal of Clinical Psychopharmacology 39:6, pages 604-610.
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Ching-En Lin, Chi-Hsiang Chung, Li-Fen Chen & Wu-Chien Chien. (2019) Increased risk for venous thromboembolism among patients with concurrent depressive, bipolar, and schizophrenic disorders. General Hospital Psychiatry 61, pages 34-40.
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Laís Bhering Martins, Nayara Mussi Monteze, Chadi Calarge, Adaliene Versiani Matos Ferreira & Antônio Lúcio Teixeira. (2019) Pathways linking obesity to neuropsychiatric disorders. Nutrition 66, pages 16-21.
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Frederik VandenbergheAlexandra Najar-GiroudLaurent HolzerPhilippe ConusChin B. EapAnne-Emmanuelle Ambresin. (2018) Second-Generation Antipsychotics in Adolescent Psychiatric Patients: Metabolic Effects and Impact of an Early Weight Change to Predict Longer Term Weight Gain. Journal of Child and Adolescent Psychopharmacology 28:4, pages 258-265.
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Alessandro Rimessi, Chiara Pavan, Elli Ioannidi, Federica Nigro, Claudia Morganti, Alberto Brugnoli, Francesco Longo, Chiara Gardin, Letizia Ferroni, Michele Morari, Vincenzo Vindigni, Barbara Zavan & Paolo Pinton. (2017) Protein Kinase C β: a New Target Therapy to Prevent the Long-Term Atypical Antipsychotic-Induced Weight Gain. Neuropsychopharmacology 42:7, pages 1491-1501.
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Fernando Pires Hartwig, Jack Bowden, Christian Loret de Mola, Luciana Tovo-Rodrigues, George Davey Smith & Bernardo Lessa Horta. (2016) Body mass index and psychiatric disorders: a Mendelian randomization study. Scientific Reports 6:1.
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W. Zheng, Y.‐T. Xiang, Y.‐Q. Xiang, X.‐B. Li, G. S. Ungvari, H. F. K. Chiu & C. U. Correll. (2016) Efficacy and safety of adjunctive topiramate for schizophrenia: a meta‐analysis of randomized controlled trials. Acta Psychiatrica Scandinavica 134:5, pages 385-398.
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Chung-Chih Hsu, Chih-Sung Liang, Yueh-Ming Tai & Shu-Li Cheng. (2016) Incongruent changes in heart rate variability and body weight after discontinuing aerobic exercise in patients with schizophrenia. International Journal of Psychophysiology 109, pages 132-137.
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Fang Wang, Weifeng Mi, Wenbin Ma, Cuicui Ma, Yongfeng Yang, Hongxing Zhang, Bo Du, Keqing Li, Chenxing Liu, Lifang Wang, Tianlan Lu, Hongyan Zhang, Luxian Lv, Dai Zhang & Weihua Yue. (2015) A pharmacogenomic study revealed an association between SLC6A4 and risperidone-induced weight gain in Chinese Han population . Pharmacogenomics 16:17, pages 1943-1949.
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Z. Whitney, R. M. Procyshyn, D. H. Fredrikson & A. M. Barr. (2015) Treatment of clozapine-associated weight gain: a systematic review. European Journal of Clinical Pharmacology 71:4, pages 389-401.
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A. Ventriglio, A. Gentile, R.J. Baldessarini, S. Martone, G. Vitrani, A. La Marca & A. Bellomo. (2020) Improvements in metabolic abnormalities among overweight schizophrenia and bipolar disorder patients. European Psychiatry 29:7, pages 402-407.
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Amy M. Kilbourne, Margretta Bramlet, Michelle M. Barbaresso, Kristina M. Nord, David E. Goodrich, Zongshan Lai, Edward P. Post, Daniel Almirall, Lilia Verchinina, Sonia A. Duffy & Mark S. Bauer. (2014) SMI Life Goals: Description of a randomized trial of a Collaborative Care Model to improve outcomes for persons with serious mental illness. Contemporary Clinical Trials 39:1, pages 74-85.
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Martha Sajatovic, Brent P Forester, Ariel Gildengers & Benoit H Mulsant. (2013) Aging changes and medical complexity in late-life bipolar disorder: emerging research findings that may help advance care. Neuropsychiatry 3:6, pages 621-633.
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Michael Berk, Lana J Williams, Felice N Jacka, Adrienne O’Neil, Julie A Pasco, Steven Moylan, Nicholas B Allen, Amanda L Stuart, Amie C Hayley, Michelle L Byrne & Michael Maes. (2013) So depression is an inflammatory disease, but where does the inflammation come from?. BMC Medicine 11:1.
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José María Martínez-Ortega, Silvia Funes-Godoy, Francisco Díaz-Atienza, Luis Gutiérrez-Rojas, Lucía Pérez-Costillas & Manuel Gurpegui. (2013) Weight gain and increase of body mass index among children and adolescents treated with antipsychotics: a critical review. European Child & Adolescent Psychiatry 22:8, pages 457-479.
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Losiana NayakHarinandan TungaRajat K. De. (2013) Disease Co-Morbidity and the Human Wnt Signaling Pathway: A Network-Wise Study. OMICS: A Journal of Integrative Biology 17:6, pages 318-337.
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Leslie CitromeLeslie Citrome. 2013. Handbook of Treatment-resistant Schizophrenia. Handbook of Treatment-resistant Schizophrenia 37 56 .
Yongfeng Yang, Wenqiang Li, Jingyuan Zhao, Hongxing Zhang, Xueqin Song, Bo Xiao, Ge Yang, Chengdi Jiang, Dai Zhang, Weihua Yue & Luxian Lv. (2012) Association between Ghrelin gene (GHRL) polymorphisms and clinical response to atypical antipsychotic drugs in Han Chinese schizophrenia patients. Behavioral and Brain Functions 8:1.
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Brian E Leonard, Markus Schwarz & Aye Mu Myint. (2012) The metabolic syndrome in schizophrenia: is inflammation a contributing cause?. Journal of Psychopharmacology 26:5_suppl, pages 33-41.
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I. KANE, H. LEE, S. SEREIKA & J. BRAR. (2011) Feasibility of pedometers for adults with schizophrenia: pilot study. Journal of Psychiatric and Mental Health Nursing 19:1, pages 8-14.
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Claus Michael Gross & Ludger Tebartz van Elst. 2012. Principles of Metabolic Surgery. Principles of Metabolic Surgery 153 157 .
Leslie Citrome. (2011) Treatment-refractory schizophrenia: what is it and what has been done about it?. Neuropsychiatry 1:4, pages 325-347.
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Leslie Citrome, Richard I.G. Holt, Daniel J. Walker & Vicki Poole Hoffmann. (2011) Weight Gain and Changes in Metabolic Variables following Olanzapine Treatment in Schizophrenia and Bipolar Disorder. Clinical Drug Investigation 31:7, pages 455-482.
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M. V. Seeman. (2011) Preventing breast cancer in women with schizophrenia. Acta Psychiatrica Scandinavica 123:2, pages 107-117.
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MARC DE HERT, CHRISTOPH U. CORRELL, JULIO BOBES, MARCELO CETKOVICH-BAKMAS, DAN COHEN, ITSUO ASAI, JOHAN DETRAUX, SHIV GAUTAM, HANS-JURGEN MÖLLER, DAVID M. NDETEI, JOHN W. NEWCOMER, RICHARD UWAKWE & STEFAN LEUCHT. (2011) Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care. World Psychiatry 10:1, pages 52-77.
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Lawrence Maayan & Leslie Citrome. 2011. Global Perspectives on Childhood Obesity. Global Perspectives on Childhood Obesity 265 277 .
Jeffrey S. Gonzalez, Sabrina A. Esbitt, Havah E. Schneider, Patricia J. Osborne & Elyse G. Kupperman. 2011. Psychological Co-morbidities of Physical Illness. Psychological Co-morbidities of Physical Illness 73 121 .
C. IGLESIAS-GARCÍA, A. TOIMIL-IGLESIAS & M. J. ALONSO-VILLA. (2010) Pilot study of the efficacy of an educational programme to reduce weight, on overweight and obese patients with chronic stable schizophrenia. Journal of Psychiatric and Mental Health Nursing 17:9, pages 849-851.
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Pornpoj Pramyothin & Lalita Khaodhiar. (2010) Metabolic syndrome with the atypical antipsychotics. Current Opinion in Endocrinology, Diabetes and Obesity 17:5, pages 460-466.
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. (2010) NUTRITION ISSUES FOR THE MENTAL HEALTH PATIENT POPULATION. Nutrition & Dietetics 67:2, pages 124-127.
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Mehrul Hasnain, W. Victor R. Vieweg & Sonja K. Fredrickson. (2010) Metformin for Atypical Antipsychotic-Induced Weight Gain and Glucose Metabolism Dysregulation. CNS Drugs 24:3, pages 193-206.
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Lawrence A. Maayan & Julia Vakhrusheva. (2010) Risperidone associated weight, leptin, and anthropometric changes in children and adolescents with psychotic disorders in early treatment. Human Psychopharmacology: Clinical and Experimental 25:2, pages 133-138.
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Edgardo Carrizo, Virginia Fernández, Lisette Connell, Ignacio Sandia, Dexy Prieto, Johana Mogollón, Dennys Valbuena, Iliana Fernández, Enma Araujo de Baptista & Trino Baptista. (2009) Extended release metformin for metabolic control assistance during prolonged clozapine administration: A 14 week, double-blind, parallel group, placebo-controlled study. Schizophrenia Research 113:1, pages 19-26.
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