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Cancer Biology & Therapy Volume 12, 2011 - Issue 12
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Research Paper

Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth

Barbara Chiavarina Departments of Stem Cell Biology and Regenerative Medicine and Cancer Biology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA
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Diana Whitaker-Menezes Departments of Stem Cell Biology and Regenerative Medicine and Cancer Biology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA
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Ubaldo E. Martinez-Outschoorn Departments of Stem Cell Biology and Regenerative Medicine and Cancer Biology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Department of Medical Oncology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA
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Agnieszka K. Witkiewicz The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Department of Pathology, Anatomy and Cell Biology; Thomas Jefferson University; Philadelphia, PA USA
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Ruth Birbe The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Department of Pathology, Anatomy and Cell Biology; Thomas Jefferson University; Philadelphia, PA USA
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Anthony Howell Manchester Breast Center and Breakthrough Breast Cancer Research Unit; Paterson Institute for Cancer Research; School of Cancer; Enabling Sciences and Technology; Manchester Academic Health Science Center; University of Manchester, UK
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Richard G. Pestell Departments of Stem Cell Biology and Regenerative Medicine and Cancer Biology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Department of Medical Oncology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA
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Johanna Smith Department of Infectious Diseases and Environmental Medicine; Thomas Jefferson University; Philadelphia, PA USA
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Rene Daniel Department of Infectious Diseases and Environmental Medicine; Thomas Jefferson University; Philadelphia, PA USA
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Federica Sotgia Departments of Stem Cell Biology and Regenerative Medicine and Cancer Biology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Manchester Breast Center and Breakthrough Breast Cancer Research Unit; Paterson Institute for Cancer Research; School of Cancer; Enabling Sciences and Technology; Manchester Academic Health Science Center; University of Manchester, UKCorrespondence[email protected] [email protected]
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Michael P. Lisanti Departments of Stem Cell Biology and Regenerative Medicine and Cancer Biology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Department of Medical Oncology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Manchester Breast Center and Breakthrough Breast Cancer Research Unit; Paterson Institute for Cancer Research; School of Cancer; Enabling Sciences and Technology; Manchester Academic Health Science Center; University of Manchester, UKCorrespondence[email protected] [email protected]
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Pages 1101-1113 | Received 27 Sep 2011, Accepted 08 Nov 2011, Published online: 15 Dec 2011

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Michael P. Lisanti, Ubaldo E. Martinez-Outschoorn & Federica Sotgia. (2013) Oncogenes induce the cancer-associated fibroblast phenotype: Metabolic symbiosis and “fibroblast addiction” are new therapeutic targets for drug discovery. Cell Cycle 12:17, pages 2723-2732.
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Ubaldo E Martinez-Outschoorn, Joseph M Curry, Ying-Hui Ko, Zhao Lin, Madalina Tuluc, David Cognetti, Ruth C Birbe, Edmund Pribitkin, Alessandro Bombonati, Richard G Pestell, Anthony Howell, Federica Sotgia & Michael P Lisanti. (2013) Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment. Cell Cycle 12:16, pages 2580-2597.
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Federica Sotgia, Diana Whitaker-Menezes, Ubaldo E. Martinez-Outschoorn, Ahmed F. Salem, Aristotelis Tsirigos, Rebecca Lamb, Sharon Sneddon, James Hulit, Anthony Howell & Michael P. Lisanti. (2012) Mitochondria “fuel” breast cancer metabolism: Fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells. Cell Cycle 11:23, pages 4390-4401.
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Ubaldo E. Martinez-Outschoorn, Renee Balliet, Zhao Lin, Diana Whitaker-Menezes, Ruth C. Birbe, Alessandro Bombonati, Stephanos Pavlides, Rebecca Lamb, Sharon Sneddon, Anthony Howell, Federica Sotgia & Michael P. Lisanti. (2012) BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment. Cell Cycle 11:23, pages 4402-4413.
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Claudia Capparelli, Barbara Chiavarina, Diana Whitaker-Menezes, Timothy G. Pestell, Richard G. Pestell, James Hulit, Sebastiano Andò, Anthony Howell, Ubaldo E. Martinez-Outschoorn, Federica Sotgia & Michael P. Lisanti. (2012) CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, “fueling” tumor growth via paracrine interactions, without an increase in neo-angiogenesis. Cell Cycle 11:19, pages 3599-3610.
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Barbara Chiavarina, Ubaldo E. Martinez-Outschoorn, Diana Whitaker-Menezes, Anthony Howell, Herbert B. Tanowitz, Richard G. Pestell, Federica Sotgia & Michael P. Lisanti. (2012) Metabolic reprogramming and two-compartment tumor metabolism. Cell Cycle 11:17, pages 3280-3289.
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Carmela Guido, Diana Whitaker-Menezes, Claudia Capparelli, Renee Balliet, Zhao Lin, Richard G. Pestell, Anthony Howell, Saveria Aquila, Sebastiano Andò, Ubaldo Martinez-Outschoorn, Federica Sotgia & Michael P. Lisanti. (2012) Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate production. Cell Cycle 11:16, pages 3019-3035.
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Ahmed F. Salem, Diana Whitaker-Menezes, Zhao Lin, Ubaldo E. Martinez-Outschoorn, Herbert B. Tanowitz, Mazhar Salim Al-Zoubi, Anthony Howell, Richard G. Pestell, Federica Sotgia & Michael P. Lisanti. (2012) Two-compartment tumor metabolism: Autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells. Cell Cycle 11:13, pages 2545-2559.
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Agnieszka K. Witkiewicz, Diana Whitaker-Menezes, Abhijit Dasgupta, Nancy J. Philp, Zhao Lin, Ricardo Gandara, Sharon Sneddon, Ubaldo E. Martinez-Outschoorn, Federica Sotgia & Michael P. Lisanti. (2012) Using the “reverse Warburg effect” to identify high-risk breast cancer patients. Cell Cycle 11:6, pages 1108-1117.
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