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Clinical Focus: Diabetes and Concomitant Disorders

Effects of Dapagliflozin on Cardiovascular Risk Factors

, MD, , MD, , MD, PhD, , MD & , MD, PhD
Pages 181-189 | Published online: 13 Mar 2015

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Read on this site (11)

Maka Siamashvili & Stephen N. Davis. (2021) Sodium–glucose cotransporter 2 inhibitors for the management of type 2 diabetes. Expert Opinion on Pharmacotherapy 22:16, pages 2181-2198.
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Angelo Maria Patti, Rosaria Vincenza Giglio, Nikolaos Papanas, Manfredi Rizzo & Ali A. Rizvi. (2019) Future perspectives of the pharmacological management of diabetic dyslipidemia. Expert Review of Clinical Pharmacology 12:2, pages 129-143.
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A. Avogaro, A. Giaccari, P. Fioretto, S. Genovese, F. Purrello, F. Giorgino & S. Del Prato. (2017) A consensus statement for the clinical use of the renal sodium-glucose co-transporter-2 inhibitor dapagliflozin in patients with type 2 diabetes mellitus. Expert Review of Clinical Pharmacology 10:7, pages 763-772.
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Catherine M Kuecker & Eva M Vivian. (2016) Patient considerations in type 2 diabetes – role of combination dapagliflozin–metformin XR. Diabetes, Metabolic Syndrome and Obesity 9, pages 25-35.
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Curt J. Carlson & Marile L. Santamarina. (2016) Update review of the safety of sodium-glucose cotransporter 2 inhibitors for the treatment of patients with type 2 diabetes mellitus. Expert Opinion on Drug Safety 15:10, pages 1401-1412.
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Helmut O. Steinberg. (2016) Sodium-glucose cotransporter 2 inhibitors and cardiovascular outcomes. Postgraduate Medicine 128:4, pages 398-408.
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André J. Scheen. (2015) SGLT2 inhibition: efficacy and safety in type 2 diabetes treatment. Expert Opinion on Drug Safety 14:12, pages 1879-1904.
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Michael A Nauck. (2014) Update on developments with SGLT2 inhibitors in the management of type 2 diabetes. Drug Design, Development and Therapy 8, pages 1380-1380.
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Rosemarie Lajara. (2014) The potential role of sodium glucose co-transporter 2 inhibitors in combination therapy for type 2 diabetes mellitus. Expert Opinion on Pharmacotherapy 15:17, pages 2565-2585.
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Tatsuhiko Urakami, Kei Yoshida & Junichi Suzuki. (2023) Efficacy of Low-dose Dapagliflozin in Young People with Type 1 Diabetes. Internal Medicine 62:2, pages 177-186.
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越 孔. (2023) Effects of Daggligin on Metabolism in Elderly Patients with Type 2 Diabetes and Heart Failure. Advances in Clinical Medicine 13:04, pages 5520-5526.
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鸿 王. (2023) Research Progress of Dapagliflozin in Treatment of Acute Myocardial Infarction Complicated with Type 2 Diabetes Mellitus. Advances in Clinical Medicine 13:02, pages 1667-1672.
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Ahasanul Hasan, Farzana Zerin, Sreelakshmi N. Menon, Md. Ashraful Alam & Raquibul Hasan. (2022) Mechanism of canagliflozin-induced vasodilation in resistance mesenteric arteries and the regulation of systemic blood pressure. Journal of Pharmacological Sciences 150:4, pages 211-222.
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Ahasanul Hasan, Sreelakshmi N. Menon, Farzana Zerin & Raquibul Hasan. (2022) Dapagliflozin induces vasodilation in resistance-size mesenteric arteries by stimulating smooth muscle cell KV7 ion channels. Heliyon 8:5, pages e09503.
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Petra Grubić Rotkvić, Zrinka Planinić, Ana-Marija Liberati Pršo, Jozica Šikić, Edvard Galić & Luka Rotkvić. (2021) The Mystery of Diabetic Cardiomyopathy: From Early Concepts and Underlying Mechanisms to Novel Therapeutic Possibilities. International Journal of Molecular Sciences 22:11, pages 5973.
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Eva Kralova, Margareta Marusakova, Katarina Hadova, Peter Krenek & Jan Klimas. (2021) Dapagliflozin elevates plasma high-density lipoprotein levels and influences visceral fat gene expression in streptozotocin-induced diabetes mellitus. Journal of Pharmacy and Pharmacology 73:6, pages 778-784.
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Zsolt Szekeres, Kalman Toth & Eszter Szabados. (2021) The Effects of SGLT2 Inhibitors on Lipid Metabolism. Metabolites 11:2, pages 87.
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Aml Mohamed Nada & Mariam Adel Younan. (2021) Dapagliflozin improves cardiovascular risk factors in Emirati patients with T2DM. Therapeutic Advances in Endocrinology and Metabolism 12, pages 204201882199536.
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Connie B Newman, Michael J Blaha, Jeffrey B Boord, Bertrand Cariou, Alan Chait, Henry G Fein, Henry N Ginsberg, Ira J Goldberg, M Hassan Murad, Savitha Subramanian & Lisa R Tannock. (2020) Lipid Management in Patients with Endocrine Disorders: An Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology & Metabolism 105:12, pages 3613-3682.
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Angelo Maria Patti, Ali A Rizvi, Rosaria Vincenza Giglio, Anca Pantea Stoian, Daniela Ligi & Ferdinando Mannello. (2020) Impact of Glucose-Lowering Medications on Cardiovascular and Metabolic Risk in Type 2 Diabetes. Journal of Clinical Medicine 9:4, pages 912.
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Ahmad Yehya & Archana Sadhu. (2020) Sodium–Glucose Cotransporter 2 Inhibitor–Associated Prolonged Euglycemic Diabetic Ketoacidosis in Type 2 Diabetes: A Case Report and Literature Review. Clinical Diabetes 38:1, pages 112-116.
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Mauro Rigato, Gian Paolo Fadini & Angelo Avogaro. 2020. Diabetes Complications, Comorbidities and Related Disorders. Diabetes Complications, Comorbidities and Related Disorders 131 159 .
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Takaaki Sakai & Shinichiro Miura. (2019) Effects of Sodium-Glucose Cotransporter 2 Inhibitor on Vascular Endothelial and Diastolic Function in Heart Failure With Preserved Ejection Fraction ― Novel Prospective Cohort Study ―. Circulation Reports 1:7, pages 286-295.
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Satoru Kuriyama. (2018) Protection of the kidney with sodium–glucose cotransporter 2 inhibitors: potential mechanisms raised by the large-scaled randomized control trials. Clinical and Experimental Nephrology 23:3, pages 304-312.
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Sang Hyun ParkYoung Ju ChoiEun-Jung Rhee & Kab Bum Huh. (2019) Retrospective Analysis of the Efficacy of Dapagliflozin in Patients with Type 2 Diabetes in a Primary Clinic in Korea. Endocrinology and Metabolism 34:1, pages 70.
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Sang Mok Yeo, Hayeon Park, Jin Hyuk Paek, Woo Yeong Park, Seungyeup Han, Sung Bae Park & Kyubok Jin. (2019) Ketoacidosis with euglycemia in a patient with type 2 diabetes mellitus taking dapagliflozin. Medicine 98:3, pages e14150.
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A.K. Pancholia. (2018) Sodium-glucose cotransporter-2 inhibition for the reduction of cardiovascular events in high-risk patients with diabetes mellitus. Indian Heart Journal 70:6, pages 915-921.
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Xiaoling Cai, Xueying Gao, Wenjia Yang, Yifei Chen, Simin Zhang, Lingli Zhou, Xueyao Han & Linong Ji. (2018) No disparity of the efficacy and all-cause mortality between Asian and non-Asian type 2 diabetes patients with sodium-glucose cotransporter 2 inhibitors treatment: A meta-analysis. Journal of Diabetes Investigation 9:4, pages 850-861.
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