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Postgraduate Medicine Volume 120, 2008 - Issue 2
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Original Articles

A Randomized, Double-Blind, Parallel-Group, Multicenter, Placebo-Controlled Study of the Safety and Efficacy of Extended-Release Guaifenesin/Pseudoephedrine Hydrochloride for Symptom Relief as an Adjunctive Therapy to Antibiotic Treatment of Acute Respiratory Infections

Craig LaForceNorth Carolina Clinical Research Inc., Raleigh, NC
, MD,
Deborah A. GentileDivision of Allergy, Asthma and Immunology, Allegheny General Hospital, Pittsburgh, PA; and Drexel University College of Medicine, Philadelphia, PA
, MD &
David P. SkonerDivision of Allergy, Asthma and Immunology, Allegheny General Hospital, Pittsburgh, PA; and Drexel University College of Medicine, Philadelphia, PACorrespondence[email protected]
, MD
Pages 53-59 | Published online: 30 Jun 2015

Citations (17)

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George Kikano. (2009) Safety and Efficacy of Extended-Release Guaifenesin/Pseudoephedrine Hydrochloride for Adjunctive Symptom Relief of Acute Respiratory Infections. Postgraduate Medicine 121:3, pages 173-175.
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Articles from other publishers (16)

Gene Clark, Dominic A. Fitzgerald & Bruce K. Rubin. (2023) Cough medicines for children- time for a reality check. Paediatric Respiratory Reviews.
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Ghazal Rouhani, Zehra Ceren Ertekin & Erdal Dinç. (2022) A Chemometric Strategy in the Development of a RP-UPLC Method for the Quantitative Resolution of a Two-Component Syrup Formulation. Journal of Chromatographic Science 60:10, pages 937-945.
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Wen-Ba Wang, Jing-Tao Li, Yi Hui, Jie Shi, Xu-Yan Wang & Shu-Guang Yan. (2022) Combination of pseudoephedrine and emodin ameliorates LPS-induced acute lung injury by regulating macrophage M1/M2 polarization through the VIP/cAMP/PKA pathway. Chinese Medicine 17:1.
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Jin Yoon, Hyun Jee Kim, Jang-Ho Seo & Hye-Ryun Kang. (2022) A Case Report of Guaifenesin-Induced Anaphylaxis. Journal of Pharmacoepidemiology and Risk Management 14:2, pages 169-172.
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Tomasz Blicharski, Katarzyna Swiader, Anna Serefko, Sylwia Kulczycka-Mamona, Michal Kolodziejczyk & Aleksandra Szopa. (2019) Challenges in technology of bilayer and multi-layer tablets: a mini-review. Current Issues in Pharmacy and Medical Sciences 32:4, pages 229-235.
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Edward J. Septimus, Helmut H. Albrecht, Gail Solomon, Tim Shea & Eric P. Guenin. (2017) Extended-Release Guaifenesin/Pseudoephedrine Hydrochloride for Symptom Relief in Support of a Wait-and-See Approach for the Treatment of Acute Upper Respiratory Tract Infections: A Randomized, Double-Blind, Placebo-Controlled Study. Current Therapeutic Research 84, pages 54-61.
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Cheol Moon & Euichaul Oh. (2016) Rationale and strategies for formulation development of oral fixed dose combination drug products. Journal of Pharmaceutical Investigation 46:7, pages 615-631.
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Bruce K. Rubin, Kostas N. Priftis, H. Joel Schmidt & Markus O. Henke. (2014) Secretory Hyperresponsiveness and Pulmonary Mucus Hypersecretion. Chest 146:2, pages 496-507.
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Admassu Abebe, Ilgaz Akseli, Omar Sprockel, Niranjan Kottala & Alberto M. Cuitiño. (2014) Review of bilayer tablet technology. International Journal of Pharmaceutics 461:1-2, pages 549-558.
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Lineau VilsonJrJr & Joel S. Owen. (2013) Pharmacokinetic Studies in Healthy Subjects for the Development of an Extended‐Release Tablet Formulation of Guaifenesin: A 505(b)(2) New Drug Application Approval. Clinical Pharmacology in Drug Development 2:1, pages 25-32.
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Niranjan Kottala, Admassu Abebe, Omar Sprockel, James Bergum, Faranak Nikfar & Alberto M. Cuitiño. (2012) Evaluation of the Performance Characteristics of Bilayer Tablets: Part II. Impact of Environmental Conditions on the Strength of Bilayer Tablets. AAPS PharmSciTech 13:4, pages 1190-1196.
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Niranjan Kottala, Admassu Abebe, Omar Sprockel, James Bergum, Faranak Nikfar & Alberto M. Cuitiño. (2012) Evaluation of the Performance Characteristics of Bilayer Tablets: Part I. Impact of Material Properties and Process Parameters on the Strength of Bilayer Tablets. AAPS PharmSciTech 13:4, pages 1236-1242.
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Gary N. Gross. (2011) What are the Primary Clinical Symptoms of Rhinitis and What Causes Them?. Immunology and Allergy Clinics of North America 31:3, pages 469-480.
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Fridrun Podczeck & Emad Al-Muti. (2010) The tensile strength of bilayered tablets made from different grades of microcrystalline cellulose. European Journal of Pharmaceutical Sciences 41:3-4, pages 483-488.
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Sivakumar R. Vaithiyalingam & Vilayat A. Sayeed. (2010) Critical factors in manufacturing multi-layer tablets—Assessing material attributes, in-process controls, manufacturing process and product performance. International Journal of Pharmaceutics 398:1-2, pages 9-13.
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. (2009) Current awareness: Pharmacoepidemiology and drug safety. Pharmacoepidemiology and Drug Safety 18:2.
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