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Cancer Biology & Therapy Volume 13, 2012 - Issue 4
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Research Paper

HIF prolyl hydroxylase-2 inhibition diminishes tumor growth through matrix metalloproteinase-induced TGFβ activation

Anne Klotzsche-von Ameln Institute of Pathology; University of Technology; Dresden, Germany; Emmy Noether Research Group; University of Technology; Dresden, Germany
,
Antje Muschter Institute of Pathology; University of Technology; Dresden, Germany; Emmy Noether Research Group; University of Technology; Dresden, Germany
,
Markus M. Heimesaat Institute for Microbiology and Hygiene; Charité—University of Medicine; Berlin, Germany
,
Georg Breier Institute of Pathology; University of Technology; Dresden, Germany; DFG Research Center and Cluster of Excellence for Regenerative Therapies; University of Technology; Dresden, Germany
&
Ben Wielockx Institute of Pathology; University of Technology; Dresden, Germany; Emmy Noether Research Group; University of Technology; Dresden, GermanyCorrespondence[email protected]
Pages 216-223 | Received 15 Sep 2011, Accepted 22 Nov 2011, Published online: 15 Feb 2012

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Ana M Meneses & Ben Wielockx. (2016) PHD2: from hypoxia regulation to disease progression. Hypoxia 4, pages 53-67.
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Jonathan Michael Harnoss, Moritz Johannes Strowitzki, Praveen Radhakrishnan, Lisa Katharina Platzer, Julian Camill Harnoss, Thomas Hank, Jun Cai, Alexis Ulrich & Martin Schneider. (2015) Therapeutic inhibition of prolyl hydroxylase domain-containing enzymes in surgery: putative applications and challenges. Hypoxia 3, pages 1-14.
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Xi Ai, Yanhui Wu, Wei Zhang, Zhanguo Zhang, Guannan Jin, Jianping Zhao, Jingjing Yu, Youzhi Lin, Wanguang Zhang, Huifang Liang, Pran K Datta, Mingzhi Zhang, Bixiang Zhang & Xiaoping Chen. (2013) Targeting the ERK pathway reduces liver metastasis of Smad4-inactivated colorectal cancer. Cancer Biology & Therapy 14:11, pages 1059-1067.
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Articles from other publishers (16)

Silvia Strocchi, Francesca Reggiani, Giulia Gobbi, Alessia Ciarrocchi & Valentina Sancisi. (2022) The multifaceted role of EGLN family prolyl hydroxylases in cancer: going beyond HIF regulation. Oncogene 41:29, pages 3665-3679.
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Jimena Druker, James W. Wilson, Fraser Child, Dilem Shakir, Temitope Fasanya & Sonia Rocha. (2021) Role of Hypoxia in the Control of the Cell Cycle. International Journal of Molecular Sciences 22:9, pages 4874.
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Diana Gaete, Diego Rodriguez, Deepika Watts, Sundary Sormendi, Triantafyllos Chavakis & Ben Wielockx. (2021) HIF-Prolyl Hydroxylase Domain Proteins (PHDs) in Cancer—Potential Targets for Anti-Tumor Therapy?. Cancers 13:5, pages 988.
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Anqi Li, Yu Zhang, Zuojun Wang, Hailing Dong, Nange Fu & Xiuzhen Han. (2019) The roles and signaling pathways of prolyl-4-hydroxylase 2 in the tumor microenvironment. Chemico-Biological Interactions 303, pages 40-49.
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Antje Egners, Maryam Rezaei, Aleksandar Kuzmanov, David Poitz, Doreen Streichert, Thomas Mueller-Reichert, Ben Wielockx & Georg Breier. (2018) PHD3 Acts as Tumor Suppressor in Mouse Osteosarcoma and Influences Tumor Vascularization via PDGF-C Signaling. Cancers 10:12, pages 496.
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Anu Laitala & Janine T. Erler. (2018) Hypoxic Signalling in Tumour Stroma. Frontiers in Oncology 8.
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Sundary Sormendi & Ben Wielockx. (2018) Hypoxia Pathway Proteins As Central Mediators of Metabolism in the Tumor Cells and Their Microenvironment. Frontiers in Immunology 9.
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Yifeng Tao, Feng Lin, Ruidong Li, Jie Shen & Zhengxin Wang. (2016) Prolyl hydroxylase-2 inhibits liver tumor cell proliferation and cyclin D1 expression in a hydroxylase-dependent manner. The International Journal of Biochemistry & Cell Biology 77, pages 129-140.
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Chris D Madsen, Jesper T Pedersen, Freja A Venning, Lukram Babloo Singh, Emad Moeendarbary, Guillaume Charras, Thomas R Cox, Erik Sahai & Janine T Erler. (2015) Hypoxia and loss of PHD 2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis . EMBO reports 16:10, pages 1394-1408.
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J. M. García-Heredia, B. Felipe-Abrio, D. A. Cano & A. Carnero. (2014) Genetic modification of hypoxia signaling in animal models and its effect on cancer. Clinical and Translational Oncology 17:2, pages 90-102.
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Li Zhen, Ning Shijie & Zhang Shuijun. (2014) Tumor PHD2 Expression Is Correlated With Clinical Features and Prognosis of Patients With HCC Receiving Liver Resection. Medicine 93:29, pages e179.
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Vaithinathan SelvarajuNarasimham L. ParinandiRam Sudheer AdluriJoshua W. GoldmanNaveed HussainJuan A. SanchezNilanjana Maulik. (2014) Molecular Mechanisms of Action and Therapeutic Uses of Pharmacological Inhibitors of HIF–Prolyl 4-Hydroxylases for Treatment of Ischemic Diseases. Antioxidants & Redox Signaling 20:16, pages 2631-2665.
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Soulafa Mamlouk, Joanna Kalucka, Rashim Pal Singh, Kristin Franke, Antje Muschter, Anika Langer, Christiane Jakob, Max Gassmann, Gustavo B. Baretton & Ben Wielockx. (2014) Loss of prolyl hydroxylase-2 in myeloid cells and T-lymphocytes impairs tumor development. International Journal of Cancer 134:4, pages 849-858.
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Soulafa Mamlouk & Ben Wielockx. (2012) Hypoxia‐inducible factors as key regulators of tumor inflammation. International Journal of Cancer 132:12, pages 2721-2729.
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J. Myllyharju. (2013) Prolyl 4‐hydroxylases, master regulators of the hypoxia response. Acta Physiologica 208:2, pages 148-165.
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Ravi KantAnjana BaliNirmal SinghAmteshwar Singh Jaggi. (2013) Prolyl 4 Hydroxylase: A Critical Target in the Pathophysiology of Diseases. The Korean Journal of Physiology & Pharmacology 17:2, pages 111.
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