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Postgraduate Medicine Volume 122, 2010 - Issue 6
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Clinical Features

Acute Intravenous Synaptamine Complex Variant KB220™ “Normalizes” Neurological Dysregulation in Patients during Protracted Abstinence from Alcohol and Opiates as Observed Using Quantitative Electroencephalographic and Genetic Analysis for Reward Polymorphisms: Part 1, Pilot Study with 2 Case Reports

David K. Miller LifeStream Solutions, Inc., Prescott, AZ; Bridging the Gaps Treatment Center, Winchester, VA; Department of Neuropsychogenetics, LifeGen, Inc., San Diego, CA
, PhD,
Abdalla Bowirrat Clinical Neuroscience and Population Genetics, Ziv Government Medical Center, Safed, Israel
, MD, PhD,
Matthew Manka LifeStream Solutions, Inc., Prescott, AZ
, PhD,
Merlene Miller LifeStream Solutions, Inc., Prescott, AZ; Bridging the Gaps Treatment Center, Winchester, VA; Department of Neuropsychogenetics, LifeGen, Inc., San Diego, CA
, MA,
Stanley Stokes Bridging the Gaps Treatment Center, Winchester, VA
, MS,
Debra Manka LifeStream Solutions, Inc., Prescott, AZ
, MHD,
Cameron Allen Synaptic Connections Research Institute, and Soterian Health Care, Charleston, SC
, BA,
Charles Gant National Integrated Health Associates, Washington, DC
, MD,
B. William Downs Department of Neuropsychogenetics, LifeGen, Inc., San Diego, CA
, BSc,
Andrew Smolen Institute for Behavioral Genetics, University of Colorado, Denver, CO
, PhD,
Emily Stevens Neurobehavioral Consultants, Lake Placid, FL
, PhD,
Swetha Yeldandi Department of Clinical Neurology, Path Foundation NY, New York, NY
&
Kenneth Blum National Integrated Health Associates, Washington, DC; Department of Clinical Neurology, Path Foundation NY, New York, NY; Department of Psychiatry and McKnight Brain Institute, University of Florida, Gainesville, FL; Department of Holistic Medicine, G&G Addiction Treatment Center, North Miami Beach, FLCorrespondence[email protected]
, PhD show all
Pages 188-213 | Published online: 13 Mar 2015

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Kenneth Blum, Yijun Liu, Wei Wang, Yarong Wang, Yi Zhang, Marlene Oscar-Berman, Andrew Smolen, Marcelo Febo, David Han, Thomas Simpatico, Frans J. Cronjé, Zsolt Demetrovics & Mark S Gold. (2015) rsfMRI effects of KB220Z™ on neural pathways in reward circuitry of abstinent genotyped heroin addicts. Postgraduate Medicine 127:2, pages 232-241.
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Rachel Harrison, Julia J. Rucklidge & Neville Blampied. (2013) Use of Micronutrients Attenuates Cannabis and Nicotine Abuse as Evidenced From a Reversal Design: A Case Study. Journal of Psychoactive Drugs 45:2, pages 168-178.
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Merlene Miller, Amanda LC Chen, Stan D. Stokes, Susan Silverman, Abdalla Bowirrat, Matthew Manka, Debra Manka, David K. Miller, Kenneth Perrine, Thomas JH Chen, John A. Bailey, William Downs, Roger L. Waite, Margaret A. Madigan, Eric R. Braverman, Uma Damle, Mallory Kerner, John Giordano, Siobhan Morse, Marlene Oscar-Berman, Debmalya Barh & Kenneth Blum. (2012) Early Intervention of Intravenous KB220IV- Neuroadaptagen Amino-Acid Therapy (NAAT)™ Improves Behavioral Outcomes in a Residential Addiction Treatment Program: A Pilot Study. Journal of Psychoactive Drugs 44:5, pages 398-409.
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Thomas J.H. Chen, Kenneth Blum, Amanda L.C. Chen, Abdalla Bowirrat, William B. Downs, Margret A. Madigan, Roger L. Waite, John A. Bailey, Mallory Kerner, Swetha Yeldandi, Neil Majmundar, John Giordano, Siohban Morse, David Miller, Frank Fornari & Eric R. Braverman. (2011) Neurogenetics and Clinical Evidence for the Putative Activation of the Brain Reward Circuitry by a Neuroadaptagen: Proposing an Addiction Candidate Gene Panel Map. Journal of Psychoactive Drugs 43:2, pages 108-127.
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Articles from other publishers (19)

Mauro Ceccanti, Kenneth Blum, Abdalla Bowirrat, Catherine A. Dennen, Eric R. Braverman, David Baron, Thomas Mclaughlin, John Giordano, Ashim Gupta, Bernard W. Downs, Debasis Bagchi, Debmalya Barh, Igor Elman, Panayotis K. Thanos, Rajendra D. Badgaiyan, Drew Edwards & Mark S. Gold. (2022) Future Newborns with Opioid-Induced Neonatal Abstinence Syndrome (NAS) Could Be Assessed with the Genetic Addiction Risk Severity (GARS) Test and Potentially Treated Using Precision Amino-Acid Enkephalinase Inhibition Therapy (KB220) as a Frontline Modality Instead of Potent Opioids. Journal of Personalized Medicine 12:12, pages 2015.
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Kenneth Blum, Abdalla Bowirrat, Luis Llanos Gomez, B. William Downs, Debasis Bagchi, Debmalya Barh, Edward J. Modestino, David Baron, Thomas McLaughlin, Panayotis Thanos, Mauro Ceccanti, Igor Elman, Rajendra D. Badgaiyan, Catherine Dennen, Ashim Gupta, Eric R. Braverman & Mark S. Gold. (2022) Why haven't we solved the addiction crisis?. Journal of the Neurological Sciences 442, pages 120404.
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Kenneth Blum, Catherine A. Dennen, Igor Elman, Abdalla Bowirrat, Panayotis K. Thanos, Rajendra D. Badgaiyan, B. William Downs, Debasis Bagchi, David Baron, Eric R. Braverman, Ashim Gupta, Richard Green, Thomas McLaughlin, Debmalya Barh & Mark S. Gold. (2022) Should Reward Deficiency Syndrome (RDS) Be Considered an Umbrella Disorder for Mental Illness and Associated Genetic and Epigenetic Induced Dysregulation of Brain Reward Circuitry?. Journal of Personalized Medicine 12:10, pages 1719.
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Anish Bajaj, Kenneth Blum, Abdalla Bowirrat, Ashim Gupta, David Baron, David Fugel, Ayo Nicholson, Taylor Fitch, B. William Downs, Debasis Bagchi, Catherine A. Dennen & Rajendra D. Badgaiyan. (2022) DNA Directed Pro-Dopamine Regulation Coupling Subluxation Repair, H-Wave® and Other Neurobiologically Based Modalities to Address Complexities of Chronic Pain in a Female Diagnosed with Reward Deficiency Syndrome (RDS): Emergence of Induction of “Dopamine Homeostasis” in the Face of the Opioid Crisis. Journal of Personalized Medicine 12:9, pages 1416.
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Kenneth Blum, David Han, David Baron, Shan Kazmi, Igor Elman, Luis Llanos Gomez, Marjorie C. Gondre -Lewis, Panyotis K Thanos, Eric R Braverman & Rajendra D Badgaiyan. (2022) Nicotinamide Adenine Dinucleotide (NAD+) and Enkephalinase Inhibition (IV1114589NAD) Infusions Significantly Attenuate Psychiatric Burden Sequalae in Substance Use Disorder (SUD) in Fifty Cases. Current Psychiatry Research and Reviews 18:2, pages 125-143.
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Bernard W. Downs, Steve Kushner, Manashi Bagchi, Kenneth Blum, Rajendra D. Badgaiyan, Sanjoy Chakraborty & Debasis Bagchi. (2021) Etiology of Neuroinflammatory Pathologies in Neurodegenerative Diseases: A Treatise. Current Psychopharmacology 10:2, pages 123-137.
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Kenneth Blum, Jag Khalsa, Jean Lud Cadet, David Baron, Abdalla Bowirrat, Brent Boyett, Lisa Lott, Raymond Brewer, Marjorie Gondré-Lewis, Gregory Bunt, Shan Kazmi & Mark S. Gold. (2021) Cannabis-Induced Hypodopaminergic Anhedonia and Cognitive Decline in Humans: Embracing Putative Induction of Dopamine Homeostasis. Frontiers in Psychiatry 12.
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Kenneth Blum, Shan Kazmi, Edward J. Modestino, Bill William Downs, Debasis Bagchi, David Baron, Thomas McLaughlin, Richard Green, Rehan Jalali, Panayotis K. Thanos, Igor Elman, Rajendra D. Badgaiyan, Abdalla Bowirrat & Mark S. Gold. (2021) A Novel Precision Approach to Overcome the “Addiction Pandemic” by Incorporating Genetic Addiction Risk Severity (GARS) and Dopamine Homeostasis Restoration. Journal of Personalized Medicine 11:3, pages 212.
Crossref
Naimesh Solanki, Tomilowo Abijo, Carine Galvao, Philippe Darius, Kenneth Blum & Marjorie C. Gondré-Lewis. (2020) Administration of a putative pro-dopamine regulator, a neuronutrient, mitigates alcohol intake in alcohol-preferring rats. Behavioural Brain Research 385, pages 112563.
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Michael Ott, Julie K. Mannchen, Fariba Jamshidi & Ursula Werneke. (2019) Management of severe arterial hypertension associated with serotonin syndrome: a case report analysis based on systematic review techniques. Therapeutic Advances in Psychopharmacology 9, pages 204512531881881.
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D. Borsook, C. Linnman, V. Faria, A.M. Strassman, L. Becerra & I. Elman. (2016) Reward deficiency and anti-reward in pain chronification. Neuroscience & Biobehavioral Reviews 68, pages 282-297.
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Kenneth Blum, Marcelo Febo, Panayotis K. Thanos, David Baron, James Fratantonio & Mark Gold. (2015) Clinically Combating Reward Deficiency Syndrome (RDS) with Dopamine Agonist Therapy as a Paradigm Shift: Dopamine for Dinner?. Molecular Neurobiology 52:3, pages 1862-1869.
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Hang Su, Zhibin Li, Jiang Du, Haifeng Jiang, Zhikang Chen, Haiming Sun & Min Zhao. (2015) Predictors of heroin relapse: Personality traits, impulsivity, COMT gene Val158met polymorphism in a 5-year prospective study in Shanghai, China. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 168:8, pages 712-719.
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Mark S. Gold, Rajendra D. Badgaiyan & Kenneth Blum. (2015) A Shared Molecular and Genetic Basis for Food and Drug Addiction. Psychiatric Clinics of North America 38:3, pages 419-462.
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Thomas Mclaughlin, Marlene Oscar-Berman, Thomas Simpatico, John Giordano, Scot Jones, Debmayla Barh, William B. Downs, Roger L. Waite, Margaret Madigan, Kristina Dushaj, Raquel Lohmann, Eric R. Braverman, David Han & Kenneth Blum. (2013) Hypothesizing repetitive paraphilia behavior of a medication refractive Tourette's syndrome patient having rapid clinical attenuation with KB220Z-nutrigenomic amino-acid therapy (NAAT). Journal of Behavioral Addictions 2:2, pages 117-124.
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Kenneth Blum, David Han, John Giordano, Raquel Lohmann, Eric R. Braverman, Margaret A. Madigan, Debmalya Barh, John Femino, Mary Hauser, B. W. Downs & Thomas Simpatico. 2013. Omics for Personalized Medicine. Omics for Personalized Medicine 365 398 .
Kenneth Blum, John Femino, Scott Teitelbaum, John Giordano, Marlene Oscar-Berman & Mark GoldKenneth Blum, John Femino, Scott Teitelbaum, John Giordano, Marlene Oscar-Berman & Mark Gold. 2013. Molecular Neurobiology of Addiction Recovery. Molecular Neurobiology of Addiction Recovery 11 82 .
Kenneth Blum, Thomas J. H. Chen, John Bailey, Abdalla Bowirrat, John Femino, Amanda L. C. Chen, Thomas Simpatico, Siobhan Morse, John Giordano, Uma Damle, Mallory Kerner, Eric R. Braverman, Frank Fornari, B. William Downs, Cynthia Rector, Debmayla Barh & Marlene Oscar-Berman. (2011) Can the Chronic Administration of the Combination of Buprenorphine and Naloxone Block Dopaminergic Activity Causing Anti-reward and Relapse Potential?. Molecular Neurobiology 44:3, pages 250-268.
Crossref
Kenneth Blum & Mark S. Gold. (2011) Neuro-chemical activation of brain reward meso-limbic circuitry is associated with relapse prevention and drug hunger: A hypothesis. Medical Hypotheses 76:4, pages 576-584.
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