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Research Paper

mTOR inhibitors blunt the p53 response to nucleolar stress by regulating RPL11 and MDM2 levels

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Pages 1499-1514 | Received 24 Mar 2014, Accepted 01 Jul 2014, Published online: 16 Dec 2014

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Wanyi Liu, Guicheng Kuang, Binbin Yang, Hanlin Liu, Yangping Lv, Yang Xiong & Yongqiu Zeng. (2023) Progress on the role and mechanism of ribosome assembly regulator PNO1 in tumor. All Life 16:1.
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Benjamin Roche, Benoît Arcangioli & Rob Martienssen. (2017) New roles for Dicer in the nucleolus and its relevance to cancer. Cell Cycle 16:18, pages 1643-1653.
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Marie Piecyk, Mouna Triki, Pierre‐Alexandre Laval, Cedric Duret, Joelle Fauvre, Laura Cussonneau, Christelle Machon, Jerôme Guitton, Nicolas Rama, Benjamin Gibert, Gabriel Ichim, Frederic Catez, Fleur Bourdelais, Sebastien Durand, Jean‐Jacques Diaz, Isabelle Coste, Toufic Renno, Serge N. Manié, Nicolas Aznar, Stephane Ansieau, Carole Ferraro‐Peyret & Cedric Chaveroux. (2023) The stress sensor GCN2 differentially controls ribosome biogenesis in colon cancer according to the nutritional context . Molecular Oncology.
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Christian Bailly & Gérard Vergoten. (2023) Interaction of Camptothecin Anticancer Drugs with Ribosomal Proteins L15 and L11: A Molecular Docking Study. Molecules 28:4, pages 1828.
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Yang Zhou, Gai Li, Hu Li, Fuchong Lai, Pingguo Duan & Ming Cheng. (2022) Epithelial to Mesenchymal Transition Relevant Subtypes with Distinct Prognosis and Responses to Chemo- or Immunotherapies in Osteosarcoma. Journal of Immunology Research 2022, pages 1-19.
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Mikael S. Lindström, Jiri Bartek & Apolinar Maya-Mendoza. (2022) p53 at the crossroad of DNA replication and ribosome biogenesis stress pathways. Cell Death & Differentiation 29:5, pages 972-982.
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Shouqiang Zhang, Hui Ren, Hanting Sun & Songhua Cao. (2021) Dieckol exerts anticancer activity in human osteosarcoma (MG-63) cells through the inhibition of PI3K/AKT/mTOR signaling pathway. Saudi Journal of Biological Sciences 28:9, pages 4908-4915.
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Yuki Uchihara, Kenji Tago, Hiroomi Tamura & Megumi Funakoshi‐Tago. (2020) EBP2, a novel NPM‐ALK‐interacting protein in the nucleolus, contributes to the proliferation of ALCL cells by regulating tumor suppressor p53. Molecular Oncology 15:1, pages 167-194.
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Sipra Mohapatra, Tapas Chakraborty, Sonoko Shimizu, Kayoko Ohta, Yoshitaka Nagahama & Kohei Ohta. (2020) Estrogen and estrogen receptors chauffeur the sex-biased autophagic action in liver. Cell Death & Differentiation 27:11, pages 3117-3130.
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Aling Shen, Youqin Chen, Liya Liu, Yue Huang, Hongwei Chen, Fei Qi, Jiumao Lin, Zhiqing Shen, Xiangyan Wu, Meizhu Wu, Qiongyu Li, Liman Qiu, Na Yu, Thomas J. Sferra & Jun Peng. (2019) EBF1-Mediated Upregulation of Ribosome Assembly Factor PNO1 Contributes to Cancer Progression by Negatively Regulating the p53 Signaling Pathway. Cancer Research 79:9, pages 2257-2270.
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Astrid S. Pfister. (2019) Emerging Role of the Nucleolar Stress Response in Autophagy. Frontiers in Cellular Neuroscience 13.
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Frédéric Lessard, Léa Brakier‐Gingras & Gerardo Ferbeyre. (2019) Ribosomal Proteins Control Tumor Suppressor Pathways in Response to Nucleolar Stress. BioEssays 41:3.
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Kaveh M. Goudarzi, Jaime A. Espinoza, Min Guo, Jiri Bartek, Monica Nistér, Mikael S. Lindström & Daniel Hägerstrand. (2018) Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype. Cancer Research 78:20, pages 5901-5916.
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Marek Orłowski, Katarzyna Popławska, Joanna Pieprzyk, Aleksandra Szczygieł-Sommer, Anna Więch, Mirosław Zarębski, Aneta Tarczewska, Jurek Dobrucki & Andrzej Ożyhar. (2018) Molecular determinants of Drosophila immunophilin FKBP39 nuclear localization . Biological Chemistry 399:5, pages 467-484.
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Jin-Cheng Huang, Zhi-Fei Cui, Shui-Mu Chen, Lian-Jun Yang, Hong-Kai Lian, Bin Liu, Zhi-Hai Su, Jin-Shi Liu, Min Wang, Zheng-Bo Hu, Jia-Yao Ouyang, Qing-Chu Li & Hai Lu. (2017) NVP-BEZ235 synergizes cisplatin sensitivity in osteosarcoma. Oncotarget 9:12, pages 10483-10496.
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Fabiana Conciatori, Ludovica Ciuffreda, Chiara Bazzichetto, Italia Falcone, Sara Pilotto, Emilio Bria, Francesco Cognetti & Michele Milella. (2018) mTOR Cross-Talk in Cancer and Potential for Combination Therapy. Cancers 10:1, pages 23.
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Laura C Armstrong, Grant Westlake, John P Snow, Bryan Cawthon, Eric Armour, Aaron B Bowman & Kevin C Ess. (2017) Heterozygous loss of TSC2 alters p53 signaling and human stem cell reprogramming. Human Molecular Genetics 26:23, pages 4629-4641.
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Diogo G. Barardo, Danielle Newby, Daniel Thornton, Taravat Ghafourian, João Pedro de Magalhães & Alex A. Freitas. (2017) Machine learning for predicting lifespan-extending chemical compounds. Aging 9:7, pages 1721-1737.
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Zhixiong Dong, Changjun Zhu, Qimin Zhan & Wei Jiang. (2017) The roles of RRP15 in nucleolar formation, ribosome biogenesis and checkpoint control in human cells. Oncotarget 8:8, pages 13240-13252.
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Kai Hu, Hai-Bo Dai & Zhi-Long Qiu. (2016) mTOR signaling in osteosarcoma: Oncogenesis and therapeutic aspects (Review). Oncology Reports 36:3, pages 1219-1225.
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Liu Ding, Liu Congwei, Qing Bei, Yang Tao, Wang Ruiguo, Yu Heze, Dou Bo & Li Zhihong. (2016) mTOR: An attractive therapeutic target for osteosarcoma?. Oncotarget 7:31, pages 50805-50813.
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Dariusz Stępiński. (2016) Nucleolus-derived mediators in oncogenic stress response and activation of p53-dependent pathways. Histochemistry and Cell Biology 146:2, pages 119-139.
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Suoyuan Li, Wei Sun, Hongsheng Wang, Dongqing Zuo, Yingqi Hua & Zhengdong Cai. (2015) Research progress on the multidrug resistance mechanisms of osteosarcoma chemotherapy and reversal. Tumor Biology 36:3, pages 1329-1338.
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