Advanced search
Publication Cover
Autophagy Volume 9, 2013 - Issue 11
Submit an article Journal homepage
3,289
Views
67
CrossRef citations to date
0
Altmetric
Review

Perturbed mitochondrial Ca2+ signals as causes or consequences of mitophagy induction

Alessandro Rimessi Department of Morphology, Surgery and Experimental Medicine; Section of General Pathology; Interdisciplinary Center for the Study of Inflammation (ICSI); Laboratory for Technologies of Advanced Therapies (LTTA); University of Ferrara; Ferrara, Italy
,
Massimo Bonora Department of Morphology, Surgery and Experimental Medicine; Section of General Pathology; Interdisciplinary Center for the Study of Inflammation (ICSI); Laboratory for Technologies of Advanced Therapies (LTTA); University of Ferrara; Ferrara, Italy
,
Saverio Marchi Department of Morphology, Surgery and Experimental Medicine; Section of General Pathology; Interdisciplinary Center for the Study of Inflammation (ICSI); Laboratory for Technologies of Advanced Therapies (LTTA); University of Ferrara; Ferrara, Italy
,
Simone Patergnani Department of Morphology, Surgery and Experimental Medicine; Section of General Pathology; Interdisciplinary Center for the Study of Inflammation (ICSI); Laboratory for Technologies of Advanced Therapies (LTTA); University of Ferrara; Ferrara, Italy
,
Carlo MT Marobbio Department of Biosciences, Biotechnologies and Biopharmaceutics; University of Bari “Aldo Moro”; Bari, Italy
,
Francesco M Lasorsa CNR Institute of Biomembranes and Bioenergetics; Bari, Italy
&
Paolo Pinton Department of Morphology, Surgery and Experimental Medicine; Section of General Pathology; Interdisciplinary Center for the Study of Inflammation (ICSI); Laboratory for Technologies of Advanced Therapies (LTTA); University of Ferrara; Ferrara, ItalyCorrespondence[email protected]
 show all
Pages 1677-1686 | Received 28 Jan 2013, Accepted 24 Apr 2013, Published online: 21 May 2013

Citations (67)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Saverio Marchi, Eliana Trapani, Mariangela Corricelli, Luca Goitre, Paolo Pinton & Saverio Francesco Retta. (2016) Beyond multiple mechanisms and a unique drug: Defective autophagy as pivotal player in cerebral cavernous malformation pathogenesis and implications for targeted therapies. Rare Diseases 4:1.
Read now
Jean-Paul Decuypere, Jan B Parys & Geert Bultynck. (2015) ITPRs/inositol 1,4,5-trisphosphate receptors in autophagy: From enemy to ally. Autophagy 11:10, pages 1944-1948.
Read now
Marta Mauro-Lizcano, Lorena Esteban-Martínez, Esther Seco, Ana Serrano-Puebla, Lucia Garcia-Ledo, Cláudia Figueiredo-Pereira, Helena L A Vieira & Patricia Boya. (2015) New method to assess mitophagy flux by flow cytometry. Autophagy 11:5, pages 833-843.
Read now

Articles from other publishers (64)

Neşe Vardar Acar & R.Köksal Özgül. (2023) A big picture of the mitochondria-mediated signals: From mitochondria to organism. Biochemical and Biophysical Research Communications 678, pages 45-61.
Crossref
Jacqueline Kaiser, Kevin Nay, Christopher R. Horne, Luke M. McAloon, Oliver K. Fuller, Abbey G. Muller, Douglas G. Whyte, Anthony R. Means, Ken Walder, Michael Berk, Anthony J. Hannan, James M. Murphy, Mark A. Febbraio, Andrew L. Gundlach & John W. Scott. (2023) CaMKK2 as an emerging treatment target for bipolar disorder. Molecular Psychiatry.
Crossref
Yong Kang, Lingling Xu, Jinrui Dong, Yongzhi Huang, Xue Yuan, Ruiyan Li, Liqun Chen, Zhen Wang & Xiaoyuan Ji. (2023) Calcium-based nanotechnology for cancer therapy. Coordination Chemistry Reviews 481, pages 215050.
Crossref
Fu-Sheng Liu, Chang Jiang, Zheng Li, Xiao-Bin Wang, Jing Li, Bing Wang, Guo-Hua Lv & Fu-Bing Liu. (2022) Ca2+ Regulates Autophagy Through CaMKKβ/AMPK/mTOR Signaling Pathway in Mechanical Spinal cord Injury: An in vitro Study. Neurochemical Research 48:2, pages 447-457.
Crossref
Yuxin Wang, Xiang Li, Shengji Zhou, Jiarui Li, Yi Zhu, Quan Wang & Fengchao Zhao. (2022) MCU Inhibitor Ruthenium Red Alleviates the Osteoclastogenesis and Ovariectomized Osteoporosis via Suppressing RANKL-Induced ROS Production and NFATc1 Activation through P38 MAPK Signaling Pathway. Oxidative Medicine and Cellular Longevity 2022, pages 1-27.
Crossref
Quangdon Tran, Hyunji Lee, Jae Hun Jung, Seung-Hee Chang, Robin Shrestha, Gyeyeong Kong, Jisoo Park, Seon-Hwan Kim, Kyu-Sang Park, Hyun-Woo Rhee, Jeanho Yun, Myung-Haing Cho, Kwang Pyo Kim & Jongsun Park. (2022) Emerging role of LETM1/GRP78 axis in lung cancer. Cell Death & Disease 13:6.
Crossref
Massimo Bonora, Carlotta Giorgi & Paolo Pinton. (2021) Molecular mechanisms and consequences of mitochondrial permeability transition. Nature Reviews Molecular Cell Biology 23:4, pages 266-285.
Crossref
He Pang, Tingrui Wu, Zhonghua Peng, Qichao Tan, Xin Peng, Zeyu Zhan, Lijun Song & Bo Wei. (2022) Baicalin induces apoptosis and autophagy in human osteosarcoma cells by increasing ROS to inhibit PI3K/Akt/mTOR, ERK1/2 and β-catenin signaling pathways. Journal of Bone Oncology 33, pages 100415.
Crossref
Wei Xiong Siow, Yaschar Kabiri, Rachel Tang, Yu-Kai Chao, Eva Plesch, Carola Eberhagen, Florian Flenkenthaler, Thomas Fröhlich, Franz Bracher, Christian Grimm, Martin Biel, Hans Zischka, Angelika M. Vollmar & Karin Bartel. (2022) Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells. Journal of Cell Science 135:6.
Crossref
Ashutosh Tripathi, Giselli Scaini, Tatiana Barichello, João Quevedo & Anilkumar Pillai. (2021) Mitophagy in depression: Pathophysiology and treatment targets. Mitochondrion 61, pages 1-10.
Crossref
Yuxin Wang, Xiang Li & Fengchao Zhao. (2021) MCU-Dependent mROS Generation Regulates Cell Metabolism and Cell Death Modulated by the AMPK/PGC-1α/SIRT3 Signaling Pathway. Frontiers in Medicine 8.
Crossref
Alberto Danese, Sara Leo, Alessandro Rimessi, Mariusz R. Wieckowski, Francesco Fiorica, Carlotta Giorgi & Paolo Pinton. (2021) Cell death as a result of calcium signaling modulation: A cancer-centric prospective. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1868:8, pages 119061.
Crossref
Zhengying Yu, Haipeng Wang, Wanyi Tang, Shaoyang Wang, Xiaoying Tian, Yujie Zhu & Hao He. (2021) Mitochondrial Ca2+ oscillation induces mitophagy initiation through the PINK1-Parkin pathway. Cell Death & Disease 12:7.
Crossref
Gemma L. Pearson, Morgan A. Gingerich, Emily M. Walker, Trevor J. Biden & Scott A. Soleimanpour. (2021) A Selective Look at Autophagy in Pancreatic β-Cells. Diabetes 70:6, pages 1229-1241.
Crossref
Manh Tien Tran. (2021) Overview of Ca2+ signaling in lung cancer progression and metastatic lung cancer with bone metastasis. Exploration of Targeted Anti-tumor Therapy.
Crossref
Massimo Bonora, Sonia Missiroli, Mariasole Perrone, Francesco Fiorica, Paolo Pinton & Carlotta Giorgi. (2021) Mitochondrial Control of Genomic Instability in Cancer. Cancers 13:8, pages 1914.
Crossref
Srimanta Patra, Kewal Kumar Mahapatra, Prakash Priyadarshi Praharaj, Debasna Pritimanjari Panigrahi, Chandra Sekhar Bhol, Soumya Ranjan Mishra, Bishnu Prasad Behera, Amruta Singh, Mrutyunjay Jena & Sujit Kumar Bhutia. (2021) Intricate role of mitochondrial calcium signalling in mitochondrial quality control for regulation of cancer cell fate. Mitochondrion 57, pages 230-240.
Crossref
Saverio Marchi & Lorenzo Galluzzi. 2021. Inter-Organellar Ca2+ Signaling in Health and Disease - Part B. Inter-Organellar Ca2+ Signaling in Health and Disease - Part B ix xv .
Saverio Marchi & Lorenzo Galluzzi. 2021. Inter-Organellar Ca2+ Signaling in Health and Disease - Part A. Inter-Organellar Ca2+ Signaling in Health and Disease - Part A xi xvii .
Eleni Georgiadou & Guy A. Rutter. (2020) Control by Ca2+ of mitochondrial structure and function in pancreatic β-cells. Cell Calcium 91, pages 102282.
Crossref
Hai-xia Xu, Su-mei Cui, Ying-mei Zhang & Jun Ren. (2020) Mitochondrial Ca2+ regulation in the etiology of heart failure: physiological and pathophysiological implications. Acta Pharmacologica Sinica 41:10, pages 1301-1309.
Crossref
Alessandro Rimessi, Chiara PozzatoLorenzo CarparelliAlice Rossi, Serena Ranucci, Ida De Fino, Cristina CiganaAnna Talarico, Mariusz R. Wieckowski, Carla M. P. Ribeiro, Claudio Trapella, Giacomo RossiGiulio CabriniAlessandra Bragonzi & Paolo Pinton. (2020) Pharmacological modulation of mitochondrial calcium uniporter controls lung inflammation in cystic fibrosis. Science Advances 6:19.
Crossref
Dankai Zhan, Xinxin Zhang, Jiahui LiXiaojiao DingYiXuan CuiJianguang Jia. (2020) MTH1 Inhibitor TH287 Suppresses Gastric Cancer Development Through the Regulation of PI3K/AKT Signaling. Cancer Biotherapy and Radiopharmaceuticals 35:3, pages 223-232.
Crossref
Carla Barceló, Pol Sisó, Oscar Maiques, Inés de la Rosa, Rosa M. Martí & Anna Macià. (2020) T-Type Calcium Channels: A Potential Novel Target in Melanoma. Cancers 12:2, pages 391.
Crossref
Peng Gao, Yanli Jiang, Hao Wu, Fang Sun, Yaohong Li, Hongbo He, Bin Wang, Zongshi Lu, Yingru Hu, Xiao Wei, Yuanting Cui, Chengkang He, Lijuan Wang, Hongting Zheng, Gangyi Yang, Daoyan Liu, Zhencheng Yan & Zhiming Zhu. (2020) Inhibition of Mitochondrial Calcium Overload by SIRT3 Prevents Obesity- or Age-Related Whitening of Brown Adipose Tissue. Diabetes 69:2, pages 165-180.
Crossref
Nicolas Rosa, Flore Sneyers, Jan B. Parys & Geert Bultynck. 2020. Cell Death Regulation in Health and Disease - Part A. Cell Death Regulation in Health and Disease - Part A 101 148 .
Ying Tang, Changxin Jia, Jianshuai He, Yang Zhao, Huayong Chen & Shilei Wang. (2019) The Application and Analytical Pathway of Dexmedetomidine in Ischemia/Reperfusion Injury. Journal of Analytical Methods in Chemistry 2019, pages 1-10.
Crossref
Juan Moreno-Felici, Petra Hyroššová, Marc Aragó, Sergio Rodríguez-Arévalo, Pablo M. García-Rovés, Carmen Escolano & Jose C. Perales. (2019) Phosphoenolpyruvate from Glycolysis and PEPCK Regulate Cancer Cell Fate by Altering Cytosolic Ca2+. Cells 9:1, pages 18.
Crossref
Pabbala Veeresh, Harpreet Kaur, Deepaneeta Sarmah, Leela Mounica, Geetesh Verma, Vignesh Kotian, Radhika Kesharwani, Kiran Kalia, Anupom Borah, Xin Wang, Kunjan R. Dave, Anne‐Marie Rodriguez, Dileep R. Yavagal & Pallab Bhattacharya. (2019) Endoplasmic reticulum–mitochondria crosstalk: from junction to function across neurological disorders. Annals of the New York Academy of Sciences 1457:1, pages 41-60.
Crossref
Diane Proudfoot. (2019) Calcium Signaling and Tissue Calcification. Cold Spring Harbor Perspectives in Biology 11:10, pages a035303.
Crossref
Xuan YangRuoyu ZhangKiichi NakahiraZhenglong Gu. (2019) Mitochondrial DNA Mutation, Diseases, and Nutrient-Regulated Mitophagy. Annual Review of Nutrition 39:1, pages 201-226.
Crossref
Yu Wang, Cuiqin Zhang, Zhenyu Shen, Ruirui Kou, Keqin Xie & Fuyong Song. (2019) Activation of PINK1-Parkin-dependent mitophagy in Tri-ortho-cresyl phosphate-treated Neuro2a cells. Chemico-Biological Interactions 308, pages 70-79.
Crossref
Simona Feno, Gaia Butera, Denis Vecellio Reane, Rosario Rizzuto & Anna Raffaello. (2019) Crosstalk between Calcium and ROS in Pathophysiological Conditions. Oxidative Medicine and Cellular Longevity 2019, pages 1-18.
Crossref
Marco Tulio Núñez & Cecilia Hidalgo. (2019) Noxious Iron–Calcium Connections in Neurodegeneration. Frontiers in Neuroscience 13.
Crossref
Dzhamilja Safiulina, Malle Kuum, Vinay Choubey, Nana Gogichaishvili, Joanna Liiv, Miriam A Hickey, Michal Cagalinec, Merle Mandel, Akbar Zeb, Mailis Liiv & Allen Kaasik. (2018) Miro proteins prime mitochondria for Parkin translocation and mitophagy. The EMBO Journal 38:2.
Crossref
Carlotta Giorgi, Saverio Marchi & Paolo Pinton. (2018) The machineries, regulation and cellular functions of mitochondrial calcium. Nature Reviews Molecular Cell Biology 19:11, pages 713-730.
Crossref
Carlotta Giorgi, Saverio Marchi, Ines C.M. Simoes, Ziyu Ren, Giampaolo Morciano, Mariasole Perrone, Paulina Patalas-Krawczyk, Sabine Borchard, Paulina Jędrak, Karolina Pierzynowska, Jędrzej Szymański, David Q. Wang, Piero Portincasa, Grzegorz Węgrzyn, Hans Zischka, Pawel Dobrzyn, Massimo Bonora, Jerzy Duszynski, Alessandro Rimessi, Agnieszka Karkucinska-Wieckowska, Agnieszka Dobrzyn, Gyorgy Szabadkai, Barbara Zavan, Paulo J. Oliveira, Vilma A. Sardao, Paolo Pinton & Mariusz R. Wieckowski. 2018. Mitochondria and Longevity. Mitochondria and Longevity 209 344 .
Alessandro Rimessi, Chiara Pavan, Elli Ioannidi, Federica Nigro, Claudia Morganti, Alberto Brugnoli, Francesco Longo, Chiara Gardin, Letizia Ferroni, Michele Morari, Vincenzo Vindigni, Barbara Zavan & Paolo Pinton. (2017) Protein Kinase C β: a New Target Therapy to Prevent the Long-Term Atypical Antipsychotic-Induced Weight Gain. Neuropsychopharmacology 42:7, pages 1491-1501.
Crossref
Sookkasem Khositseth, Komgrid Charngkaew, Chatikorn Boonkrai, Poorichaya Somparn, Panapat Uawithya, Nusara Chomanee, D. Michael Payne, Robert A. Fenton & Trairak Pisitkun. (2017) Hypercalcemia induces targeted autophagic degradation of aquaporin-2 at the onset of nephrogenic diabetes insipidus. Kidney International 91:5, pages 1070-1087.
Crossref
Isabella Canazza, Andrea Ossato, Fabrizio Vincenzi, Adolfo Gregori, Fabiana Di Rosa, Federica Nigro, Alessandro Rimessi, Paolo Pinton, Katia Varani, Pier Andrea Borea & Matteo Marti. (2017) Pharmaco-toxicological effects of the novel third-generation fluorinate synthetic cannabinoids, 5F-ADBINACA, AB-FUBINACA, and STS-135 in mice. In vitro and in vivo studies. Human Psychopharmacology: Clinical and Experimental 32:3, pages e2601.
Crossref
S. Marchi, M. Bonora, S. Patergnani, C. Giorgi & P. Pinton. 2017. Molecular Characterization of Autophagic Responses, Part B. Molecular Characterization of Autophagic Responses, Part B 171 186 .
S. Patergnani, V. Fossati, M. Bonora, C. Giorgi, S. Marchi, S. Missiroli, T. Rusielewicz, M.R. Wieckowski & P. Pinton. 2017. 49 103 .
Gemma Roest, Rita M. La Rovere, Geert Bultynck & Jan B. Parys. 2017. Membrane Dynamics and Calcium Signaling. Membrane Dynamics and Calcium Signaling 149 178 .
Lelin Hu, Hao Wang, Li Huang, Yong Zhao & Junjie Wang. (2016) Crosstalk between autophagy and intracellular radiation response (Review). International Journal of Oncology 49:6, pages 2217-2226.
Crossref
Avinash Chandel, Krishna K. Das & Anand K. Bachhawat. (2016) Glutathione depletion activates the yeast vacuolar transient receptor potential channel, Yvc1p, by reversible glutathionylation of specific cysteines. Molecular Biology of the Cell 27:24, pages 3913-3925.
Crossref
Alessandro Rimessi, Maurizio Previati, Federica Nigro, Mariusz R. Wieckowski & Paolo Pinton. (2016) Mitochondrial reactive oxygen species and inflammation: Molecular mechanisms, diseases and promising therapies. The International Journal of Biochemistry & Cell Biology 81, pages 281-293.
Crossref
Hao Wu, Huifang Wei, Sheikh Arslan Sehgal, Lei Liu & Quan Chen. (2016) Mitophagy receptors sense stress signals and couple mitochondrial dynamic machinery for mitochondrial quality control. Free Radical Biology and Medicine 100, pages 199-209.
Crossref
Eduardo Cremonese Filippi-Chiela, Michelle S. Viegas, Marcos Paulo Thomé, Andreia Buffon, Marcia R. Wink & Guido Lenz. (2016) Modulation of Autophagy by Calcium Signalosome in Human Disease. Molecular Pharmacology 90:3, pages 371-384.
Crossref
Shoushui Yu, Shengfa Zheng, Jing Leng, Shilei Wang, Tao Zhao & Jia Liu. (2016) Inhibition of mitochondrial calcium uniporter protects neurocytes from ischemia/reperfusion injury via the inhibition of excessive mitophagy. Neuroscience Letters 628, pages 24-29.
Crossref
Rita M.L. La Rovere, Gemma Roest, Geert Bultynck & Jan B. Parys. (2016) Intracellular Ca 2+ signaling and Ca 2+ microdomains in the control of cell survival, apoptosis and autophagy. Cell Calcium 60:2, pages 74-87.
Crossref
Mart Bittremieux, Jan B. Parys, Paolo Pinton & Geert Bultynck. (2016) ER functions of oncogenes and tumor suppressors: Modulators of intracellular Ca2+ signaling. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1863:6, pages 1364-1378.
Crossref
Qin-qin Li, Le Zhang, Hai-ying Wan, Min Liu, Xin Li & Hua Tang. (2015) CREB1-driven expression of miR-320a promotes mitophagy by down-regulating VDAC1 expression during serum starvation in cervical cancer cells. Oncotarget 6:33, pages 34924-34940.
Crossref
Ana Paula Arruda & Gökhan S. Hotamisligil. (2015) Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes. Cell Metabolism 22:3, pages 381-397.
Crossref
Simone Patergnani, Sonia Missiroli, Saverio Marchi & Carlotta Giorgi. (2015) Mitochondria-Associated Endoplasmic Reticulum Membranes Microenvironment: Targeting Autophagic and Apoptotic Pathways in Cancer Therapy. Frontiers in Oncology 5.
Crossref
Madhuri Chaurasia, Shashank Misra, Anant N. Bhatt, Asmita Das, Bilikere Dwarakanath & Kulbhushan Sharma. (2015) Metabolic Imbalance Associated Mitophagy in Tumor Cells: Genesis and Implications. Journal of Cancer Research Updates 4:2.
Crossref
Massimo Bonora, Paolo Pinton & Keisuke Ito. (2015) Mitochondrial control of hematopoietic stem cell balance and hematopoiesis. Frontiers in Biology 10:2, pages 117-124.
Crossref
F Rossin, M D'Eletto, L Falasca, S Sepe, S Cocco, G M Fimia, M Campanella, P G Mastroberardino, M G Farrace & M Piacentini. (2014) Transglutaminase 2 ablation leads to mitophagy impairment associated with a metabolic shift towards aerobic glycolysis. Cell Death & Differentiation 22:3, pages 408-418.
Crossref
Alessandro Rimessi, Valentino Bezzerri, Simone Patergnani, Saverio Marchi, Giulio Cabrini & Paolo Pinton. (2015) Mitochondrial Ca2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis. Nature Communications 6:1.
Crossref
Anthony K. Campbell. 2014. Intracellular Calcium. Intracellular Calcium 617 737 .
Massimo Bonora & Paolo Pinton. (2014) The Mitochondrial Permeability Transition Pore and Cancer: Molecular Mechanisms Involved in Cell Death. Frontiers in Oncology 4.
Crossref
Haidar Akl, Tamara Vervloessem, Santeri Kiviluoto, Mart Bittremieux, Jan B. Parys, Humbert De Smedt & Geert Bultynck. (2014) A dual role for the anti-apoptotic Bcl-2 protein in cancer: Mitochondria versus endoplasmic reticulum. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843:10, pages 2240-2252.
Crossref
James D. Johnson, Michael J. Bround & Tobias Albrecht. (2014) Ca 2+ -dependent Signal Transduction . Colloquium Series on Building Blocks of the Cell: Cell Structure and Function 2:3, pages 1-68.
Crossref
Saverio Marchi, Simone Patergnani & Paolo Pinton. (2014) The endoplasmic reticulum–mitochondria connection: One touch, multiple functions. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1837:4, pages 461-469.
Crossref
Steven Wink, Steven Hiemstra, Suzanna Huppelschoten, Erik Danen, Marije Niemeijer, Giel Hendriks, Harry Vrieling, Bram Herpers & Bob van de Water. (2014) Quantitative High Content Imaging of Cellular Adaptive Stress Response Pathways in Toxicity for Chemical Safety Assessment. Chemical Research in Toxicology 27:3, pages 338-355.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.