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The pancreatic cancer microenvironment: an immunologic battleground

Article: e950171 | Received 25 Jun 2014, Accepted 02 Jul 2014, Published online: 29 Oct 2014

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Gi-Ho Sung, Hyun Chang, Ji-Yong Lee, Si Young Song & Han-Soo Kim. (2018) Pancreatic-cancer-cell-derived trefoil factor 2 impairs maturation and migration of human monocyte-derived dendritic cells in vitro. Animal Cells and Systems 22:6, pages 368-381.
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Aitziber Buqué, Norma Bloy, Fernando Aranda, Isabelle Cremer, Alexander Eggermont, Wolf Hervé Fridman, Jitka Fucikova, Jérôme Galon, Radek Spisek, Eric Tartour, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2016) Trial Watch—Small molecules targeting the immunological tumor microenvironment for cancer therapy. OncoImmunology 5:6.
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Articles from other publishers (21)

Feihong Chen, Deming Zhao, Ying Huang, Xin Wen & Shicheng Feng. (2023) Synergetic impact of combined navoximod with cisplatin mitigates chemo-immune resistance via blockading IDO1+ CAFs-secreted Kyn/AhR/IL-6 and pol ζ-prevented CIN in human oral squamous cell carcinoma. Life Sciences 335, pages 122239.
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Xiaofeng Zou, Deming Zhao, Xin Wen & Feihong Chen. (2023) NLG-919 combined with cisplatin to enhance inhibitory effect on cell migration and invasion via IDO1–Kyn–AhR pathway in human nasopharyngeal carcinoma cell. Canadian Journal of Physiology and Pharmacology 101:11, pages 599-609.
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Shenao Fu, Shaokang Xu & Shubing Zhang. (2023) The role of amino acid metabolism alterations in pancreatic cancer: From mechanism to application. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1878:3, pages 188893.
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Rishav Sharma & Rishabha Malviya. (2023) Correlation between hypoxia and HGF/c-MET expression in the management of pancreatic cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1878:3, pages 188869.
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Heng Liang, Tianqi Li, Xin Fang, Zikang Xing, Shengnan Zhang, Lei Shi, Weirui Li, Leilei Guo, Chunxiang Kuang, Hongrui Liu & Qing Yang. (2021) IDO1/TDO dual inhibitor RY103 targets Kyn-AhR pathway and exhibits preclinical efficacy on pancreatic cancer. Cancer Letters 522, pages 32-43.
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Xiaodong Hao, Yidan Ren, Maoxiao Feng, Qin Wang & Yunshan Wang. (2021) Metabolic reprogramming due to hypoxia in pancreatic cancer: Implications for tumor formation, immunity, and more. Biomedicine & Pharmacotherapy 141, pages 111798.
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Monia Cecati, Matteo Giulietti, Alessandra Righetti, Berina Sabanovic & Francesco Piva. (2021) Effects of CXCL12 isoforms in a pancreatic pre-tumour cellular model: Microarray analysis. World Journal of Gastroenterology 27:15, pages 1616-1629.
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Juan Iovanna. (2021) Implementing biological markers as a tool to guide clinical care of patients with pancreatic cancer. Translational Oncology 14:1, pages 100965.
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Gabriel Benyomo Mpilla, Philip Agop Philip, Bassel El-Rayes & Asfar Sohail Azmi. (2020) Pancreatic neuroendocrine tumors: Therapeutic challenges and research limitations. World Journal of Gastroenterology 26:28, pages 4036-4054.
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Javed Mahmood, Allen A. Alexander, Santanu Samanta, Shriya Kamlapurkar, Prerna Singh, Ali Saeed, France Carrier, Xuefang Cao, Hem D Shukla & Zeljko Vujaskovic. (2020) A Combination of Radiotherapy, Hyperthermia, and Immunotherapy Inhibits Pancreatic Tumor Growth and Prolongs the Survival of Mice. Cancers 12:4, pages 1015.
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S. K. Daniel, K. M. Sullivan, K. P. Labadie & V. G. Pillarisetty. (2019) Hypoxia as a barrier to immunotherapy in pancreatic adenocarcinoma. Clinical and Translational Medicine 8:1.
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Priyanka Ray, Magda Ferraro, Rainer Haag & Mohiuddin Quadir. (2019) Dendritic Polyglycerol‐Derived Nano‐Architectures as Delivery Platforms of Gemcitabine for Pancreatic Cancer. Macromolecular Bioscience 19:7.
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Kyösti Tahkola, Joni Leppänen, Maarit Ahtiainen, Juha Väyrynen, Kirsi-Maria Haapasaari, Tuomo Karttunen, Ilmo Kellokumpu, Olli Helminen & Jan Böhm. (2019) Immune cell score in pancreatic cancer—comparison of hotspot and whole-section techniques. Virchows Archiv 474:6, pages 691-699.
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Gabriela M Wiedemann, Celina Aithal, Angelina Kraechan, Constanze Heise, Bruno L Cadilha, Jin Zhang, Peter Duewell, Robert Ballotti, Stefan Endres, Corine Bertolotto & Sebastian Kobold. (2019) Microphthalmia-Associated Transcription Factor (MITF) Regulates Immune Cell Migration into Melanoma. Translational Oncology 12:2, pages 350-360.
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Mirna Perusina Lanfranca, Jenny Lazarus, Xia Shao, Hari Nathan, Marina Pasca Di Magliano, Weiping Zou, Morand Piert & Timothy L. Frankel. (2018) Tracking Macrophage Infiltration in a Mouse Model of Pancreatic Cancer with the Positron Emission Tomography Tracer [11C]PBR28. Journal of Surgical Research 232, pages 570-577.
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David B. Zhen, Andrew Coveler, Silvia Zanon, Michele Reni & E. Gabriela Chiorean. (2018) Biomarker-driven and molecularly targeted therapies for pancreatic adenocarcinoma. Seminars in Oncology 45:3, pages 107-115.
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Kyösti Tahkola, Jukka-Pekka Mecklin, Erkki-Ville Wirta, Maarit Ahtiainen, Olli Helminen, Jan Böhm & Ilmo Kellokumpu. (2018) High immune cell score predicts improved survival in pancreatic cancer. Virchows Archiv 472:4, pages 653-665.
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Rachel L. O. Olson, Judith V. Forner, Pilar Navarro, Martin E. Fernandez-Zapico & Ahmed M. Elamir. 2018. Pancreatic Cancer. Pancreatic Cancer 539 552 .
Rachel L. O. Olson, Judith V. Forner, Pilar Navarro, Martin E. Fernandez-Zapico & Ahmed M. Elamir. 2017. Pancreatic Cancer. Pancreatic Cancer 1 14 .
X Wang, M Lang, T Zhao, X Feng, C Zheng, C Huang, J Hao, J Dong, L Luo, X Li, C Lan, W Yu, M Yu, S Yang & H Ren. (2016) Cancer-FOXP3 directly activated CCL5 to recruit FOXP3+Treg cells in pancreatic ductal adenocarcinoma. Oncogene 36:21, pages 3048-3058.
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Y D Seo & V G Pillarisetty. (2016) T-cell programming in pancreatic adenocarcinoma: a review. Cancer Gene Therapy 24:3, pages 106-113.
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