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Research Paper

Increased apoptosis in cancer cells in vitro and in vivo by ceramides in transferrin-modified liposomes

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Pages 50-60 | Received 30 Aug 2011, Accepted 28 Nov 2011, Published online: 01 Jan 2012

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Crossref
. 2016. Controlled Release Systems. Controlled Release Systems 441 464 .
Liangliang Dai, Junjie Liu, Zhong Luo, Menghuan Li & Kaiyong Cai. (2016) Tumor therapy: targeted drug delivery systems. Journal of Materials Chemistry B 4:42, pages 6758-6772.
Crossref
Kristina M. Hamill, Ezequiel Wexselblatt, Wenyong Tong, Jeffrey D. Esko & Yitzhak Tor. (2016) Delivery of an active lysosomal enzyme using GNeosomes. Journal of Materials Chemistry B 4:35, pages 5794-5797.
Crossref
Kalyani C. Patil & Jatinder Vir Yakhmi. 2016. Nanobiomaterials in Cancer Therapy. Nanobiomaterials in Cancer Therapy 395 470 .
Bhawani Aryasomayajula & Vladimir P. Torchilin. 2016. Nanobiomaterials in Cancer Therapy. Nanobiomaterials in Cancer Therapy 307 330 .
N. Başaran Mutlu Ağardan & Vladimir P. Torchilin. 2016. Engineering of Nanobiomaterials. Engineering of Nanobiomaterials 1 28 .
Caitlin O. McAtee, Abigail R. Berkebile, Christian G. Elowsky, Teresa Fangman, Joseph J. Barycki, James K. WahlIIIIII, Oleh Khalimonchuk, Naava Naslavsky, Steve Caplan & Melanie A. Simpson. (2015) Hyaluronidase Hyal1 Increases Tumor Cell Proliferation and Motility through Accelerated Vesicle Trafficking. Journal of Biological Chemistry 290:21, pages 13144-13156.
Crossref
Ezequiel Wexselblatt, Jeffrey D. Esko & Yitzhak Tor. (2015) GNeosomes: Highly Lysosomotropic Nanoassemblies for Lysosomal Delivery. ACS Nano 9:4, pages 3961-3968.
Crossref
Karolina Werengowska-Ciećwierz, Marek Wiśniewski, Artur P. Terzyk & Sylwester Furmaniak. (2015) The Chemistry of Bioconjugation in Nanoparticles-Based Drug Delivery System. Advances in Condensed Matter Physics 2015, pages 1-27.
Crossref
Nuno A. Fonseca, Lígia C. Gomes-da-Silva, Vera Moura, Sérgio Simões & João Nuno Moreira. (2014) Simultaneous active intracellular delivery of doxorubicin and C6-ceramide shifts the additive/antagonistic drug interaction of non-encapsulated combination. Journal of Controlled Release 196, pages 122-131.
Crossref
Vladimir P. Torchilin. (2014) Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery. Nature Reviews Drug Discovery 13:11, pages 813-827.
Crossref
A. A. Rosenkranz, A. V. Ulasov, T. A. Slastnikova, Y. V. Khramtsov & A. S. Sobolev. (2014) Use of intracellular transport processes for targeted drug delivery into a specified cellular compartment. Biochemistry (Moscow) 79:9, pages 928-946.
Crossref
Kuan-Boone Tan, Leong-Uung Ling, Ralph M Bunte, Wee-Joo Chng & Gigi NC Chiu. (2014) Liposomal codelivery of a synergistic combination of bioactive lipids in the treatment of acute myeloid leukemia. Nanomedicine 9:11, pages 1665-1679.
Crossref
Shravan Kumar Sriraman & Vladimir P. Torchilin. 2014. Advanced Biomaterials and Biodevices. Advanced Biomaterials and Biodevices 79 119 .
Mayur Yergeri, Sonali Kapse-Mistry, Rohit Srivastava & Thirumala Govender. (2014) Nanodrug delivery in reversing multidrug resistance in cancer cells. Frontiers in Pharmacology 5.
Crossref
Georg Pabst, Norbert Kučerka, Mu-Ping Nieh & John KatsarasAleksandr Piroyan, Alexander Koshkaryev, Robert Riehle & Vladimir Torchilin. 2014. Liposomes, Lipid Bilayers and Model Membranes. Liposomes, Lipid Bilayers and Model Membranes 317 340 .
Peng Zou, Stephan T. Stern & Duxin Sun. (2013) PLGA/Liposome Hybrid Nanoparticles for Short-Chain Ceramide Delivery. Pharmaceutical Research 31:3, pages 684-693.
Crossref
Rupa R. Sawant, Aditi M. Jhaveri, Alexander Koshkaryev, Lin Zhu, Farooq Qureshi & Vladimir P. Torchilin. (2013) Targeted Transferrin-Modified Polymeric Micelles: Enhanced Efficacy in Vitro and in Vivo in Ovarian Carcinoma. Molecular Pharmaceutics 11:2, pages 375-381.
Crossref
Swati Biswas & Vladimir P. Torchilin. (2014) Nanopreparations for organelle-specific delivery in cancer. Advanced Drug Delivery Reviews 66, pages 26-41.
Crossref
E. Crucianelli, P. Bruni, A. Frontini, L. Massaccesi, M. Pisani, A. Smorlesi & G. Mobbili. (2014) Liposomes containing mannose-6-phosphate-cholesteryl conjugates for lysosome-specific delivery. RSC Adv. 4:102, pages 58204-58207.
Crossref
Gavin T. Noble, Jared F. Stefanick, Jonathan D. Ashley, Tanyel Kiziltepe & Basar Bilgicer. (2014) Ligand-targeted liposome design: challenges and fundamental considerations. Trends in Biotechnology 32:1, pages 32-45.
Crossref
Rogério S. Gaspar, Helena F. Florindo, Liana C. Silva, Mafalda A. Videira, M. Luísa Corvo, Bárbara F. Martins & Beatriz Silva-Lima. 2014. Nano-Oncologicals. Nano-Oncologicals 425 452 .
Prasad V. Pawar, Abraham J. Domb & Neeraj Kumar. 2014. Focal Controlled Drug Delivery. Focal Controlled Drug Delivery 61 91 .
Pranali P Deshpande, Swati Biswas & Vladimir P Torchilin. (2013) Current trends in the use of liposomes for tumor targeting. Nanomedicine 8:9, pages 1509-1528.
Crossref
Long Nguyen, Segundo Joel Cardenas-Goicoechea, Pierre Gordon, Christina Curtin, Mazdak Momeni, Linus Chuang & David Fishman. (2013) Biomarkers for Early Detection of Ovarian Cancer. Women's Health 9:2, pages 171-187.
Crossref
Jody L. Hankins, Ushma A. Doshi, Jeremy K. Haakenson, Megan M. Young, Brian M. Barth & Mark Kester. 2013. Sphingolipids: Basic Science and Drug Development. Sphingolipids: Basic Science and Drug Development 197 210 .

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