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Cancer Biology & Therapy Volume 13, 2012 - Issue 7
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Research Paper

p63 expression correlates with sensitivity to the Eg5 inhibitor AZD4877 in bladder cancer cells

Lauren Marquis Department of Cancer Biology; University of Texas MD Anderson Cancer Center; Houston, TX USA; Graduate School of Biomedical Sciences; University of Texas—Houston; Houston, TX USA
,
Mai Tran Department of Cancer Biology; University of Texas MD Anderson Cancer Center; Houston, TX USA; Graduate School of Biomedical Sciences; University of Texas—Houston; Houston, TX USA
,
Woonyoung Choi Department of Cancer Biology; University of Texas MD Anderson Cancer Center; Houston, TX USA; Department of Urology; University of Texas MD Anderson Cancer Center; Houston, TX USA
,
I-ling Lee Department of Urology; University of Texas MD Anderson Cancer Center; Houston, TX USA
,
Dennis Huszar Astra-Zeneca; Waltham, MA
,
Arlene Siefker-Radtke Department of GU Medical Oncology; University of Texas MD Anderson Cancer Center; Houston, TX USA
,
Colin P. Dinney Department of Cancer Biology; University of Texas MD Anderson Cancer Center; Houston, TX USA; Department of Urology; University of Texas MD Anderson Cancer Center; Houston, TX USA
&
David J. McConkey Department of Cancer Biology; University of Texas MD Anderson Cancer Center; Houston, TX USA; Department of Urology; University of Texas MD Anderson Cancer Center; Houston, TX USA; Graduate School of Biomedical Sciences; University of Texas—Houston; Houston, TX USACorrespondence[email protected]
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Pages 477-486 | Received 05 Aug 2011, Accepted 03 Feb 2012, Published online: 01 May 2012

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Articles from other publishers (14)

Maria Ramal, Sonia Corral, Mark Kalisz, Eleonora Lapi & Francisco X. Real. (2023) The urothelial gene regulatory network: understanding biology to improve bladder cancer management. Oncogene.
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Rinkal Chamariya & Vasanti Suvarna. (2022) Role of KSP Inhibitors as Anti-Cancer Therapeutics: An Update. Anti-Cancer Agents in Medicinal Chemistry 22:14, pages 2517-2538.
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Francesca Sanguedolce, Magda Zanelli, Andrea Palicelli, Stefano Ascani, Maurizio Zizzo, Giorgia Cocco, Lars Björnebo, Anna Lantz, Ugo Giovanni Falagario, Luigi Cormio & Giuseppe Carrieri. (2022) Are We Ready to Implement Molecular Subtyping of Bladder Cancer in Clinical Practice? Part 1: General Issues and Marker Expression. International Journal of Molecular Sciences 23:14, pages 7819.
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Qin Jin, Fang Huang, Xudong Wang, Huijun Zhu, Yun Xian, Jieying Li, Shu Zhang & Qichao Ni. (2017) High Eg5 expression predicts poor prognosis in breast cancer. Oncotarget 8:37, pages 62208-62216.
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Danijel Sikic, Bastian Keck, Sven Wach, Helge Taubert, Bernd Wullich, Peter J. Goebell, Andreas Kahlmeyer, Peter Olbert, Philipp Isfort, Wilhelm Nimphius, Arndt Hartmann & Johannes Giedl. (2017) Immunohistochemiocal subtyping using CK20 and CK5 can identify urothelial carcinomas of the upper urinary tract with a poor prognosis. PLOS ONE 12:6, pages e0179602.
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Beat Roth, Isuru Jayaratna, Debasish Sundi, Tiewei Cheng, Jonathan Melquist, Woonyoung Choi, Sima Porten, Giovanni Nitti, Neema Navai, Matthew Wszolek, Charles Guo, Bogdan Czerniak, David McConkey & Colin Dinney. (2016) Employing an orthotopic model to study the role of epithelial-mesenchymal transition in bladder cancer metastasis. Oncotarget 8:21, pages 34205-34222.
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Meiping Lu, Huijun Zhu, Xudong Wang, Dawei Zhang, Lin Xiong, Li Xu & Yiwen You. (2016) The prognostic role of Eg5 expression in laryngeal squamous cell carcinoma. Pathology 48:3, pages 214-218.
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Rosalyn M. Adam & David J. DeGraff. (2015) Molecular mechanisms of squamous differentiation in urothelial cell carcinoma: A paradigm for molecular subtyping of urothelial cell carcinoma of the bladder. Urologic Oncology: Seminars and Original Investigations 33:10, pages 444-450.
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Gayathri Chandrasekaran, Péter Tátrai & Fanni Gergely. (2015) Hitting the brakes: targeting microtubule motors in cancer. British Journal of Cancer 113:5, pages 693-698.
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David J. McConkey, Woonyoung Choi, Andrea Ochoa, Arlene Siefker-Radtke, Bogdan Czerniak & Colin P.N. Dinney. (2015) Therapeutic Opportunities in the Intrinsic Subtypes of Muscle-Invasive Bladder Cancer. Hematology/Oncology Clinics of North America 29:2, pages 377-394.
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Woonyoung Choi, Sima Porten, Seungchan Kim, Daniel Willis, Elizabeth R. Plimack, Jean Hoffman-Censits, Beat Roth, Tiewei Cheng, Mai Tran, I-Ling Lee, Jonathan Melquist, Jolanta Bondaruk, Tadeusz Majewski, Shizhen Zhang, Shanna Pretzsch, Keith Baggerly, Arlene Siefker-Radtke, Bogdan Czerniak, Colin P.N. Dinney & David J. McConkey. (2014) Identification of Distinct Basal and Luminal Subtypes of Muscle-Invasive Bladder Cancer with Different Sensitivities to Frontline Chemotherapy. Cancer Cell 25:2, pages 152-165.
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Hala Bakr El-Nassan. (2013) Advances in the discovery of kinesin spindle protein (Eg5) inhibitors as antitumor agents. European Journal of Medicinal Chemistry 62, pages 614-631.
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Tiewei Cheng, Beat Roth, Woonyoung Choi, Peter C. Black, Colin Dinney & David J. McConkey. (2013) Fibroblast Growth Factor Receptors-1 and -3 Play Distinct Roles in the Regulation of Bladder Cancer Growth and Metastasis: Implications for Therapeutic Targeting. PLoS ONE 8:2, pages e57284.
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Mai N. Tran, Woonyoung Choi, Matthew F. Wszolek, Neema Navai, I-Ling C. Lee, Giovanni Nitti, Sijin Wen, Elsa R. Flores, Arlene Siefker-Radtke, Bogdan Czerniak, Colin Dinney, Michelle Barton & David J. McConkey. (2013) The p63 Protein Isoform ΔNp63α Inhibits Epithelial-Mesenchymal Transition in Human Bladder Cancer Cells. Journal of Biological Chemistry 288:5, pages 3275-3288.
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