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Cancer Biology & Therapy Volume 12, 2011 - Issue 7
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Research Paper

Combinatorial therapies improve the therapeutic efficacy of nanoliposomal ceramide for pancreatic cancer

Yixing Jiang Penn State College of Medicine; Hershey, PA USA
,
Nicole A. DiVittore Penn State Hershey Cancer Institute; Hershey, PA USA
,
James M. Kaiser Penn State College of Medicine; Hershey, PA USA
,
Sriram S. Shanmugavelandy Penn Stat College of Medicine; Hershey, PA USA
,
Jennifer L. Fritz Penn State College of Medicine; Hershey, PA USA
,
Yasser Heakal Penn State College of Medicine; Hershey, PA USA
,
Hephzibah Rani S. Tagaram Penn State College of Medicine; Hershey, PA USA
,
Hua Cheng Penn State College of Medicine; Hershey, PA USA
,
Myles C. Cabot 5John Wayne Cancer Institute at Saint John’s Health Center; Santa Monica, CA USA
,
Kevin F. Staveley-O'Carroll Penn State College of Medicine; Hershey, PA USA
,
Melissa A. Tran Penn State College of Medicine; Hershey, PA USA
,
Todd E. Fox Penn State College of Medicine; Hershey, PA USA
,
Brian M. Barth Penn State College of Medicine; Hershey, PA USA
&
Mark Kester Penn State College of Medicine; Hershey, PA USACorrespondence[email protected]
 show all
Pages 574-585 | Received 09 Dec 2010, Accepted 22 Jun 2011, Published online: 01 Oct 2011

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Ping Lu, Shai White-Gilbertson, Rose Nganga, Mark Kester & Christina Voelkel-Johnson. (2019) Expression of the SNAI2 transcriptional repressor is regulated by C16-ceramide. Cancer Biology & Therapy 20:6, pages 922-930.
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Ying-Yu Ma, Xiao-Zhou Mou, Ya-Hui Ding, Hai Zou & Dong-Sheng Huang. (2016) Delivery systems of ceramide in targeted cancer therapy: ceramide alone or in combination with other anti-tumor agents. Expert Opinion on Drug Delivery 13:10, pages 1397-1406.
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Rebecca J. Watters, Todd E. Fox, Su-Fern Tan, Sriram Shanmugavelandy, Jacob E. Choby, Kathleen Broeg, Jason Liao, Mark Kester, Myles C. Cabot, Thomas P. Loughran & Xin Liu. (2013) Targeting glucosylceramide synthase synergizes with C6-ceramide nanoliposomes to induce apoptosis in natural killer cell leukemia. Leukemia & Lymphoma 54:6, pages 1288-1296.
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Clara De Palma & Cristiana Perrotta. (2012) Ceramide as a target of chemotherapy: its role in apoptosis and autophagy. Clinical Lipidology 7:1, pages 111-119.
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Han Zhu, Hua-Jie Chen, Hai-Yan Wen, Zhi-Gang Wang & Shu-Lin Liu. (2023) Engineered Lipidic Nanomaterials Inspired by Sphingomyelin Metabolism for Cancer Therapy. Molecules 28:14, pages 5366.
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Sunil C. Gurumallu & Rajesha Javaraiah. (2021) Bioactives in Disease Prevention and Health Promotion: Exploiting Combinatorial Effects. Current Bioactive Compounds 17:4, pages 299-317.
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Feng Gao, Xiaoxu Chen, Junyan Lu, Shulei Hu, Hui Xu, Yuqiang Shi, Mingshun Feng, Jian Ding, Hong Liu, Cheng Luo, Zuoquan Xie & Jiang Wang. (2021) Discovery of novel ceramide analogs with favorable pharmacokinetic properties and combination with AKT inhibitor against colon cancer. European Journal of Medicinal Chemistry 215, pages 113274.
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Yoshiaki Yura, Atsushi Masui & Masakazu Hamada. (2020) Inhibitors of Ceramide- and Sphingosine-Metabolizing Enzymes as Sensitizers in Radiotherapy and Chemotherapy for Head and Neck Squamous Cell Carcinoma. Cancers 12:8, pages 2062.
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Kai-Fu Chang, Jinghua Tsai Chang, Xiao-Fan Huang, Yu-Ling Lin, Kuang-Wen Liao, Chien-Wei Huang & Nu-Man Tsai. (2020) Antitumor Effects of N-Butylidenephthalide Encapsulated in Lipopolyplexs in Colorectal Cancer Cells. Molecules 25:10, pages 2394.
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Min-Koo Choi & Im-Sook Song. (2020) Recent advances in the formulation of sphingolipid anticancer therapeutics. Journal of Pharmaceutical Investigation 50:3, pages 295-307.
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Jianzhong Chen, Sachin K Khiste, Xiaomei Fu, Kartik R. Roy, Yixuan Dong, Jian Zhang, Mei Liu, Yong-Yu Liu & Zhijun Liu. (2020) Rubusoside-assisted solubilization of poorly soluble C6-Ceramide for a pilot pharmacokinetic study. Prostaglandins & Other Lipid Mediators 146, pages 106402.
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Anna Kovilakath & L. Ashley Cowart. (2020) Sphingolipid Mediators of Myocardial Pathology. Journal of Lipid and Atherosclerosis 9:1, pages 23.
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Chang Moo Kang, BoKyeong Yun, Minju Kim, Mina Song, Yeon-hee Kim, Sung Hwan Lee, Hosun Lee, Song Mi Lee & Seung-Min Lee. (2019) Postoperative serum metabolites of patients on a low carbohydrate ketogenic diet after pancreatectomy for pancreatobiliary cancer: a nontargeted metabolomics pilot study. Scientific Reports 9:1.
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Hamad Alrbyawi, Ishwor Poudel, Ranjeet Prasad Dash, Nuggehally R. Srinivas, Amit K Tiwari, Robert D. Arnold & R. Jayachandra Babu. (2019) Role of Ceramides in Drug Delivery. AAPS PharmSciTech 20:7.
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Ruofan Cao, Horst Wallrabe, Chunbo Huang, Su-Fern Tan, David Feith, Yuan Xing, Yong Wang, Jose Oberholzer, Mark Kester, Thomas P. Loughran & Ammasi Periasamy. (2019) FLIM Imaging of NAD(P)H to track metabolic changes of non-adherent leukemia cells using micro cell trapping arrays. FLIM Imaging of NAD(P)H to track metabolic changes of non-adherent leukemia cells using micro cell trapping arrays.
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