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Review

Trial Watch: Proteasomal inhibitors for anticancer therapy

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Article: e974463 | Received 03 Aug 2014, Accepted 17 Sep 2014, Published online: 26 Feb 2015

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Ouadie Mohamed El Yaagoubi, Larbi Oularbi, Abdelhakim Bouyahya, Hamid Samaki, Said El Antri & Souad Aboudkhil. (2021) The role of the ubiquitin-proteasome pathway in skin cancer development: 26S proteasome-activated NF-κB signal transduction. Cancer Biology & Therapy 22:10-12, pages 479-492.
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L. Masuelli, M. Granato, M. Benvenuto, R. Mattera, R. Bernardini, M. Mattei, G. d'Amati, G. D'Orazi, A. Faggioni, R. Bei & M. Cirone. (2017) Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice. OncoImmunology 6:11.
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Antonella Sistigu, Gwenola Manic, Florine Obrist & Ilio Vitale. (2016) Trial watch – inhibiting PARP enzymes for anticancer therapy. Molecular & Cellular Oncology 3:2.
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Gwenola Manic, Florine Obrist, Antonella Sistigu & Ilio Vitale. (2015) Trial Watch: Targeting ATM–CHK2 and ATR–CHK1 pathways for anticancer therapy. Molecular & Cellular Oncology 2:4.
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Articles from other publishers (11)

Ricardo Lemes Gonçalves, Gabriel Augusto Pires de Souza, Mateus de Souza Terceti, Renato Fróes Goulart de Castro, Breno de Mello Silva, Romulo Dias Novaes, Luiz Cosme Cotta Malaquias & Luiz Felipe Leomil Coelho. (2022) Integrative transcriptome analysis of SARS-CoV-2 human-infected cells combined with deep learning algorithms identifies two potential cellular targets for the treatment of coronavirus disease. Brazilian Journal of Microbiology 54:1, pages 53-68.
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Carlota Leonardo-Sousa, Andreia Neves Carvalho, Romina A. Guedes, Pedro M. P. Fernandes, Natália Aniceto, Jorge A. R. Salvador, Maria João Gama & Rita C. Guedes. (2022) Revisiting Proteasome Inhibitors: Molecular Underpinnings of Their Development, Mechanisms of Resistance and Strategies to Overcome Anti-Cancer Drug Resistance. Molecules 27:7, pages 2201.
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Jun-O Jin, Nidhi Puranik, Quyen Thu Bui, Dhananjay Yadav & Peter Chang-Whan Lee. (2021) The Ubiquitin System: An Emerging Therapeutic Target for Lung Cancer. International Journal of Molecular Sciences 22:17, pages 9629.
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Nam & Jeon. (2019) Proteostasis In The Endoplasmic Reticulum: Road to Cure. Cancers 11:11, pages 1793.
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Tanja Heitmeier, Akylbek Sydykov, Christina Lukas, Christina Vroom, Martina Korfei, Aleksandar Petrovic, Karin Klingel, Andreas Günther, Oliver Eickelberg, Norbert Weissmann, Hossein Ardeschir Ghofrani, Werner Seeger, Friedrich Grimminger, Ralph Theo Schermuly, Silke Meiners & Djuro Kosanovic. (2019) Altered proteasome function in right ventricular hypertrophy. Cardiovascular Research.
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Elisa Bergaggio, Chiara Riganti, Giulia Garaffo, Nicoletta Vitale, Elisabetta Mereu, Cecilia BandiniElisa Pellegrino, Verdiana Pullano, Paola OmedèKatia TodoertiLuciano Cascione, Valentina Audrito, Anna Riccio, Antonio Rossi, Francesco Bertoni, Silvia Deaglio, Antonino Neri, Antonio Palumbo & Roberto Piva. (2019) IDH2 inhibition enhances proteasome inhibitor responsiveness in hematological malignancies. Blood 133:2, pages 156-167.
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K. Patatsos, T. M. Shekhar & C. J. Hawkins. (2018) Pre-clinical evaluation of proteasome inhibitors for canine and human osteosarcoma. Veterinary and Comparative Oncology 16:4, pages 544-553.
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Binita Das, Beth K. Neilsen, Kurt W. Fisher, Drew Gehring, Youcai Hu, Deanna J. Volle, Hyun Seok Kim, Jamie L. McCall, David L. Kelly, John B. MacMillan, Michael A. White & Robert E. Lewis. (2018) A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells. Scientific Reports 8:1.
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Justyna Sidor-Kaczmarek, Mirosława Cichorek, Jan Henryk Spodnik, Sławomir Wójcik & Janusz Moryś. (2017) Proteasome inhibitors against amelanotic melanoma. Cell Biology and Toxicology 33:6, pages 557-573.
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Mary Iconomou & Darren N. Saunders. (2016) Systematic approaches to identify E3 ligase substrates. Biochemical Journal 473:22, pages 4083-4101.
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