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Cell Adhesion & Migration Volume 6, 2012 - Issue 3
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Review

The mesenchymal tumor microenvironment

A drug-resistant niche

Edna Cukierman Cancer Biology Program; Fox Chase Cancer Center; Philadelphia PA USACorrespondence[email protected]
&
Daniel E. Bassi Cancer Biology Program; Fox Chase Cancer Center; Philadelphia PA USA
Pages 285-296 | Published online: 01 May 2012

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Vladimir M Perelmuter, Liubov A Tashireva, Olga E Savelieva, Evgeny V Denisov, Evgeniya V Kaigorodova, Marina V Zavyalova & Nadezhda V Cherdyntseva. (2019) Mechanisms behind prometastatic changes induced by neoadjuvant chemotherapy in the breast cancer microenvironment. Breast Cancer: Targets and Therapy 11, pages 209-219.
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Runbi Ji, Bin Zhang, Xu Zhang, Jianguo Xue, Xiao Yuan, Yongmin Yan, Mei Wang, Wei Zhu, Hui Qian & Wenrong Xu. (2015) Exosomes derived from human mesenchymal stem cells confer drug resistance in gastric cancer. Cell Cycle 14:15, pages 2473-2483.
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Jacky G. Goetz. (2012) Tumor microenvironment indoctrination. Cell Adhesion & Migration 6:3, pages 190-192.
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Hamidreza Aboulkheyr Es, Bahareh Bigdeli, Sareh Zhand, Amir R. Aref, Jean P. Thiery & Majid E. Warkiani. (2020) Mesenchymal stem cells induce PD‐L1 expression through the secretion of CCL5 in breast cancer cells. Journal of Cellular Physiology 236:5, pages 3918-3928.
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Tao Ran, ZhiJi Chen, LiWen Zhao, Wei Ran, JinYu Fan, SiYa Hong & ZhaoXia Yang. (2021) LAMB1 Is Related to the T Stage and Indicates Poor Prognosis in Gastric Cancer. Technology in Cancer Research & Treatment 20, pages 153303382110049.
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Tao Luo, Qiaoyuan Liu, Aihua Tan, Lixia Duan, Yuxian Jia, Li Nong, Jing Tang, Wenxian Zhou, Weimin Xie, Yongkui Lu, Qiang Yu & Yan Liu. (2020) Mesenchymal Stem Cell-Secreted Exosome Promotes Chemoresistance in Breast Cancer via Enhancing miR-21-5p-Mediated S100A6 Expression. Molecular Therapy - Oncolytics 19, pages 283-293.
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J. M. Houthuijzen & J. Jonkers. (2018) Cancer-associated fibroblasts as key regulators of the breast cancer tumor microenvironment. Cancer and Metastasis Reviews 37:4, pages 577-597.
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Stephanie Lemmo Ham, Pradip Shahi Thakuri, Madison Plaster, Jun Li, Kathryn E. Luker, Gary D. Luker & Hossein Tavana. (2017) Three-dimensional tumor model mimics stromal - breast cancer cells signaling. Oncotarget 9:1, pages 249-267.
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Sten Friberg & Andreas M. Nyström. (2016) NANOMEDICINE: will it offer possibilities to overcome multiple drug resistance in cancer?. Journal of Nanobiotechnology 14:1.
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Hongbing Gu, Runbi Ji, Xu Zhang, Mei Wang, Wei Zhu, Hui Qian, Yongchang Chen, Pengcheng Jiang & Wenrong Xu. (2016) Exosomes derived from human mesenchymal stem cells promote gastric cancer cell growth and migration via the activation of the Akt pathway. Molecular Medicine Reports 14:4, pages 3452-3458.
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Lijuan Yin, Fang Fang, Xinglei Song, Yan Wang, Gaoxiang Huang, Jie Su, Ning Hui & Jian Lu. (2016) The pro-adhesive and pro-survival effects of glucocorticoid in human ovarian cancer cells. Journal of Molecular Endocrinology 57:1, pages 61-72.
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Sithul Hima & Sreeharshan Sreeja. (2016) Modulatory role of 17 β -estradiol in the tumor microenvironment of thyroid cancer . IUBMB Life 68:2, pages 85-96.
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Sandra Schmitz, Gabriela Bindea, Roxana Irina Albu, Bernhard Mlecnik & Jean-Pascal Machiels. (2015) Cetuximab promotes epithelial to mesenchymal transition and cancer associated fibroblasts in patients with head and neck cancer. Oncotarget 6:33, pages 34288-34299.
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Florian Klemm & Johanna A. Joyce. (2015) Microenvironmental regulation of therapeutic response in cancer. Trends in Cell Biology 25:4, pages 198-213.
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Hamid Bolouri. (2015) Network dynamics in the tumor microenvironment. Seminars in Cancer Biology 30, pages 52-59.
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Anna Astashkina & David W. Grainger. (2014) Critical analysis of 3-D organoid in vitro cell culture models for high-throughput drug candidate toxicity assessments. Advanced Drug Delivery Reviews 69-70, pages 1-18.
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Irene Tadeo, Ana P. Berbegall, Luis M. Escudero, Tomás Ãlvaro & Rosa Noguera. (2014) Biotensegrity of the Extracellular Matrix: Physiology, Dynamic Mechanical Balance, and Implications in Oncology and Mechanotherapy. Frontiers in Oncology 4.
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Hideki Nakayama. (2014) Overexpression of fibronectin confers cell adhesion‑mediated drug resistance (CAM-DR) against 5-FU in oral squamous cell carcinoma cells. International Journal of Oncology.
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Sunitha Kakarla, Kevin KH Chow, Melinda Mata, Donald R Shaffer, Xiao-Tong Song, Meng-Fen Wu, Hao Liu, Lisa L Wang, David R Rowley, Klaus Pfizenmaier & Stephen Gottschalk. (2013) Antitumor Effects of Chimeric Receptor Engineered Human T Cells Directed to Tumor Stroma. Molecular Therapy 21:8, pages 1611-1620.
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Felix Nwajei & Marina Konopleva. (2013) The Bone Marrow Microenvironment as Niche Retreats for Hematopoietic and Leukemic Stem Cells. Advances in Hematology 2013, pages 1-8.
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Xiaoli Wang, Sonam Prakash, Min Lu, Joseph Tripodi, Fei Ye, Vesna Najfeld, Yan Li, Myron Schwartz, Rona Weinberg, Paul Roda, Attilio Orazi & Ronald Hoffman. (2012) Spleens of myelofibrosis patients contain malignant hematopoietic stem cells. Journal of Clinical Investigation 122:11, pages 3888-3899.
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Maria Håkanson, Stefan Kobel, Matthias P. Lutolf, Marcus Textor, Edna Cukierman & Mirren Charnley. (2012) Controlled Breast Cancer Microarrays for the Deconvolution of Cellular Multilayering and Density Effects upon Drug Responses. PLoS ONE 7:6, pages e40141.
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