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Clinical Features

Salicylate Intoxication: A Clinical Review

, MD, FACP & , MD
Pages 162-168 | Published online: 13 Mar 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Mary O’Keefe, Matthew Stanton, Ryan Feldman & Jillian Theobald. (2023) Incidence of rebound salicylate toxicity following cessation of urine alkalinization. Clinical Toxicology 61:7, pages 536-542.
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Han Peng & Fereidoon Shahidi. (2023) Metabolic, toxicological, chemical, and commercial perspectives on esterification of dietary polyphenols: a review. Critical Reviews in Food Science and Nutrition 0:0, pages 1-40.
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Jill Vanmassenhove & Norbert Lameire. (2019) Approach to the patient presenting with metabolic acidosis. Acta Clinica Belgica 74:1, pages 21-27.
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Rachel M. Shively, Robert S. Hoffman & Alex F. Manini. (2017) Acute salicylate poisoning: risk factors for severe outcome. Clinical Toxicology 55:3, pages 175-180.
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Articles from other publishers (40)

Chan Suen Wah, Chan Chi Keung, Ng Yau Tak, Lui Chun Tat & Fung Hin Tat. (2022) Prediction rule of supratherapeutic peak serum salicylate level in poisoning patients attending emergency departments. Hong Kong Journal of Emergency Medicine 30:6, pages 358-368.
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Younes Zebbiche, Abderrahmane Kori Yahia, Nour El Yakine Keraghel, Fiala Sarah, Chebli Akli Islam & Achouri Mohammed Yacine. (2023) Validation of a simple spectrophotometric method for the rapid determination of salicylates in plasma. Journal of Pharmacological and Toxicological Methods 124, pages 107475.
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Erik Gerner, Paula Milena Giraldo-Osorno, Anna Johansson Loo, Rininta Firdaus, Heithem Ben Amara, Maria Werthén, Anders Palmquist, Peter Thomsen, Omar Omar, Sofia Almqvist & Margarita Trobos. (2023) Targeting Pseudomonas aeruginosa quorum sensing with sodium salicylate modulates immune responses in vitro and in vivo. Frontiers in Cellular and Infection Microbiology 13.
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Edric K. Wong, Thomas E. Dunn, Bryan P. Beaver, Zachary J. Neronha & Andy Chuu. (2023) Current Evidence Surrounding the Use of Sodium Bicarbonate in the Critically Ill Patient. Current Emergency and Hospital Medicine Reports 11:1, pages 26-34.
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C. J. Borgert, C. Fuentes & L. D. Burgoon. (2021) Principles of dose-setting in toxicology studies: the importance of kinetics for ensuring human safety. Archives of Toxicology 95:12, pages 3651-3664.
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Jose M. Brum, Roger D. Gibb, David L. Ramsey, Guhan Balan & Bruce R. Yacyshyn. (2020) Systematic Review and Meta-Analyses Assessment of the Clinical Efficacy of Bismuth Subsalicylate for Prevention and Treatment of Infectious Diarrhea. Digestive Diseases and Sciences 66:7, pages 2323-2335.
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Wisit Kaewput, Charat Thongprayoon, Tananchai Petnak, Wisit Cheungpasitporn, Fawad Qureshi, Boonphiphop Boonpheng, Saraschandra Vallabhajosyula, Tarun Bathini, Sohail Abdul Salim & Tibor Fülöp. (2021) Rhabdomyolysis among hospitalized patients for salicylate intoxication in the United States: Nationwide inpatient sample 2003–2014. PLOS ONE 16:3, pages e0248242.
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Charat Thongprayoon, Tananchai Petnak, Wisit Kaewput, Fawad Qureshi, Michael A. Mao, Aleksandra I. Pivovarova, Boonphiphop Boonpheng, Tarun Bathini, Saraschandra Vallabhajosyula, Juan Medaura & Wisit Cheungpasitporn. (2020) Acute kidney injury among salicylate intoxication hospitalisations in the United States. International Journal of Clinical Practice 75:3.
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Tananchai Petnak, Charat Thongprayoon, Wisit Kaewput, Fawad Qureshi, Boonphiphop Boonpheng, Saraschandra Vallabhajosyula, Tarun Bathini, Michael A. Mao, Ploypin Lertjitbanjong & Wisit Cheungpasitporn. (2021) Circulatory Shock among Hospitalized Patients for Salicylate Intoxication. Diseases 9:1, pages 7.
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Sheliza Halani & Peter E Wu. (2020) Salicylate toxicity from chronic bismuth subsalicylate use. BMJ Case Reports 13:11, pages e236929.
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Charat Thongprayoon, Tananchai Petnak, Wisit Kaewput, Michael A. Mao, Karthik Kovvuru, Swetha R. Kanduri, Boonphiphop Boonpheng, Tarun Bathini, Saraschandra Vallabhajosyula, Aleksandra I. Pivovarova, Himmat S. Brar, Juan Medaura & Wisit Cheungpasitporn. (2020) Hospitalizations for Acute Salicylate Intoxication in the United States. Journal of Clinical Medicine 9:8, pages 2638.
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Jessica Winne, Barbara C. Boerner, Thawann Malfatti, Elis Brisa, Jhulimar Doerl, Ingrid Nogueira, Katarina E. Leão & Richardson N. Leão. (2020) Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT. Experimental Neurology 326, pages 113175.
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Eric S. McGillis, Travis D. Olives, Sara A. Love & Jon B. Cole. (2020) A Young Man with Accelerated Hyperthermia, Hypercapnia, and Profound Muscle Rigidity after Ingestion of a Weight Loss Agent. Annals of the American Thoracic Society 17:3, pages 361-366.
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Nikolas Harbord. (2020) Common Toxidromes and the Role of Extracorporeal Detoxification. Advances in Chronic Kidney Disease 27:1, pages 11-17.
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Amitava Dasgupta & Matthew D. Krasowski. 2020. Therapeutic Drug Monitoring Data. Therapeutic Drug Monitoring Data 309 330 .
Christopher McCudden. 2020. Toxicology Cases for the Clinical and Forensic Laboratory. Toxicology Cases for the Clinical and Forensic Laboratory 67 74 .
Reza Soleimani, Karl Brousmiche, Julien Favresse, Vincent Haufroid, Damien Gruson, Philippe Hantson & Pierre Wallemacq. (2019) Intentional acetylsalicylic acid acute intoxication and its clinical management. Clinical Case Reports 7:9, pages 1697-1701.
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Jessica Winne, Rafael Franzon, Aron de Miranda, Thawann Malfatti, João Patriota, Sanja Mikulovic, Katarina E. Leão & Richardson N. Leão. (2019) Salicylate induces anxiety-like behavior and slow theta oscillation and abolishes the relationship between running speed and fast theta oscillation frequency. Hippocampus 29:1, pages 15-25.
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Yuichiro Otani, Keishi Kanno, Ezekiel Wong Toh Yoon & Susumu Tazuma. (2018) Acute respiratory distress syndrome caused by salicylate intoxication. Clinical Case Reports 6:9, pages 1905-1906.
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Trung Nguyen, Noel Cranswick, Jeremy Rosenbaum, Ben Gelbart & Shidan Tosif. (2018) Chronic use of teething gel causing salicylate toxicity. Journal of Paediatrics and Child Health 54:5, pages 576-578.
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Petr Handlos, Matěj Uvíra, Klára Marecová, Marie Staňková, Margita Smatanová, Igor Dvořáček & Marek Joukal. (2017) Fatal Ingestion of Chlumsky Disinfectant Solution. Journal of Forensic Sciences 63:2, pages 626-630.
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Nirit Bernstein, Muhammad Akram, Muhammad Daniyal, Hinanit Koltai, Marcelo Fridlender & Jonathan Gorelick. 2018. 131 183 .
Zayan Mahmooth, James G Malcolm, Jeremy S Wetzel & Faiz U Ahmad. (2017) Unusual cause of encephalopathy after brain surgery. BMJ Case Reports, pages bcr-2017-222253.
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Daniel J. McCabe & Jenny J. Lu. (2017) The association of hemodialysis and survival in intubated salicylate-poisoned patients. The American Journal of Emergency Medicine 35:6, pages 899-903.
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Brit Long & Alex Koyfman. (2017) Clinical Mimics: An Emergency Medicine–Focused Review of Sepsis Mimics. The Journal of Emergency Medicine 52:1, pages 34-42.
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Ludmila Mut, Thomas Grobosch, Torsten Binscheck-Domaß & Wolfgang Frenzel. (2016) Toxicological screening of human plasma by on-line SPE-HPLC-DAD: identification and quantification of acidic and neutral drugs. Biomedical Chromatography 30:3, pages 343-362.
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Sai HS. Boddu, Jwala Renukuntla, Alan Rega & Kenneth Alexander. 2015. Excipient Applications in Formulation Design and Drug Delivery. Excipient Applications in Formulation Design and Drug Delivery 613 636 .
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Biff F. Palmer. (2012) Evaluation and Treatment of Respiratory Alkalosis. American Journal of Kidney Diseases 60:5, pages 834-838.
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James K. Glisson, Telciane S. Vesa & Mark R. Bowling. (2011) Current Management of Salicylate-Induced Pulmonary Edema. Southern Medical Journal 104:3, pages 225-232.
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Gary D WilliamsEdwin P KirkCallum J WilsonCaroline A MeadowsBetty S Chan. (2011) Salicylate intoxication from teething gel in infancy. Medical Journal of Australia 194:3, pages 146-148.
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