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Cell Cycle Volume 13, 2014 - Issue 17
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Novel GHRH antagonists suppress the growth of human malignant melanoma by restoring nuclear p27 function

Luca SzalontayVeterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education; Miami, FLUSAView further author information
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Andrew V SchallyVeterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education; Miami, FLUSA;Department of Pathology; University of Miami; Miller School of Medicine; Miami, FLUSA;Divisions of Hematology/Oncology; University of Miami; Miller School of Medicine; Miami, FLUSA;Department of Endocrinology; University of Miami; Miller School of Medicine; Miami, FLUSA;Sylvester Comprehensive Cancer Center; University of Miami; Miller School of Medicine; Miami, FLUSAView further author information
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Petra PopovicsVeterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education; Miami, FLUSA;Cardiovascular Diseases; Department of Medicine; University of Miami; Miller School of Medicine; Miami, FLUSAView further author information
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Irving VidaurreVeterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education; Miami, FLUSAView further author information
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Awtar KrishanDepartment of Pathology; University of Miami; Miller School of Medicine; Miami, FLUSAView further author information
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Marta ZarandiVeterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education; Miami, FLUSA;Department of Pathology; University of Miami; Miller School of Medicine; Miami, FLUSAView further author information
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Ren-Zhi CaiVeterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education; Miami, FLUSA;Department of Pathology; University of Miami; Miller School of Medicine; Miami, FLUSAView further author information
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Anna KlukovitsVeterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education; Miami, FLUSA;Department of Pathology; University of Miami; Miller School of Medicine; Miami, FLUSAView further author information
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Norman L BlockVeterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education; Miami, FLUSA;Department of Pathology; University of Miami; Miller School of Medicine; Miami, FLUSA;Divisions of Hematology/Oncology; University of Miami; Miller School of Medicine; Miami, FLUSAView further author information
&
Ferenc G RickVeterans Affairs Medical Center and South Florida Veterans Affairs Foundation for Research and Education; Miami, FLUSA;Department of Urology; Herbert Wertheim College of Medicine; Florida International University; Miami, FL, USACorrespondence[email protected]
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Pages 2790-2797 | Received 22 May 2014, Accepted 16 Jun 2014, Published online: 30 Oct 2014

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Zodwa Dlamini, Rodney Hull, Sikhumbuzo Z Mbatha, Mohammed Alaouna, You-Lin Qiao, Herbert Yu & Aristotelis Chatziioannou. (2021) Prognostic Alternative Splicing Signatures in Esophageal Carcinoma. Cancer Management and Research 13, pages 4509-4527.
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Andrew V Schally, Roberto Perez, Norman L Block & Ferenc G Rick. (2015) Potentiating effects of GHRH analogs on the response to chemotherapy. Cell Cycle 14:5, pages 699-704.
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Articles from other publishers (21)

Zexu Lin, Xin Lin, Yuming Sun, Shaorong Lei, Gengming Cai & Zhexuan Li. (2023) Melanoma molecular subtyping and scoring model construction based on ligand-receptor pairs. Frontiers in Genetics 14.
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Renzhi Cai, Xianyang Zhang, Haibo Wang, Tengjiao Cui, Gabor Halmos, Wei Sha, Jinlin He, Petra Popovics, Irving Vidaurre, Chongxu Zhang, Mehdi Mirsaeidi & Andrew V. Schally. (2022) Synthesis of potent antagonists of receptors for growth hormone-releasing hormone with antitumor and anti-inflammatory activity. Peptides 150, pages 170716.
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Lucia Recinella, Annalisa Chiavaroli, Serena Veschi, Valentina Di Valerio, Rossano Lattanzio, Giustino Orlando, Claudio Ferrante, Iacopo Gesmundo, Riccarda Granata, Renzhi Cai, Wei Sha, Andrew V. Schally, Luigi Brunetti & Sheila Leone. (2022) Antagonist of growth hormone-releasing hormone MIA-690 attenuates the progression and inhibits growth of colorectal cancer in mice. Biomedicine & Pharmacotherapy 146, pages 112554.
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Fabrizio Panarese, Giulio Gualdi, Marta Di Nicola, Cosimo Giannini, Nella Polidori, Federica Giuliani, Angelika Mohn & Paolo Amerio. (2022) Effects of Growth Hormone (GH) Supplementation on Dermatoscopic Evolution of Pigmentary Lesions in Children with Growth Hormone Deficiency (GHD). Journal of Clinical Medicine 11:3, pages 736.
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Lucia Recinella, Annalisa Chiavaroli, Giustino Orlando, Claudio Ferrante, Iacopo Gesmundo, Riccarda Granata, Renzhi Cai, Wei Sha, Andrew V. Schally, Luigi Brunetti & Sheila Leone. (2021) Growth hormone-releasing hormone antagonistic analog MIA-690 stimulates food intake in mice. Peptides 142, pages 170582.
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Xiao XiongXiurong KeLu WangZhimeng YaoYi GuoXianyang ZhangYuping ChenChi Pui PangAndrew V. SchallyHao Zhang. (2020) Splice variant of growth hormone-releasing hormone receptor drives esophageal squamous cell carcinoma conferring a therapeutic target. Proceedings of the National Academy of Sciences 117:12, pages 6726-6732.
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Cesar Luiz Boguszewski & Margaret Cristina da Silva Boguszewski. (2019) Growth Hormone’s Links to Cancer. Endocrine Reviews 40:2, pages 558-574.
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Yong Jie Qin, Wai Kit Chu, Li Huang, Clara Hoi Yen Ng, Tommy Chung Yan Chan, Di Cao, Cheng Yang, Liang Zhang, Shao Ping Huang, Juan Li, Hong Liang Lin, Wen Qian Li, Li Chen, Andrew V. Schally, Sun On Chan, Hong Yang Zhang & Chi Pui Pang. (2018) Induction of Apoptosis in Pterygium Cells by Antagonists of Growth Hormone–Releasing Hormone Receptors. Investigative Opthalmology & Visual Science 59:12, pages 5060.
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Haibo Wang, Xianyang Zhang, Irving Vidaurre, Renzhi Cai, Wei Sha & Andrew V. Schally. (2018) Inhibition of experimental small-cell and non-small-cell lung cancers by novel antagonists of growth hormone-releasing hormone. International Journal of Cancer 142:11, pages 2394-2404.
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Tiffanie S Stewart, Abhignyan Nagesetti, Rakesh Guduru, Ping Liang, Emmanuel Stimphil, Ali Hadjikhani, Luis Salgueiro, Jeffrey Horstmyer, Renzhi Cai, Andrew Schally & Sakhrat Khizroev. (2018) Magnetoelectric nanoparticles for delivery of antitumor peptides into glioblastoma cells by magnetic fields. Nanomedicine 13:4, pages 423-438.
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Helena Pópulo, Bruno Nunes, Cristina Sampaio, Rui Batista, Marta Teixeira Pinto, Tiago B. Gaspar, Leandro Miranda-Alves, Ren-Zhi Cai, Xian Yang Zhang, Andrew V. Schally, Manuel Sobrinho-Simões & Paula Soares. (2017) Inhibitory Effects of Antagonists of Growth Hormone-Releasing Hormone (GHRH) in Thyroid Cancer. Hormones and Cancer 8:5-6, pages 314-324.
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Frank Köster, Li Jin, Yuanming Shen, Andrew V. Schally, Ren-Zhi Cai, Norman L. Block, Daniela Hornung, Gabriele Marschner, Achim Rody, Jörg B. Engel & Dominique Finas. (2017) Effects of an Antagonistic Analog of Growth Hormone-Releasing Hormone on Endometriosis in a Mouse Model and In Vitro. Reproductive Sciences 24:11, pages 1503-1511.
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Reetobrata Basu, Shiyong Wu & John J. Kopchick. (2017) Targeting growth hormone receptor in human melanoma cells attenuates tumor progression and epithelial mesenchymal transition via suppression of multiple oncogenic pathways. Oncotarget 8:13, pages 21579-21598.
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Marta Zarandi, Renzhi Cai, Magdolna Kovacs, Petra Popovics, Luca Szalontay, Tengjiao Cui, Wei Sha, Miklos Jaszberenyi, Jozsef Varga, XianYang Zhang, Norman L. Block, Ferenc G. Rick, Gabor Halmos & Andrew V. Schally. (2017) Synthesis and structure-activity studies on novel analogs of human growth hormone releasing hormone (GHRH) with enhanced inhibitory activities on tumor growth. Peptides 89, pages 60-70.
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M.-T. Matsoukas & G. A. Spyroulias. (2017) Dynamic properties of the growth hormone releasing hormone receptor (GHRHR) and molecular determinants of GHRH binding. Mol. BioSyst. 13:7, pages 1313-1322.
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Wai Kit ChuKa Sin LawSun On ChanJason Cheuk Sing YamLi Jia ChenHao ZhangHerman S. CheungNorman L. BlockAndrew V. Schally & Chi Pui Pang. (2016) Antagonists of growth hormone-releasing hormone receptor induce apoptosis specifically in retinoblastoma cells. Proceedings of the National Academy of Sciences 113:50, pages 14396-14401.
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Leonid E. Fridlyand, Natalia A. Tamarina, Andrew V. Schally & Louis H. Philipson. (2016) Growth Hormone-Releasing Hormone in Diabetes. Frontiers in Endocrinology 7.
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Laura Muñoz-Moreno, Maria Isabel Arenas, María J. Carmena, Andrew V. Schally, Manuel Sánchez-Chapado, Juan C. Prieto & Ana M. Bajo. (2016) Anti-proliferative and pro-apoptotic effects of GHRH antagonists in prostate cancer. Oncotarget 7:32, pages 52195-52206.
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Adrian F Daly, Philippe A Lysy, Céline Desfilles, Liliya Rostomyan, Amira Mohamed, Jean-Hubert Caberg, Veronique Raverot, Emilie Castermans, Etienne Marbaix, Dominique Maiter, Chloe Brunelle, Giampaolo Trivellin, Constantine A Stratakis, Vincent Bours, Christian Raftopoulos, Veronique Beauloye, Anne Barlier & Albert Beckers. (2016) GHRH excess and blockade in X-LAG syndrome. Endocrine-Related Cancer 23:3, pages 161-170.
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Rosemeire M. Kanashiro-Takeuchi, Luca Szalontay, Andrew V. Schally, Lauro M. Takeuchi, Petra Popovics, Miklos Jaszberenyi, Irving Vidaurre, Marta Zarandi, Ren-Zhi Cai, Norman L. Block, Joshua M. Hare & Ferenc G. Rick. (2015) New therapeutic approach to heart failure due to myocardial infarction based on targeting growth hormone-releasing hormone receptor. Oncotarget 6:12, pages 9728-9739.
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Roberto Perez, Andrew V. Schally, Petra Popovics, Renzhi Cai, Wei Sha, Ricardo Rincon & Ferenc G. Rick. (2014) Antagonistic analogs of growth hormone-releasing hormone increase the efficacy of treatment of triple negative breast cancer in nude mice with doxorubicin; A preclinical study. Oncoscience 1:10, pages 665-673.
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