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Commentary

The tumor suppressor gene ARHI(DIRAS3) inhibits ovarian cancer cell migration through multiple mechanisms

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Pages 232-236 | Received 15 Nov 2012, Accepted 17 Jan 2013, Published online: 28 Jan 2013

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Peng Kuang, An Xie, Jianxiong Deng, Jiaming Tang, Peijun Wang & Feng Yu. (2022) GTP-binding protein Di-RAS3 diminishes the migration and invasion of non-small cell lung cancer by inhibiting the RAS/extracellular-regulated kinase pathway. Bioengineered 13:3, pages 5663-5674.
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Takashi Saitoh, Ha-Neul Kim, Riku Narita, Ibuki Ohtsuka, Weiyu Mo, Ki-Young Lee, Masahiro Enomoto, Geneviève M.C. Gasmi-Seabrook, Christopher B. Marshall & Mitsuhiko Ikura. (2023) Biochemical and biophysical characterization of the RAS family small GTPase protein DiRAS3. Protein Expression and Purification 212, pages 106361.
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Iveta Yotova, Katharina Proestling, Isabella Haslinger, Matthias Witzmann-Stern, Barbara Widmar, Lorenz Kuessel, Heinrich Husslein, René Wenzl & Quanah J Hudson. (2023) DIRAS3 regulates autophagy in an endometriosis epithelial cell line. Reproductive BioMedicine Online 47:4, pages 103251.
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Pengfei Xu, Sujuan Xu, Haiyue Pan, Chencheng Dai, Yiran Xu, Luyao Wang, Yu Cong, Huilin Zhang, Jian Cao, Lili Ge & Xuemei Jia. (2023) Differential effects of the LncRNA RNF157-AS1 on epithelial ovarian cancer cells through suppression of DIRAS3- and ULK1-mediated autophagy. Cell Death & Disease 14:2.
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Wenli Xue, Hongbo Zhu, Hongye Liu & Hongxia He. (2022) DIRAS2 Is a Prognostic Biomarker and Linked With Immune Infiltrates in Melanoma. Frontiers in Oncology 12.
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Gamze Bildik, Xiaowen Liang, Margie N. Sutton, Robert C. BastJrJr & Zhen Lu. (2022) DIRAS3: An Imprinted Tumor Suppressor Gene that Regulates RAS and PI3K-driven Cancer Growth, Motility, Autophagy, and Tumor Dormancy. Molecular Cancer Therapeutics 21:1, pages 25-37.
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Xue-Ling Xu, Shou-Long Deng, Zheng-Xing Lian & Kun Yu. (2021) Resveratrol Targets a Variety of Oncogenic and Oncosuppressive Signaling for Ovarian Cancer Prevention and Treatment. Antioxidants 10:11, pages 1718.
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Jinsoo Ahn, In-Sul Hwang, Mi-Ryung Park, Seongsoo Hwang & Kichoon Lee. (2021) Genomic Imprinting at the Porcine DIRAS3 Locus. Animals 11:5, pages 1315.
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Alicia M. Blessing, Janice M. Santiago‐O'Farrill, Weiqun Mao, Lan Pang, Jing Ning, Daewoo Pak, Lakshmi Reddy Bollu, Philip Rask, LaKesla Iles, Hailing Yang, Samantha Tran, Ezzeddine Elmir, Geoffrey Bartholomeusz, Robert Langley, Zhen Lu & Robert C. BastJrJr. (2020) Elimination of dormant, autophagic ovarian cancer cells and xenografts through enhanced sensitivity to anaplastic lymphoma kinase inhibition. Cancer 126:15, pages 3579-3592.
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Xiaozhuan Liu, Tingting Zhang, Yanjun Li, Yuwei Zhang, Hui Zhang, Xiangdong Wang & Li Li. 2020. Single-cell Sequencing and Methylation. Single-cell Sequencing and Methylation 123 132 .
Zeinab Safarpour Lima, Mostafa Ghadamzadeh, Farzad Tahmasebi Arashloo, Ghazaleh Amjad, Mohammad Reza Ebadi & Ladan Younesi. (2019) Recent advances of therapeutic targets based on the molecular signature in breast cancer: genetic mutations and implications for current treatment paradigms. Journal of Hematology & Oncology 12:1.
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Xueli Li, Shuiping Liu, Xiao Fang, Chao He & Xiaotong Hu. (2018) The mechanisms of DIRAS family members in role of tumor suppressor. Journal of Cellular Physiology 234:5, pages 5564-5577.
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Jingping Qiu, Xiaoting Li, Yingjian He, Dan Sun, Wenhui Li & Yan Xin. (2018) Distinct subgroup of the Ras family member 3 (DIRAS3) expression impairs metastasis and induces autophagy of gastric cancer cells in mice. Journal of Cancer Research and Clinical Oncology 144:10, pages 1869-1886.
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Li-Xia Zhong, Jun-Hua Nie, Jia Liu & Li-Zhu Lin. (2018) Correlation of ARHI upregulation with growth suppression and STAT3 inactivation in resveratrol-treated ovarian cancer cells. Cancer Biomarkers 21:4, pages 787-795.
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Paola Tiberio, Ludmila Lozneanu, Valentina Angeloni, Elena Cavadini, Patrizia Pinciroli, Maurizio Callari, Maria Luisa Carcangiu, Domenica Lorusso, Francesco Raspagliesi, Valentina Pala, Maria Grazia Daidone & Valentina Appierto. (2017) Involvement of AF1q/MLLT11 in the progression of ovarian cancer. Oncotarget 8:14, pages 23246-23264.
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Alessandra Ferraresi, Suratchanee Phadngam, Federica Morani, Alessandra Galetto, Oscar Alabiso, Giovanna Chiorino & Ciro Isidoro. (2017) Resveratrol inhibits IL-6-induced ovarian cancer cell migration through epigenetic up-regulation of autophagy. Molecular Carcinogenesis 56:3, pages 1164-1181.
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Argentina Ornelas, Christopher R. McCullough, Zhen Lu, Niki M. Zacharias, Lindsay E. Kelderhouse, Joshua Gray, Hailing Yang, Brian J. Engel, Yan Wang, Weiqun Mao, Margie N. Sutton, Pratip K. Bhattacharya, Robert C. BastJr.Jr. & Steven W. Millward. (2016) Induction of autophagy by ARHI (DIRAS3) alters fundamental metabolic pathways in ovarian cancer models. BMC Cancer 16:1.
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Kannan Muthu, Manivel Panneerselvam, Nishith Saurav Topno, Manikandan Jayaraman & Krishna Ramadas. (2015) Structural perspective of ARHI mediated inhibition of STAT3 signaling: An insight into the inactive to active transition of ARHI and its interaction with STAT3 and importinβ. Cellular Signalling 27:4, pages 739-755.
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Ana-Maria Dragoi, Rachel Swiss, Beile Gao & Hervé Agaisse. (2014) Novel Strategies to Enforce an Epithelial Phenotype in Mesenchymal Cells. Cancer Research 74:14, pages 3659-3672.
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Qiaoying Zhu, Jianming Hu, Huijuan Meng, Yufei Shen, Jinhua Zhou & Zhihong Zhu. (2014) S-Phase Cell Cycle Arrest, Apoptosis, and Molecular Mechanisms of Aplasia Ras homolog Member I?Induced Human Ovarian Cancer SKOV3 Cell Lines. International Journal of Gynecological Cancer 24:4, pages 629-634.
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Xiaoxiao Zuo, Yan Qin, Xiaojin Zhang, Qian Ning, Shan Shao, Minna Luo, Na Yuan, Shangke Huang & Xinhan Zhao. (2014) Breast cancer cells are arrested at different phases of the cell cycle following the re-expression of ARHI. Oncology Reports.
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Jing Chen, Songsheng Shi, Weizhong Yang & Chunmei Chen. (2014) Over-expression of ARHI decreases tumor growth, migration, and invasion in human glioma. Medical Oncology 31:3.
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B Liu, X Wen & Y Cheng. (2013) Survival or death: disequilibrating the oncogenic and tumor suppressive autophagy in cancer. Cell Death & Disease 4:10, pages e892-e892.
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Malwina Niemczyk, Yoko Ito, Joanna Huddleston, Anna Git, Sayeda Abu-Amero, Carlos Caldas, Gudrun E. Moore, Lovorka Stojic & Adele Murrell. (2013) Imprinted Chromatin around DIRAS3 Regulates Alternative Splicing of GNG12-AS1, a Long Noncoding RNA. The American Journal of Human Genetics 93:2, pages 224-235.
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