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Cancer Biology & Therapy Volume 12, 2011 - Issue 12
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Research Paper

Cardiac and gastrointestinal liabilities caused by deficiency in the immune modulatory enzyme indoleamine 2,3-dioxygenase

Mee Young Chang Lankenau Institute for Medical Research; Wynnewood, PA USA
,
Courtney Smith Lankenau Institute for Medical Research; Wynnewood, PA USA
,
James B. DuHadaway Lankenau Institute for Medical Research; Wynnewood, PA USA
,
Jennifer R. Pyle Lankenau Institute for Medical Research; Wynnewood, PA USA
,
Janette Boulden Lankenau Institute for Medical Research; Wynnewood, PA USA
,
Alejandro Peralta Soler Lankenau Institute for Medical Research; Wynnewood, PA USA; Richfield Laboratory of Dermatopathology; Cincinnati, OH USA
,
Alexander J. Muller Lankenau Institute for Medical Research; Wynnewood, PA USA
,
Lisa D. Laury-Kleintop Lankenau Institute for Medical Research; Wynnewood, PA USA
&
George C. Prendergast Lankenau Institute for Medical Research; Wynnewood, PA USA; Department of Pathology; Anatomy and Cell Biology; Jefferson Medical College and Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USACorrespondence[email protected]
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Pages 1050-1058 | Received 09 Aug 2011, Accepted 18 Sep 2011, Published online: 15 Dec 2011

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Stefan Moritsch, Bernadette Mödl, Irene Scharf, Lukas Janker, Daniela Zwolanek, Gerald Timelthaler, Emilio Casanova, Maria Sibilia, Thomas Mohr, Lukas Kenner, Dietmar Herndler-Brandstetter, Christopher Gerner, Mathias Müller, Birgit Strobl & Robert Eferl. (2022) Tyk2 is a tumor suppressor in colorectal cancer. OncoImmunology 11:1.
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Richard Metz, Sonja Rust, James B. DuHadaway, Mario R. Mautino, David H. Munn, Nicholas N. Vahanian, Charles J. Link & George C. Prendergast. (2012) IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan. OncoImmunology 1:9, pages 1460-1468.
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Articles from other publishers (36)

Simon Klaessens, Vincent Stroobant, Etienne De Plaen & Benoit J. Van den Eynde. (2022) Systemic tryptophan homeostasis. Frontiers in Molecular Biosciences 9.
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Aastha Arora, Gustavo Luis Tripodi, Ilona Kareinen, Martin Berg, Maria Josefa Forteza, Anton Gisterå, Silke Griepke, Felipe Beccaria Casagrande, Joilson O. Martins, Dulcineia Saes Parra Abdalla, Jennifer Cole, Claudia Monaco & Daniel F. J. Ketelhuth. (2022) Genetic Deficiency of Indoleamine 2,3-dioxygenase Aggravates Vascular but Not Liver Disease in a Nonalcoholic Steatohepatitis and Atherosclerosis Comorbidity Model. International Journal of Molecular Sciences 23:9, pages 5203.
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Zhicheng Zhao, Li Lu & Weidong Li. (2020) N‐(3′,4′‐dimethoxycinnamonyl) anthranilic acid alleviates severe acute pancreatitis by inhibiting intestinal barrier dysfunction and NF‐ κ B activation . Drug Development Research 82:3, pages 458-464.
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Vetalise C Konje, Thekkelnaycke M Rajendiran, Keith Bellovich, Crystal A Gadegbeku, Debbie S Gipson, Farsad Afshinnia & Anna V Mathew. (2021) Tryptophan levels associate with incident cardiovascular disease in chronic kidney disease. Clinical Kidney Journal 14:4, pages 1097-1105.
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Delia Hoffmann, Tereza Dvorakova, Florence Schramme, Vincent Stroobant & Benoit J. Van den Eynde. (2020) Tryptophan 2,3-Dioxygenase Expression Identified in Murine Decidual Stromal Cells Is Not Essential for Feto-Maternal Tolerance. Frontiers in Immunology 11.
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Xinyu Liu, Yiwen Zhang, Huaichuan Duan, Qing Luo, Wei Liu, Li Liang, Hua Wan, Shan Chang, Jianping Hu & Hubing Shi. (2020) Inhibition Mechanism of Indoleamine 2, 3-Dioxygenase 1 (IDO1) by Amidoxime Derivatives and Its Revelation in Drug Design: Comparative Molecular Dynamics Simulations. Frontiers in Molecular Biosciences 6.
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Christiane A. Opitz, Luis F. Somarribas Patterson, Soumya R. Mohapatra, Dyah L. Dewi, Ahmed Sadik, Michael Platten & Saskia Trump. (2019) The therapeutic potential of targeting tryptophan catabolism in cancer. British Journal of Cancer 122:1, pages 30-44.
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Concetta Elisa Onesti, François Boemer, Claire Josse, Stephane Leduc, Vincent Bours & Guy Jerusalem. (2019) Tryptophan catabolism increases in breast cancer patients compared to healthy controls without affecting the cancer outcome or response to chemotherapy. Journal of Translational Medicine 17:1.
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Daniel F J Ketelhuth. (2019) The immunometabolic role of indoleamine 2,3-dioxygenase in atherosclerotic cardiovascular disease: immune homeostatic mechanisms in the artery wall. Cardiovascular Research 115:9, pages 1408-1415.
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Zhuoya Wan, Jingjing Sun, Jieni Xu, Pearl Moharil, Jing Chen, Junchi Xu, Junjie Zhu, Jiang Li, Yixian Huang, Pengfei Xu, Xiaochao Ma, Wen Xie, Binfeng Lu & Song Li. (2019) Dual functional immunostimulatory polymeric prodrug carrier with pendent indoximod for enhanced cancer immunochemotherapy. Acta Biomaterialia 90, pages 300-313.
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Aleksandar Acovic, Marina Gazdic, Nemanja Jovicic, C. Randall Harrell, Crissy Fellabaum, Nebojsa Arsenijevic & Vladislav Volarevic. (2018) Role of indoleamine 2,3-dioxygenase in pathology of the gastrointestinal tract. Therapeutic Advances in Gastroenterology 11, pages 175628481881533.
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George C. Prendergast, Arpita Mondal, Souvik Dey, Lisa D. Laury-Kleintop & Alexander J. Muller. (2018) Inflammatory Reprogramming with IDO1 Inhibitors: Turning Immunologically Unresponsive ‘Cold’ Tumors ‘Hot’. Trends in Cancer 4:1, pages 38-58.
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George C. Prendergast, William P. Malachowski, James B. DuHadaway & Alexander J. Muller. (2017) Discovery of IDO1 Inhibitors: From Bench to Bedside. Cancer Research 77:24, pages 6795-6811.
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Marc Hennequart, Luc Pilotte, Stefania Cane, Delia Hoffmann, Vincent Stroobant, Etienne De Plaen & Benoît J. Van den Eynde. (2017) Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance. Cancer Immunology Research 5:8, pages 695-709.
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Ping Song, Tharmarajan Ramprasath, Huan Wang & Ming-Hui Zou. (2017) Abnormal kynurenine pathway of tryptophan catabolism in cardiovascular diseases. Cellular and Molecular Life Sciences 74:16, pages 2899-2916.
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Weichao Zhong, Lei Gao, Zhenting Zhou, Haiyan Lin, Chun Chen, Peng Huang, Weiliang Huang, Chuying Zhou, Shaohui Huang, Linghui Nie, Ye Liu, Youming Chen, Daqiao Zhou & Zhiping Lv. (2017) Indoleamine 2,3-dioxygenase 1 deficiency attenuates CCl4-induced fibrosis through Th17 cells down-regulation and tryptophan 2,3-dioxygenase compensation. Oncotarget 8:25, pages 40486-40500.
Crossref
Sunil Thomas, Jacques Izard, Emily Walsh, Kristen Batich, Pakawat Chongsathidkiet, Gerard Clarke, David A. Sela, Alexander J. Muller, James M. Mullin, Korin Albert, John P. Gilligan, Katherine DiGuilio, Rima Dilbarova, Walker Alexander & George C. Prendergast. (2017) The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists. Cancer Research 77:8, pages 1783-1812.
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Gang Liu, Shuai Chen, Jin Zhong, Kunling Teng & Yulong Yin. (2017) Crosstalk between Tryptophan Metabolism and Cardiovascular Disease, Mechanisms, and Therapeutic Implications. Oxidative Medicine and Cellular Longevity 2017, pages 1-5.
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Paul B. Larkin, Korrapati V. Sathyasaikumar, Francesca M. Notarangelo, Hiroshi Funakoshi, Toshikazu Nakamura, Robert Schwarcz & Paul J. Muchowski. (2016) Tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase 1 make separate, tissue-specific contributions to basal and inflammation-induced kynurenine pathway metabolism in mice. Biochimica et Biophysica Acta (BBA) - General Subjects 1860:11, pages 2345-2354.
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Dianelys Gonzalez-Pena, Scott E. Nixon, Bruce R. Southey, Marcus A. Lawson, Robert H. McCusker, Alvaro G. Hernandez, Robert Dantzer, Keith W. Kelley & Sandra L. Rodriguez-Zas. (2016) Differential Transcriptome Networks between IDO1-Knockout and Wild-Type Mice in Brain Microglia and Macrophages. PLOS ONE 11:6, pages e0157727.
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Daniel F.J. KetelhuthGöran K. Hansson. (2016) Adaptive Response of T and B Cells in Atherosclerosis. Circulation Research 118:4, pages 668-678.
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Amanda W.S. Yeung, Andrew C. TerentisNicholas J.C. King & Shane R. Thomas. (2015) Role of indoleamine 2,3-dioxygenase in health and disease. Clinical Science 129:7, pages 601-672.
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Manabu Takamatsu, Akihiro Hirata, Hirofumi Ohtaki, Masato Hoshi, Tatsuya Ando, Hiroyasu Ito, Yuichiro Hatano, Hiroyuki Tomita, Toshiya Kuno, Kuniaki Saito, Mitsuru Seishima & Akira Hara. (2015) Inhibition of indoleamine 2,3‐dioxygenase 1 expression alters immune response in colon tumor microenvironment in mice. Cancer Science 106:8, pages 1008-1015.
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Konstantinos A. Polyzos, Olga Ovchinnikova, Martin Berg, Roland Baumgartner, Hanna Agardh, John Pirault, Anton Gisterå, Alice Assinger, Andres Laguna-Fernandez, Magnus Bäck, Göran K. Hansson & Daniel F.J. Ketelhuth. (2015) Inhibition of indoleamine 2,3-dioxygenase promotes vascular inflammation and increases atherosclerosis in Apoe−/− mice. Cardiovascular Research 106:2, pages 295-302.
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Nicolas van Baren & Benoît J. Van den Eynde. (2015) Tryptophan-Degrading Enzymes in Tumoral Immune Resistance. Frontiers in Immunology 6.
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Yangzom D. Bhutia, Ellappan Babu & Vadivel Ganapathy. (2015) Interferon-γ induces a tryptophan-selective amino acid transporter in human colonic epithelial cells and mouse dendritic cells. Biochimica et Biophysica Acta (BBA) - Biomembranes 1848:2, pages 453-462.
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K. A. Polyzos & D. F. J. Ketelhuth. (2017) The role of the kynurenine pathway of tryptophan metabolism in cardiovascular disease. Hämostaseologie 35:02, pages 128-136.
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Kinan Drak Alsibai. (2014) Cancer Metabolic and Immune Reprogramming: The Intimate Interaction Between Cancer Cells and Microenvironment. Journal of Cancer Prevention & Current Research 1:2.
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George C. Prendergast, Courtney Smith, Sunil Thomas, Laura Mandik-Nayak, Lisa Laury-Kleintop, Richard Metz & Alexander J. Muller. (2014) Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer. Cancer Immunology, Immunotherapy 63:7, pages 721-735.
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George C. Prendergast, Courtney Smith, Sunil Thomas, Laura Mandik-Nayak, Lisa Laury-Kleintop, Richard Metz & Alexander J. Muller. 2014. Tumor-Induced Immune Suppression. Tumor-Induced Immune Suppression 311 346 .
Amos A. Fatokun, Nicholas H. Hunt & Helen J. Ball. (2013) Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease. Amino Acids 45:6, pages 1319-1329.
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Ameet I. Thaker, M. Suprada Rao, Kumar S. Bishnupuri, Thomas A. Kerr, Lynne Foster, Jeffrey M. Marinshaw, Rodney D. Newberry, William F. Stenson & Matthew A. Ciorba. (2013) IDO1 Metabolites Activate β-catenin Signaling to Promote Cancer Cell Proliferation and Colon Tumorigenesis in Mice. Gastroenterology 145:2, pages 416-425.e4.
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Bridget P. Keenan, Elizabeth M. Jaffee & Todd D. Armstrong. (2013) Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances. Cancer Immunology Research 1:1, pages 16-23.
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Matthew A. Ciorba. (2013) Indoleamine 2,3 dioxygenase in intestinal disease. Current Opinion in Gastroenterology 29:2, pages 146-152.
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Alexander J. Muller, Courtney Smith, Richard Metz & George C. Prendergast. 2013. Cancer Immunotherapy. Cancer Immunotherapy 565 581 .
Michael Platten, Wolfgang Wick & Benoît J. Van den Eynde. (2012) Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion. Cancer Research 72:21, pages 5435-5440.
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