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Research Paper

Sunitinib inhibits papillary thyroid carcinoma with RET/PTC rearrangement but not BRAF mutation

Pages 458-465 | Received 13 Apr 2011, Accepted 08 Jun 2011, Published online: 01 Sep 2011

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Mariantonia Nacchio, Pasquale Pisapia, Francesco Pepe, Gianluca Russo, Elena Vigliar, Tommaso Porcelli, Cristina Luongo, Antonino Iaccarino, Fabio Pagni, Domenico Salvatore, Giancarlo Troncone, Umberto Malapelle & Claudio Bellevicine. (2022) Predictive molecular pathology in metastatic thyroid cancer: the role of RET fusions. Expert Review of Endocrinology & Metabolism 17:2, pages 167-178.
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Maria Grazia Borrello, Elena Ardini, Laura D Locati, Angela Greco, Lisa Licitra & Marco A Pierotti. (2013) RET inhibition: implications in cancer therapy. Expert Opinion on Therapeutic Targets 17:4, pages 403-419.
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Articles from other publishers (24)

Angelina T. Regua, Mariana Najjar & Hui-Wen Lo. (2022) RET signaling pathway and RET inhibitors in human cancer. Frontiers in Oncology 12.
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Poupak Fallahi, Silvia Martina Ferrari, Giusy Elia, Francesca Ragusa, Armando Patrizio, Sabrina Rosaria Paparo, Gianni Marone, Maria Rosaria Galdiero, Giovanni Guglielmi, Rudy Foddis, Alfonso Cristaudo & Alessandro Antonelli. (2022) Primary cell cultures for the personalized therapy in aggressive thyroid cancer of follicular origin. Seminars in Cancer Biology 79, pages 203-216.
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Yuanyuan Liu, Shafei Wu, Liangrui Zhou, Yong Guo & Xuan Zeng. (2021) Pitfalls in RET Fusion Detection Using Break-Apart FISH Probes in Papillary Thyroid Carcinoma . The Journal of Clinical Endocrinology & Metabolism 106:4, pages e1129-e1138.
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Yan Gu, Taosha Li, Anil Kapoor, Pierre Major & Damu Tang. (2020) Contactin 1: An Important and Emerging Oncogenic Protein Promoting Cancer Progression and Metastasis. Genes 11:8, pages 874.
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Yuchen Jin, Min Liu, Ri Sa, Hao Fu, Lin Cheng & Libo Chen. (2020) Mouse models of thyroid cancer: Bridging pathogenesis and novel therapeutics. Cancer Letters 469, pages 35-53.
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Andrew Y. Li, Michael G. McCusker, Alessandro Russo, Katherine A. Scilla, Allison Gittens, Katherine Arensmeyer, Ranee Mehra, Vincenzo Adamo & Christian Rolfo. (2019) RET fusions in solid tumors. Cancer Treatment Reviews 81, pages 101911.
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Silvia Martina Ferrari, Marco Centanni, Camilla Virili, Mario Miccoli, Paola Ferrari, Ilaria Ruffilli, Francesca Ragusa, Alessandro Antonelli & Poupak Fallahi. (2019) Sunitinib in the Treatment of Thyroid Cancer. Current Medicinal Chemistry 26:6, pages 963-972.
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Sara Redaelli, Ivan Plaza-Menacho & Luca Mologni. (2018) Novel targeted therapeutics for MEN2. Endocrine-Related Cancer 25:2, pages T53-T68.
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R. Nazari-Vanani, N. Azarpira, H. Heli, K. Karimian & N. Sattarahmady. (2017) A novel self-nanoemulsifying formulation for sunitinib: Evaluation of anticancer efficacy. Colloids and Surfaces B: Biointerfaces 160, pages 65-72.
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Swapnil P. Bhujbal, Pavithra K. Balasubramanian & Seung Joo Cho. (2017) In silico studies on 2-substituted phenol quinazoline derivatives as RET receptor tyrosine kinase antagonists. Medicinal Chemistry Research 26:12, pages 3228-3239.
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Ting-Hsuan Yang, Chun-I Lee, Wen-Hsin Huang & An-Rong Lee. (2017) Synthesis and Evaluation of Novel 2-Pyrrolidone-Fused (2-Oxoindolin-3-ylidene)methylpyrrole Derivatives as Potential Multi-Target Tyrosine Kinase Receptor Inhibitors. Molecules 22:6, pages 913.
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Giuseppe Tridente. 2017. Adverse Events and Oncotargeted Kinase Inhibitors. Adverse Events and Oncotargeted Kinase Inhibitors 167 197 .
Silvia Martina Ferrari, Poupak Fallahi, Ugo Politti, Gabriele Materazzi, Enke Baldini, Salvatore Ulisse, Paolo Miccoli & Alessandro Antonelli. (2015) Molecular Targeted Therapies of Aggressive Thyroid Cancer. Frontiers in Endocrinology 6.
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Jennifer A. Morrison, Laura A. Pike, Greg Lund, Qiong Zhou, Brittelle E. Kessler, Kevin T. Bauerle, Sharon B. Sams, Bryan R. Haugen & Rebecca E. Schweppe. (2015) Characterization of Thyroid Cancer Cell Lines in Murine Orthotopic and Intracardiac Metastasis Models. Hormones and Cancer 6:2-3, pages 87-99.
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Omar Abdel-Rahman. (2015) Targeting vascular endothelial growth factor (VEGF) pathway in iodine-refractory differentiated thyroid carcinoma (DTC): From bench to bedside. Critical Reviews in Oncology/Hematology 94:1, pages 45-54.
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Poupak Fallahi, Valeria Mazzi, Roberto Vita, Silvia Ferrari, Gabriele Materazzi, David Galleri, Salvatore Benvenga, Paolo Miccoli & Alessandro Antonelli. (2015) New Therapies for Dedifferentiated Papillary Thyroid Cancer. International Journal of Molecular Sciences 16:12, pages 6153-6182.
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Tianwei Zhang, Yachao Lu, Qingqing Ye, Meizhuo Zhang, Li Zheng, Xiaolu Yin, Paul Gavine, Zhongsheng Sun, Qunsheng Ji, Guanshan Zhu & Xinying Su. (2015) An evaluation and recommendation of the optimal methodologies to detect RET gene rearrangements in papillary thyroid carcinoma . Genes, Chromosomes and Cancer 54:3, pages 168-176.
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Adebowale J. Adeniran. 2015. Molecular Oncology Testing for Solid Tumors. Molecular Oncology Testing for Solid Tumors 341 374 .
Vivek Subbiah, Funda Meric-Bernstam, Gordon B Mills, Kenna R Mills Shaw, Ann Marie Bailey, Priya Rao, John F Ward & Lance C Pagliaro. (2014) Next generation sequencing analysis of platinum refractory advanced germ cell tumor sensitive to Sunitinib (Sutent®) a VEGFR2/PDGFRβ/c-kit/ FLT3/RET/CSF1R inhibitor in a phase II trial. Journal of Hematology & Oncology 7:1.
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Chandra P Belani, Nobuyuki Yamamoto, Igor M Bondarenko, Artem Poltoratskiy, Silvia Novello, Jie Tang, Paul Bycott, Andreas G Niethammer, Antonella Ingrosso, Sinil Kim & Giorgio V Scagliotti. (2014) Randomized phase II study of pemetrexed/cisplatin with or without axitinib for non-squamous non-small-cell lung cancer. BMC Cancer 14:1.
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Heounjeong Go, Yoo Jin Jung, Hyun Woong Kang, In-Kyu Park, Chang-Hyun Kang, Jung Wan Lee, Young Seok Ju, Jeong-Sun Seo, Doo Hyun Chung & Young Tae Kim. (2013) Diagnostic method for the detection of KIF5B-RET transformation in lung adenocarcinoma. Lung Cancer 82:1, pages 44-50.
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D. P. Modest, P. Camaj, V. Heinemann, B. Schwarz, A. Jung, R. P. Laubender, S. Gamba, C. Haertl, S. Stintzing, S. Primo & C. J. Bruns. (2013) KRAS allel-specific activity of sunitinib in an isogenic disease model of colorectal cancer. Journal of Cancer Research and Clinical Oncology 139:6, pages 953-961.
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Anabel Sorolla, Andrée Yeramian, Joan Valls, Xavier Dolcet, Laura Bergadà, Antoni Llombart-Cussac, Rosa Maria Martí & Xavier Matias-Guiu. (2012) Blockade of NFκB activity by Sunitinib increases cell death in Bortezomib-treated endometrial carcinoma cells. Molecular Oncology 6:5, pages 530-541.
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Annamaria Piscazzi, Eleonora Costantino, Francesca Maddalena, Maria Iole Natalicchio, Assunta Maria Teresa Gerardi, Raffaele Antonetti, Mauro Cignarelli & Matteo Landriscina. (2012) Activation of the RAS/RAF/ERK Signaling Pathway Contributes to Resistance to Sunitinib in Thyroid Carcinoma Cell Lines. The Journal of Clinical Endocrinology & Metabolism 97:6, pages E898-E906.
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