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Cancer Biology & Therapy Volume 13, 2012 - Issue 7
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Research Paper

The chemopreventive and clinically used agent curcumin sensitizes HPV- but not HPV+ HNSCC to ionizing radiation, in vitro and in a mouse orthotopic model

Stephen Tuttle Department of Radiation Oncology; Perelman School of Medicine; University of Pennsylvania, Philadelphia, PA USACorrespondence[email protected] [email protected]
,
Lauren Hertan Department of Radiation Oncology; Perelman School of Medicine; University of Pennsylvania, Philadelphia, PA USA
,
Natalie Daurio Department of Radiation Oncology; Perelman School of Medicine; University of Pennsylvania, Philadelphia, PA USA
,
Sarah Porter Department of Radiation Oncology; Perelman School of Medicine; University of Pennsylvania, Philadelphia, PA USA; SUPERS@PENN Program; Perelman School of Medicine; University of Pennsylvania, Philadelphia, PA USA
,
Charanya Kaushick Department of Radiation Oncology; Perelman School of Medicine; University of Pennsylvania, Philadelphia, PA USA; SUPERS@PENN Program; Perelman School of Medicine; University of Pennsylvania, Philadelphia, PA USA
,
Daqing Li Department of Otorhinolaryngology; Perelman School of Medicine; University of Pennsylvania, Philadelphia, PA USA
,
Shunsuke Myamoto Department of Otorhinolaryngology; Perelman School of Medicine; University of Pennsylvania, Philadelphia, PA USA; Department of Otorhinolarlyngology; Kitasato University School of Medicine; Kanagawa, Japan
,
Alex Lin Department of Radiation Oncology; Perelman School of Medicine; University of Pennsylvania, Philadelphia, PA USA
,
Bert W. O’Malley Department of Otorhinolaryngology; Perelman School of Medicine; University of Pennsylvania, Philadelphia, PA USA
&
Constantinos Koumenis Department of Radiation Oncology; Perelman School of Medicine; University of Pennsylvania, Philadelphia, PA USACorrespondence[email protected] [email protected]
 show all
Pages 575-584 | Received 23 Jan 2012, Accepted 20 Feb 2012, Published online: 01 May 2012

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Katrin Sak. (2020) Radiosensitizing Potential of Curcumin in Different Cancer Models. Nutrition and Cancer 72:8, pages 1276-1289.
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Chengzhi Zhao, Xueer Zhou, Zhiwei Cao, Li Ye, Yubin Cao & Jian Pan. (2023) Curcumin and analogues against head and neck cancer: From drug delivery to molecular mechanisms. Phytomedicine 119, pages 154986.
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Hendrik Setia Budi & Bagher Farhood. (2023) Tumor microenvironment remodeling in oral cancer: Application of plant derived-natural products and nanomaterials. Environmental Research 233, pages 116432.
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Alberto Boretti. (2023) Evidence for the use of curcumin in radioprotection and radiosensitization. Phytotherapy Research.
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Alberto Peraza-Labrador, Diana Marcela Buitrago, Ericsson Coy-Barrera & Sandra J. Perdomo-Lara. (2022) Antiproliferative and Pro-Apoptotic Effects of a Phenolic-Rich Extract from Lycium barbarum Fruits on Human Papillomavirus (HPV) 16-Positive Head Cancer Cell Lines. Molecules 27:11, pages 3568.
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Zhenfan Wang, Shuqing He, Minjun Jiang, Xue Li & Na Chen. (2022) Mechanism Study on Radiosensitization Effect of Curcumin in Bladder Cancer Cells Regulated by Filamin A. Dose-Response 20:2, pages 155932582211009.
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Raghavendra S. Patwardhan, Deepak Sharma & Santosh K. Sandur. (2022) Thioredoxin reductase: An emerging pharmacologic target for radiosensitization of cancer. Translational Oncology 17, pages 101341.
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Gan Huang & Shu-Ting Pan. (2020) ROS-Mediated Therapeutic Strategy in Chemo-/Radiotherapy of Head and Neck Cancer. Oxidative Medicine and Cellular Longevity 2020, pages 1-30.
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Zijian Deng, Xiangkun Xu, Tomas Garzon-Muvdi, Yuanxuan Xia, Eileen Kim, Zineb Belcaid, Andrew Luksik, Russell Maxwell, John Choi, Hailun Wang, Jingjing Yu, Iulian Iordachita, Michael Lim, John W. Wong & Ken Kang-Hsin Wang. (2020) In Vivo Bioluminescence Tomography Center of Mass-Guided Conformal Irradiation. International Journal of Radiation Oncology*Biology*Physics 106:3, pages 612-620.
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Xintong Lyu, Miao Zhang, Guangqi Li, Yiru Cai, Guang Li & Qiao Qiao. (2019) Interleukin‐6 production mediated by the IRE 1‐ XBP 1 pathway confers radioresistance in human papillomavirus‐negative oropharyngeal carcinoma . Cancer Science 110:8, pages 2471-2484.
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Bahare Salehi, Pia Lopez-Jornet, Eduardo Pons-Fuster López, Daniela Calina, Mehdi Sharifi-Rad, Karina Ramírez-Alarcón, Katherine Forman, Marcos Fernández, Miquel Martorell, William Setzer, Natália Martins, Célia Rodrigues & Javad Sharifi-Rad. (2019) Plant-Derived Bioactives in Oral Mucosal Lesions: A Key Emphasis to Curcumin, Lycopene, Chamomile, Aloe vera, Green Tea and Coffee Properties. Biomolecules 9:3, pages 106.
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Miao Zhang, Ning Han, Yuanjun Jiang, Jie Wang, Gaiyan Li, Xintong Lv, Guang Li & Qiao Qiao. (2018) EGFR confers radioresistance in human oropharyngeal carcinoma by activating endoplasmic reticulum stress signaling PERK-eIF2α-GRP94 and IRE1α-XBP1-GRP78. Cancer Medicine 7:12, pages 6234-6246.
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Krzysztof Siemianowicz, Wirginia Likus, Mariola Dorecka, Renata Wilk, Włodzimierz Dziubdziela & Jarosław Markowski. (2018) Chemoprevention of Head and Neck Cancers: Does It Have Only One Face?. BioMed Research International 2018, pages 1-15.
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Kyle Crooker, Rana Aliani, Megha Ananth, Levi Arnold, Shrikant Anant & Sufi Mary Thomas. (2018) A Review of Promising Natural Chemopreventive Agents for Head and Neck Cancer. Cancer Prevention Research 11:8, pages 441-450.
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Katherine S. Williams, Timothy W. Secomb & Ardith W. El-Kareh. (2017) Additive Damage Models for Cellular Pharmacodynamics of Radiation–Chemotherapy Combinations. Bulletin of Mathematical Biology 80:5, pages 1236-1258.
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Chaonan Sun, Chuyang Han, Yuanjun Jiang, Ning Han, Miao Zhang, Guang Li & Qiao Qiao. (2017) Inhibition of GRP78 abrogates radioresistance in oropharyngeal carcinoma cells after EGFR inhibition by cetuximab. PLOS ONE 12:12, pages e0188932.
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Qiao Qiao, Chaonan Sun, Chuyang Han, Ning Han, Miao Zhang & Guang Li. (2017) Endoplasmic reticulum stress pathway PERK-eIF2α confers radioresistance in oropharyngeal carcinoma by activating NF-κB. Cancer Science 108:7, pages 1421-1431.
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Ioannis I. Verginadis, Rahul Kanade, Brett Bell, Sravya Koduri, Edgar Ben-Josef & Constantinos Koumenis. (2017) A Novel Mouse Model to Study Image-Guided, Radiation-Induced Intestinal Injury and Preclinical Screening of Radioprotectors. Cancer Research 77:4, pages 908-917.
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Vicky N. Yamamoto, David S. Thylur, Michael Bauschard, Isaac Schmale & Uttam K. Sinha. (2016) Overcoming radioresistance in head and neck squamous cell carcinoma. Oral Oncology 63, pages 44-51.
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Mario R. Castellanos & Quintin Pan. (2016) Novel p53 therapies for head and neck cancer. World Journal of Otorhinolaryngology - Head and Neck Surgery 2:2, pages 68-75.
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Jharna Datta, Mozaffarul Islam, Samidha Dutta, Sounak Roy, Quintin Pan & Theodoros N. Teknos. (2016) Suberoylanilide hydroxamic acid inhibits growth of head and neck cancer cell lines by reactivation of tumor suppressor microRNAs. Oral Oncology 56, pages 32-39.
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Vivek Verma. (2016) Relationship and interactions of curcumin with radiation therapy. World Journal of Clinical Oncology 7:3, pages 275.
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Fausto Chiesa, Angelo Ostuni, Roberto Grigolato, Luca Calabrese & Mohssen Ansarin. 2016. Head and Neck Cancer. Head and Neck Cancer 59 76 .
Sylwia Gorlach, Jakub Fichna & Urszula Lewandowska. (2015) Polyphenols as mitochondria-targeted anticancer drugs. Cancer Letters 366:2, pages 141-149.
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Alok Mishra & Bhudev C Das. (2015) Curcumin as an anti-human papillomavirus and anti-cancer compound. Future Oncology 11:18, pages 2487-2490.
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Jisha Jayadevan Pillai, Arun Kumar Theralikattu Thulasidasan, Ruby John Anto, Devika Nandan Chithralekha, Ashwanikumar Narayanan & Gopalakrishnapillai Sankaramangalam Kumar. (2014) Folic acid conjugated cross-linked acrylic polymer (FA-CLAP) hydrogel for site specific delivery of hydrophobic drugs to cancer cells. Journal of Nanobiotechnology 12:1.
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Robert Vander Broek, Grace E. Snow, Zhong Chen & Carter Van Waes. (2014) Chemoprevention of head and neck squamous cell carcinoma through inhibition of NF-κB signaling. Oral Oncology 50:10, pages 930-941.
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Y. Zhang & S.G. Martin. (2014) Redox Proteins and Radiotherapy. Clinical Oncology 26:5, pages 289-300.
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Ayelet Zlotogorski, Aliza Dayan, Dan Dayan, Gavriel Chaushu, Tuula Salo & Marilena Vered. (2013) Nutraceuticals as new treatment approaches for oral cancer – I: Curcumin. Oral Oncology 49:3, pages 187-191.
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