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Original Articles

Insights from the first putative biosynthetic gene cluster for a lichen depside and depsidone

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Pages 741-754 | Received 22 Dec 2010, Accepted 28 Dec 2010, Published online: 20 Jan 2017

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Xiaolong Yuan, Yunqing Li, Ting Luo, Wei Bi, Jiaojun Yu & Yi Wang. (2023) Genomic Analysis of the Xanthoria elegans and Polyketide Synthase Gene Mining Based on the Whole Genome. Mycobiology 51:1, pages 36-48.
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Sabrin R. M. Ibrahim, Ahmed E. Altyar, Shaimaa G. A. Mohamed & Gamal A. Mohamed. (2022) Genus Thielavia: phytochemicals, industrial importance and biological relevance. Natural Product Research 36:19, pages 5108-5123.
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Mostafa E. Elshobary, Mohamed E. Osman, Atef M. Abo-Shady, Emy Komatsu, Hélène Perreault, John Sorensen & Michele D. Piercey-Normore. (2016) Algal carbohydrates affect polyketide synthesis of the lichen-forming fungus Cladonia rangiferina. Mycologia 108:4, pages 646-656.
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Amitav Bhattacharya. 2019. Effect of High Temperature on Crop Productivity and Metabolism of Macro Molecules. Effect of High Temperature on Crop Productivity and Metabolism of Macro Molecules 391 484 .
Mostafa E. Elshobary, Michael G. Becker, Jenna L. Kalichuk, Ainsley C. Chan, Mark F. Belmonte & Michele D. Piercey-Normore. (2018) Tissue-specific localization of polyketide synthase and other associated genes in the lichen, Cladonia rangiferina, using laser microdissection. Phytochemistry 156, pages 142-150.
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Robert L Bertrand & John L Sorensen. (2018) A comprehensive catalogue of polyketide synthase gene clusters in lichenizing fungi. Journal of Industrial Microbiology and Biotechnology 45:12, pages 1067-1081.
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Sabrin R.M. Ibrahim, Gamal A. Mohamed, Rwaida A. Al Haidari, Amal A. El-Kholy, Mohamed F. Zayed & Maan T. Khayat. (2018) Biologically active fungal depsidones: Chemistry, biosynthesis, structural characterization, and bioactivities. Fitoterapia 129, pages 317-365.
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Mona E. Abdel-Hameed, Robert L. Bertrand, Lynda J. Donald & John L. Sorensen. (2018) Lichen ketosynthase domains are not responsible for inoperative polyketide synthases in Ascomycota hosts. Biochemical and Biophysical Research Communications 503:3, pages 1228-1234.
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Yi Wang, Changan Geng, Xiaolong Yuan, Mei Hua, Fenghua Tian & Changtian Li. (2018) Identification of a putative polyketide synthase gene involved in usnic acid biosynthesis in the lichen Nephromopsis pallescens. PLOS ONE 13:7, pages e0199110.
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Robert L. Bertrand, Mona Abdel-Hameed & John L. Sorensen. (2018) Lichen Biosynthetic Gene Clusters. Part I. Genome Sequencing Reveals a Rich Biosynthetic Potential. Journal of Natural Products 81:4, pages 723-731.
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Ken-ichi Nakashima, Junko Tomida, Tetsuro Kamiya, Takao Hirai, Yuji Morita, Hirokazu Hara, Yoshiaki Kawamura, Tetsuo Adachi & Makoto Inoue. (2018) Diaporthols A and B: Bioactive diphenyl ether derivatives from an endophytic fungus Diaporthe sp.. Tetrahedron Letters 59:13, pages 1212-1215.
Crossref
Mahmud T. Morshed, Daniel Vuong, Andrew Crombie, Alastair E. Lacey, Peter Karuso, Ernest Lacey & Andrew M. Piggott. (2018) Expanding antibiotic chemical space around the nidulin pharmacophore. Organic & Biomolecular Chemistry 16:16, pages 3038-3051.
Crossref
Mark J. Calcott, David F. Ackerley, Allison Knight, Robert A. Keyzers & Jeremy G. Owen. (2018) Secondary metabolism in the lichen symbiosis. Chemical Society Reviews 47:5, pages 1730-1760.
Crossref
Martin Grube & Mats Wedin. 2017. The Fungal Kingdom. The Fungal Kingdom 749 765 .
Martin Grube & Mats Wedin. (2016) Lichenized Fungi and the Evolution of Symbiotic Organization. Microbiology Spectrum 4:6.
Crossref
Mona Abdel-Hameed, Robert L. Bertrand, Michele D. Piercey-Normore & John L. Sorensen. (2016) Identification of 6-Hydroxymellein Synthase and Accessory Genes in the Lichen Cladonia uncialis . Journal of Natural Products 79:6, pages 1645-1650.
Crossref
Bastian Greshake, Simonida Zehr, Francesco Dal Grande, Anjuli Meiser, Imke Schmitt & Ingo Ebersberger. (2016) Potential and pitfalls of eukaryotic metagenome skimming: a test case for lichens. Molecular Ecology Resources 16:2, pages 511-523.
Crossref
Mona Abdel-Hameed, Robert L. Bertrand, Michele D. Piercey-Normore & John L. Sorensen. (2016) Putative identification of the usnic acid biosynthetic gene cluster by de novo whole-genome sequencing of a lichen-forming fungus. Fungal Biology 120:3, pages 306-316.
Crossref
Senhua Chen, Zhaoming Liu, Yayue Liu, Yongjun Lu, Lei He & Zhigang She. (2015) New depsidones and isoindolinones from the mangrove endophytic fungus Meyerozyma guilliermondii (HZ-Y 2 ) isolated from the South China Sea . Beilstein Journal of Organic Chemistry 11, pages 1187-1193.
Crossref
Markus Gressler, Peter Hortschansky, Elena Geib & Matthias Brock. (2015) A new high-performance heterologous fungal expression system based on regulatory elements from the Aspergillus terreus terrein gene cluster. Frontiers in Microbiology 6.
Crossref
Lena Hammerschmidt, Antonius Ola, Werner E.G. Müller, WenHan Lin, Attila Mándi, Tibor Kurtán, Peter Proksch & Amal H. Aly. (2015) Two new metabolites from the endophytic fungus Xylaria sp. isolated from the medicinal plant Curcuma xanthorrhiza. Tetrahedron Letters 56:10, pages 1193-1197.
Crossref
Lívia S. de Medeiros, Lucas M. Abreu, Anita Nielsen, Hanne Ingmer, Thomas O. Larsen, Kristian F. Nielsen & Edson Rodrigues-Filho. (2015) Dereplication-guided isolation of depsides thielavins S–T and lecanorins D–F from the endophytic fungus Setophoma sp.. Phytochemistry 111, pages 154-162.
Crossref
Christina Hametner & Elfie Stocker-Wörgötter. 2015. Recent Advances in Lichenology. Recent Advances in Lichenology 95 110 .
Cécile Gueidan, David J. Hill, Jolanta Miadlikowska & Francois Lutzoni. 2015. Systematics and Evolution. Systematics and Evolution 89 120 .
Brinda A. Timsina, Georg Hausner & Michele D. Piercey-Normore. (2014) Evolution of ketosynthase domains of polyketide synthase genes in the Cladonia chlorophaea species complex (Cladoniaceae). Fungal Biology 118:11, pages 896-909.
Crossref
Simon Hartung Jørgensen, Rasmus John Norman Frandsen, Kristian Fog Nielsen, Erik Lysøe, Teis Esben Sondergaard, Reinhard Wimmer, Henriette Giese & Jens Laurids Sørensen. (2014) Fusarium graminearum PKS14 is involved in orsellinic acid and orcinol synthesis. Fungal Genetics and Biology 70, pages 24-31.
Crossref
Siwen Niu, Dong Liu, Xinxin Hu, Peter Proksch, Zhongzhe Shao & Wenhan Lin. (2014) Spiromastixones A–O, Antibacterial Chlorodepsidones from a Deep-Sea-Derived Spiromastix sp. Fungus . Journal of Natural Products 77:4, pages 1021-1030.
Crossref
Yan-Yan Wang, Bin Liu, Xin-Yu Zhang, Qi-Ming Zhou, Tao Zhang, Hui Li, Yu-Fei Yu, Xiao-Ling Zhang, Xi-Yan Hao, Meng Wang, Lei Wang & Jiang-Chun Wei. (2014) Genome characteristics reveal the impact of lichenization on lichen-forming fungus Endocarpon pusillum Hedwig (Verrucariales, Ascomycota). BMC Genomics 15:1, pages 34.
Crossref
Sammer Yousuf, M. Iqbal Choudhary & Atta-ur-Rahman. 2014. 223 259 .
Martin Grube, Gabriele Berg, Ólafur S. Andrésson, Oddur Vilhelmsson, Paul S. Dyer & Vivian P.W. Miao. 2013. The Ecological Genomics of Fungi. The Ecological Genomics of Fungi 191 212 .
Brinda A. Timsina, John L. Sorensen, Dirk Weihrauch & Michele D. Piercey-Normore. (2013) Effect of aposymbiotic conditions on colony growth and secondary metabolite production in the lichen-forming fungus Ramalina dilacerata. Fungal Biology 117:11-12, pages 731-743.
Crossref
Festus Basden C. Okoye, Su Lu, Chukwuemeka S. Nworu, Charles O. Esimone, Peter Proksch, Ahmed Chadli & Abdessamad Debbab. (2013) Depsidone and diaryl ether derivatives from the fungus Corynespora cassiicola, an endophyte of Gongronema latifolium. Tetrahedron Letters 54:32, pages 4210-4214.
Crossref
Nan Hee Yu, Jung A Kim, Min Hye Jeong, Yong Hwa Cheong, Jae Sung Jung & Jae-Seoun Hur. (2012) Characterization of two novel non-reducing polyketide synthase genes from the lichen-forming fungus Hypogymnia physodes. Mycological Progress 12:3, pages 519-524.
Crossref
Tami R. McDonald, Ester Gaya & François Lutzoni. (2013) Twenty-five cultures of lichenizing fungi available for experimental studies on symbiotic systems. Symbiosis 59:3, pages 165-171.
Crossref
Sanya Sureram, Chatchai Kesornpun, Chulabhorn Mahidol, Somsak Ruchirawat & Prasat Kittakoop. (2013) Directed biosynthesis through biohalogenation of secondary metabolites of the marine-derived fungus Aspergillus unguis. RSC Adv. 3:6, pages 1781-1788.
Crossref
Elfie Stocker-Wörgötter, Lucimara Mach Cortes Cordeiro & Marcello Iacomini. 2013. 337 380 .
Brinda A. TimsinaE. Stocker-WörgötterMichele D. Piercey-Normore. (2012) Monophyly of some North American species of Ramalina and inferred polyketide synthase gene function . Botany 90:12, pages 1295-1307.
Crossref
Jie Li, Ye Deng, Chunhua Yuan, Li Pan, Heebyung Chai, William J. Keller & A. Douglas Kinghorn. (2012) Antioxidant and Quinone Reductase-Inducing Constituents of Black Chokeberry (Aronia melanocarpa) Fruits. Journal of Agricultural and Food Chemistry 60:46, pages 11551-11559.
Crossref
Brendan P. Hodkinson & Sarah Z. Hodkinson. (2012) Recent literature on lichens—224. The Bryologist 115:1, pages 183-193.
Crossref
R. Honegger. 2012. Fungal Associations. Fungal Associations 287 339 .

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