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Postgraduate Medicine Volume 126, 2014 - Issue 3
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Clinical Features

Proton-Pump Inhibitors in Patients Requiring Antiplatelet Therapy: New FDA Labeling

David A. Johnson Chief of Gastroenterology, Professor of Medicine, Division of Gastroenterology, Eastern Virginia Medical School, Norfolk, VACorrespondence[email protected]
, MD, MACG, FASGE, FACP,
Robert Chilton Associate Professor, Department of Medicine, Division of Cardiology, University of Texas Health Science Center, San Antonio, TX
, DO, FACC &
Harley R. Liker Assistant Clinical Professor, David Geffen School of Medicine, University of California, Los Angeles, CA
, MD
Pages 239-245 | Published online: 13 Mar 2015

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Abdallah Damin Abukhalil, Tala Al Sheikh, Sandra Muallem, Ni’meh Al-Shami & Hani A Naseef. (2023) Prevalence and Safety of Prescribing PPIs with Clopidogrel in Palestine. Patient Preference and Adherence 17, pages 749-759.
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Zhi-Yu Wang, Meng Chen, Ling-Ling Zhu, Lu-Shan Yu, Su Zeng, Mei-Xiang Xiang & Quan Zhou. (2015) Pharmacokinetic drug interactions with clopidogrel: updated review and risk management in combination therapy. Therapeutics and Clinical Risk Management 11, pages 449-467.
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Articles from other publishers (15)

Fitriya Yusof, Siriprapha Sanguanhong, Suchada Soorapan & Juraporn Pongwecharak. (2023) Trends in prescribing volumes and costs of proton pump inhibitors in three outpatient specialties: a three-year retrospective study in a tertiary hospital in Thailand. International Journal of Pharmacy Practice 31:1, pages 80-85.
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Mohitosh Biswas, Shawonur Rahaman, Tapash Kumar Biswas & Baharudin Ibrahim. (2021) Risk of major adverse cardiovascular events for concomitant use of clopidogrel and proton pump inhibitors in patients inheriting CYP2C19 loss-of-function alleles: meta-analysis. International Journal of Clinical Pharmacy 43:5, pages 1360-1369.
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Chen Chen, Hui Liu, Ruqiao Duan, Fangfang Wang & Liping Duan. (2021) The efficacy and safety of acid suppressants for gastrointestinal bleeding prophylaxis in cardiac care unit patients. Journal of Gastroenterology and Hepatology 36:8, pages 2131-2140.
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Virginia Ruiz Pizarro, David Vivas, Esther Bernardo, Aránzazu Ortega, Cristina Sánchez Enrique, Daniel Enríquez, Julián Palacios Rubio, Isidre Vilacosta, Antonio Fernández Ortiz & Carlos Macaya. (2021) Platelet reactivity in patients with coronary artery disease on treatment with ivabradine and clopidogrel: The PLATIVA study. Drugs & Therapy Perspectives 37:5, pages 222-227.
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Alex M. Lynch, Laura K. Ruterbories, Emily Griffith, Rita M. Hanel, Alyssa P. Stablein & Marjory B. Brooks. (2020) The influence of feeding and gastroprotectant medications on the Factor Xa inhibitory activity of orally administered rivaroxaban in normal dogs. Journal of Veterinary Emergency and Critical Care 31:1, pages 59-65.
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D. I. Trukhan, E. N. Degovtsov & A. L. Mazurov. (2019) Choice of protonic pump inhibitor with regard to multimorbidity: a focus on rabeprazol. Medical Council:3, pages 34-42.
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Khalid Ahmed Jassim Al Khaja, Sindhan Veeramuthu, Husain Ahmed Isa & Reginald Paul Sequeira. (2017) Prescription audit of NSAIDs and gastroprotective strategy in elderly in primary care. International Journal of Risk & Safety in Medicine 29:1-2, pages 57-68.
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Leonardo Henry Eusebi, Stefano Rabitti, Maria Laura Artesiani, Dania Gelli, Marco Montagnani, Rocco Maurizio Zagari & Franco Bazzoli. (2017) Proton pump inhibitors: Risks of long-term use. Journal of Gastroenterology and Hepatology 32:7, pages 1295-1302.
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Qiang Niu, Zhongsu Wang, Yong Zhang, Jiangrong Wang, Pei Zhang, Cong Wang, Xiangcui Yin & Yinglong Hou. (2016) Combination Use of Clopidogrel and Proton Pump Inhibitors Increases Major Adverse Cardiovascular Events in Patients With Coronary Artery Disease. Journal of Cardiovascular Pharmacology and Therapeutics 22:2, pages 142-152.
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Cesare Tosetti & Ilaria Nanni. (2017) Use of proton pump inhibitors in general practice. World Journal of Gastrointestinal Pharmacology and Therapeutics 8:3, pages 180.
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Estelle Ayme-Dietrich, Gaëlle Aubertin-Kirch, Emmanuel Andrès & Laurent Monassier. (2016) Quand l’ésoméprazole induit une résistance à la fluindione : une interaction méconnue. Therapies 71:3, pages 337-341.
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Alina Mărginean, Claudia Bănescu, Alina Scridon & Minodora Dobreanu. (2016) Anti-platelet Therapy Resistance – Concept, Mechanisms and Platelet Function Tests in Intensive Care Facilities. The Journal of Critical Care Medicine 2:1, pages 6-15.
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Francesco Pelliccia, Fabiana Rollini, Giuseppe Marazzi, Cesare Greco, Carlo Gaudio & Dominick J. Angiolillo. (2015) Drug–drug interactions between clopidogrel and novel cardiovascular drugs. European Journal of Pharmacology 765, pages 332-336.
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Jeffrey Wallace & Douglas S. Paauw. (2015) Appropriate Prescribing and Important Drug Interactions in Older Adults. Medical Clinics of North America 99:2, pages 295-310.
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Karin Sandoval & Ken Witt. 2015. A worldwide yearly survey of new data in adverse drug reactions. A worldwide yearly survey of new data in adverse drug reactions 433 459 .

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