Search in:

Cell Cycle Volume 13, 2014 - Issue 16

Submit an article Journal homepage

Open access

3,031

Views

CrossRef citations to date

Altmetric

PERSPECTIVE

Insulin resistance in the liver: Deficiency or excess of insulin?

Roberto B BazotteDepartment of Pharmacology and Therapeutics; State University of Maringá; Maringá, Paraná, PR BrazilCorrespondence[email protected]
View further author information

Lorena G SilvaDepartment of Pharmacology and Therapeutics; State University of Maringá; Maringá, Paraná, PR BrazilView further author information

Fabiana PM SchiavonDepartment of Pharmacology and Therapeutics; State University of Maringá; Maringá, Paraná, PR BrazilView further author information

Pages 2494-2500 | Received 12 May 2014, Accepted 03 Jul 2014, Published online: 30 Oct 2014

Cite this article
https://doi.org/10.4161/15384101.2014.947750
CrossMark

Full Article
Figures & data
References
Citations
Metrics
Licensing
Reprints & Permissions
View PDF PDF

Citations (39)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Articles from other publishers (39)

Marko Groeger, Koji Matsuo, Emad Heidary Arash, Ashley Pereira, Dounia Le Guillou, Cindy Pino, Kayque A. Telles-Silva, Jacquelyn J. Maher, Edward C. Hsiao & Holger Willenbring. (2023) Modeling and therapeutic targeting of inflammation-induced hepatic insulin resistance using human iPSC-derived hepatocytes and macrophages. Nature Communications 14:1.
Crossref

Lanzhou Li, Siyu Zhai, Ruochen Wang, Fange Kong, Anhui Yang, Chunyue Wang, Han Yu, Yu Li & Di Wang. (2023) Anti-Obesity Effect of Auricularia delicate Involves Intestinal-Microbiota-Mediated Oxidative Stress Regulation in High-Fat-Diet-Fed Mice. Nutrients 15:4, pages 872.
Crossref

G. Godoy, C.C.O. Bernardo, L. Casagrande, M.L.M. Sérgio, J.N. Zanoni, J.V.C.M. Perles, R. Curi & R.B. Bazotte. (2023) Linseed oil attenuates fatty liver disease in mice fed a high-carbohydrate diet. Brazilian Journal of Medical and Biological Research 56.
Crossref

Guilherme Godoy, Marina Masetto Antunes, Ingrid de Lima FernandesLuciana Pelissari ManinCaroline ZappieloLaureane Nunes MasiJuliana Vanessa Colombo Martins PerlesJesuí Vergílio VisentainerRui CuriRoberto Barbosa Bazotte. (2022) Linseed Oil Attenuates Liver Inflammation, Fatty Acid Accumulation, and Lipid Distribution in Periportal and Perivenous Hepatocytes Induced by a High-Carbohydrate Diet in Mice. Journal of Medicinal Food 25:12, pages 1133-1145.
Crossref

Arnold N. Onyango. (2022) Excessive gluconeogenesis causes the hepatic insulin resistance paradox and its sequelae. Heliyon 8:12, pages e12294.
Crossref

Sicong Li, Jinshan He, Xinyi Zhang, Yuchun Cai, Jian Liu, Xiaoyan Nie & Luwen Shi. (2022) Cardiovascular adverse events in chronic myeloid leukemia patients treated with nilotinib or imatinib: A systematic review, meta-analysis and integrative bioinformatics analysis. Frontiers in Cardiovascular Medicine 9.
Crossref

Neha Deora & Krishnan Venkatraman. (2022) Aloe vera in diabetic dyslipidemia: Improving blood glucose and lipoprotein levels in pre-clinical and clinical studies. Journal of Ayurveda and Integrative Medicine 13:4, pages 100675.
Crossref

Marina Masetto Antunes, Guilherme GodoyRui CuriJesuí Vergílio VisentainerRoberto Barbosa Bazotte. (2022) The Myristic Acid:Docosahexaenoic Acid Ratio Versus the n-6 Polyunsaturated Fatty Acid:n-3 Polyunsaturated Fatty Acid Ratio as Nonalcoholic Fatty Liver Disease Biomarkers. Metabolic Syndrome and Related Disorders 20:2, pages 69-78.
Crossref

Roberto Carlos Frias-Soler, Natalie A. Kelsey, Lilian Villarín Pildaín, Michael Wink & Franz Bairlein. (2022) Transcriptome signature changes in the liver of a migratory passerine. Genomics 114:2, pages 110283.
Crossref

Teodora Beljić-Živković. (2022) Prediabetes: From diagnosis to prognosis. Galenika Medical Journal 1:1, pages 57-61.
Crossref

Reka Annamaria Schmiedt, Robert Aurelian Tiuca, Raluca Maria Tilinca, Lucia Mihaela Custura, Oana Detesan, Brigitta Iren Bacso, Bianca Larisa Abalasei, Andrew Corneliu Bell, Maria Alexandra Streza & Mariana Cornelia Tilinca. (2021) Insulin resistance as risk factor for the development of type 2 diabetes mellitus: a systematic approach. Acta Marisiensis - Seria Medica 67:4, pages 187-192.
Crossref

Wilson Eik FilhoBruna Juliana Wanczinski FerrariMarina Masetto AntunesPatrícia Batista TravassosHelenir Medri de SouzaEniuce Menezes de SouzaRoberto Barbosa Bazotte. (2021) Glycerol Potentiates the Effects of Glucose in Promoting Glucose Recovery During Hypoglycemia: From Basic to Clinical Investigations and Their Therapeutic Application. Journal of Medicinal Food 24:9, pages 908-915.
Crossref

Marleigh Hefner, Vineet Baliga, Kailinn Amphay, Daniela Ramos & Vijay Hegde. (2021) Cardiometabolic Modification of Amyloid Beta in Alzheimer’s Disease Pathology. Frontiers in Aging Neuroscience 13.
Crossref

Jhovan Eduardo Miranda-Nuñez, Alejandro Zamilpa-Alvarez, Angeles Fortis-Barrera, Francisco Javier Alarcon-Aguilar, Hilda Loza-Rodriguez, Luis E. Gomez-Quiroz, Soraya Salas-Silva, Maria Flores-Cruz, Miguel Angel Zavala-Sanchez & Gerardo Blancas-Flores. (2021) GLUT4 translocation in C2C12 myoblasts and primary mouse hepatocytes by an antihyperglycemic flavone from Tillandsia usneoides. Phytomedicine 89, pages 153622.
Crossref

Iris M. de Hoogh, Johanneke E. Oosterman, Wilma Otten, Anne-Margreeth Krijger, Susanne Berbée-Zadelaar, Wilrike J. Pasman, Ben van Ommen, Hanno Pijl & Suzan Wopereis. (2021) The Effect of a Lifestyle Intervention on Type 2 Diabetes Pathophysiology and Remission: The Stevenshof Pilot Study. Nutrients 13:7, pages 2193.
Crossref

Md Saidur Rahman, Khandkar Shaharina Hossain, Sharnali Das, Sushmita Kundu, Elikanah Olusayo Adegoke, Md. Ataur Rahman, Md. Abdul Hannan, Md Jamal Uddin & Myung-Geol Pang. (2021) Role of Insulin in Health and Disease: An Update. International Journal of Molecular Sciences 22:12, pages 6403.
Crossref

Sreelekshmi Mohan, Genu George & K.G. Raghu. (2021) Vanillic acid retains redox status in HepG2 cells during hyperinsulinemic shock using the mitochondrial pathway. Food Bioscience 41, pages 101016.
Crossref

Wenyi Wang, Ko Willems van Dijk, Carolien A. Wijsman, Maarten P. Rozing, Simon P. Mooijaart, Marian Beekman, P. Eline Slagboom, J. Wouter Jukema, Raymond Noordam & Diana van Heemst. (2021) Differential insulin sensitivity of NMR-based metabolomic measures in a two-step hyperinsulinemic euglycemic clamp study. Metabolomics 17:6.
Crossref

Alyssa S. Zembroski, Kimberly K. Buhman & Uma K. Aryal. (2021) Proteome and phosphoproteome characterization of liver in the postprandial state from diet-induced obese and lean mice. Journal of Proteomics 232, pages 104072.
Crossref

Songhua Zhang, Aryanna Sousa, Mengqui Lin, Ayako Iwano, Rishubh Jain, Bing Ma, Chang Min Lee, Jin Wook Park, Suchitra Kamle, Rolf Carlson, Ghun Geun Lee, Jack A. Elias & Jack R. Wands. (2021) Role of Chitinase 3-Like 1 Protein in the Pathogenesis of Hepatic Insulin Resistance in Nonalcoholic Fatty Liver Disease. Cells 10:2, pages 201.
Crossref

Marie Tremblay-Franco, Nathalie Poupin, Aurélien Amiel, Cécile Canlet, Didier Rémond, Laurent Debrauwer, Dominique Dardevet, Fabien Jourdan, Isabelle Savary-Auzeloux & Sergio Polakof. (2020) Postprandial NMR-Based Metabolic Exchanges Reflect Impaired Phenotypic Flexibility across Splanchnic Organs in the Obese Yucatan Mini-Pig. Nutrients 12:8, pages 2442.
Crossref

Itzel Y. Rojas, Benjamin J. Moyer, Carol S. Ringelberg & Craig R. Tomlinson. (2020) Reversal of obesity and liver steatosis in mice via inhibition of aryl hydrocarbon receptor and altered gene expression of CYP1B1, PPARα, SCD1, and osteopontin. International Journal of Obesity 44:4, pages 948-963.
Crossref

Qi Ge, Fan Feng, Lanlan Liu, Liang Chen, Peng Lv, Shangshang Ma, Keping Chen & Qin Yao. (2020) RNA-Seq analysis of the pathogenesis of STZ-induced male diabetic mouse liver. Journal of Diabetes and its Complications 34:2, pages 107444.
Crossref

Yan Lu, Lei Zhang, Ran Zhu, Huijuan Zhou, Huaying Fan & Qiang Wang. (2020) RETRACTED: PFKFB3, a key glucose metabolic enzyme regulated by pathogen recognition receptor TLR4 in liver cells. Therapeutic Advances in Endocrinology and Metabolism 11, pages 204201882092347.
Crossref

Bhoomika M. Patel & Ramesh K. Goyal. (2019) Liver and insulin resistance: New wine in old bottle!!!. European Journal of Pharmacology 862, pages 172657.
Crossref

Jing Qiao, Lei Li, Yanchun Ma, Ruhui Shi & Mei Teng. (2019) Biological function of dipeptidyl peptidase-4 on type 2 diabetes patients and diabetic mice. Current Research in Translational Medicine 67:3, pages 89-92.
Crossref

Feier Cheng, Lin Han, Yao Xiao, Chuanying Pan, Yunlong Li, Xinhui Ge, Yao Zhang, Shaoqing Yan & Min Wang. (2019) d - chiro -Inositol Ameliorates High Fat Diet-Induced Hepatic Steatosis and Insulin Resistance via PKCε-PI3K/AKT Pathway . Journal of Agricultural and Food Chemistry 67:21, pages 5957-5967.
Crossref

Guadalupe García, Erika J. Gutiérrez-Lara, David Centurión, Vinicio Granados-Soto & Janet Murbartián. (2019) Fructose-Induced Insulin Resistance as a Model of Neuropathic Pain in Rats. Neuroscience 404, pages 233-245.
Crossref

Xiaomin Song, Bolun Li, Haoran Wang, Xuan Zou, Ran Gao, Wei Zhang, Ting Shu, Hongmei Zhao, Bin Liu & Jing Wang. (2019) Asthma alleviates obesity in males through regulating metabolism and energy expenditure. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1865:2, pages 350-359.
Crossref

Katia Mariniello, Yoeju Min & Kebreab Ghebremeskel. (2019) Phosphorylation of protein kinase B, the key enzyme in insulin-signaling cascade, is enhanced in linoleic and arachidonic acid–treated HT29 and HepG2 cells. Nutrition 57, pages 52-58.
Crossref

Gemma Sangüesa, Núria Roglans, Juan Carlos Laguna & Marta Alegret. 2019. Molecular Nutrition: Carbohydrates. Molecular Nutrition: Carbohydrates 149 172 .

Lorena Gimenez da Silva-Santi, Marina Masetto Antunes, Marco Mori, Camila Biesdorf de Almeida-Souza, Jesuí Vergílio Visentainer, Fabiana Carbonera, Amanda Rabello Crisma, Laureane Nunes Masi, Sandro Massao Hirabara, Rui Curi & Roberto Barbosa Bazotte. (2018) Brain Fatty Acid Composition and Inflammation in Mice Fed with High-Carbohydrate Diet or High-Fat Diet. Nutrients 10:9, pages 1277.
Crossref

Cheng Chen, Xiuqing Han, Ping Dong, Zhaojie Li, Teruyoshi Yanagita, Changhu Xue, Tiantian Zhang & Yuming Wang. (2018) Sea cucumber saponin liposomes ameliorate obesity-induced inflammation and insulin resistance in high-fat-diet-fed mice. Food & Function 9:2, pages 861-870.
Crossref

Erika J. Gutiérrez-Lara, Gabriel Navarrete-Vázquez, Araceli Sánchez-López & David Centurión. (2017) Pharmacological evaluation of metformin and N-benzylbiguanide, a novel analogue of metformin, on the vasopressor responses to adrenergic system stimulation in pithed rats with fructose-induced insulin resistance. European Journal of Pharmacology 814, pages 313-323.
Crossref

Hely de Morais, Flaviane de Fatima Silva, Francemilson Goulart da Silva, Milene Ortiz Silva, Maria Fernanda Rodrigues Graciano, Maria Isabel Lovo Martins, Ângelo Rafael Carpinelli, Tânia Longo Mazucco, Roberto Barbosa Bazotte & Helenir Medri de Souza. (2017) Insulin, not glutamine dipeptide, reduces lipases expression and prevents fat wasting and weight loss in Walker 256 tumor-bearing rats. European Journal of Pharmacology 806, pages 67-74.
Crossref

Heber Amilcar Martins, Roberto Barbosa Bazotte, Geraldo Emilio Vicentini, Mariana Machado Lima, Flavia Alessandra Guarnier, Catchia Hermes-Uliana, Flavia Cristina Vieira Frez, Gleison Daion Piovezana Bossolani, Luciane Fracaro, Larissa dos Santos Fávaro, Mariana Inocêncio Manzano & Jacqueline Nelisis Zanoni. (2017) l -Glutamine supplementation promotes an improved energetic balance in Walker-256 tumor–bearing rats . Tumor Biology 39:3, pages 101042831769596.
Crossref

Lorena da Silva-Santi, Marina Antunes, Silvana Caparroz-Assef, Fabiana Carbonera, Laureane Masi, Rui Curi, Jesuí Visentainer & Roberto Bazotte. (2016) Liver Fatty Acid Composition and Inflammation in Mice Fed with High-Carbohydrate Diet or High-Fat Diet. Nutrients 8:11, pages 682.
Crossref

Damien Bouvier, Marion Rouzaire, Geoffroy Marceau, Cécile Prat, Bruno Pereira, Romain Lemarié, Philippe Deruelle, Isabelle Fajardy, Denis Gallot, Loïc Blanchon, Anne Vambergue & Vincent Sapin. (2015) Aquaporins and Fetal Membranes From Diabetic Parturient Women: Expression Abnormalities and Regulation by Insulin. The Journal of Clinical Endocrinology & Metabolism 100:10, pages E1270-E1279.
Crossref

Arnold Onyango. (2022) Excessive Gluconeogenesis Causes the Hepatic Insulin Resistance Paradox and Its Sequelae. SSRN Electronic Journal.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.

People also read
Recommended articles
Cited by

To cite this article:

Reference style: APA Chicago Harvard

Citation copied to clipboard

Reference styles above use APA (6th edition), Chicago (16th edition) & Harvard (10th edition)

Download citation

Download a citation file in RIS format that can be imported by citation management software including EndNote, ProCite, RefWorks and Reference Manager.

Choose format: RIS BibTex RefWorks Direct Export

Choose options: Citation Citation & abstract Citation & references

Insulin resistance in the liver: Deficiency or excess of insulin?

Articles from other publishers (39)

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Insulin resistance in the liver: Deficiency or excess of insulin?

Citations (39)

Articles from other publishers (39)

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date