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Cancer Biology & Therapy Volume 13, 2012 - Issue 4
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Research Paper

HIPK2 downregulates vimentin and inhibits breast cancer cell invasion

Cristina Nodale Department of Experimental Oncology; Molecular Oncogenesis Laboratory; National Cancer Institute “Regina Elena”; Rome, Italy
,
Michal Sheffer Department of Physics of Complex Systems; Weizmann Institute of Science; Rehovot, Israel
,
Jasmine Jacob-Hirsch Cancer Research Center; Chaim Sheba Medical Center; Tel-Hashomer and Sachler School of Medicine; Tel-Aviv University; Tel-Aviv, Israel
,
Valentina Folgiero Department of Experimental Oncology; Molecular Oncogenesis Laboratory; National Cancer Institute “Regina Elena”; Rome, Italy
,
Rita Falcioni Department of Experimental Oncology; Molecular Oncogenesis Laboratory; National Cancer Institute “Regina Elena”; Rome, Italy
,
Aurora Aiello Department of Experimental Oncology; Molecular Oncogenesis Laboratory; National Cancer Institute “Regina Elena”; Rome, Italy; Department of Endocrinology; Catholic University; Rome, Italy
,
Alessia Garufi Department of Experimental Oncology; Molecular Oncogenesis Laboratory; National Cancer Institute “Regina Elena”; Rome, Italy
,
Gideon Rechavi Cancer Research Center; Chaim Sheba Medical Center; Tel-Hashomer and Sachler School of Medicine; Tel-Aviv University; Tel-Aviv, Israel
,
David Givol Department of Molecular Cell Biology; Weizmann Institute of Science; Rehovot, Israel
&
Gabriella D’Orazi Department of Experimental Oncology; Molecular Oncogenesis Laboratory; National Cancer Institute “Regina Elena”; Rome, Italy; Department of Oncology and Experimental Medicine; University “G. d’Annunzio”; Chieti, ItalyCorrespondence[email protected]
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Pages 198-205 | Received 04 Aug 2011, Accepted 07 Nov 2011, Published online: 15 Feb 2012

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Yifei Liu, Li Qian, Juanjuan Yang, Hua Huang, Jia Feng, Xiaoli Li, Tingting Bian, Honggang Ke, Jian Liu & Jianguo Zhang. (2018) The expression level and prognostic value of HIPK3 among non-small-cell lung cancer patients in China. OncoTargets and Therapy 11, pages 7459-7469.
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Articles from other publishers (23)

Alessia Garufi, Valerio D’Orazi, Giuseppa Pistritto, Mara Cirone & Gabriella D’Orazi. (2023) The Sweet Side of HIPK2. Cancers 15:10, pages 2678.
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Alessia Garufi, Giuseppa Pistritto & Gabriella D’Orazi. (2023) HIPK2 as a Novel Regulator of Fibrosis. Cancers 15:4, pages 1059.
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Impyo Lee, Chae-Eun Kim, Harim Cho, Hana Im, Ki Soon Shin & Shin Jung Kang. (2022) TRAF2 regulates the protein stability of HIPK2. Biochemical and Biophysical Research Communications 627, pages 97-102.
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Na ZHANG, Hong MENG, Aixia TIAN & Yuhua CHEN. (2022) Expression of HIPK2 in gastric cancer and its effects on cell function in vitro. Minerva Gastroenterology 68:2.
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Lifeng Zhou & Hong Wang. (2022) A Combined Feature Screening Approach of Random Forest and Filterbased Methods for Ultra-high Dimensional Data. Current Bioinformatics 17:4, pages 344-357.
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Wen Xiao, Tao Wang, Yuzhong Ye, Xuegang Wang, Bin Chen, Jinchun Xing, Hongmei Yang & Xiaoping Zhang. (2021) Identification of HIPK3 as a potential biomarker and an inhibitor of clear cell renal cell carcinoma. Aging 13:3, pages 3536-3553.
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Xueqing Zheng, Yuemei Pan, Xinming Chen, Shu Xia, Yaying Hu, Yi Zhou & Jiali Zhang. (2020) Inactivation of homeodomain‐interacting protein kinase 2 promotes oral squamous cell carcinoma metastasis through inhibition of P53‐dependent E‐cadherin expression. Cancer Science 112:1, pages 117-132.
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Xiaoping Pan, Xiaolv Hong, Sumei Li, Ping Meng & Feng Xiao. (2021) METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner. Experimental & Molecular Medicine 53:1, pages 91-102.
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Jana Haas, Daniel Bloesel, Susanne Bacher, Michael Kracht & M. Lienhard Schmitz. (2020) Chromatin Targeting of HIPK2 Leads to Acetylation-Dependent Chromatin Decondensation. Frontiers in Cell and Developmental Biology 8.
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Yuan Li, Fengxiao Ge & Shuaihua Wang. (2020) Four genes predict the survival of osteosarcoma patients based on TARGET database. Journal of Bioenergetics and Biomembranes 52:4, pages 291-299.
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Alessia Garufi, Gianandrea Traversi, Mara Cirone & Gabriella D'Orazi. (2019) HIPK2 role in the tumor–host interaction: Impact on fibroblasts transdifferentiation CAF‐like. IUBMB Life 71:12, pages 2055-2061.
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Bing Feng, Ying Zhu, Chaoyue Sun, Zuqing Su, Lipeng Tang, Caiyun Li & Guangjuan Zheng. (2019) Basil polysaccharide inhibits hypoxia-induced hepatocellular carcinoma metastasis and progression through suppression of HIF-1α-mediated epithelial-mesenchymal transition. International Journal of Biological Macromolecules 137, pages 32-44.
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Chen-Yeh Ke, Hua-Hsuan Mei, Fen-Hwa Wong & Lun-Jou Lo. (2019) IRF6 and TAK1 coordinately promote the activation of HIPK2 to stimulate apoptosis during palate fusion. Science Signaling 12:593.
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Satomi Yogosawa & Kiyotsugu Yoshida. (2018) Tumor suppressive role for kinases phosphorylating p53 in DNA damage‐induced apoptosis . Cancer Science 109:11, pages 3376-3382.
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Xiaoyan Tan, Haiying Tang, Jian Bi, Na Li & Yujie Jia. (2018) MicroRNA‐222‐3p associated with Helicobacter pylori targets HIPK2 to promote cell proliferation, invasion, and inhibits apoptosis in gastric cancer . Journal of Cellular Biochemistry 119:7, pages 5153-5162.
Crossref
Zhen Zhang, Penghai Wen, Fangfang Li, Chuanshan Yao, Tongfu Wang, Bing Liang, Qingle Yang, Lei Ma & Limin He. (2017) HIPK2 inhibits cell metastasis and improves chemosensitivity in esophageal squamous cell carcinoma. Experimental and Therapeutic Medicine.
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James Neil Fisher, Mineko Terao, Maddalena Fratelli, Mami Kurosaki, Gabriela Paroni, Adriana Zanetti, Maurizio Gianni, Marco Bolis, Monica Lupi, Anna Tsykin, Gregory J. Goodall & Enrico Garattini. (2015) MicroRNA networks regulated by all-trans retinoic acid and Lapatinib control the growth, survival and motility of breast cancer cells . Oncotarget 6:15, pages 13176-13200.
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Feng-Ming Hsu, Jason Chia-Hsien Cheng, Yih-Leong Chang, Jang-Ming Lee, Albert C. Koong & Eric Y. Chuang. (2015) Circulating mRNA Profiling in Esophageal Squamous Cell Carcinoma Identifies FAM84B As A Biomarker In Predicting Pathological Response to Neoadjuvant Chemoradiation. Scientific Reports 5:1.
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Lihong Zhou, Yuanyuan Feng, Yongjie Jin, Xuan Liu, Hua Sui, Ni Chai, Xingzhu Chen, Ningning Liu, Qing Ji, Yan Wang & Qi Li. (2014) Verbascoside promotes apoptosis by regulating HIPK2–p53 signaling in human colorectal cancer. BMC Cancer 14:1.
Crossref
Mingyue Tan, Hua Gong, Yigang Zeng, Le Tao, Jun Wang, Juntao Jiang, Dongliang Xu, Erdun Bao, Jianxin Qiu & Zhihong Liu. (2014) Downregulation of Homeodomain-Interacting Protein Kinase-2 Contributes to Bladder Cancer Metastasis by Regulating Wnt Signaling. Journal of Cellular Biochemistry 115:10, pages 1762-1767.
Crossref
Caroline Olivieri da Silva Frozza, Tanara da Silva Ribeiro, Gabriela Gambato, Caroline Menti, Sidnei Moura, Paulo Marcos Pinto, Charley Christian Staats, Francine Ferreira Padilha, Karine Rech Begnini, Priscila Marques Moura de Leon, Sibele Borsuk, Lucielli Savegnago, Odir Dellagostin, Tiago Collares, Fabiana Kömmling Seixas, João Antonio Pêgas Henriques & Mariana Roesch-Ely. (2014) Proteomic analysis identifies differentially expressed proteins after red propolis treatment in Hep-2 cells. Food and Chemical Toxicology 63, pages 195-204.
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Slavica Berber, Estelle Llamosas, Priya Thaivalappil, Peter R. Boag, Merlin Crossley & Hannah R. Nicholas. (2013) Homeodomain interacting protein kinase (HPK-1) is required in the soma for robust germline proliferation in C. elegans . Developmental Dynamics 242:11, pages 1250-1261.
Crossref
B.-W. Park, S. Park, J. S. Koo, S. I. Kim, J. M. Park, J. H. Cho & H. S. Park. (2012) Homeodomain-interacting Protein Kinase 1 (HIPK1) Expression in Breast Cancer Tissues. Japanese Journal of Clinical Oncology 42:12, pages 1138-1145.
Crossref

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