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Review

Rapamycins: Mechanisms of Action and Cellular Resistance

Pages 222-232 | Published online: 20 Mar 2003

Keep up to date with the latest research on this topic with citation updates for this article.

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Varadharajan Thiyagarajan, Kuan-Wei Lee, Max K. Leong & Ching-Feng Weng. (2018) Potential natural mTOR inhibitors screened by in silico approach and suppress hepatic stellate cells activation. Journal of Biomolecular Structure and Dynamics 36:16, pages 4220-4234.
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Azam Roohi & Mohammad Hojjat-Farsangi. (2017) Recent advances in targeting mTOR signaling pathway using small molecule inhibitors. Journal of Drug Targeting 25:3, pages 189-201.
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Masaaki Takai, Takatoshi Nakagawa, Akiko Tanabe, Yoshito Terai, Masahide Ohmichi & Michio Asahi. (2015) Crosstalk between PI3K and Ras pathways via protein phosphatase 2A in human ovarian clear cell carcinoma . Cancer Biology & Therapy 16:2, pages 325-335.
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Di Ge, Lei Han, ShuYa Huang, Nan Peng, PengChong Wang, Zheng Jiang, Jing Zhao, Le Su, ShangLi Zhang, Yun Zhang, HsiangFu Kung, BaoXiang Zhao & JunYing Miao. (2014) Identification of a novel MTOR activator and discovery of a competing endogenous RNA regulating autophagy in vascular endothelial cells. Autophagy 10:6, pages 957-971.
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Won-Mo Lee, Ji-Sun Paik, Won-Kyung Cho, Eun-Hye Oh, Seong-Beom Lee & Suk-Woo Yang. (2013) Rapamycin Enhances TNF-α-Induced Secretion of IL-6 and IL-8 through Suppressing PDCD4 Degradation in Orbital Fibroblasts. Current Eye Research 38:6, pages 699-706.
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Rosário Pinto-Leite, Regina Arantes-Rodrigues, Carlos Palmeira, Isabel Gaivão, Maria Luís Cardoso, Aura Colaço, Lúcio Santos & Paula Oliveira. (2012) Everolimus Enhances Gemcitabine-Induced Cytotoxicity in Bladder-Cancer Cell Lines. Journal of Toxicology and Environmental Health, Part A 75:13-15, pages 788-799.
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Ryan D Gentzler, Jessica K Altman & Leonidas C Platanias. (2012) An overview of the mTOR pathway as a target in cancer therapy. Expert Opinion on Therapeutic Targets 16:5, pages 481-489.
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Florian John, Stefan Roffler, Thomas Wicker & Christoph Ringli. (2011) Plant TOR signaling components. Plant Signaling & Behavior 6:11, pages 1700-1705.
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Joseph Gera & Alan Lichtenstein. (2011) The mammalian target of rapamycin pathway as a therapeutic target in multiple myeloma. Leukemia & Lymphoma 52:10, pages 1857-1866.
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Nicolas Picard & Pierre Marquet. (2011) The influence of pharmacogenetics and cofactors on clinical outcomes in kidney transplantation. Expert Opinion on Drug Metabolism & Toxicology 7:6, pages 731-743.
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Philip A. Gruppuso, Joan M. Boylan & Jennifer A. Sanders. (2011) The physiology and pathophysiology of rapamycin resistance. Cell Cycle 10:7, pages 1050-1058.
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Angelica Fasolo & Cristiana Sessa. (2011) Current and future directions in mammalian target of rapamycin inhibitors development. Expert Opinion on Investigational Drugs 20:3, pages 381-394.
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S Allan Schaffer & Heather J Ross. (2010) Everolimus: efficacy and safety in cardiac transplantation. Expert Opinion on Drug Safety 9:5, pages 843-854.
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Justin P Favaro & Daniel J George. (2005) Targeted therapy in renal cell carcinoma. Expert Opinion on Investigational Drugs 14:10, pages 1251-1258.
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Janet E Dancey. (2005) Inhibitors of the mammalian target of rapamycin. Expert Opinion on Investigational Drugs 14:3, pages 313-328.
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Francis J Giles, Hagop Kantarjian & Jorge Cortes. (2004) Novel therapies for patients with chronic myeloid leukemia. Expert Review of Anticancer Therapy 4:2, pages 271-282.
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