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Clinical Focus: Metabolic Disorders, Diabetes, and Cardiovascular Disease

Advantages of Extended-Release Metformin in Patients with Type 2 Diabetes Mellitus

, MD & , MD
Pages 15-23 | Published online: 13 Mar 2015

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K M Prasanna Kumar, Manoj Chawla, Ami Sanghvi, Nadiminty G Sastry, Chaitanya Kotla, Sanjeev Phatak & Sanjay Choudhari. (2019) Adherence, satisfaction, and experience with metformin 500 mg prolonged release formulation in Indian patients with type 2 diabetes mellitus: a postmarketing observational study. International Journal of General Medicine 12, pages 147-159.
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Stewart B. Harris. (2016) The power of two: an update on fixed-dose combinations for type 2 diabetes. Expert Review of Clinical Pharmacology 9:11, pages 1453-1462.
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Qingwei Zhao, Dongsheng Hong, Dongsheng Zheng, Yao Xiao & Baohua Wu. (2014) Risk of diarrhea in patients with type 2 diabetes mellitus treated with sitagliptin: a meta-analysis of 30 randomized clinical trials. Drug Design, Development and Therapy 8, pages 2283-2294.
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André J Scheen. (2012) Saxagliptin plus metformin combination therapy. Expert Review of Endocrinology & Metabolism 7:2, pages 151-164.
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Articles from other publishers (42)

Sun Ho Kim, Jung Han Kook, Dong-Wan Seo & Myung Joo Kang. (2023) The Effect of Compression Pressure on the First Layer Surface Roughness and Delamination of Metformin and Evogliptin Bilayer and Trilayer Tablets. Pharmaceuticals 16:11, pages 1523.
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Amod S. Patil, Anand B. Mundada, Ravindra S. Shravane, Pooja A. Mundada & Sanjay J. Surana. (2023) Normal- and reversed-phase high-performance thin-layer chromatography methods for the simultaneous determination of remogliflozin etabonate and metformin hydrochloride antidiabetic drugs in bulk and tablet formulation. JPC – Journal of Planar Chromatography – Modern TLC 36:1, pages 89-97.
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Kumar Venkatesan, Saad M. Alshahrani, Amal M. Alsubaiyel, Maram H. Abduljabbar, Manal E. Alosaimi, Maria Grishina & Saeed Shirazian. (2023) Experimental - Theoretical approach for determination of Metformin solubility in supercritical carbon dioxide: Thermodynamic modeling. Case Studies in Thermal Engineering 41, pages 102649.
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Yaser Mohammed Al-Worafi, Long Chiau Ming, Abdullah Ahmed Dhabali, Abdulkareem Mohammed Al-Shami & Ammar Ali Saleh Jaber. 2023. Clinical Case Studies on Medication Safety. Clinical Case Studies on Medication Safety 5 32 .
Zeeshan Mansuri, Ramkrishna Makani, Chintan Trivedi, Mahwish Adnan, Ramu Vadukapuram, John Rafael, Ashutosh Lodhi & Abhishek Reddy. (2022) The role of metformin in treatment of weight gain associated with atypical antipsychotic treatment in children and adolescents: A systematic review and meta-analysis of randomized controlled trials. Frontiers in Psychiatry 13.
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Ji Hoon Kim, Kyeongjin Kim & Hyo-Eon Jin. (2022) Three-Dimensional Printing for Oral Pharmaceutical Dosage Forms. Journal of Pharmaceutical Investigation 52:3, pages 293-317.
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Abdul Mushib Ibrahim & Stephen Lawrence. (2022) Improving Diabetes Care: A Fijian Diabetes Service Improvement Study. International Journal of Chronic Diseases 2022, pages 1-9.
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Aedrian A. Abrilla, A. Nico Nahar I. Pajes & Cecilia A. Jimeno. (2021) Metformin extended-release versus metformin immediate-release for adults with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials. Diabetes Research and Clinical Practice 178, pages 108824.
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Ayesha Akram. (2021) Reactive Hypoglycemia From Metformin Immediate-Release Monotherapy Resolved by a Switch to Metformin Extended-Release: Conceptualizing Their Concentration-Time Curves. Cureus.
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Mahesh Attimarad, Anroop B. Nair, Nagaraja Sreeharsha, Bandar E. Al-Dhubiab, Katharigatta N. Venugopala & Pottathil Shinu. (2021) Development and Validation of Green UV Derivative Spectrophotometric Methods for Simultaneous Determination Metformin and Remogliflozin from Formulation: Evaluation of Greenness. International Journal of Environmental Research and Public Health 18:2, pages 448.
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Tariq Chukir, Lindsay Mandel, Beverly G. Tchang, Nada A. Al- Mulla, Leon I. Igel, Rekha B. Kumar, Jonathan Waitman, Louis J. Aronne & Alpana P. Shukla. (2021) Metformin-induced weight loss in patients with or without type 2 diabetes/prediabetes: A retrospective cohort study. Obesity Research & Clinical Practice 15:1, pages 64-68.
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Sanjeeb Kumar Kar, Susovita Khuntia & Shubhrata Nayak. (2020) Metformin related adverse events: A prospective observational study in health care centers of western Odisha. Journal of Pharmacovigilance and Drug Research 1:2, pages 32-34.
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Mahesh Attimarad, Rafea Elamin Elgack Elgorashe, Rajasekaran Subramaniam, Mohammed Monirul Islam, Katharigatta N. Venugopala, Sreeharsha Nagaraja & Abdulmalek Ahmed Balgoname. (2020) Development and Validation of Rapid RP-HPLC and Green Second-Derivative UV Spectroscopic Methods for Simultaneous Quantification of Metformin and Remogliflozin in Formulation Using Experimental Design. Separations 7:4, pages 59.
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Elizabeth M. Vaughan, Jaime J. Rueda, Susan L. Samson & David J. Hyman. (2020) Reducing the Burden of Diabetes Treatment: A Review of Low-cost Oral Hypoglycemic Medications. Current Diabetes Reviews 16:8, pages 851-858.
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Chiamaka Esther Amaefule, Angeliki Bolou, Zoe Drymoussi, Francisco Jose Gonzalez Carreras, Maria del Carmen Pardo Llorente, Doris Lanz, Julie Dodds, Lorna Sweeney, Elena Pizzo, Maria D’Amico, Amy Thomas, James Heighway, Jahnavi Daru, Soha Sobhy, John Robson, Anita Sanghi, Javier Zamora, Angela Harden, Graham Hitman, Khalid Khan, Teresa Pérez, Mohammed SB Huda & Shakila Thangaratinam. (2020) Effectiveness and acceptability of metformin in preventing the onset of type 2 diabetes after gestational diabetes in postnatal women: a protocol for a randomised, placebo-controlled, double-blind feasibility trialOptimising health outcomes with Metformin to prevent diAbetes After pregnancy (OMAhA). BMJ Open 10:5, pages e036198.
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Veronika Piskovatska, Kenneth B. Storey, Alexander M. Vaiserman & Oleh Lushchak. 2020. Reviews on New Drug Targets in Age-Related Disorders. Reviews on New Drug Targets in Age-Related Disorders 319 332 .
Ragada El-Damanawi, Andrea K Viecelli, Elaine M Pascoe, Jonathan C Craig, David W Johnson, Andrew J Mallett, Carmel M Hawley & Thomas F Hiemstra. (2019) Metformin for preventing the progression of chronic kidney disease. Cochrane Database of Systematic Reviews.
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V. V. Salukhov & B. V. Romashevsky. (2019) Modern aspects for preventive therapy of type 2 diabetes mellitus. Medical Council:4, pages 6-13.
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Elena A. Christofides. (2019) Practical Insights Into Improving Adherence to Metformin Therapy in Patients With Type 2 Diabetes. Clinical Diabetes 37:3, pages 234-241.
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Bo-Bae Seo, Mi-Ran Park & Soo-Chang Song. (2019) Sustained Release of Exendin 4 Using Injectable and Ionic-Nano-Complex Forming Polymer Hydrogel System for Long-Term Treatment of Type 2 Diabetes Mellitus. ACS Applied Materials & Interfaces 11:17, pages 15201-15211.
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