Advanced search
Publication Cover
Cancer Biology & Therapy Volume 11, 2011 - Issue 5
Submit an article Journal homepage
984
Views
70
CrossRef citations to date
0
Altmetric
Research Paper

BMP-2 inhibits the tumorigenicity of cancer stem cells in human osteosarcoma OS99-1 cell line

Lin Wang University of Michigan Medical School, Ann Arbor, MI USA
,
Paul Park Spine Research Laboratory, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan
,
Huina Zhang University of Michigan Medical School, Ann Arbor, MI USA
,
Frank La Marca University of Michigan Medical School, Ann Arbor, MI USA
,
Amy Claeson University of Michigan Medical School, Ann Arbor, MI USA
,
Juan Valdivia University of Michigan Medical School, Ann Arbor, MI USA
&
Chia-Ying Lin Spine Research Laboratory, Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan Correspondence[email protected]
 show all
Pages 457-463 | Received 03 Aug 2010, Accepted 03 Dec 2010, Published online: 01 Mar 2011

Citations (70)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Qisheng Xiong, Xuesong Wang, Lizhen Wang, Yan Huang, Xiaodong Tian, Yubo Fan & Chia-Ying Lin. (2018) BMP-2 inhibits lung metastasis of osteosarcoma: an early investigation using an orthotopic model. OncoTargets and Therapy 11, pages 7543-7553.
Read now

Articles from other publishers (69)

Wei Zhou, Kun Yan & Qiaoran Xi. (2023) BMP signaling in cancer stemness and differentiation. Cell Regeneration 12:1.
Crossref
Boren Tian, Xiaoyun Du, Shiyu Zheng & Yan Zhang. (2022) The Role of Tumor Microenvironment in Regulating the Plasticity of Osteosarcoma Cells. International Journal of Molecular Sciences 23:24, pages 16155.
Crossref
Tong-tong Li, Yong-wei Lai, Xu Han, Xin Niu & Peng-xia Zhang. (2022) BMP2 as a promising anticancer approach: functions and molecular mechanisms. Investigational New Drugs 40:6, pages 1322-1332.
Crossref
Weifei Zhang, Liangchen Wei, Jian Weng, Fei Yu, Haotian Qin, Deli Wang & Hui Zeng. (2022) Advances in the research of osteosarcoma stem cells and its related genes. Cell Biology International 46:3, pages 336-343.
Crossref
Bénédicte Brounais Le-Royer & Frédéric Lézot. 2022. Bone Cancer. Bone Cancer 221 239 .
Aglaia Mantsou, Maria Pitou, Eleni Papachristou, Rigini M. Papi, Paraskevas Lamprou & Theodora Choli-Papadopoulou. (2021) Effect of a Bone Morphogenetic Protein-2-derived peptide on the expression of tumor marker ZNF217 in osteoblasts and MCF-7 cells. Bone Reports 15, pages 101125.
Crossref
Chunfeng Xu, Mingjie Wang, Behrouz Zandieh-Doulabi, Wei Sun, Lingfei Wei & Yuelian Liu. (2021) To B (Bone Morphogenic Protein-2) or Not to B (Bone Morphogenic Protein-2): Mesenchymal Stem Cells May Explain the Protein’s Role in Osteosarcomagenesis. Frontiers in Cell and Developmental Biology 9.
Crossref
Alishba Maryam & Y. Rebecca Chin. (2021) ANLN Enhances Triple-Negative Breast Cancer Stemness Through TWIST1 and BMP2 and Promotes its Spheroid Growth. Frontiers in Molecular Biosciences 8.
Crossref
Claudia Maria Hattinger, Maria Pia Patrizio, Leonardo Fantoni, Chiara Casotti, Chiara Riganti & Massimo Serra. (2021) Drug Resistance in Osteosarcoma: Emerging Biomarkers, Therapeutic Targets and Treatment Strategies. Cancers 13:12, pages 2878.
Crossref
Houping Chen, Runsang Pan, Hao Li, Wenguang Zhang, Chong Ren, Qiaoying Lu, Hui Chen, Xiangyan Zhang & Yingjie Nie. (2021) CHRDL2 promotes osteosarcoma cell proliferation and metastasis through the BMP‐9/PI3K/AKT pathway. Cell Biology International 45:3, pages 623-632.
Crossref
Georg Sedlmeier, Vanessa Al‐Rawi, Justyna Buchert, Klaus Yserentant, Melanie Rothley, Anastasia Steshina, Simone Gräßle, Ruo‐Lin Wu, Thomas Hurrle, Wilfrid Richer, Charles Decraene, Wilko Thiele, Jochen Utikal, Wasim Abuillan, Motomu Tanaka, Dirk‐Peter Herten, Caroline S. Hill, Boyan K. Garvalov, Nicole Jung, Stefan Bräse & Jonathan P. Sleeman. (2020) Id1 and Id3 Are Regulated Through Matrix‐Assisted Autocrine BMP Signaling and Represent Therapeutic Targets in Melanoma. Advanced Therapeutics 4:2, pages 2000065.
Crossref
Joseph K. Kendal, Arvind Singla, Asmaa Affan, Kurt Hildebrand, Abdullah Al-Ani, Mark Ungrin, Douglas J. Mahoney, Doha Itani, Frank R. Jirik & Michael J. Monument. (2020) Is Use of BMP-2 Associated with Tumor Growth and Osteoblastic Differentiation in Murine Models of Osteosarcoma?. Clinical Orthopaedics & Related Research 478:12, pages 2921-2933.
Crossref
Chao Wang, Yunqing Chen, Hongfei Xiang, Xiaolin Wu, Qian Tang, Xuexiao Ma & Lu Zhang. (2020) ADAMTS7 degrades Comp to fuel BMP2‐dependent osteogenic differentiation and ameliorate oncogenic potential in osteosarcomas. FEBS Open Bio 10:9, pages 1856-1867.
Crossref
Zhenhua Zhou, Yan Li, Muyu Kuang, Xudong Wang, Qi Jia, Jiashi Cao, Jingjing Hu, Sujia Wu, Zhiwei Wang & Jianru Xiao. (2020) The CD24+ cell subset promotes invasion and metastasis in human osteosarcoma. EBioMedicine 51, pages 102598.
Crossref
Pierrick G.J. Fournier, Liria M. Fajardo-Yamamoto & Patricia Juárez. 2020. Encyclopedia of Bone Biology. Encyclopedia of Bone Biology 281 293 .
Abul Arif, Marc F. Hansen, Cynthia B. Alander, David K. Monson, Nickolas B. Reimer & Hicham Drissi. (2019) Cancer Stem Cells and Osteosarcoma: Opportunities and Limitations. Techniques in Orthopaedics 34:4, pages 275-286.
Crossref
Yongjie Wang, Lin Zeng, Chao Liang, Rui Zan, Weiping Ji, Zhichang Zhang, Yuxuan Wei, Shikui Tu & Yang Dong. (2019) Integrated analysis of transcriptome-wide m 6 A methylome of osteosarcoma stem cells enriched by chemotherapy . Epigenomics 11:15, pages 1693-1715.
Crossref
Valer, Sánchez-de-Diego, Pimenta-Lopes, Rosa & Ventura. (2019) ACVR1 Function in Health and Disease. Cells 8:11, pages 1366.
Crossref
Cristina Sánchez-de-Diego, José Antonio Valer, Carolina Pimenta-Lopes, José Luis Rosa & Francesc Ventura. (2019) Interplay between BMPs and Reactive Oxygen Species in Cell Signaling and Pathology. Biomolecules 9:10, pages 534.
Crossref
Maria R. Ward Rashidi, Pooja Mehta, Michael Bregenzer, Shreya Raghavan, Elyse M. Fleck, Eric N. Horst, Zainab Harissa, Visweswaran Ravikumar, Samuel Brady, Andrea Bild, Arvind Rao, Ronald J. Buckanovich & Geeta Mehta. (2019) Engineered 3D Model of Cancer Stem Cell Enrichment and Chemoresistance. Neoplasia 21:8, pages 822-836.
Crossref
Haijun Tian, Tangjun Zhou, Hongfang Chen, Chenshuang Li, Ziyue Jiang, Lifeng Lao, Suzana Assad Kahn, Maria Eugenia Leite Duarte, Jie Zhao, Michael D. Daubs, Zorica Buser, Elsa J. Brochmann, Jeffrey C. Wang & Samuel S. Murray. (2019) Bone morphogenetic protein‐2 promotes osteosarcoma growth by promoting epithelial‐mesenchymal transition (EMT) through the Wnt/β‐catenin signaling pathway. Journal of Orthopaedic Research 37:7, pages 1638-1648.
Crossref
Xueqing Chen & Yingjian Zhang. (2019) BMP‑2 and miR‑29c in osteosarcoma tissues on proliferation and invasion of osteosarcoma cells. Oncology Letters.
Crossref
Xinhua Xi, Qiang Wu, Yongzheng Bao, Maoren Lin, Xueren Zhong, Xiangheng Dai & Hongsheng Lin. (2019) Overexpression of TBL1XR1 confers tumorigenic capability and promotes recurrence of osteosarcoma. European Journal of Pharmacology 844, pages 259-267.
Crossref
V. S. Kuznetsova, A. V. Vasilyev, T. B. Buharova, D. V. Goldshtein & A. A. Kulakov. (2019) Safety and efficacy of BMP-2 and BMP-7 use in dentistry. Stomatologiya 98:1, pages 64.
Crossref
Jiri Hatina, Michaela Kripnerova, Katerina Houfkova, Martin Pesta, Jitka Kuncova, Jiri Sana, Ondrej Slaby & René Rodríguez. 2019. Stem Cells Heterogeneity - Novel Concepts. Stem Cells Heterogeneity - Novel Concepts 95 118 .
R. E. G. Rici, S. E. A. L. Will, A. C. L. Luna, L. F. Melo, A. C. Santos, R. F. Rodrigues, R. M. Leandro & D. A. Maria. (2018) Combination therapy of canine osteosarcoma with canine bone marrow stem cells, bone morphogenetic protein and carboplatin in an in vivo model. Veterinary and Comparative Oncology 16:4, pages 478-488.
Crossref
Peide Huang, Anan Chen, Weiyi He, Zhen Li, Guanglin Zhang, Zhong Liu, Ge Liu, Xueting Liu, Shuilian He, Gang Xiao, Feicheng Huang, Jan Stenvang, Nils Brünner, An Hong & Ju Wang. (2017) BMP-2 induces EMT and breast cancer stemness through Rb and CD44. Cell Death Discovery 3:1.
Crossref
Meng-He Wang, Xiao-Min Zhou, Mei-Yin Zhang, Lu Shi, Ruo-Wen Xiao, Li-Si Zeng, Xian-Zi Yang, X.F. Steven Zheng, Hui-Yun Wang & Shi-Juan Mai. (2017) BMP2 promotes proliferation and invasion of nasopharyngeal carcinoma cells via mTORC1 pathway. Aging 9:4, pages 1326-1340.
Crossref
Haijun Tian, Jie Zhao, Elsa J. Brochmann, Jeffrey C. Wang & Samuel S. Murray. (2017) Bone morphogenetic protein-2 and tumor growth: Diverse effects and possibilities for therapy. Cytokine & Growth Factor Reviews 34, pages 73-91.
Crossref
Jonathan Gill, Patrick Connolly, Michael Roth, So Hak Chung, Wendong Zhang, Sajida Piperdi, Bang Hoang, Rui Yang, Hillary Guzik, Jonathan Morris, Richard Gorlick & David S. Geller. (2017) The effect of bone morphogenetic protein-2 on osteosarcoma metastasis. PLOS ONE 12:3, pages e0173322.
Crossref
E. Fomekong, D. Dufrane, B. Vande Berg, W. Andr?N. Aouassar, S. Veriter & C. Raftopoulos. (2016) Application of a three-dimensional graft of autologous osteodifferentiated adipose stem cells in patients undergoing minimally invasive transforaminal lumbar interbody fusion: clinical proof of concept. Acta Neurochirurgica 159:3, pages 527-536.
Crossref
Jian Sun, Xuan Liu, Hong Gao, Long Zhang, Qing Ji, Ziyuan Wang, Lihong Zhou, Yan Wang, Hua Sui, Zhongze Fan & Qi Li. (2016) Overexpression of colorectal cancer oncogene CHRDL2 predicts a poor prognosis. Oncotarget 8:7, pages 11489-11506.
Crossref
Yu-Hua Zeng, Lin-Yun Zhou, Qian-Zhao Chen, Yang Li, Ying Shao, Wen-Yan Ren, Yun-Peng Liao, Han Wang, Jia-Hui Zhu, Ming Huang, Fang He, Jin Wang, Ke Wu & Bai-Cheng He. (2017) Resveratrol inactivates PI3K/Akt signaling through upregulating BMP7 in human colon cancer cells. Oncology Reports 38:1, pages 456-464.
Crossref
Myrto Bami, Andreas F. Mavrogenis, Andrea Angelini, Mandy Milonaki, Evanthia Mitsiokapa, Dimitrios Stamoulis & Panayotis N. Soucacos. (2016) Bone morphogenetic protein signaling in musculoskeletal cancer. Journal of Cancer Research and Clinical Oncology 142:10, pages 2061-2072.
Crossref
Zuozhang Yang, Xiaojuan Li, Yihao Yang, Zewei He, Xin Qu & Ya Zhang. (2016) Long noncoding RNAs in the progression, metastasis, and prognosis of osteosarcoma. Cell Death & Disease 7:9, pages e2389-e2389.
Crossref
Khaled Waleed Zaid, Mansour Chantiri & Ghassan Bassit. (2016) Recombinant Human Bone Morphogenetic Protein-2 in Development and Progression of Oral Squamous Cell Carcinoma. Asian Pacific Journal of Cancer Prevention 17:3, pages 927-932.
Crossref
Anna Julie Peired, Alessandro Sisti & Paola Romagnani. (2016) Renal Cancer Stem Cells: Characterization and Targeted Therapies. Stem Cells International 2016, pages 1-12.
Crossref
Tomohiro Fujiwara & Toshifumi Ozaki. (2016) Overcoming Therapeutic Resistance of Bone Sarcomas: Overview of the Molecular Mechanisms and Therapeutic Targets for Bone Sarcoma Stem Cells. Stem Cells International 2016, pages 1-13.
Crossref
Guang-Ning Yan, Yang-Fan Lv & Qiao-Nan Guo. (2016) Advances in osteosarcoma stem cell research and opportunities for novel therapeutic targets. Cancer Letters 370:2, pages 268-274.
Crossref
Branko Skovrlj, Steven M. Koehler, Paul A. Anderson, Sheeraz A. Qureshi, Andrew C. Hecht, James C. Iatridis & Samuel K. Cho. (2015) Association Between BMP-2 and Carcinogenicity. SPINE 40:23, pages 1862-1871.
Crossref
Miao Zhou, Xin Peng, Chi Mao, Jia-he Tian, Shu-wen Zhang, Fang Xu, Jing-jing Tu, Sheng Liu, Min Hu & Guang-yan Yu. (2015) The Value of SPECT/CT in Monitoring Prefabricated Tissue-Engineered Bone and Orthotopic rhBMP-2 Implants for Mandibular Reconstruction. PLOS ONE 10:9, pages e0137167.
Crossref
David S. Geller, Jonathan Gill, Michael Roth & Richard Gorlick. (2015) To B(MP-2) or Not To B(MP-2): Cytokines and Tumor Surgery—Letter. Clinical Cancer Research 21:17, pages 4022-4022.
Crossref
Arantzazu Alfranca, Lucia Martinez-Cruzado, Juan Tornin, Ander Abarrategi, Teresa Amaral, Enrique de Alava, Pablo Menendez, Javier Garcia-Castro & Rene Rodriguez. (2015) Bone microenvironment signals in osteosarcoma development. Cellular and Molecular Life Sciences 72:16, pages 3097-3113.
Crossref
David S. Geller, Michael Y. Singh, Wendong Zhang, Jonathan Gill, Michael E. Roth, Mimi Y. Kim, Xianhong Xie, Christopher K. Singh, Howard D. Dorfman, Esperanza Villanueva-Siles, Amy Park, Sajida Piperdi & Richard Gorlick. (2015) Development of a Model System to Evaluate Local Recurrence in Osteosarcoma and Assessment of the Effects of Bone Morphogenetic Protein-2. Clinical Cancer Research 21:13, pages 3003-3012.
Crossref
Lin Wang, Paul Park, Frank La Marca, Khoi D. Than & Chia-Ying Lin. (2014) BMP-2 inhibits tumor-initiating ability in human renal cancer stem cells and induces bone formation. Journal of Cancer Research and Clinical Oncology 141:6, pages 1013-1024.
Crossref
Yu Cong, Cheng-Jun Li, Jian-Ning Zhao, Xiao-Zhou Liu & Xin Shi. (2014) Associations of polymorphisms in the bone morphogenetic protein-2 gene with risk and prognosis of osteosarcoma in a Chinese population. Tumor Biology 36:3, pages 2059-2064.
Crossref
Virginia Tirino, Francesca Paino, Federica Papaccio, Marcella La Noce, Gianpaolo Papaccio & Vincenzo Desiderio. 2015. Bone Cancer. Bone Cancer 205 211 .
Pierre J. Marie, Olivia Fromigué & Dominique Modrowski. 2015. Bone Cancer. Bone Cancer 39 54 .
Ali Khammanivong, Raj Gopalakrishnan & Erin B Dickerson. (2014) SMURF1 silencing diminishes a CD44-high cancer stem cell-like population in head and neck squamous cell carcinoma. Molecular Cancer 13:1.
Crossref
Alan Nguyen, Michelle A. Scott, Sarah M. Dry & Aaron W. James. (2014) Roles of bone morphogenetic protein signaling in osteosarcoma. International Orthopaedics 38:11, pages 2313-2322.
Crossref
Ying Zheng, Xuemei Wang, Haidong Wang, Wei Yan, Quan Zhang & Xin Chang. (2014) Bone morphogenetic protein 2 inhibits hepatocellular carcinoma growth and migration through downregulation of the PI3K/AKT pathway. Tumor Biology 35:6, pages 5189-5198.
Crossref
Kenneth Yan, Qiulian Wu, Diana H. Yan, Christine H. Lee, Nasiha Rahim, Isabel Tritschler, Jennifer DeVecchio, Matthew F. Kalady, Anita B. Hjelmeland & Jeremy N. Rich. (2014) Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy. Genes & Development 28:10, pages 1085-1100.
Crossref
Ruth Rubio, Ander Abarrategi, Javier Garcia‐Castro, Lucia Martinez‐Cruzado, Carlos Suarez, Juan Tornin, Laura Santos, Aurora Astudillo, Isabel Colmenero, Francisca Mulero, Michael Rosu‐Myles, Pablo Menendez & Rene Rodriguez. (2014) Bone Environment is Essential for Osteosarcoma Development from Transformed Mesenchymal Stem Cells. STEM CELLS 32:5, pages 1136-1148.
Crossref
Madonna M. McManus, Kurt R. Weiss & Dennis P. M. Hughes. 2014. Current Advances in Osteosarcoma. Current Advances in Osteosarcoma 67 92 .
Jessica L. Brusgard & Antonino Passaniti. 2014. Nuclear Signaling Pathways and Targeting Transcription in Cancer. Nuclear Signaling Pathways and Targeting Transcription in Cancer 57 86 .
Qiong Shi. (2013) Bone morphogenetic protein 9 regulates tumor growth of osteosarcoma cells through the Wnt/β-catenin pathway. Oncology Reports.
Crossref
Rohit Duggal, Ulrike Geissinger, Qian Zhang, Jason Aguilar, Nanhai G Chen, Elena Binda, Angelo L Vescovi & Aladar A Szalay. (2013) Vaccinia virus expressing bone morphogenetic protein-4 in novel glioblastoma orthotopic models facilitates enhanced tumor regression and long-term survival. Journal of Translational Medicine 11:1.
Crossref
Marica Gemei, Claudia Corbo, Francesca D'Alessio, Rosa Di Noto, Renza Vento & Luigi Del Vecchio. (2013) Surface proteomic analysis of differentiated versus stem-like osteosarcoma human cells. PROTEOMICS 13:22, pages 3293-3297.
Crossref
Upal Basu-Roy, Claudio Basilico & Alka Mansukhani. (2013) Perspectives on cancer stem cells in osteosarcoma. Cancer Letters 338:1, pages 158-167.
Crossref
Chia-Ying Lin. (2013) Bone formation induced by BMP-2 in human osteosarcoma cells. International Journal of Oncology.
Crossref
Riccardo Di Fiore, Daniele Fanale, Rosa Drago-Ferrante, Ferdinando Chiaradonna, Michela Giuliano, Anna De Blasio, Valeria Amodeo, Lidia R. Corsini, Viviana Bazan, Giovanni Tesoriere, Renza Vento & Antonio Russo. (2013) Genetic and molecular characterization of the human Osteosarcoma 3AB-OS cancer stem cell line: A possible model for studying osteosarcoma origin and stemness. Journal of Cellular Physiology 228:6, pages 1189-1201.
Crossref
Amitabha Bandyopadhyay, Prem Swaroop Yadav & Paritosh Prashar. (2013) BMP signaling in development and diseases: A pharmacological perspective. Biochemical Pharmacology 85:7, pages 857-864.
Crossref
Hyunjin Park, Olivier Drevelle, Alex Daviau, Helena Senta, Eric Bergeron & Nathalie Faucheux. (2013) Preventing MEK1 activation influences the responses of human osteosarcoma cells to bone morphogenetic proteins 2 and 9. Anti-Cancer Drugs 24:3, pages 278-290.
Crossref
Rose Eli Grassi Rici, Dayane Alcântara, Paula Fratini, Cristiane Valverde Wenceslau, Carlos Eduardo Ambrósio, Maria Angelica Miglino & Durvanei Augusto Maria. (2012) Mesenchymal stem cells with rhBMP-2 inhibits the growth of canine osteosarcoma cells. BMC Veterinary Research 8:1.
Crossref
Lin Wang, Paul Park, Huina Zhang, Frank La Marca, Amy Claeson, Khoi Than, Shayan Rahman & Chia-Ying Lin. (2012) BMP-2 inhibits tumor growth of human renal cell carcinoma and induces bone formation. International Journal of Cancer 131:8, pages 1941-1950.
Crossref
X-Y Ye, X-M. Niu, N-W. Tang, Y-H. Xu, Z-M. Li, Y-F. Yu, S. Lu & Z-W. Chen. (2012) Adenovirus Mediated Knockdown and Bone Morphogenetic Protein 2 Inhibits Human Lung Cancer Growth and Invasion In Vitro and in Vivo . International Journal of Immunopathology and Pharmacology 25:4, pages 967-976.
Crossref
Wesley Hsu, Ahmed Mohyeldin, Sagar R. Shah, Ziya L. Gokaslan & Alfredo Quinones-Hinojosa. (2012) Role of Cancer Stem Cells in Spine Tumors. Neurosurgery 71:1, pages 117-125.
Crossref
Lin Wang, Paul Park, Frank La Marca, Khoi Than, Shayan Rahman & Chia-Ying Lin. (2012) Advancements in Suppression of Osteosarcoma Tumorigenicity: A Prospective Look. Journal of Cancer Therapy 03:04, pages 327-330.
Crossref
M. Reza Sadaie. (2011) Can heparins stimulate bone cancer stem cells and interfere with tumorigenesis?. Therapeutic Advances in Drug Safety 2:6, pages 271-282.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.