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Cancer Biology & Therapy Volume 13, 2012 - Issue 4
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Research Paper

Thymosin β-4 in colorectal cancer is localized predominantly at the invasion front in tumor cells undergoing epithelial mesenchymal transition

Sonia Nemolato 1 Dipartimento di Citomorfologia; Divisione di Anatomia Patologica; University of Cagliari; Cagliari, ItalyCorrespondence[email protected]
,
Angelo Restivo Dipartimento di Scienze Chirurgiche; University of Cagliari; Cagliari, Italy
,
Tiziana Cabras Dipartimento di Scienze Applicate ai Biosistemi; University of Cagliari; Cagliari, Italy
,
Pierpaolo Coni 1 Dipartimento di Citomorfologia; Divisione di Anatomia Patologica; University of Cagliari; Cagliari, Italy
,
Luigi Zorcolo Dipartimento di Scienze Chirurgiche; University of Cagliari; Cagliari, Italy
,
Germano Orrù Dipartimento di Chirurgia e Scienze Odontostomatologiche; Universita’ degli Studi di Cagliari; Cagliari, Italy
,
Mattia Fanari 1 Dipartimento di Citomorfologia; Divisione di Anatomia Patologica; University of Cagliari; Cagliari, Italy
,
Flaviana Cau 1 Dipartimento di Citomorfologia; Divisione di Anatomia Patologica; University of Cagliari; Cagliari, Italy
,
Clara Gerosa 1 Dipartimento di Citomorfologia; Divisione di Anatomia Patologica; University of Cagliari; Cagliari, Italy
,
Daniela Fanni 1 Dipartimento di Citomorfologia; Divisione di Anatomia Patologica; University of Cagliari; Cagliari, Italy
,
Irene Messana Dipartimento di Scienze Applicate ai Biosistemi; University of Cagliari; Cagliari, Italy
,
Massimo Castagnola Dipartimento di Biochimica e di Biochimica Clinica; Catholic University of Rome; Rome, Italy
,
Giuseppe Casula Dipartimento di Scienze Chirurgiche; University of Cagliari; Cagliari, Italy
&
Gavino Faa 1 Dipartimento di Citomorfologia; Divisione di Anatomia Patologica; University of Cagliari; Cagliari, Italy
 show all
Pages 191-197 | Received 01 Jul 2011, Accepted 07 Nov 2011, Published online: 15 Feb 2012

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Wen-chao Wang, Xiao-feng Zhang, Er-jiang Tang, A-jian Li, Lei Chen, Jia-qi Wang, Jun-yong Ma, Xiao-feng Zhang & Bin Sun. (2023) Thymosin β4, a potential marker of malignancy and prognosis in hepatocellular carcinoma. Scandinavian Journal of Gastroenterology 58:4, pages 380-391.
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Tiziana Cabras, Federica Iavarone, Claudia Martelli, Daniela Delfino, Diana Valeria Rossetti, Ilaria Inserra, Barbara Manconi, Claudia Desiderio, Irene Messana, Ewald Hannappel, Gavino Faa & Massimo Castagnola. (2015) High-resolution mass spectrometry for thymosins detection and characterization. Expert Opinion on Biological Therapy 15:sup1, pages 191-201.
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Sirinapa Sribenja, Sopit Wongkham, Chaisiri Wongkham, Qizhi Yao & Changyi Chen. (2013) Roles and Mechanisms of β-Thymosins in Cell Migration and Cancer Metastasis: An Update. Cancer Investigation 31:2, pages 103-110.
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Massimo Castagnola, Tiziana Cabras, Federica Iavarone, Federica Vincenzoni, Alberto Vitali, Elisabetta Pisano, Sonia Nemolato, Emanuele Scarano, Antonella Fiorita, Giovanni Vento, Chiara Tirone, Costantino Romagnoli, Massimo Cordaro, Gaetano Paludetti, Gavino Faa & Irene Messana. (2012) Top-down platform for deciphering the human salivary proteome. The Journal of Maternal-Fetal & Neonatal Medicine 25:sup5, pages 27-43.
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Articles from other publishers (29)

Jieun Kim, Chanbin Lee, Jinsol Han, Hayeong Jeong, Sihyung Wang, Yung Hyun Choi & Youngmi Jung. (2023) Targeted Deletion of Thymosin Beta 4 in Hepatic Stellate Cells Ameliorates Liver Fibrosis in a Transgenic Mouse Model. Cells 12:12, pages 1658.
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Yuqiang Li, Dan Wang, Heming Ge, Cenap Güngör, Xuejun Gong & Yongheng Chen. (2022) Cytoskeletal and Cytoskeleton-Associated Proteins: Key Regulators of Cancer Stem Cell Properties. Pharmaceuticals 15:11, pages 1369.
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Chi-Yu Kuo, Jie-Yang Jhuang, Wen-Chien Huang & Shih-Ping Cheng. (2022) Aberrant Expression of Thymosin Beta-4 Correlates With Advanced Disease and BRAF V600E Mutation in Thyroid Cancer. Journal of Histochemistry & Cytochemistry 70:10, pages 707-716.
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Damián Sánchez-Ramírez, Rafael Medrano-Guzmán, Fernando Candanedo-González, Jazmín De Anda-González, Luis Enrique García-Rios, Vadim Pérez-Koldenkova, Marcos Gutiérrez-de la Barrera, Sara Rodríguez-Enríquez, Marco Velasco-Velázquez, Silvia Cecilia Pacheco-Velázquez, Patricia Piña-Sánchez, Héctor Mayani, Alejandro Gómez-Delgado, Alberto Monroy-García, Ana Karen Martínez-Lara & Juan José Montesinos. (2022) High expression of both desmoplastic stroma and epithelial to mesenchymal transition markers associate with shorter survival in pancreatic ductal adenocarcinoma. European Journal of Histochemistry 66:1.
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Rodney P. Rocconi, Annelise M. Wilhite, Lindsay Schambeau, Jennifer Scalici, Lewis Pannell & Michael A. Finan. (2022) A novel proteomic-based screening method for ovarian cancer using cervicovaginal fluids: A window into the abdomen. Gynecologic Oncology 164:1, pages 181-186.
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Masataka Tsuge. (2021) Are Humanized Mouse Models Useful for Basic Research of Hepatocarcinogenesis through Chronic Hepatitis B Virus Infection?. Viruses 13:10, pages 1920.
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Claudia Desiderio, Diana Valeria Rossetti, Massimo Castagnola, Luca Massimi & Gianpiero Tamburrini. (2020) Adamantinomatous craniopharyngioma: advances in proteomic research. Child's Nervous System 37:3, pages 789-797.
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Jaya Aseervatham. (2020) Cytoskeletal Remodeling in Cancer. Biology 9:11, pages 385.
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H. Igarashi, H. Taniguchi, K. Nosho, K. Ishigami, H. Koide, K. Mitsuhashi, K. Okita, I. Takemasa, K. Imai & H. Nakase. (2019) PRDM14 promotes malignant phenotype and correlates with poor prognosis in colorectal cancer. Clinical and Translational Oncology 22:7, pages 1126-1137.
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Pierpaolo Coni, Monica Piras, Anna Mateddu, Marco Piludu, Germano Orru, Alessandra Scano, Tiziana Cabras, Valentina Piras, Joanna Izabela Lachowicz, Mariusz Jaremko, Gavino Faa, Massimo Castagnola & Giuseppina Pichiri. (2020) Thymosin β4 cytoplasmic/nuclear translocation as a new marker of cellular stress. A Caco2 case study. RSC Advances 10:21, pages 12680-12688.
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Joanna Izabela Lachowicz, Mariusz Jaremko, Lukasz Jaremko, Giuseppina Pichiri, Pierpaolo Coni & Marco Piludu. (2019) Metal coordination of thymosin β4: Chemistry and possible implications. Coordination Chemistry Reviews 396, pages 117-123.
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Manish Chand, Deborah S Keller, Reza Mirnezami, Marc Bullock, Aneel Bhangu, Brendan Moran, Paris P Tekkis, Gina Brown, Alex Mirnezami & Mariana Berho. (2018) Novel biomarkers for patient stratification in colorectal cancer: A review of definitions, emerging concepts, and data. World Journal of Gastrointestinal Oncology 10:7, pages 145-158.
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Germano Orrù, Mauro Giovanni Carta & Alessia Bramanti. (2018) Design of FRET Probes for SNP RS1006737, Related to Mood Disorder. Clinical Practice & Epidemiology in Mental Health 14:1, pages 53-62.
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Germano Orrù & Mauro Giovanni Carta. (2018) Genetic Variants Involved in Bipolar Disorder, a Rough Road Ahead. Clinical Practice & Epidemiology in Mental Health 14:1, pages 37-45.
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Xiankui Li, Lei Wang & Cai Chen. (2017) Effects of exogenous thymosin β4 on carbon tetrachloride-induced liver injury and fibrosis. Scientific Reports 7:1.
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Luca Massimi, Claudia Martelli, Massimo Caldarelli, Massimo Castagnola & Claudia Desiderio. (2017) Proteomics in pediatric cystic craniopharyngioma. Brain Pathology 27:3, pages 370-376.
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Seung Yun Lee, Mee Ja Park, Hye Kyung Lee, Hyun Jin Son, Chang Nam Kim, Joo Heon Kim & Dong Wook Kang. (2017) Increased Expression of Thymosin β4 Is Independently Correlated with Hypoxia Inducible Factor-1α (HIF-1α) and Worse Clinical Outcome in Human Colorectal Cancer. Journal of Pathology and Translational Medicine 51:1, pages 9-16.
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I. V. Kondakova, N. V. Yunusova, L. V. Spirina, E. E. Shashova, E. S. Kolegova, L. A. Kolomiets, E. M. Slonimskaya & A. B. Villert. Locomotor proteins in tissues of primary tumors and metastases of ovarian and breast cancer. Locomotor proteins in tissues of primary tumors and metastases of ovarian and breast cancer.
J. Kim & Y. Jung. 2016. Thymosins. Thymosins 121 149 .
E.D. Marks & A. Kumar. 2016. Thymosins. Thymosins 227 249 .
Kyoung-Ok Hong, Jae-Il Lee, Sam-Pyo Hong & Seong-Doo Hong. (2015) Thymosin β4 induces proliferation, invasion, and epithelial-to-mesenchymal transition of oral squamous cell carcinoma. Amino Acids 48:1, pages 117-127.
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Marco Piludu, Monica Piras, Giuseppina Pichiri, Pierpaolo Coni, Germano Orrù, Tiziana Cabras, Irene Messana, Gavino Faa & Massimo Castagnola. (2015) Thymosin Beta 4 May Translocate from the Cytoplasm in to the Nucleus in HepG2 Cells following Serum Starvation. An Ultrastructural Study. PLOS ONE 10:4, pages e0119642.
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Kenneth W. Jackson, Victoria J. Christiansen, Vivek R. Yadav, Robert Silasi-Mansat, Florea Lupu, Vibhudutta Awasthi, Roy R. Zhang & Patrick A. McKee. (2015) Suppression of Tumor Growth in Mice by Rationally Designed Pseudopeptide Inhibitors of Fibroblast Activation Protein and Prolyl Oligopeptidase. Neoplasia 17:1, pages 43-54.
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Nai-Jun Fan, Ke Li, Qing-Yin Liu, Xiu-Li Wang, Liang Hu, Jun-Tang Li & Chun-Fang Gao. (2013) Identification of tubulin beta chain, thymosin beta-4-like protein 3, and cytochrome b–c1 complex subunit 1 as serological diagnostic biomarkers of gastric cancer. Clinical Biochemistry 46:15, pages 1578-1584.
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Sonia Nemolato, Tiziana Cabras, Angelo Restivo, Luigi Zorcolo, Eliana Di Felice, Daniela Fanni, Clara Gerosa, Irene Messana, Massimo Castagnola, Gavino Faa & Giuseppe Casula. (2013) Thymosin ß4 expression in colorectal polyps and adenomas. Clinics 68:9, pages 1220-1224.
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Giuseppina Pichiri, Pierpaolo Coni, Sonia Nemolato, Tiziana Cabras, Mattia Umberto Fanari, Alice Sanna, Eliana Di Felice, Irene Messana, Massimo Castagnola & Gavino Faa. (2013) Cellular Trafficking of Thymosin Beta-4 in HEPG2 Cells Following Serum Starvation. PLoS ONE 8:8, pages e67999.
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Aneel Bhangu, Gemma Wood, Alex Mirnezami, Ara Darzi, Paris Tekkis & Robert Goldin. (2012) Epithelial mesenchymal transition in colorectal cancer: Seminal role in promoting disease progression and resistance to neoadjuvant therapy. Surgical Oncology 21:4, pages 316-323.
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Gavino Faa, Sonia Nemolato, Tiziana Cabras, Daniela Fanni, Clara Gerosa, Mattia Fanari, Annalisa Locci, Vassilios Fanos, Irene Messana & Massimo Castagnola. (2012) Thymosin β4 expression reveals intriguing similarities between fetal and cancer cells. Annals of the New York Academy of Sciences 1269:1, pages 53-60.
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