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OncoImmunology Volume 3, 2014 - Issue 8
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Original Research

Stress-related and homeostatic cytokines regulate Vγ9Vδ2 T-cell surveillance of mevalonate metabolism

Georg GruenbacherCell Therapy Unit; Department of Urology; K1 Center for Personalized Cancer Medicine; Innsbruck Medical University and oncotyrol; Innsbruck, Austria
,
Oliver NussbaumerPeter Gorer Department of Immunobiology; King’s College London; London, UK
,
Hubert GanderCell Therapy Unit; Department of Urology; K1 Center for Personalized Cancer Medicine; Innsbruck Medical University and oncotyrol; Innsbruck, Austria
,
Bernhard SteinerCell Therapy Unit; Department of Urology; K1 Center for Personalized Cancer Medicine; Innsbruck Medical University and oncotyrol; Innsbruck, Austria
,
Nicolai LeonhartsbergerCell Therapy Unit; Department of Urology; K1 Center for Personalized Cancer Medicine; Innsbruck Medical University and oncotyrol; Innsbruck, Austria
&
Martin ThurnherCell Therapy Unit; Department of Urology; K1 Center for Personalized Cancer Medicine; Innsbruck Medical University and oncotyrol; Innsbruck, AustriaCorrespondence[email protected]
Article: e953410 | Received 16 Apr 2014, Accepted 25 Jun 2014, Published online: 29 Oct 2014

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Teruki Shimizu, Mako Tomogane, Masatsugu Miyashita, Osamu Ukimura & Eishi Ashihara. (2018) Low dose gemcitabine increases the cytotoxicity of human Vγ9Vδ2 T cells in bladder cancer cells in vitro and in an orthotopic xenograft model. OncoImmunology 7:5.
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Georg Gruenbacher & Martin Thurnher. (2017) Mevalonate metabolism governs cancer immune surveillance. OncoImmunology 6:10.
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Erika Vacchelli, Fernando Aranda, Norma Bloy, Aitziber Buqué, Isabelle Cremer, Alexander Eggermont, Wolf Hervé Fridman, Jitka Fucikova, Jérôme Galon, Radek Spisek, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi. (2016) Trial Watch—Immunostimulation with cytokines in cancer therapy. OncoImmunology 5:2.
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Articles from other publishers (31)

Kirsty R. Field, Kathleen M. Wragg, Wen Shi Lee, Marc Rigau, Adam P. Uldrich, Stephen J. Kent & Jennifer A. Juno. (2023) Cytokines enhance human Vγ9Vδ2 T‐cell TCR‐dependent and TCR‐independent effector functions. European Journal of Immunology 53:6.
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Jani-Sofia Almeida, José Manuel Casanova, Manuel Santos-Rosa, Raquel Tarazona, Rafael Solana & Paulo Rodrigues-Santos. (2023) Natural Killer T-like Cells: Immunobiology and Role in Disease. International Journal of Molecular Sciences 24:3, pages 2743.
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Moulay Yassine Belghali, Lahcen El Moumou, Raja Hazime, Maroua Brahimi, Malak El Marrakchi, Hasna Ait Belaid, Said Ait Benali, Mouna Khouchani, Saadia Ba‐M'hamed & Brahim Admou. (2022) Phenotypic characterization of human peripheral γδT‐cell subsets in glioblastoma. Microbiology and Immunology 66:10, pages 465-476.
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José Saura-Esteller, Milon de Jong, Lisa A. King, Erik Ensing, Benjamin Winograd, Tanja D. de Gruijl, Paul W. H. I. Parren & Hans J. van der Vliet. (2022) Gamma Delta T-Cell Based Cancer Immunotherapy: Past-Present-Future. Frontiers in Immunology 13.
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Chenxiao Liu, Karolina Skorupinska-Tudek, Sven-Göran Eriksson & Ingela Parmryd. (2022) Potentiating Vγ9Vδ2 T cell proliferation and assessing their cytotoxicity towards adherent cancer cells at the single cell level. Biology Open 11:1.
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Fanny Martini & Eric Champagne. (2021) The Contribution of Human Herpes Viruses to γδ T Cell Mobilisation in Co-Infections. Viruses 13:12, pages 2372.
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Feifei Xu, Zining Wang, Hongxia Zhang, Jiemin Chen, Xiaojuan Wang, Lei Cui, Chunyuan Xie, Mengyun Li, Fang Wang, Penghui Zhou, Jinyun Liu, Peng Huang, Xiaodong Xia & Xiaojun Xia. (2021) Mevalonate Blockade in Cancer Cells Triggers CLEC9A+ Dendritic Cell-Mediated Antitumor Immunity. Cancer Research 81:17, pages 4514-4528.
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Jasper Nörenberg, Pál Jaksó & Alíz Barakonyi. (2021) Gamma/Delta T Cells in the Course of Healthy Human Pregnancy: Cytotoxic Potential and the Tendency of CD8 Expression Make CD56+ γδT Cells a Unique Lymphocyte Subset. Frontiers in Immunology 11.
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Huanzi Lu, Wenxiao Dai, Junyi Guo, Dikan Wang, Shuqiong Wen, Lisa Yang, Dongjia Lin, Wenqiang Xie, Liling Wen, Juan Fang & Zhi Wang. (2020) High Abundance of Intratumoral γδ T Cells Favors a Better Prognosis in Head and Neck Squamous Cell Carcinoma: A Bioinformatic Analysis. Frontiers in Immunology 11.
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Marco P. La Manna, Valentina Orlando, Bartolo Tamburini, Giusto D. Badami, Francesco Dieli & Nadia Caccamo. (2020) Harnessing Unconventional T Cells for Immunotherapy of Tuberculosis. Frontiers in Immunology 11.
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Dieter Kabelitz, Ruben Serrano, Léonce Kouakanou, Christian Peters & Shirin Kalyan. (2020) Cancer immunotherapy with γδ T cells: many paths ahead of us. Cellular & Molecular Immunology 17:9, pages 925-939.
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Pia Aehnlich, Ana Micaela Carnaz Simões, Signe Koggersbøl Skadborg, Gitte Holmen Olofsson & Per thor Straten. (2020) Expansion With IL-15 Increases Cytotoxicity of Vγ9Vδ2 T Cells and Is Associated With Higher Levels of Cytotoxic Molecules and T-bet. Frontiers in Immunology 11.
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Oliver Nussbaumer & Martin Thurnher. (2020) Functional Phenotypes of Human Vγ9Vδ2 T Cells in Lymphoid Stress Surveillance. Cells 9:3, pages 772.
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Heleen H. Van Acker, Zoë P. Van Acker, Maarten Versteven, Peter Ponsaerts, Daniela Pende, Zwi N. Berneman, Sébastien Anguille, Viggo F. Van Tendeloo & Evelien L. Smits. (2019) CD56 Homodimerization and Participation in Anti-Tumor Immune Effector Cell Functioning: A Role for Interleukin-15. Cancers 11:7, pages 1029.
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Oliver Nussbaumer & Michael Koslowski. (2019) The emerging role of γδ T cells in cancer immunotherapy. Immuno-Oncology Technology 1, pages 3-10.
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Li Gong, Yi Xiao, Fan Xia, Pei Wu, Tingting Zhao, Shulin Xie, Ran Wang, Qiaocheng Wen, Wensu Zhou, Huilan Xu, Lingyan Zhu, Zeqi Zheng, Tianlun Yang, Zihua Chen & Qiong Duan. (2019) The mevalonate coordinates energy input and cell proliferation. Cell Death & Disease 10:4.
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Chenxiao Liu, S. Noushin Emami, Jean Pettersson, Lisa Ranford-Cartwright, Ingrid Faye & Ingela Parmryd. (2018) Vγ9Vδ2 T cells proliferate in response to phosphoantigens released from erythrocytes infected with asexual and gametocyte stage Plasmodium falciparum. Cellular Immunology 334, pages 11-19.
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Georg Gruenbacher & Martin Thurnher. (2018) Mevalonate Metabolism in Cancer Stemness and Trained Immunity. Frontiers in Oncology 8.
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Chiara Riganti, Barbara Castella & Massimo Massaia. (2018) ABCA1, apoA-I, and BTN3A1: A Legitimate Ménage à Trois in Dendritic Cells. Frontiers in Immunology 9.
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Vito Pistoia, Nicola Tumino, Paola Vacca, Irene Veneziani, Alessandro Moretta, Franco Locatelli & Lorenzo Moretta. (2018) Human γδ T-Cells: From Surface Receptors to the Therapy of High-Risk Leukemias. Frontiers in Immunology 9.
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Timm Hoeres, Manfred Smetak, Dominik Pretscher & Martin Wilhelm. (2018) Improving the Efficiency of Vγ9Vδ2 T-Cell Immunotherapy in Cancer. Frontiers in Immunology 9.
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Morgane Moulin, Javier Alguacil, Siyi Gu, Asmaa Mehtougui, Erin J. Adams, Suzanne Peyrottes & Eric Champagne. (2017) Vγ9Vδ2 T cell activation by strongly agonistic nucleotidic phosphoantigens. Cellular and Molecular Life Sciences 74:23, pages 4353-4367.
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Guranda Chitadze, Hans-Heinrich Oberg, Daniela Wesch & Dieter Kabelitz. (2017) The Ambiguous Role of γδ T Lymphocytes in Antitumor Immunity. Trends in Immunology 38:9, pages 668-678.
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Heleen H. Van Acker, Anna Capsomidis, Evelien L. Smits & Viggo F. Van Tendeloo. (2017) CD56 in the Immune System: More Than a Marker for Cytotoxicity?. Frontiers in Immunology 8.
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Barbara Castella, Joanna Kopecka, Patrizia Sciancalepore, Giorgia Mandili, Myriam Foglietta, Nico Mitro, Donatella Caruso, Francesco Novelli, Chiara Riganti & Massimo Massaia. (2017) The ATP-binding cassette transporter A1 regulates phosphoantigen release and Vγ9Vδ2 T cell activation by dendritic cells. Nature Communications 8:1.
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Heleen H. Van Acker, Ottavio Beretta, Sébastien Anguille, Lien De Caluwé, Angela Papagna, Johan M. Van den Bergh, Yannick Willemen, Herman Goossens, Zwi N. Berneman, Viggo F. Van Tendeloo, Evelien L. Smits, Maria Foti & Eva Lion. (2017) Desirable cytolytic immune effector cell recruitment by interleukin-15 dendritic cells. Oncotarget 8:8, pages 13652-13665.
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Heleen H. Van Acker, Sébastien Anguille, Yannick Willemen, Johan M. Van den Bergh, Zwi N. Berneman, Eva Lion, Evelien L. Smits & Viggo F. Van Tendeloo. (2016) Interleukin-15 enhances the proliferation, stimulatory phenotype, and antitumor effector functions of human gamma delta T cells. Journal of Hematology & Oncology 9:1.
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Patrik Theodor Nerdal, Christian Peters, Hans-Heinrich Oberg, Hristo Zlatev, Marcus Lettau, Elgar Susanne Quabius, Sofia Sousa, Daniel Gonnermann, Seppo Auriola, Daniel Olive, Jorma Määttä, Ottmar Janssen & Dieter Kabelitz. (2016) Butyrophilin 3A/CD277–Dependent Activation of Human γδ T Cells: Accessory Cell Capacity of Distinct Leukocyte Populations. The Journal of Immunology 197:8, pages 3059-3068.
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Georg Gruenbacher, Hubert Gander, Andrea Rahm, Marco Idzko, Oliver Nussbaumer & Martin Thurnher. (2016) Ecto-ATPase CD39 Inactivates Isoprenoid-Derived Vγ9Vδ2 T Cell Phosphoantigens. Cell Reports 16:2, pages 444-456.
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Martin ThurnherGeorg Gruenbacher. (2015) T lymphocyte regulation by mevalonate metabolism. Science Signaling 8:370.
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