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Clinical Focus: Protocols and Treatment Options for Cardiovascular Disease

Statin Wars: The Heavyweight Match-Atorvastatin versus Rosuvastatin for the Treatment of Atherosclerosis, Heart Failure, and Chronic Kidney Disease

, PharmD, , MD, FACC, FACP, FCCP, , MD, PhD & , MD
Pages 7-16 | Published online: 13 Mar 2015

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R. C. R. M. do Nascimento, A. A. Guerra Jr.J. Alvares, I. C. Gomes, B. Godman, M. Bennie, A. B. Kurdi & F. A. de Acurcio. (2018) Statin use in Brazil: findings and implications. Current Medical Research and Opinion 34:10, pages 1809-1817.
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N. G. Gogolashvili. (2023) Moderate-intensity statin therapy. Efficacy and safety issues. Russian Journal of Cardiology 28:6, pages 5485.
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Zheng Lian, Jun-Xian Song, Shi-Ran Yu, Li-Na Su, Yu-Xia Cui, Su-Fang Li, Chong-Yoo Lee, Hui-Zhu Liang & Hong Chen. (2021) Therapeutic targets of rosuvastatin on heart failure and associated biological mechanisms: A study of network pharmacology and experimental validation. European Journal of Pharmacology 895, pages 173888.
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YiNing Dai, JieLeng Huang, LiHuan Zeng, ZhiHua Huang, ChongYang Duan, Shuai Shao, HongHuan Chen, Ling Xue, JiYan Chen, Ning Tan, PengCheng He, YuanHui Liu & DanQing Yu. (2020) Comparison of the preventive efficacy of rosuvastatin versus atorvastatin in post-contrast acute kidney injury in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention. Biomedicine & Pharmacotherapy 128, pages 110336.
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Yvette N. Lamb. (2020) Rosuvastatin/Ezetimibe: A Review in Hypercholesterolemia. American Journal of Cardiovascular Drugs 20:4, pages 381-392.
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HayderM Al-Kuraishy, AliI Al-Gareeb & MarwaThaier Naji. (2020) Brain natriuretic peptide in patients with acute ischemic stroke: Role of statins. Biomedical and Biotechnology Research Journal (BBRJ) 4:3, pages 239.
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Li-Mei Wu, Shao-Guo Wu, Fei Chen, Qian Wu, Chang-Meng Wu, Chun-Min Kang, Xin He, Ru-Yi Zhang, Zhi-Feng Lu, Xue-Heng Li, Yuan-Jun Xu, Li-Min Li, Li Ding, Huan-Lan Bai, Xue-Hui Liu, Yan-Wei Hu & Lei Zheng. (2020) Atorvastatin inhibits pyroptosis through the lncRNA NEXN-AS1/NEXN pathway in human vascular endothelial cells. Atherosclerosis 293, pages 26-34.
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Yang Wang, Jinsong Wang & Shenming Wang. (2018) Comparative Effectiveness of Inclisiran 100, 300, and 500 mg in a Population with Hyperlipidemia: A Network Meta-Analysis of Randomized Controlled Trials. American Journal of Cardiovascular Drugs 18:4, pages 271-282.
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Sai Wang Seto, Dennis Chang, Hosen Kiat, Ning Wang & Alan Bensoussan. (2018) Chinese Herbal Medicine as a Potential Treatment of Abdominal Aortic Aneurysm. Frontiers in Cardiovascular Medicine 5.
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Titus WL Lau, Kevin E.K. Tan, Jason C.J. Choo, Tsun-Gun Ng, Subramaniam Tavintharan & Juliana C.N. Chan. (2018) Regional evidence and international recommendations to guide lipid management in Asian patients with type 2 diabetes with special reference to renal dysfunction. Journal of Diabetes 10:3, pages 200-212.
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Mustafa Zafer Temiz, Emrah Yuruk, Kasim Ertas, Oguzhan Zengi & Atilla Semercioz. (2017) Effects of statin treatment with atorvastatin on urolithiasis-associated urinary metabolic risk factors: an experimental study. International Urology and Nephrology 50:2, pages 231-236.
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Lin Cong, Shuhao Fu, Jinling Zhang, Jin Zhao & Yuyan Zhang. (2017) Effects of atorvastatin on porcine aqueous humour outflow and trabecular meshwork cells. Experimental and Therapeutic Medicine.
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Weiwei Jiang, Yanyan Cen, Yi Song, Pan Li, Rongxin Qin, Chao Liu, Yibo Zhao, Jiang Zheng & Hong Zhou. (2016) Artesunate attenuated progression of atherosclerosis lesion formation alone or combined with rosuvastatin through inhibition of pro-inflammatory cytokines and pro-inflammatory chemokines. Phytomedicine 23:11, pages 1259-1266.
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Ankur Rohilla, Ayaz Ahmad, M.U. Khan & Razia Khanam. (2015) A comparative study on the cardioprotective potential of atorvastatin and simvastatin in hyperhomocysteinemic rat hearts. European Journal of Pharmacology 764, pages 48-54.
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Shuang Chen, Baoqin Liu, Dehui Kong, Si Li, Chao Li, Huaqin Wang & Yingxian Sun. (2015) Atorvastatin Calcium Inhibits Phenotypic Modulation of PDGF-BB-Induced VSMCs via Down-Regulation the Akt Signaling Pathway. PLOS ONE 10:4, pages e0122577.
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Anthony C. Chyou, Anay Thodge, Dmitriy N. Feldman & Rajesh V. Swaminathan. (2015) Statins in the Prevention of Contrast-Induced Nephropathy. Current Treatment Options in Cardiovascular Medicine 17:4.
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Dick de Zeeuw, Deborah A Anzalone, Valerie A Cain, Michael D Cressman, Hiddo J Lambers Heerspink, Bruce A Molitoris, John T Monyak, Hans-Henrik Parving, Giuseppe Remuzzi, James R Sowers & Donald G Vidt. (2015) Renal effects of atorvastatin and rosuvastatin in patients with diabetes who have progressive renal disease (PLANET I): a randomised clinical trial. The Lancet Diabetes & Endocrinology 3:3, pages 181-190.
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Yang Qu, Lixin Wei & Haiqing Zhang. (2014) Inhibition of inflammation mediates the protective effect of atorvastatin reload in patients with coronary artery disease undergoing noncardiac emergency surgery. Coronary Artery Disease 25:8, pages 678-684.
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Yong Liu, Yuan-hui Liu, Ning Tan, Ji-yan Chen, Ying-ling Zhou, Li-wen Li, Chong-yang Duan, Ping-Yan Chen, Jian-fang Luo, Hua-long Li & Wei-Guo. (2014) Comparison of the Efficacy of Rosuvastatin versus Atorvastatin in Preventing Contrast Induced Nephropathy in Patient with Chronic Kidney Disease Undergoing Percutaneous Coronary Intervention. PLoS ONE 9:10, pages e111124.
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Naoki Takahashi, Koji Maeda, Yukiyasu Asano & Nobuhide Watanabe. (2014) Synthesis and pharmacological characterization of 1-benzyl-4-aminoindole-based thyroid hormone receptor β agonists. Bioorganic & Medicinal Chemistry 22:1, pages 488-498.
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Jennifer F. T. Teng, Tara Gomes, Ximena Camacho, Scott Grundy, David N. Juurlink & Muhammad M. Mamdani. (2013) Impact of the JUPITER Trial on Statin Prescribing for Primary Prevention . Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 34:1, pages 9-18.
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JIANTING GAN, PING LI, ZHENGDONG WANG, JIAN CHEN, XIANGWEN LIANG, MING LIU, WENCHAO XIE, RUIXING YIN & FENG HUANG. (2013) Rosuvastatin suppresses platelet-derived growth factor-BB-induced vascular smooth muscle cell proliferation and migration via the MAPK signaling pathway. Experimental and Therapeutic Medicine 6:4, pages 899-903.
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