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Bioanalysis Volume 8, 2016 - Issue 24
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Research Article

LC–MS/MS Strategies for Therapeutic Antibodies and Investigation Into The Quantitative Impact of Antidrug-Antibodies

Matthew Ewles1 Bioanalytical Services, Covance Laboratories Ltd., Otley Road, Harrogate, HG31PY, UKCorrespondence[email protected]
,
Ranbir Mannu1 Bioanalytical Services, Covance Laboratories Ltd., Otley Road, Harrogate, HG31PY, UK
,
Chris Fox1 Bioanalytical Services, Covance Laboratories Ltd., Otley Road, Harrogate, HG31PY, UK
,
Johannes Stanta1 Bioanalytical Services, Covance Laboratories Ltd., Otley Road, Harrogate, HG31PY, UK
,
Graeme Evans1 Bioanalytical Services, Covance Laboratories Ltd., Otley Road, Harrogate, HG31PY, UK
,
Lee Goodwin1 Bioanalytical Services, Covance Laboratories Ltd., Otley Road, Harrogate, HG31PY, UK
,
James Duffy2 Biopharmaceutical CMC Solutions, Covance Laboratories Ltd, Otley Road, Harrogate, HG31PY, UK
,
Len Bell2 Biopharmaceutical CMC Solutions, Covance Laboratories Ltd, Otley Road, Harrogate, HG31PY, UK
,
Sian Estdale2 Biopharmaceutical CMC Solutions, Covance Laboratories Ltd, Otley Road, Harrogate, HG31PY, UK
&
David Firth2 Biopharmaceutical CMC Solutions, Covance Laboratories Ltd, Otley Road, Harrogate, HG31PY, UK
 show all
Pages 2565-2579 | Received 18 Jul 2016, Accepted 11 Oct 2016, Published online: 25 Nov 2016

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Noritaka Hashii, Yoshiko Tousaka, Koji Arai, Yoshimasa Enoki, Suguru Fukuda, Ryoya Goda, Noriko Inoue, Mitsuhiko Kawabata, Kazuyuki Murata, Mio Nakatsuji, Takeshi Okuzono, Takuma Shigeyama, Hidehisa Tachiki, Takeru Yamaguchi, Shinichi Yamane, Mariko Yamaoka, Yoshiro Saito & Akiko Ishii-Watabe. (2021) Bioanalysis of Therapeutic Monoclonal Antibody by Peptide Adsorption-Controlled LC–MS. Bioanalysis 13:4, pages 265-276.
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Karen A M de Jong, Suse J van Breugel, Michel J X Hillebrand, Hilde Rosing, Alwin D R Huitema & Jos H Beijnen. (2020) Bottom-Up Sample Preparation for the LC–MS/MS Quantification of Anti-Cancer Monoclonal Antibodies in Bio Matrices. Bioanalysis 12:19, pages 1405-1425.
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Nico C van de Merbel. (2019) Protein Quantification by LC–MS: A Decade of Progress Through the Pages of Bioanalysis. Bioanalysis 11:7, pages 629-644.
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Luna Liu, Keyang Xu, Jenny Li, Mauricio Maia, Mary Mathieu, Rebecca Elliott, Jihong Yang, Ihsan Nijem & Surinder Kaur. (2018) Optimizing Hybrid LC–MS/MS Binding Conditions is Critical: Impact of Biotransformation on Quantification of Trastuzumab. Bioanalysis 10:22, pages 1819-1831.
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Brian P Booth & Brian Furmanski. (2018) Hybrid Assays: The Next Big Thing?. Bioanalysis 10:13, pages 975-977.
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Kjetil Hansen, Szabolcs Szarka, Emilie Escoffier, Amandine Berthet, Joris Venet, Justine Collet-Brose, Sophie Hepburn, Michael Wright, Robert Wheller, Robert Nelson & Richard G Kay. (2018) Glu-C, an Alternative Digestive Enzyme for the Quantitative Lc–Ms/Ms Analysis of an Igg-Based Antibody Biotherapeutic. Bioanalysis 10:13, pages 997-1007.
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Gregor Jordan, Ichio Onami, Julia Heinrich & Roland F Staack. (2017) Evaluation of The Potential Use of Hybrid LC–MS/MS for Active Drug Quantification Applying The ‘Free Analyte Qc Concept’. Bioanalysis 9:21, pages 1705-1717.
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