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Clinical Features

Ruxolitinib: An Oral Janus Kinase 1 and Janus Kinase 2 Inhibitor in the Management of Myelofibrosis

, MD, PhD
Pages 128-135 | Published online: 13 Mar 2015

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Sairaj Satarker, Antriya Annie Tom, Roshitha Ann Shaji, Aaja Alosious, Mariya Luvis & Madhavan Nampoothiri. (2021) JAK-STAT Pathway Inhibition and their Implications in COVID-19 Therapy. Postgraduate Medicine 133:5, pages 489-507.
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Yu-Fon Chen, Chien-Hsiang Chang, Zih-Ning Huang, Yu-Chu Su, Sue-Joan Chang & Jeng-Shiung Jan. (2019) The JAK inhibitor antcin H exhibits direct anticancer activity while enhancing chemotherapy against LMP1-expressed lymphoma. Leukemia & Lymphoma 60:5, pages 1193-1203.
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Krisstina L Gowin & Ruben A Mesa. (2015) Profile of pomalidomide and its potential in the treatment of myelofibrosis. Therapeutics and Clinical Risk Management 11, pages 549-556.
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Ali Tabarroki, Yogen Saunthararajah, Valeria Visconte, Tracy Cinalli, Kristin Colaluca, Heesun J. Rogers, Mikkael A. Sekeres, Hien K. Duong, Brady L. Stein & Ramon V. Tiu. (2015) Ruxolitinib in combination with DNA methyltransferase inhibitors: clinical responses in patients with symptomatic myelofibrosis with cytopenias and elevated blast(s) counts. Leukemia & Lymphoma 56:2, pages 497-499.
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Srdan Verstovsek. (2014) Tips on using ruxolitinib in everyday practice as therapy for myelofibrosis. Leukemia & Lymphoma 55:1, pages 5-6.
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Silvia Salmoiraghi, Marie Lorena Guinea Montalvo, Elena D’Agostini, Giulia Amicarelli, Giulia Minnucci, Orietta Spinelli & Alessandro Rambaldi. (2013) Mutations and chromosomal rearrangements of JAK2: not only a myeloid issue. Expert Review of Hematology 6:4, pages 429-439.
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Articles from other publishers (23)

Uarlei Nogueira Porto, Gisele Corrêa de Oliveira Zigmundo, Felippe José Almeida Loureiro, Jéssica Onofre de Brito Lima, Vinícius Coelho Carrard, Manoela Domingues Martins, Marco Antônio Trevizani Martins & Fernanda Visioli. (2023) Oral manifestation of Langerhan cell histiocytosis in a patient previously diagnosed with primary myelofibrosis. Oral Oncology Reports 7, pages 100075.
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Lakshana Sreenivasan, Ling Vicky Li, Pascal Leclair & Chinten James Lim. (2022) Targeting the gp130/STAT3 Axis Attenuates Tumor Microenvironment Mediated Chemoresistance in Group 3 Medulloblastoma Cells. Cells 11:3, pages 381.
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Yuying Li, Fang Guo, Tinggui Chen, Liwei Zhang & Yu Qin. (2021) Anthraquinone derivative C10 inhibits proliferation and cell cycle progression in colon cancer cells via the Jak2/Stat3 signaling pathway. Toxicology and Applied Pharmacology 418, pages 115481.
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Mesut GÖÇER & Erdal KURTOĞLU. (2020) Myelofibrozis hastalarında Ruxolitinib kullanımı: tek merkez deneyimi ve JAK-2 allel yükü ile Ruxolitinib yanıtı arasındaki ilişki. Pamukkale Medical Journal.
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P. Troitzsch, R. Panzer, S. Emmert & A. Thiem. (2020) Aquagener Pruritus als Warnzeichen eines inneren Tumorleidens – eine Fallvorstellung und Literaturübersicht. Aktuelle Dermatologie 46:08/09, pages 389-393.
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Jingjie Sun, Yuping Du, Xinxin Zhang, Zhuoya Wang, Yuxi Lin, Qiaoling Song, Xiao Wang, Jihui Guo, Shanshan Li, Jing Nan & Jinbo Yang. (2019) Discovery and evaluation of Atopaxar hydrobromide, a novel JAK1 and JAK2 inhibitor, selectively induces apoptosis of cancer cells with constitutively activated STAT3. Investigational New Drugs 38:4, pages 1003-1011.
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Annekatrin Arlt, Frederike Bonin, Thorsten Rehberg, Paula Perez‐Rubio, Julia C. Engelmann, Katharina Limm, Sarah Reinke, Christian Dullin, Xueni Sun, Rieke Specht, Markus Maulhardt, Franziska Linke, Gertrude Bunt, Wolfram Klapper, Martina Vockerodt, Jörg Wilting, Tobias Pukrop, Katja Dettmer, Wolfram Gronwald, Peter J. Oefner, Rainer Spang & Dieter Kube. (2020) High CD206 levels in Hodgkin lymphoma‐educated macrophages are linked to matrix‐remodeling and lymphoma dissemination. Molecular Oncology 14:3, pages 571-589.
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Ruben A. Mesa, Yun Su, Adrien Woolfson, Josef T. Prchal, Kathleen Turnbull, Elias Jabbour, Robyn Scherber, Alan L. Shields, Meaghan Krohe, Funke Ojo, Farrah Pompilus, Joseph C. Cappelleri & Claire Harrison. (2019) Development of a symptom assessment in patients with myelofibrosis: qualitative study findings. Health and Quality of Life Outcomes 17:1.
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Wenyin Jin & Yinfeng Shen. (2019) Da-Cheng-Qi Decoction Alleviates Intestinal Injury in Rats with Severe Acute Pancreatitis by Inhibiting the JAK2-STAT3 Signaling Pathway. Evidence-Based Complementary and Alternative Medicine 2019, pages 1-12.
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Renato Sampaio Tavares, Alexandre Nonino, Katia Borgia Barbosa Pagnano, Ana Clara Kneese Virgilio do Nascimento, Monika Conchon, Laura Maria Fogliatto, Vaneuza Araújo Moreira Funke, Israel Bendit, Nelma Cristina Diogo Clementino, Maria de Lourdes Lopes Ferrari Chauffaille, Wanderley Marques Bernardo & Fabio Pires de Souza Santos. (2019) Guideline on myeloproliferative neoplasms: Associacão Brasileira de Hematologia, Hemoterapia e Terapia Cellular. Hematology, Transfusion and Cell Therapy 41, pages 1-73.
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Julia Song, Alice Song, Trisa Palmares, Michael Song & Harold Song. (2017) Ruxolitinib found to cause eyelash growth: a case report. Journal of Medical Case Reports 11:1.
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Samah Alimam & Claire Harrison. (2017) Experience with ruxolitinib in the treatment of polycythaemia vera. Therapeutic Advances in Hematology 8:4, pages 139-151.
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Patricia R Taylor, Sanhita Roy, Evan C Meszaros, Yan Sun, Scott J Howell, Charles J Malemud & Eric Pearlman. (2016) JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL-6/23-stimulated neutrophil, IL-17, elastase, and MMP9 activity . Journal of Leukocyte Biology 100:1, pages 213-222.
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Sibasish Dolai, Keith C.S. Sia, Alissa K. Robbins, Ling Zhong, Sue L. Heatley, Tiffaney L. Vincent, Falko Hochgräfe, Rosemary Sutton, Raushan T. Kurmasheva, Tamas Revesz, Deborah L. White, Peter J. Houghton, Malcolm A. Smith, David T. Teachey, Roger J. Daly, Mark J. Raftery & Richard B. Lock. (2016) Quantitative Phosphotyrosine Profiling of Patient-Derived Xenografts Identifies Therapeutic Targets in Pediatric Leukemia. Cancer Research 76:9, pages 2766-2777.
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Thomas J. Anastasio. (2015) Computational identification of potential multi-drug combinations for reduction of microglial inflammation in Alzheimer disease. Frontiers in Pharmacology 6.
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Srdan VerstovsekSrdan Verstovsek. 2015. Novel Insights into Myelofibrosis Pathophysiology and Treatment. Novel Insights into Myelofibrosis Pathophysiology and Treatment 2 5 .
Srdan Verstovsek. 2015. Novel Insights into Myelofibrosis Pathophysiology and Treatment. Novel Insights into Myelofibrosis Pathophysiology and Treatment.
K Adekola, U Popat & S O Ciurea. (2014) An update on allogeneic hematopoietic progenitor cell transplantation for myeloproliferative neoplasms in the era of tyrosine kinase inhibitors. Bone Marrow Transplantation 49:11, pages 1352-1359.
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Elena Liew & Jeffrey H Lipton. (2014) Ruxolitinib for the treatment of disease-related splenomegaly or symptoms in adult patients with myelofibrosis. International Journal of Hematologic Oncology 3:5, pages 335-342.
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Yu-Fon Chen, Sheng-Hung Wang, Sue-Joan Chang, Ai-Li Shiau, Lu-Shiun Her, Gia-Shing Shieh, Chin-Fu Chen, Chao-Ching Chang, Yu-Chu Su, Chao-Liang Wu & Tian-Shung Wu. (2014) Zhankuic acid A as a novel JAK2 inhibitor for the treatment of concanavalin A-induced hepatitis. Biochemical Pharmacology 91:2, pages 217-230.
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A Tabarroki, D J Lindner, V Visconte, L Zhang, H J Rogers, Y Parker, H K Duong, A Lichtin, M E Kalaycio, M A Sekeres, S E Mountantonakis, G A Heresi & R V Tiu. (2014) Ruxolitinib leads to improvement of pulmonary hypertension in patients with myelofibrosis. Leukemia 28:7, pages 1486-1493.
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Annabelle Chow, Amy Wong, Giulio Francia, Shan Man, Robert S. Kerbel & Urban Emmenegger. (2013) Preclinical analysis of resistance and cross-resistance to low-dose metronomic chemotherapy. Investigational New Drugs 32:1, pages 47-59.
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Anne Trécul, Franck Morceau, Anthoula Gaigneaux, Marion Orsini, Sébastien Chateauvieux, Cindy Grandjenette, Mario Dicato & Marc Diederich. (2013) Polyphenol tri-vanillic ester 13c inhibits P-JAK2V617F and Bcr–Abl oncokinase expression in correlation with STAT3/STAT5 inactivation and apoptosis induction in human leukemia cells. Cancer Letters 340:1, pages 30-42.
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