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Clinical Focus: Diabetes and Concomitant Disorders

Cardiovascular Effects of Dipeptidyl Peptidase-4 Inhibitors: From Risk Factors to Clinical Outcomes

, MD, PhD
Pages 7-20 | Published online: 13 Mar 2015

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Elizabeth Mary Lamos, Maka Hedrington & Stephen N Davis. (2019) An update on the safety and efficacy of oral antidiabetic drugs: DPP-4 inhibitors and SGLT-2 inhibitors. Expert Opinion on Drug Safety 18:8, pages 691-701.
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Daisuke Yabe & Yutaka Seino. (2016) Alogliptin for the treatment of type 2 diabetes: a drug safety evaluation. Expert Opinion on Drug Safety 15:2, pages 249-264.
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Syed Khalid Imam. (2015) The role of hormonal treatment in type 2 diabetes mellitus. Research and Reports in Endocrine Disorders 5, pages 31-45.
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André J Scheen. (2015) Safety of dipeptidyl peptidase-4 inhibitors for treating type 2 diabetes. Expert Opinion on Drug Safety 14:4, pages 505-524.
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André J Scheen. (2015) A review of gliptins for 2014. Expert Opinion on Pharmacotherapy 16:1, pages 43-62.
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Hiroyuki Konya, Yuzo Yano, Satoshi Matsutani, Taku Tsunoda, Takashi Ikawa, Yoshiki Kusunoki, Toshihiro Matsuo, Masayuki Miuchi, Tomoyuki Katsuno, Tomoya Hamaguchi, Jun-ichiro Miyagawa & Mitsuyoshi Namba. (2014) Profile of saxagliptin in the treatment of type 2 diabetes: focus on Japanese patients. Therapeutics and Clinical Risk Management 10, pages 547-558.
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André J. Scheen. (2023) Clinical pharmacology of antidiabetic drugs: What can be expected of their use?. La Presse Médicale 52:1, pages 104158.
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Elisha Ngetich, Pierfrancesco Lapolla, Anirudh Chandrashekar, Ashok Handa & Regent Lee. (2021) The role of dipeptidyl peptidase-IV in abdominal aortic aneurysm pathogenesis: A systematic review. Vascular Medicine 27:1, pages 77-87.
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Luis D’Marco. 2022. Diabetes and Kidney Disease. Diabetes and Kidney Disease 431 440 .
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Giovanni Cioffi, Carlo Bruno Giorda, Donata Lucci, Elisa Nada, Federica Ognibeni, Costantino Mancusi, Roberto Latini & Aldo P Maggioni. (2021) Effects of linagliptin on left ventricular DYsfunction in patients with type 2 DiAbetes and concentric left ventricular geometry: results of the DYDA 2 trial. European Journal of Preventive Cardiology 28:1, pages 8-17.
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Qi Cheng, Jinluo Cheng, Dennis Cordato & Jianqun Gao. (2020) Can dipeptidyl peptidase-4 inhibitors treat cognitive disorders?. Pharmacology & Therapeutics 212, pages 107559.
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Anca Pantea Stoian, Alexandros Sachinidis, Roxana Adriana Stoica, Dragana Nikolic, Angelo Maria Patti & Ali A. Rizvi. (2020) The efficacy and safety of dipeptidyl peptidase-4 inhibitors compared to other oral glucose-lowering medications in the treatment of type 2 diabetes. Metabolism 109, pages 154295.
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Habib Yaribeygi, Stephen L. Atkin, Tannaz Jamialahmadi & Amirhossein Sahebkar. (2020) A Review on the Effects of New Anti-Diabetic Drugs on Platelet Function. Endocrine, Metabolic & Immune Disorders - Drug Targets 20:3, pages 328-334.
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Carlo Bruno Giorda, Giovanni Cioffi, Donata Lucci, Elisa Nada, Federica Ognibeni, Costantino Mancusi, Roberto Latini & Aldo P. Maggioni. (2019) Effects of Dipeptidyl Peptidase-4 Inhibitor Linagliptin on Left Ventricular Dysfunction in Patients with Type 2 Diabetes and Concentric Left Ventricular Geometry (the DYDA 2™ Trial). Rationale, Design, and Baseline Characteristics of the Study Population. Cardiovascular Drugs and Therapy 33:5, pages 547-555.
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Bo Ahrén. (2019) DPP-4 Inhibition and the Path to Clinical Proof. Frontiers in Endocrinology 10.
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Ipseeta Ray Mohanty, Manjusha Borde, Selvaa Kumar C & Ujwala Maheshwari. (2019) Dipeptidyl peptidase IV Inhibitory activity of Terminalia arjuna attributes to its cardioprotective effects in experimental diabetes: In silico, in vitro and in vivo analyses. Phytomedicine 57, pages 158-165.
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Amankeldi A. Salybekov, Haruchika Masuda, Kozo Miyazaki, Yin Sheng, Atsuko Sato, Tomoko Shizuno, Yumi Iida, Yoshinori Okada & Takayuki Asahara. (2019) Dipeptidyl dipeptidase-4 inhibitor recovered ischemia through an increase in vasculogenic endothelial progenitor cells and regeneration-associated cells in diet-induced obese mice. PLOS ONE 14:3, pages e0205477.
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Samah S. Abbas, Hesham M. Mahmoud, Mona F. Schaalan & Hanan S. El-Abhar. (2018) Involvement of brain natriuretic peptide signaling pathway in the cardioprotective action of sitagliptin. Pharmacological Reports 70:4, pages 720-729.
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Francisco Carlos Carramiñana Barrera. (2018) Seguridad de los inhibidores de la dipeptidil peptidasa 4. Medicina de Familia. SEMERGEN 44, pages 10-17.
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André J. Scheen. (2018) Cardiovascular Effects of New Oral Glucose-Lowering Agents. Circulation Research 122:10, pages 1439-1459.
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Rajesh Kumar Suman. (2018) Natural dipeptidyl peptidase-4 inhibitor Terminalia arjuna mitigates myocardial infarction co-existing with diabetes in experimental rats. Journal of Diabetes, Metabolic Disorders & Control 5:2, pages 48-56.
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Michael R. Cobretti, Benjamin Bowman, Ted Grabarczyk & Emily Potter. (2018) Dipeptidyl Peptidase‐4 Inhibitors and Heart Failure Exacerbation in the Veteran Population: An Observational Study. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 38:3, pages 334-340.
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Phiwayinkosi V. Dludla, Elizabeth Joubert, Christo J.F. Muller, Johan Louw & Rabia Johnson. (2017) Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside. Nutrition & Metabolism 14:1.
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Raffaella Dell’Oro, Alessandro Maloberti, Francesco Nicoli, Paolo Villa, Pierluigi Gamba, Michele Bombelli, Giuseppe Mancia & Guido Grassi. (2017) Long-term Saxagliptin Treatment Improves Endothelial Function but not Pulse Wave Velocity and Intima-Media Thickness in Type 2 Diabetic Patients. High Blood Pressure & Cardiovascular Prevention 24:4, pages 393-400.
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