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OncoImmunology Volume 3, 2014 - Issue 12
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Original Research

Interleukin-6 receptor and its ligand interleukin-6 are opposite markers for survival and infiltration with mature myeloid cells in ovarian cancer

MCA WoutersDepartment of Gynecologic Oncology; University of Groningen; University Medical Center Groningen; Hanzeplein; Groningen, The Netherlands;Department of Medical Microbiology; University of Groningen; University Medical Center Groningen; Hanzeplein, Groningen, The Netherlands
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EM DijkgraafDepartment of ClinicalOncology; Leiden University Medical Center; Albinusdreef, Leiden, The Netherlands
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ML KuijjerDepartment of Biostatistics and Computational Biology; Dana-Farber Cancer Institute; Boston, MAUSA;Department of Biostatistics; Harvard School of Public Health; Boston, MAUSA
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ES JordanovaCenter for Gynaecological Oncology Amsterdam; VUMC, De Boelelaan, Amsterdam, The Netherlands
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H HollemaDepartment of Pathology; University of Groningen; University Medical Center Groningen; Hanzeplein, Groningen, The Netherlands
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MJP WeltersDepartment of ClinicalOncology; Leiden University Medical Center; Albinusdreef, Leiden, The Netherlands
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JJM van der HoevenDepartment of ClinicalOncology; Leiden University Medical Center; Albinusdreef, Leiden, The Netherlands
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T DaemenDepartment of Medical Microbiology; University of Groningen; University Medical Center Groningen; Hanzeplein, Groningen, The NetherlandsORCID Iconhttps://orcid.org/0000-0003-0166-512X
ORCID Icon,
JR KroepDepartment of ClinicalOncology; Leiden University Medical Center; Albinusdreef, Leiden, The Netherlands
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HW NijmanDepartment of Gynecologic Oncology; University of Groningen; University Medical Center Groningen; Hanzeplein; Groningen, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-1821-3042
ORCID Icon &
SH van der BurgDepartment of ClinicalOncology; Leiden University Medical Center; Albinusdreef, Leiden, The NetherlandsCorrespondence[email protected]
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Article: e962397 | Received 10 Aug 2014, Accepted 30 Oct 2014, Published online: 29 Oct 2014

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S. J. A. M. Santegoets, A. F. de Groot, E. M. Dijkgraaf, A. M. Carnaz Simões, V. E. van der Noord, J. J. van Ham, M. J. P. Welters, J. R. Kroep & S. H. van der Burg. (2018) The blood mMDSC to DC ratio is a sensitive and easy to assess independent predictive factor for epithelial ovarian cancer survival. OncoImmunology 7:8.
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Articles from other publishers (21)

Els M E Verdegaal, Saskia J Santegoets, Marij J P Welters, Linda de Bruin, Marten Visser, Caroline E van der Minne, Pita M de Kok, Nikki M Loof, Sanne Boekestijn, Inge Roozen, Inge M Westra, Pauline Meij, Sjoerd H Van der Burg & Judith R Kroep. (2023) Timed adoptive T cell transfer during chemotherapy in patients with recurrent platinum-sensitive epithelial ovarian cancer. Journal for ImmunoTherapy of Cancer 11:11, pages e007697.
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Katarzyna Aneta Pankowska, Grażyna Ewa Będkowska, Joanna Chociej-Stypułkowska, Małgorzata Rusak, Milena Dąbrowska & Joanna Osada. (2023) Crosstalk of Immune Cells and Platelets in an Ovarian Cancer Microenvironment and Their Prognostic Significance. International Journal of Molecular Sciences 24:11, pages 9279.
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Hui-Juan Yang, Ye Kang, Yi-Zi Li, Fang-Hua Liu, Shi Yan, Song Gao, Yun-Long Huo, Ting-Ting Gong & Qi-Jun Wu. (2022) Relationship between different forms of dietary choline and ovarian cancer survival: findings from the ovarian cancer follow-up study, a prospective cohort study. Food & Function 13:23, pages 12342-12352.
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Shuo Gao, Wenyuan Zhang, Na Yan, Min Li, Xiaowei Mu, Huaxia Yin & Jinhua Wang. (2021) The impact of STAT3 and phospho-STAT3 expression on the prognosis and clinicopathology of ovarian cancer: a systematic review and meta-analysis. Journal of Ovarian Research 14:1.
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Brigida Anna Maiorano, Mauro Francesco Pio Maiorano, Domenica Lorusso & Evaristo Maiello. (2021) Ovarian Cancer in the Era of Immune Checkpoint Inhibitors: State of the Art and Future Perspectives. Cancers 13:17, pages 4438.
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C. Schweitzer, M. Garrido, R. Paredes, C. Stoore, M. Reyes, R. Bologna-Molina, A. Fernández & Marcela Hernández Rios. (2021) Localization of interleukin-6 signaling complex in epithelialized apical lesions of endodontic origin. Clinical Oral Investigations 25:6, pages 4075-4083.
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Min Yang, Wen-Yun Li, Jing Xie, Zi-Lin Wang, Yan-Long Wen, Cun-Chao Zhao, Liang Tao, Ling-Fei Li, Yang Tian & Jun Sheng. (2021) Astragalin Inhibits the Proliferation and Migration of Human Colon Cancer HCT116 Cells by Regulating the NF-κB Signaling Pathway. Frontiers in Pharmacology 12.
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Shiwen Xu, Chunyan Yu, Xiaoxia Ma, Yan Li, Yangyang Shen, Yan Chen, Suhui Huang, Tongshuo Zhang, Weimin Deng & Yue Wang. (2021) IL-6 promotes nuclear translocation of HIF-1α to aggravate chemoresistance of ovarian cancer cells. European Journal of Pharmacology 894, pages 173817.
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Lei Zhang, Wen-Xu Chen, Ling-Li Li, Yu-Zhu Cao, Ya-Di Geng, Xiao-Jun Feng, Ai-Yun Wang, Zhao-Lin Chen, Yin Lu & Ai-Zong Shen. (2020) Paeonol Suppresses Proliferation and Motility of Non-Small-Cell Lung Cancer Cells by Disrupting STAT3/NF-κB Signaling. Frontiers in Pharmacology 11.
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Saskia J Santegoets, Chantal L Duurland, Ekaterina J Jordanova, Vanessa J van Ham, Ilina Ehsan, Nikki M Loof, Vipin Narang, Charles A Dutertre, Florent Ginhoux, Sylvia L van Egmond, Marij J P Welters & Sjoerd H van der Burg. (2020) CD163 + cytokine-producing cDC2 stimulate intratumoral type 1 T cell responses in HPV16-induced oropharyngeal cancer . Journal for ImmunoTherapy of Cancer 8:2, pages e001053.
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Zi‐Meng Zheng, Hui‐Li Yang, Zhen‐Zhen Lai, Cheng‐Jie Wang, Shao‐Liang Yang, Ming‐Qing Li & Jun Shao. (2020) Myeloid‐derived suppressor cells in obstetrical and gynecological diseases. American Journal of Reproductive Immunology 84:2.
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Hassan Yousefi, Majid Momeny, Seyed H. Ghaffari, Nazanin Parsanejad, Arash Poursheikhani, Sepehr Javadikooshesh, Ghazaleh Zarrinrad, Fatemeh Esmaeili, Zivar Alishahi, Zahra Sabourinejad, Ghazaleh Sankanian, Sahar Shamsaiegahkani, Davood Bashash, Narjes Shahsavani, Javad Tavakkoly-Bazzaz, Kamran Alimoghaddam & Ardeshir Ghavamzadeh. (2018) IL-6/IL-6R pathway is a therapeutic target in chemoresistant ovarian cancer. Tumori Journal 105:1, pages 84-91.
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Hirotake Tsukamoto, Koji Fujieda, Satoru Senju, Tokunori Ikeda, Hiroyuki Oshiumi & Yasuharu Nishimura. (2018) Immune-suppressive effects of interleukin-6 on T-cell-mediated anti-tumor immunity. Cancer Science 109:3, pages 523-530.
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Liangliang Wu, Zhaoyang Deng, Yaojun Peng, Lu Han, Jing Liu, Linxiong Wang, Bohua Li, Jian Zhao, Shunchang Jiao & Huafeng Wei. (2017) Ascites-derived IL-6 and IL-10 synergistically expand CD14+HLA-DR-/low myeloid-derived suppressor cells in ovarian cancer patients. Oncotarget 8:44, pages 76843-76856.
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Qu Chen, Bin Xu, Lei Lan, Da Yang, Min Yang, Jingting Jiang, Binfeng Lu & Yueping Shen. (2017) High mRNA expression level of IL-6R was associated with better prognosis for patients with ovarian cancer: a pooled meta-analysis. Scientific Reports 7:1.
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Marij J. WeltersTetje C. van der SluisHélène van MeirNikki M. LoofVanessa J. van HamSuzanne van DuikerenSaskia J. SantegoetsRamon ArensMarieke L. de KamAdam F. CohenMariette I. van PoelgeestGemma G. KenterJudith R. KroepJacobus BurggraafCornelis J. MeliefSjoerd H. van der Burg. (2016) Vaccination during myeloid cell depletion by cancer chemotherapy fosters robust T cell responses. Science Translational Medicine 8:334.
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Ira Mellman, Vanessa M. Hubbard-Lucey, Matthew J. Tontonoz, Michael D. Kalos, Daniel S. Chen, James P. Allison, Charles G. Drake, Hy Levitsky, Nils Lonberg, Sjoerd H. van der Burg, Douglas T. Fearon, E. John Wherry, Israel Lowy, Robert H. Vonderheide & Patrick Hwu. (2016) De-Risking Immunotherapy: Report of a Consensus Workshop of the Cancer Immunotherapy Consortium of the Cancer Research Institute. Cancer Immunology Research 4:4, pages 279-288.
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Sjoerd H. van der Burg, Ramon Arens, Ferry Ossendorp, Thorbald van Hall & Cornelis J. M. Melief. (2016) Vaccines for established cancer: overcoming the challenges posed by immune evasion. Nature Reviews Cancer 16:4, pages 219-233.
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Masamitsu Tanaka, Shintaro Shimamura, Sei Kuriyama, Daichi Maeda, Akiteru Goto & Namiko Aiba. (2016) SKAP2 Promotes Podosome Formation to Facilitate Tumor-Associated Macrophage Infiltration and Metastatic Progression. Cancer Research 76:2, pages 358-369.
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M. Yao, G. Brummer, D. Acevedo & N. Cheng. 2016. Molecular and Cellular Basis of Metastasis: Road to Therapy. Molecular and Cellular Basis of Metastasis: Road to Therapy 265 367 .
Lei Zhang, Li Tao, Tianlu Shi, Feng Zhang, Xiaobo Sheng, Yuzhu Cao, Shizhong Zheng, Aiyun Wang, Wenhui Qian, Ling Jiang & Yin Lu. (2015) Paeonol inhibits B16F10 melanoma metastasis In vitro and In Vivo via disrupting proinflammatory cytokines-mediated NF-κB and STAT3 pathways . IUBMB Life 67:10, pages 778-788.
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