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Review

Ex Vivo Tumor Culture Systems for Functional Drug Testing and Therapy Response Prediction

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Article: FSO190 | Received 06 Jan 2017, Accepted 23 Feb 2017, Published online: 27 Mar 2017

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Crossref
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Milad Rismanian, Mohammad Said Saidi & Navid Kashaninejad. (2020) A microfluidic concentration gradient generator for simultaneous delivery of two reagents on a millimeter-sized sample. Journal of Flow Chemistry 10:4, pages 615-625.
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Crossref
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L. F. Horowitz, A. D. Rodriguez, Z. Dereli-Korkut, R. Lin, K. Castro, A. M. Mikheev, R. J. MonnatJr.Jr., A. Folch & R. C. Rostomily. (2020) Multiplexed drug testing of tumor slices using a microfluidic platform. npj Precision Oncology 4:1.
Crossref
Aurimas Stulpinas, Aušra Imbrasaitė, Natalija Krestnikova & Audronė Valerija Kalvelytė. 2020. Tumor Progression and Metastasis. Tumor Progression and Metastasis.
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Crossref
Ana Salas, Judith López, Ricardo Reyes, Carmen Évora, Francisco Montes de Oca, Delia Báez, Araceli Delgado & Teresa A. Almeida. (2020) Organotypic culture as a research and preclinical model to study uterine leiomyomas. Scientific Reports 10:1.
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Crossref
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Crossref
Anna A. Popova & Pavel A. Levkin. (2020) Precision Medicine in Oncology: In Vitro Drug Sensitivity and Resistance Test (DSRT) for Selection of Personalized Anticancer Therapy. Advanced Therapeutics 3:2.
Crossref
Joshua D. Greenlee & Michael R. King. (2020) Engineered fluidic systems to understand lymphatic cancer metastasis. Biomicrofluidics 14:1.
Crossref
Hafsa Munir, Corrado Mazzaglia & Jacqueline D. Shields. (2020) Stromal regulation of tumor-associated lymphatics. Advanced Drug Delivery Reviews 161-162, pages 75-89.
Crossref
Bo Cai, Qiying Lv, Zheng Wang & Lin Wang. 2020. Biomaterials for 3D Tumor Modeling. Biomaterials for 3D Tumor Modeling 533 550 .
Santu Maity, Aroni Chatterjee & Jhuma Ganguly. 2020. Green Approaches in Medicinal Chemistry for Sustainable Drug Design. Green Approaches in Medicinal Chemistry for Sustainable Drug Design 617 649 .
Ramya Sivakumar, Marina Chan, Jiye Stella Shin, Nao Nishida-Aoki, Heidi L. Kenerson, Olivier Elemento, Himisha Beltran, Raymond Yeung & Taranjit S. Gujral. (2019) Organotypic tumor slice cultures provide a versatile platform for immuno-oncology and drug discovery. OncoImmunology 8:12, pages e1670019.
Crossref
Steve Z. Martin, Daniel C. Wagner, Nina Hörner, David Horst, Hauke Lang, Katrin E. Tagscherer & Wilfried Roth. (2019) Ex vivo tissue slice culture system to measure drug-response rates of hepatic metastatic colorectal cancer. BMC Cancer 19:1.
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Crossref
Dünker & Jendrossek. (2019) Implementation of the Chick Chorioallantoic Membrane (CAM) Model in Radiation Biology and Experimental Radiation Oncology Research. Cancers 11:10, pages 1499.
Crossref
Assal Daneshgar, Peter Tang, Christopher Remde, Michael Lommel, Simon Moosburner, Ulrich Kertzscher, Oliver Klein, Marie Weinhart, Johann Pratschke, Igor M. Sauer & Karl H. Hillebrandt. (2019) Teburu—Open source 3D printable bioreactor for tissue slices as dynamic three‐dimensional cell culture models. Artificial Organs 43:10, pages 1035-1041.
Crossref
Laura J. Bray, Dietmar W. Hutmacher & Nathalie Bock. (2019) Addressing Patient Specificity in the Engineering of Tumor Models. Frontiers in Bioengineering and Biotechnology 7.
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Grissel Trujillo-de Santiago, Brenda Giselle Flores-Garza, Jorge Alfonso Tavares-Negrete, Itzel Montserrat Lara-Mayorga, Ivonne González-Gamboa, Yu Shrike Zhang, Augusto Rojas-Martínez, Rocío Ortiz-López & Mario Moisés Álvarez. (2019) The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors. Materials 12:18, pages 2945.
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A. S. Polyakov, Ya. A. Noskov, Yu. V. Nikitin, V. V. Tyrenko, S. N. Kolubaeva, A. N. Bogdanov, V. N. Semelev, O. R. Petrova, S. V. Bondarchuk, D. K. Zhogolev, A. D. Zolotarev, A. V. Kovalev & Yu. E. Puchkova. (2019) Ex vivo-model design and evaluation of the sensitivity of blast cells to chemotherapy as a way to personalize the treatment of acute myeloid leukemia. Oncohematology 14:2, pages 59-69.
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Andreas Blaeser, Sarah C. Heilshorn & Daniela F. Duarte Campos. (2019) Smart Bioinks as de novo Building Blocks to Bioengineer Living Tissues. Gels 5:2, pages 29.
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Jumpei Kondo & Masahiro Inoue. (2019) Application of Cancer Organoid Model for Drug Screening and Personalized Therapy. Cells 8:5, pages 470.
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R. Kennedy, D. Kuvshinov, A. Sdrolia, E. Kuvshinova, K. Hilton, S. Crank, A. W. Beavis, V. Green & J. Greenman. (2019) A patient tumour-on-a-chip system for personalised investigation of radiotherapy based treatment regimens. Scientific Reports 9:1.
Crossref
I-Chi Lee. (2019) Cancer-on-a-chip for Drug Screening. Current Pharmaceutical Design 24:45, pages 5407-5418.
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Sangjo Shim, Maura C. Belanger, Alexandra R. Harris, Jennifer M. Munson & Rebecca R. Pompano. (2019) Two-way communication between ex vivo tissues on a microfluidic chip: application to tumor–lymph node interaction . Lab on a Chip 19:6, pages 1013-1026.
Crossref
Xin Xin, Hopen Yang, Fengli Zhang & Shang-Tian Yang. (2019) 3D cell coculture tumor model: A promising approach for future cancer drug discovery. Process Biochemistry 78, pages 148-160.
Crossref
Wenhao Zhang, Wytske M. van Weerden, Corrina M. A. de Ridder, Sigrun Erkens‐Schulze, Edgar Schönfeld, Titia G. Meijer, Roland Kanaar, Dik C. van Gent & Julie Nonnekens. (2018) Ex vivo treatment of prostate tumor tissue recapitulates in vivo therapy response. The Prostate 79:4, pages 390-402.
Crossref
Victor Coutinho Bastos, Núbia Braga Pereira, Marina Gonçalves Diniz, Luciana Oliveira Andrade, Wagner Henriques Castro, Gregory Thomas Kitten, Ricardo Santiago Gomez & Carolina Cavalieri Gomes. (2019) Bringing benign ectomesenchymal odontogenic tumours to the lab: An in vitro study using an organotypic culture model. Journal of Oral Pathology & Medicine 48:2, pages 174-179.
Crossref
Susmita Ghosh, Manu Prasad, Kiran Kundu, Limor Cohen, Ksenia M. Yegodayev, Jonathan Zorea, Ben-Zion Joshua, Batel Lasry, Orr Dimitstein, Anat Bahat-Dinur, Aviram Mizrachi, Vladimir Lazar, Moshe Elkabets & Angel Porgador. (2019) Tumor Tissue Explant Culture of Patient-Derived Xenograft as Potential Prioritization Tool for Targeted Therapy. Frontiers in Oncology 9.
Crossref
Albert van den Berg, Christine L. Mummery, Robert Passier & Andries D. van der Meer. (2019) Personalised organs-on-chips: functional testing for precision medicine. Lab on a Chip 19:2, pages 198-205.
Crossref
Gerhard Hamilton & Barbara Rath. (2018) Applicability of tumor spheroids for in vitro chemosensitivity assays . Expert Opinion on Drug Metabolism & Toxicology 15:1, pages 15-23.
Crossref
Andreas Kurtz, Magdi Elsallab, Ralf Sanzenbacher & Mohamed Abou-El-Enein. (2019) Linking Scattered Stem Cell-Based Data to Advance Therapeutic Development. Trends in Molecular Medicine 25:1, pages 8-19.
Crossref
Albert Grinshpun, Nancy Gavert, Roy Zvi Granit, Hadas Masuri, Ittai Ben-Porath, Shani Breuer, Aviad Zick, Shai Rosenberg, Myriam Maoz, Avital Granit, Eli Pikarsky, Ravid Strausmman, Tamar Peretz & Amir Sonnenblick. (2018) Ev vivo organ culture as potential prioritization tool for breast cancer targeted therapy. Cancer Biology & Therapy 19:8, pages 645-648.
Crossref
Florian Janker, Walter Weder, Jae-Hwi Jang & Wolfgang Jungraithmayr. (2018) Preclinical, non-genetic models of lung adenocarcinoma: a comparative survey. Oncotarget 9:55, pages 30527-30538.
Crossref
Darren Rodenhizer, Teresa Dean, Elisa D'Arcangelo & Alison P. McGuigan. (2018) The Current Landscape of 3D In Vitro Tumor Models: What Cancer Hallmarks Are Accessible for Drug Discovery?. Advanced Healthcare Materials 7:8.
Crossref
Ronan T. Swords, Diana Azzam, Hassan Al-Ali, Ines Lohse, Claude-Henry Volmar, Justin M. Watts, Aymee Perez, Ana Rodriguez, Fernando Vargas, Roy Elias, Francisco Vega, Arthur Zelent, Shaun P. Brothers, Taher Abbasi, Jonathan Trent, Shaukat Rangwala, Yehuda Deutsch, Eibhlin Conneally, Leylah Drusbosky, Christopher R. Cogle & Claes Wahlestedt. (2018) Ex-vivo sensitivity profiling to guide clinical decision making in acute myeloid leukemia: A pilot study. Leukemia Research 64, pages 34-41.
Crossref
Daniela Senft, Mark D.M. Leiserson, Eytan Ruppin & Ze’ev A. Ronai. (2017) Precision Oncology: The Road Ahead. Trends in Molecular Medicine 23:10, pages 874-898.
Crossref